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Fusion gene ID: 34956 |
FusionGeneSummary for SMO_STRIP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SMO_STRIP2 | Fusion gene ID: 34956 | Hgene | Tgene | Gene symbol | SMO | STRIP2 | Gene ID | 54498 | 57464 |
| Gene name | spermine oxidase | striatin interacting protein 2 | |
| Synonyms | C20orf16|PAO|PAO-1|PAO1|PAOH|PAOH1|SMO | FAM40B|FAR11B | |
| Cytomap | 20p13 | 7q32.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | spermine oxidaseflavin containing amine oxidaseflavin-containing spermine oxidasepolyamine oxidase 1putative cyclin G1 interacting protein | striatin-interacting protein 2FAR11 factor arrest 11 homolog Bfamily with sequence similarity 40, member Bhomolog of yeast FAR11 protein 2protein FAM40B | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q99835 | Q9ULQ0 | |
| Ensembl transtripts involved in fusion gene | ENST00000249373, | ENST00000249344, ENST00000435494, | |
| Fusion gene scores | * DoF score | 6 X 6 X 3=108 | 3 X 3 X 3=27 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SMO [Title/Abstract] AND STRIP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SMO | GO:0006598 | polyamine catabolic process | 12477380 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | HNSC | TCGA-DQ-7592-01A | SMO | chr7 | 128849238 | + | STRIP2 | chr7 | 129104453 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000249373 | ENST00000249344 | SMO | chr7 | 128849238 | + | STRIP2 | chr7 | 129104453 | + |
| In-frame | ENST00000249373 | ENST00000435494 | SMO | chr7 | 128849238 | + | STRIP2 | chr7 | 129104453 | + |
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FusionProtFeatures for SMO_STRIP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SMO | STRIP2 |
| G protein-coupled receptor that probably associates withthe patched protein (PTCH) to transduce the hedgehog's proteinssignal. Binding of sonic hedgehog (SHH) to its receptor patched isthought to prevent normal inhibition by patched of smoothened(SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in thecilia (PubMed:19592253). Interacts with DLG5 at the ciliary baseto induce the accumulation of KIF7 and GLI2 at the ciliary tip forGLI2 activation (By similarity). {ECO:0000250|UniProtKB:P56726,ECO:0000269|PubMed:19592253}. | Plays a role in the regulation of cell morphology andcytoskeletal organization. Required in the control of cell shape.{ECO:0000269|PubMed:21834987}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SMO | chr7:128849238 | chr7:129104453 | ENST00000249373 | + | 8 | 12 | 65_181 | 488 | 788 | Domain | FZ |
| Hgene | SMO | chr7:128849238 | chr7:129104453 | ENST00000249373 | + | 8 | 12 | 255_262 | 488 | 788 | Topological domain | Cytoplasmic |
| Hgene | SMO | chr7:128849238 | chr7:129104453 | ENST00000249373 | + | 8 | 12 | 284_314 | 488 | 788 | Topological domain | Extracellular |
| Hgene | SMO | chr7:128849238 | chr7:129104453 | ENST00000249373 | + | 8 | 12 | 28_233 | 488 | 788 | Topological domain | Extracellular |
| Hgene | SMO | chr7:128849238 | chr7:129104453 | ENST00000249373 | + | 8 | 12 | 336_358 | 488 | 788 | Topological domain | Cytoplasmic |
| Hgene | SMO | chr7:128849238 | chr7:129104453 | ENST00000249373 | + | 8 | 12 | 380_402 | 488 | 788 | Topological domain | Extracellular |
| Hgene | SMO | chr7:128849238 | chr7:129104453 | ENST00000249373 | + | 8 | 12 | 424_451 | 488 | 788 | Topological domain | Cytoplasmic |
| Hgene | SMO | chr7:128849238 | chr7:129104453 | ENST00000249373 | + | 8 | 12 | 234_254 | 488 | 788 | Transmembrane | Helical%3B Name%3D1 |
| Hgene | SMO | chr7:128849238 | chr7:129104453 | ENST00000249373 | + | 8 | 12 | 263_283 | 488 | 788 | Transmembrane | Helical%3B Name%3D2 |
| Hgene | SMO | chr7:128849238 | chr7:129104453 | ENST00000249373 | + | 8 | 12 | 315_335 | 488 | 788 | Transmembrane | Helical%3B Name%3D3 |
| Hgene | SMO | chr7:128849238 | chr7:129104453 | ENST00000249373 | + | 8 | 12 | 359_379 | 488 | 788 | Transmembrane | Helical%3B Name%3D4 |
| Hgene | SMO | chr7:128849238 | chr7:129104453 | ENST00000249373 | + | 8 | 12 | 403_423 | 488 | 788 | Transmembrane | Helical%3B Name%3D5 |
| Hgene | SMO | chr7:128849238 | chr7:129104453 | ENST00000249373 | + | 8 | 12 | 452_472 | 488 | 788 | Transmembrane | Helical%3B Name%3D6 |
| Tgene | >STRIP2 | chr7:128849238 | chr7:129104453 | ENST00000249344 | + | 14 | 21 | 577_582 | 549 | 835 | Compositional bias | Note=Poly-Leu |
| Tgene | >STRIP2 | chr7:128849238 | chr7:129104453 | ENST00000435494 | + | 14 | 20 | 577_582 | 549 | 759 | Compositional bias | Note=Poly-Leu |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SMO | chr7:128849238 | chr7:129104453 | ENST00000249373 | + | 8 | 12 | 473_524 | 488 | 788 | Topological domain | Extracellular |
| Hgene | >SMO | chr7:128849238 | chr7:129104453 | ENST00000249373 | + | 8 | 12 | 546_787 | 488 | 788 | Topological domain | Cytoplasmic |
| Hgene | >SMO | chr7:128849238 | chr7:129104453 | ENST00000249373 | + | 8 | 12 | 525_545 | 488 | 788 | Transmembrane | Helical%3B Name%3D7 |
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FusionGeneSequence for SMO_STRIP2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SMO_ENST00000249373_chr7_128849238_+_STRIP2_ENST00000249344_chr7_129104453_+_774aa MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATST LLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYV NACFFVGSIGWLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETML RLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLITVLQSMKLGIDVNRHKEIIVKSISTLLLLLLKHFKLNHIYQFEYVSQHLV FANCIPLILKFFNQNILSYITAKNSISVLDYPCCTIQDLPELTTESLEAGDNSQFCWRNLFSCINLLRLLNKLTKWKHSRTMMLVVFKSA PILKRALKVKQAMLQLYVLKLLKLQTKYLGRQWRKSNMKTMSAIYQKVRHRMNDDWAYGNDIDARPWDFQAEECTLRANIEAFNSRRYDR >In-frame_SMO_ENST00000249373_chr7_128849238_+_STRIP2_ENST00000435494_chr7_129104453_+_698aa MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATST LLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYV NACFFVGSIGWLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETML RLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLITVLQSMKLGIDVNRHKEIIVKSISTLLLLLLKHFKLNHIYQFEYVSQHLV FANCIPLILKFFNQNILSYITAKNSISVLDYPCCTIQDLPELTTESLEAGDNSQFCWRNLFSCINLLRLLNKLTKWKHSRTMMLVVFKSA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SMO_ENST00000249373_chr7_128849238_+_STRIP2_ENST00000249344_chr7_129104453_+_2322nt ATGGCCGCTGCCCGCCCAGCGCGGGGGCCGGAGCTCCCGCTCCTGGGGCTGCTGCTGCTGCTGCTGCTGGGGGACCCGGGCCGGGGGGCG GCCTCGAGCGGGAACGCGACCGGGCCTGGGCCTCGGAGCGCGGGCGGGAGCGCGAGGAGGAGCGCGGCGGTGACTGGCCCTCCGCCGCCG CTGAGCCACTGCGGCCGGGCTGCCCCCTGCGAGCCGCTGCGCTACAACGTGTGCCTGGGCTCGGTGCTGCCCTACGGGGCCACCTCCACA CTGCTGGCCGGAGACTCGGACTCCCAGGAGGAAGCGCACGGCAAGCTCGTGCTCTGGTCGGGCCTCCGGAATGCCCCCCGCTGCTGGGCA GTGATCCAGCCCCTGCTGTGTGCCGTATACATGCCCAAGTGTGAGAATGACCGGGTGGAGCTGCCCAGCCGTACCCTCTGCCAGGCCACC CGAGGCCCCTGTGCCATCGTGGAGAGGGAGCGGGGCTGGCCTGACTTCCTGCGCTGCACTCCTGACCGCTTCCCTGAAGGCTGCACGAAT GAGGTGCAGAACATCAAGTTCAACAGTTCAGGCCAGTGCGAAGTGCCCTTGGTTCGGACAGACAACCCCAAGAGCTGGTACGAGGACGTG GAGGGCTGCGGCATCCAGTGCCAGAACCCGCTCTTCACAGAGGCTGAGCACCAGGACATGCACAGCTACATCGCGGCCTTCGGGGCCGTC ACGGGCCTCTGCACGCTCTTCACCCTGGCCACATTCGTGGCTGACTGGCGGAACTCGAATCGCTACCCTGCTGTTATTCTCTTCTACGTC AATGCGTGCTTCTTTGTGGGCAGCATTGGCTGGCTGGCCCAGTTCATGGATGGTGCCCGCCGAGAGATCGTCTGCCGTGCAGATGGCACC ATGAGGCTTGGGGAGCCCACCTCCAATGAGACTCTGTCCTGCGTCATCATCTTTGTCATCGTGTACTACGCCCTGATGGCTGGTGTGGTT TGGTTTGTGGTCCTCACCTATGCCTGGCACACTTCCTTCAAAGCCCTGGGCACCACCTACCAGCCTCTCTCGGGCAAGACCTCCTACTTC CACCTGCTCACCTGGTCACTCCCCTTTGTCCTCACTGTGGCAATCCTTGCTGTGGCGCAGGTGGATGGGGACTCTGTGAGTGGGATTTGT TTTGTGGGCTACAAGAACTACCGATACCGTGCGGGCTTCGTGCTGGCCCCAATCGGCCTGGTGCTCATCGTGGGAGGCTACTTCCTCATC CGAGGAGTCATGACTCTGTTCTCCATCAAGAGCAACCACCCCGGGCTGCTGAGTGAGAAGGCTGCCAGCAAGATCAACGAGACCATGCTG CGCCTGGGCATTTTTGGCTTCCTGGCCTTTGGCTTTGTGCTCATTACCTTCAGCTGCCACTTCTACGACTTCTTCAACCAGGCTGAGTGG GAGCGCAGCTTCCGGGACTATGTGCTCATCACTGTTCTCCAGAGCATGAAGCTGGGCATCGATGTGAACAGGCACAAGGAGATTATTGTA AAGAGTATCTCTACCCTGCTTCTGCTACTCCTCAAACACTTCAAACTCAACCATATCTACCAGTTTGAATATGTATCGCAACATTTGGTA TTTGCCAACTGCATCCCCTTGATCCTGAAGTTCTTCAATCAAAATATCTTGTCATACATCACTGCCAAAAACAGCATCTCAGTCCTGGAT TATCCTTGCTGTACCATCCAGGATTTGCCGGAGCTTACTACTGAAAGTCTGGAAGCTGGAGACAACAGCCAGTTCTGCTGGAGGAACCTC TTTTCCTGCATCAACCTCCTGAGGCTGCTCAATAAACTGACCAAATGGAAACATTCCCGGACCATGATGCTGGTAGTGTTTAAATCGGCA CCAATCTTAAAGCGGGCCCTCAAGGTCAAACAGGCCATGCTGCAACTTTATGTCCTAAAGCTACTAAAGTTACAGACCAAGTACCTGGGG CGCCAATGGAGGAAAAGCAACATGAAAACCATGTCAGCCATTTACCAGAAAGTGCGTCACCGCATGAACGATGACTGGGCTTACGGGAAT GACATCGATGCCAGACCATGGGACTTCCAAGCAGAAGAATGTACCTTGAGGGCCAACATTGAGGCTTTTAACAGCCGTCGCTATGACAGA CCCCAGGACTCTGAGTTTTCACCTGTGGATAACTGCTTGCAGAGCGTACTGGGGCAGAGGTTGGATCTGCCTGAAGATTTCCACTATTCA >In-frame_SMO_ENST00000249373_chr7_128849238_+_STRIP2_ENST00000435494_chr7_129104453_+_2094nt ATGGCCGCTGCCCGCCCAGCGCGGGGGCCGGAGCTCCCGCTCCTGGGGCTGCTGCTGCTGCTGCTGCTGGGGGACCCGGGCCGGGGGGCG GCCTCGAGCGGGAACGCGACCGGGCCTGGGCCTCGGAGCGCGGGCGGGAGCGCGAGGAGGAGCGCGGCGGTGACTGGCCCTCCGCCGCCG CTGAGCCACTGCGGCCGGGCTGCCCCCTGCGAGCCGCTGCGCTACAACGTGTGCCTGGGCTCGGTGCTGCCCTACGGGGCCACCTCCACA CTGCTGGCCGGAGACTCGGACTCCCAGGAGGAAGCGCACGGCAAGCTCGTGCTCTGGTCGGGCCTCCGGAATGCCCCCCGCTGCTGGGCA GTGATCCAGCCCCTGCTGTGTGCCGTATACATGCCCAAGTGTGAGAATGACCGGGTGGAGCTGCCCAGCCGTACCCTCTGCCAGGCCACC CGAGGCCCCTGTGCCATCGTGGAGAGGGAGCGGGGCTGGCCTGACTTCCTGCGCTGCACTCCTGACCGCTTCCCTGAAGGCTGCACGAAT GAGGTGCAGAACATCAAGTTCAACAGTTCAGGCCAGTGCGAAGTGCCCTTGGTTCGGACAGACAACCCCAAGAGCTGGTACGAGGACGTG GAGGGCTGCGGCATCCAGTGCCAGAACCCGCTCTTCACAGAGGCTGAGCACCAGGACATGCACAGCTACATCGCGGCCTTCGGGGCCGTC ACGGGCCTCTGCACGCTCTTCACCCTGGCCACATTCGTGGCTGACTGGCGGAACTCGAATCGCTACCCTGCTGTTATTCTCTTCTACGTC AATGCGTGCTTCTTTGTGGGCAGCATTGGCTGGCTGGCCCAGTTCATGGATGGTGCCCGCCGAGAGATCGTCTGCCGTGCAGATGGCACC ATGAGGCTTGGGGAGCCCACCTCCAATGAGACTCTGTCCTGCGTCATCATCTTTGTCATCGTGTACTACGCCCTGATGGCTGGTGTGGTT TGGTTTGTGGTCCTCACCTATGCCTGGCACACTTCCTTCAAAGCCCTGGGCACCACCTACCAGCCTCTCTCGGGCAAGACCTCCTACTTC CACCTGCTCACCTGGTCACTCCCCTTTGTCCTCACTGTGGCAATCCTTGCTGTGGCGCAGGTGGATGGGGACTCTGTGAGTGGGATTTGT TTTGTGGGCTACAAGAACTACCGATACCGTGCGGGCTTCGTGCTGGCCCCAATCGGCCTGGTGCTCATCGTGGGAGGCTACTTCCTCATC CGAGGAGTCATGACTCTGTTCTCCATCAAGAGCAACCACCCCGGGCTGCTGAGTGAGAAGGCTGCCAGCAAGATCAACGAGACCATGCTG CGCCTGGGCATTTTTGGCTTCCTGGCCTTTGGCTTTGTGCTCATTACCTTCAGCTGCCACTTCTACGACTTCTTCAACCAGGCTGAGTGG GAGCGCAGCTTCCGGGACTATGTGCTCATCACTGTTCTCCAGAGCATGAAGCTGGGCATCGATGTGAACAGGCACAAGGAGATTATTGTA AAGAGTATCTCTACCCTGCTTCTGCTACTCCTCAAACACTTCAAACTCAACCATATCTACCAGTTTGAATATGTATCGCAACATTTGGTA TTTGCCAACTGCATCCCCTTGATCCTGAAGTTCTTCAATCAAAATATCTTGTCATACATCACTGCCAAAAACAGCATCTCAGTCCTGGAT TATCCTTGCTGTACCATCCAGGATTTGCCGGAGCTTACTACTGAAAGTCTGGAAGCTGGAGACAACAGCCAGTTCTGCTGGAGGAACCTC TTTTCCTGCATCAACCTCCTGAGGCTGCTCAATAAACTGACCAAATGGAAACATTCCCGGACCATGATGCTGGTAGTGTTTAAATCGGCA CCAATCTTAAAGCGGGCCCTCAAGGTCAAACAGGCCATGCTGCAACTTTATGTCCTAAAGCTACTAAAGTTACAGACCAAGTACCTGGGG CGCCAATGGAGGAAAAGCAACATGAAAACCATGTCAGCCATTTACCAGAAAGTGCGTCACCGCATGAACGATGACTGGGCTTACGGGAAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SMO_ENST00000249373_chr7_128849238_+_STRIP2_ENST00000249344_chr7_129104453_+_5172nt GGGCTGAAGACAACTTGGATTGCGAGGCTAGGGCTTGGGGAGTCGTGCATCCCGTTCCGGGCCTCCGCAGCCCAACATGGGCCCCGGGTT CCAAAGTTTGCGAAGTTGGGCGCCGAGGGGCCGGGGCGCGCGGAGCGTCCGGGGGGGCCCGGGCCCGGATTCTCTGGGCGCACAGGTCGC CTGAGCCGCCTCCGCGGCCGCCGAGGTCGTGCGTGTGGCCGGGGGGCTCCGAGGAGCAGGCGGGGGCGCCGGGGCTTTTGCTGAGTTGGC GGGGTTGGCCATGGCCGCTGCCCGCCCAGCGCGGGGGCCGGAGCTCCCGCTCCTGGGGCTGCTGCTGCTGCTGCTGCTGGGGGACCCGGG CCGGGGGGCGGCCTCGAGCGGGAACGCGACCGGGCCTGGGCCTCGGAGCGCGGGCGGGAGCGCGAGGAGGAGCGCGGCGGTGACTGGCCC TCCGCCGCCGCTGAGCCACTGCGGCCGGGCTGCCCCCTGCGAGCCGCTGCGCTACAACGTGTGCCTGGGCTCGGTGCTGCCCTACGGGGC CACCTCCACACTGCTGGCCGGAGACTCGGACTCCCAGGAGGAAGCGCACGGCAAGCTCGTGCTCTGGTCGGGCCTCCGGAATGCCCCCCG CTGCTGGGCAGTGATCCAGCCCCTGCTGTGTGCCGTATACATGCCCAAGTGTGAGAATGACCGGGTGGAGCTGCCCAGCCGTACCCTCTG CCAGGCCACCCGAGGCCCCTGTGCCATCGTGGAGAGGGAGCGGGGCTGGCCTGACTTCCTGCGCTGCACTCCTGACCGCTTCCCTGAAGG CTGCACGAATGAGGTGCAGAACATCAAGTTCAACAGTTCAGGCCAGTGCGAAGTGCCCTTGGTTCGGACAGACAACCCCAAGAGCTGGTA CGAGGACGTGGAGGGCTGCGGCATCCAGTGCCAGAACCCGCTCTTCACAGAGGCTGAGCACCAGGACATGCACAGCTACATCGCGGCCTT CGGGGCCGTCACGGGCCTCTGCACGCTCTTCACCCTGGCCACATTCGTGGCTGACTGGCGGAACTCGAATCGCTACCCTGCTGTTATTCT CTTCTACGTCAATGCGTGCTTCTTTGTGGGCAGCATTGGCTGGCTGGCCCAGTTCATGGATGGTGCCCGCCGAGAGATCGTCTGCCGTGC AGATGGCACCATGAGGCTTGGGGAGCCCACCTCCAATGAGACTCTGTCCTGCGTCATCATCTTTGTCATCGTGTACTACGCCCTGATGGC TGGTGTGGTTTGGTTTGTGGTCCTCACCTATGCCTGGCACACTTCCTTCAAAGCCCTGGGCACCACCTACCAGCCTCTCTCGGGCAAGAC CTCCTACTTCCACCTGCTCACCTGGTCACTCCCCTTTGTCCTCACTGTGGCAATCCTTGCTGTGGCGCAGGTGGATGGGGACTCTGTGAG TGGGATTTGTTTTGTGGGCTACAAGAACTACCGATACCGTGCGGGCTTCGTGCTGGCCCCAATCGGCCTGGTGCTCATCGTGGGAGGCTA CTTCCTCATCCGAGGAGTCATGACTCTGTTCTCCATCAAGAGCAACCACCCCGGGCTGCTGAGTGAGAAGGCTGCCAGCAAGATCAACGA GACCATGCTGCGCCTGGGCATTTTTGGCTTCCTGGCCTTTGGCTTTGTGCTCATTACCTTCAGCTGCCACTTCTACGACTTCTTCAACCA GGCTGAGTGGGAGCGCAGCTTCCGGGACTATGTGCTCATCACTGTTCTCCAGAGCATGAAGCTGGGCATCGATGTGAACAGGCACAAGGA GATTATTGTAAAGAGTATCTCTACCCTGCTTCTGCTACTCCTCAAACACTTCAAACTCAACCATATCTACCAGTTTGAATATGTATCGCA ACATTTGGTATTTGCCAACTGCATCCCCTTGATCCTGAAGTTCTTCAATCAAAATATCTTGTCATACATCACTGCCAAAAACAGCATCTC AGTCCTGGATTATCCTTGCTGTACCATCCAGGATTTGCCGGAGCTTACTACTGAAAGTCTGGAAGCTGGAGACAACAGCCAGTTCTGCTG GAGGAACCTCTTTTCCTGCATCAACCTCCTGAGGCTGCTCAATAAACTGACCAAATGGAAACATTCCCGGACCATGATGCTGGTAGTGTT TAAATCGGCACCAATCTTAAAGCGGGCCCTCAAGGTCAAACAGGCCATGCTGCAACTTTATGTCCTAAAGCTACTAAAGTTACAGACCAA GTACCTGGGGCGCCAATGGAGGAAAAGCAACATGAAAACCATGTCAGCCATTTACCAGAAAGTGCGTCACCGCATGAACGATGACTGGGC TTACGGGAATGACATCGATGCCAGACCATGGGACTTCCAAGCAGAAGAATGTACCTTGAGGGCCAACATTGAGGCTTTTAACAGCCGTCG CTATGACAGACCCCAGGACTCTGAGTTTTCACCTGTGGATAACTGCTTGCAGAGCGTACTGGGGCAGAGGTTGGATCTGCCTGAAGATTT CCACTATTCATATGAGCTCTGGCTCGAGAGAGAGGTGTTTTCACAGCCCATCTGTTGGGAGGAGCTGCTCCAGAATCACTGACTAAGTTC TTGTCAACAAGCATCAATAGATAGAGGTCAGCTCCAATAAACTGTGCTCTGCCTACCCTGTCCATACAGGCGCTGTTACCAGTTCAGGGC TCTTCTGGGGGCTCTTGGGCCTAAAGATGGTGCAAGGGTGGGATCCTGAATCACAATAAAATGATCAACTTGCCCTGGGGTCAGTTGGGT GCCCAGTTGGCCTTGGAAATCTTTTGGTGGATCAATTCTAGACAAGCTCTTTGGTAGGACCTTTTCCTGCTTTAGTCTTGGCTACAACCA GGCTAGACTTTGCTGGCTCTAAAAGAGGAAATTTGTTATGGCATTTGACCCATGGCATTCATCACAGATAGTGGGAGGTACAAGTCATAA AATAGGGAGAAAGTTTTCTTCTTGCTCACACTGGATTCCTAGGACTTATCAGAGATTTGGAAAAACCAACTTTGAAATTAAGTTTGCATT TTAAATTTCAAATTTGGAAGCCTCTTTCTGAAATCATTAGCTCTAAGATTATTTTAGAGCACCTGCACCTTCTTTGTGAAGGATGATGAT TTACTATTCCCTCAATACTGCATGTTATCGAAAAGTGTGTTGTGTAAAGTGTTTTTTTCCTCATTCTGTAAGAGATCTATATTCAATGTG AAAATTATTTCCTTGTGTACTCTGTATAGGGCATGGAATGCTCTGCCATTTTTAAAGAGCCACAACCAATATGAAATAATTAGGTCCTCT CTAAGGATGTTTCATGTTTTTCTTAAATGACTCCAGTCTTCAAATGGCTGAGCATACTGCAGAAAATTATCCTTTTCATCTAATTCATTT TTTAAATGACAAGTTAACTACAGGAGGCTTTATTTATTCAGATGGTATGTCCACTTGTGGTCGTGATCAATATATTTTTCTAATTGAAAA GTAAAAGCATCACAGCTTACCATTTTTCTTTTTCTGCAGTGTTGATTAATGATTTTTTTCCCGTTTATTGCTAGCAGTTTCAAAGTGTCA TGTGGAGATTTAGCAATACTGTCTCTACTTAAAAGTATTGCACATTTCATTGAAAATGTGAGAGTTGATATACCAGCCTCTTTATATTTC TCTTTTACAGCAGAATCACATACTTCTCAAGATAAACAAGGTTTTTAAAAAAGTTTCTGATTTAGTTAGGATCATATGCTTTTTTTTTTT TTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTTTCGCTCTTGTTGCCCAAGCTGGAGTGCAATGGCACGATCTCGGCTCACTGCAACCT CCGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGGAGCTGGGATTACAGGCACGCACCACCATGCCTGGCTAATTTTTTG TATTTTTAGTAGAAACAGGGTTTCACCATGTTAGCCAGGCTGACCTCAAACTCCTGACCTCAGGTGATCCGCCCGCCTCCACCTCCCAGG GTGCTGGGATTACAGGTGTGAGCCACCATGCCCAGCCTCTTCAAGCTTTTTTACTATACATGTTGCCCCTCTCCCCCAACTTAGGCACTA CTGAATTTTTTATGATGGCACCAGGTCACTTTATGCTGGGTGATATAGTCAAAATTTGCTTATTTACTCTGCCCCTCGTCAACCACAGTA TCATTTCAAGGACATGAATAAAATACTTGACAGTATCCAAAGGAGCTATACCAAAATCTAACAAGTAAATTTTGGATTTTGCCTCTTTGT GCTTTAAAGTACCAGGATTTCTGTCTCTATGGATAGGTCTTGGAGAATGTTAAGTAATGGATGAAACTTTTTAAAATAATTTGTAAATTT TACCTAAGTAGGACAGTAGTCCTTACTGCAATCAAAATAATTTACTGAGCACAACTCCTGTAAATTAATCTACAGTCAGGCTAGTATGAT TTTAATATGATTTGAGTAAAAAGATAATTTTCAAGGAAAGAGTAATCATCCATCAATTTATTATAAAGCCAGATAGTATTCAATTTATGT CAAGAACAAAGAAATTGCCCTTTTAAAAGCATGTACGTGAATGCTTTTTGAGGCACAGAAGTATGCTAAGCTTTAACATTTTGTATTTAT TTACAACCCTTTTCTAAGGGAAGGTTACTTCTCAGTGCAGATGGAGAAACTGAAGCACTAAGGATAAATGATTAGTTTCCAATCACATCA TTTTTTTCCACAGACTTGCTGGGACTAGCTTTCAGGTATTGACAGCCAGCCCCATATATTAAGGTAACCAGGTTGAATCTTCCAATTTGA GAACCCATGTATGGGTTGCAGTGAGCCGAGATCATGCCACTGCACTCCATCCTGGGCAACAAGAACGAAACTCCGTCTCAAAAACAAAGA AGGATATAATAAAGTTAATATATAAACCATGTATGTGGTTAGGAATAAATTCAAATTCACCAGTCTCCAATGGTGATTACTTTTACTACA TAGAAAAACATTTTAGTGACTTACAGAGGATTTTTATTTGTGAATATTTCAGTAAAGTTTGTGTTGATTGTTGATAACACTGTTCATCTA >In-frame_SMO_ENST00000249373_chr7_128849238_+_STRIP2_ENST00000435494_chr7_129104453_+_2936nt GGGCTGAAGACAACTTGGATTGCGAGGCTAGGGCTTGGGGAGTCGTGCATCCCGTTCCGGGCCTCCGCAGCCCAACATGGGCCCCGGGTT CCAAAGTTTGCGAAGTTGGGCGCCGAGGGGCCGGGGCGCGCGGAGCGTCCGGGGGGGCCCGGGCCCGGATTCTCTGGGCGCACAGGTCGC CTGAGCCGCCTCCGCGGCCGCCGAGGTCGTGCGTGTGGCCGGGGGGCTCCGAGGAGCAGGCGGGGGCGCCGGGGCTTTTGCTGAGTTGGC GGGGTTGGCCATGGCCGCTGCCCGCCCAGCGCGGGGGCCGGAGCTCCCGCTCCTGGGGCTGCTGCTGCTGCTGCTGCTGGGGGACCCGGG CCGGGGGGCGGCCTCGAGCGGGAACGCGACCGGGCCTGGGCCTCGGAGCGCGGGCGGGAGCGCGAGGAGGAGCGCGGCGGTGACTGGCCC TCCGCCGCCGCTGAGCCACTGCGGCCGGGCTGCCCCCTGCGAGCCGCTGCGCTACAACGTGTGCCTGGGCTCGGTGCTGCCCTACGGGGC CACCTCCACACTGCTGGCCGGAGACTCGGACTCCCAGGAGGAAGCGCACGGCAAGCTCGTGCTCTGGTCGGGCCTCCGGAATGCCCCCCG CTGCTGGGCAGTGATCCAGCCCCTGCTGTGTGCCGTATACATGCCCAAGTGTGAGAATGACCGGGTGGAGCTGCCCAGCCGTACCCTCTG CCAGGCCACCCGAGGCCCCTGTGCCATCGTGGAGAGGGAGCGGGGCTGGCCTGACTTCCTGCGCTGCACTCCTGACCGCTTCCCTGAAGG CTGCACGAATGAGGTGCAGAACATCAAGTTCAACAGTTCAGGCCAGTGCGAAGTGCCCTTGGTTCGGACAGACAACCCCAAGAGCTGGTA CGAGGACGTGGAGGGCTGCGGCATCCAGTGCCAGAACCCGCTCTTCACAGAGGCTGAGCACCAGGACATGCACAGCTACATCGCGGCCTT CGGGGCCGTCACGGGCCTCTGCACGCTCTTCACCCTGGCCACATTCGTGGCTGACTGGCGGAACTCGAATCGCTACCCTGCTGTTATTCT CTTCTACGTCAATGCGTGCTTCTTTGTGGGCAGCATTGGCTGGCTGGCCCAGTTCATGGATGGTGCCCGCCGAGAGATCGTCTGCCGTGC AGATGGCACCATGAGGCTTGGGGAGCCCACCTCCAATGAGACTCTGTCCTGCGTCATCATCTTTGTCATCGTGTACTACGCCCTGATGGC TGGTGTGGTTTGGTTTGTGGTCCTCACCTATGCCTGGCACACTTCCTTCAAAGCCCTGGGCACCACCTACCAGCCTCTCTCGGGCAAGAC CTCCTACTTCCACCTGCTCACCTGGTCACTCCCCTTTGTCCTCACTGTGGCAATCCTTGCTGTGGCGCAGGTGGATGGGGACTCTGTGAG TGGGATTTGTTTTGTGGGCTACAAGAACTACCGATACCGTGCGGGCTTCGTGCTGGCCCCAATCGGCCTGGTGCTCATCGTGGGAGGCTA CTTCCTCATCCGAGGAGTCATGACTCTGTTCTCCATCAAGAGCAACCACCCCGGGCTGCTGAGTGAGAAGGCTGCCAGCAAGATCAACGA GACCATGCTGCGCCTGGGCATTTTTGGCTTCCTGGCCTTTGGCTTTGTGCTCATTACCTTCAGCTGCCACTTCTACGACTTCTTCAACCA GGCTGAGTGGGAGCGCAGCTTCCGGGACTATGTGCTCATCACTGTTCTCCAGAGCATGAAGCTGGGCATCGATGTGAACAGGCACAAGGA GATTATTGTAAAGAGTATCTCTACCCTGCTTCTGCTACTCCTCAAACACTTCAAACTCAACCATATCTACCAGTTTGAATATGTATCGCA ACATTTGGTATTTGCCAACTGCATCCCCTTGATCCTGAAGTTCTTCAATCAAAATATCTTGTCATACATCACTGCCAAAAACAGCATCTC AGTCCTGGATTATCCTTGCTGTACCATCCAGGATTTGCCGGAGCTTACTACTGAAAGTCTGGAAGCTGGAGACAACAGCCAGTTCTGCTG GAGGAACCTCTTTTCCTGCATCAACCTCCTGAGGCTGCTCAATAAACTGACCAAATGGAAACATTCCCGGACCATGATGCTGGTAGTGTT TAAATCGGCACCAATCTTAAAGCGGGCCCTCAAGGTCAAACAGGCCATGCTGCAACTTTATGTCCTAAAGCTACTAAAGTTACAGACCAA GTACCTGGGGCGCCAATGGAGGAAAAGCAACATGAAAACCATGTCAGCCATTTACCAGAAAGTGCGTCACCGCATGAACGATGACTGGGC TTACGGGAATGGTGAGTCTTCCCAAAGCTCTTGACTTCCTGGAGTTTCCTGGGGTTTAGACAAAACTAAATAAATATTTATCACTCCTCT TTTGGCATGAATTGTTACATATTTTAGATGAAAAAATATGTGATTATAGGTCAGGCGCTGATACACCAAACTTTAAGGTTATGCCTCAAA TTCTAGTATGTACCCTTGTCCTATGTAAACTATGAAAATCCGTTTTATAAAACAAGTAAATTGAGAGATAATTAATTGCCTTTCCAAAAC ATTCTTTTAAATGACAGCTTTCTCCAAAAGATTTAAATTAAAACAACTTTTTATTATTACAAAGCAGTTAGAAAAAAAGATAGAAAATAC AAGTAAACAAACATTTTACTATATTATATTTATGCCATATTTGTACTATGCAGAAATTGCCACCATTAACATCTTATTGTATATTCCTCC AGATCTTTTTCTATGCATATACATGCATATTTTATCAAAATGAAAGCAAGTTATGTATGCTATTTTGTAATTTTCTCTTTTAACATTATC |
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FusionGenePPI for SMO_STRIP2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SMO | PTCH1, PTCH2, BCL6, NEDD4, CHEK1, ATM, KIT, FAM189B | STRIP2 | CTTNBP2, CTTNBP2NL, STRIP1, MOB4, STK26, SIKE1, STK24, STK25, STRN, STRN3, TRAF3IP3, ZRANB1, APP, PPP2CB, SLMAP, PPP2CA, FGFR1OP2, PRDM14 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | SMO | chr7:128849238 | chr7:129104453 | ENST00000249373 | + | 8 | 12 | 538_569 | 488 | 788 | BBS5 and BBS7 |
| Hgene | SMO | chr7:128849238 | chr7:129104453 | ENST00000249373 | + | 8 | 12 | 581_593 | 488 | 788 | DLG5 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SMO_STRIP2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | SMO | Q99835 | DB01047 | Fluocinonide | Smoothened homolog | small molecule | approved|investigational |
| Hgene | SMO | Q99835 | DB08828 | Vismodegib | Smoothened homolog | small molecule | approved|investigational |
| Hgene | SMO | Q99835 | DB09143 | Sonidegib | Smoothened homolog | small molecule | approved|investigational |
| Hgene | SMO | Q99835 | DB06786 | Halcinonide | Smoothened homolog | small molecule | approved|investigational|withdrawn |
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RelatedDiseases for SMO_STRIP2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SMO | C0007117 | Basal cell carcinoma | 2 | CTD_human;HPO |
| Hgene | SMO | C0002448 | Ameloblastoma | 1 | CTD_human |
| Hgene | SMO | C0006118 | Brain Neoplasms | 1 | CTD_human |
| Hgene | SMO | C0022360 | Jaw Abnormalities | 1 | CTD_human |
| Hgene | SMO | C0023487 | Acute Promyelocytic Leukemia | 1 | CTD_human |
| Hgene | SMO | C0024954 | Maxillary Neoplasms | 1 | CTD_human |
| Hgene | SMO | C0025286 | Meningioma | 1 | CTD_human |
| Hgene | SMO | C0037286 | Skin Neoplasms | 1 | CTD_human |
| Hgene | SMO | C0206663 | Neuroectodermal Tumor, Primitive | 1 | CTD_human |
| Hgene | SMO | C0795915 | Winter Shortland Temple syndrome | 1 | ORPHANET;UNIPROT |
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