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Fusion gene ID: 34912 |
FusionGeneSummary for SMG6_SHPK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SMG6_SHPK | Fusion gene ID: 34912 | Hgene | Tgene | Gene symbol | SMG6 | SHPK | Gene ID | 23293 | 23729 |
| Gene name | SMG6, nonsense mediated mRNA decay factor | sedoheptulokinase | |
| Synonyms | C17orf31|EST1A|SMG-6|hSMG5/7a | CARKL|SHK | |
| Cytomap | 17p13.3 | 17p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | telomerase-binding protein EST1AEST1 telomerase component homolog Aever shorter telomeres 1Asmg-6 homolog, nonsense mediated mRNA decay factortelomerase subunit EST1A | sedoheptulokinasecarbohydrate kinase-like protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q86US8 | Q9UHJ6 | |
| Ensembl transtripts involved in fusion gene | ENST00000544865, ENST00000263073, ENST00000354901, ENST00000536871, ENST00000573166, | ENST00000225519, ENST00000572705, | |
| Fusion gene scores | * DoF score | 12 X 8 X 5=480 | 2 X 2 X 2=8 |
| # samples | 12 | 2 | |
| ** MAII score | log2(12/480*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: SMG6 [Title/Abstract] AND SHPK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SMG6 | GO:1904354 | negative regulation of telomere capping | 12676087 |
| Tgene | SHPK | GO:0005975 | carbohydrate metabolic process | 19413330 |
| Tgene | SHPK | GO:0016310 | phosphorylation | 19413330 |
| Tgene | SHPK | GO:0071222 | cellular response to lipopolysaccharide | 22682222 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-HC-8265-01B | SMG6 | chr17 | 2139786 | - | SHPK | chr17 | 3518831 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000544865 | ENST00000225519 | SMG6 | chr17 | 2139786 | - | SHPK | chr17 | 3518831 | - |
| 5CDS-intron | ENST00000544865 | ENST00000572705 | SMG6 | chr17 | 2139786 | - | SHPK | chr17 | 3518831 | - |
| In-frame | ENST00000263073 | ENST00000225519 | SMG6 | chr17 | 2139786 | - | SHPK | chr17 | 3518831 | - |
| 5CDS-intron | ENST00000263073 | ENST00000572705 | SMG6 | chr17 | 2139786 | - | SHPK | chr17 | 3518831 | - |
| In-frame | ENST00000354901 | ENST00000225519 | SMG6 | chr17 | 2139786 | - | SHPK | chr17 | 3518831 | - |
| 5CDS-intron | ENST00000354901 | ENST00000572705 | SMG6 | chr17 | 2139786 | - | SHPK | chr17 | 3518831 | - |
| In-frame | ENST00000536871 | ENST00000225519 | SMG6 | chr17 | 2139786 | - | SHPK | chr17 | 3518831 | - |
| 5CDS-intron | ENST00000536871 | ENST00000572705 | SMG6 | chr17 | 2139786 | - | SHPK | chr17 | 3518831 | - |
| intron-3CDS | ENST00000573166 | ENST00000225519 | SMG6 | chr17 | 2139786 | - | SHPK | chr17 | 3518831 | - |
| intron-intron | ENST00000573166 | ENST00000572705 | SMG6 | chr17 | 2139786 | - | SHPK | chr17 | 3518831 | - |
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FusionProtFeatures for SMG6_SHPK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SMG6 | SHPK |
| Component of the telomerase ribonucleoprotein (RNP)complex that is essential for the replication of chromosometermini. May have a general role in telomere regulation. Promotesin vitro the ability of TERT to elongate telomeres. Overexpressioninduces telomere uncapping, chromosomal end-to-end fusions(telomeric DNA persists at the fusion points) and did not perturbTRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNAtemplate component (TER). Plays a role in nonsense-mediated mRNA decay. Is thoughtto provide a link to the mRNA degradation machinery as it hasendonuclease activity required to initiate NMD, and to serve as anadapter for UPF1 to protein phosphatase 2A (PP2A), therebytriggering UPF1 dephosphorylation. Degrades single-stranded RNA(ssRNA), but not ssDNA or dsRNA. | Acts as a modulator of macrophage activation throughcontrol of glucose metabolism. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SMG6 | chr17:2139786 | chr17:3518831 | ENST00000263073 | - | 10 | 19 | 163_193 | 956 | 1420 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SMG6 | chr17:2139786 | chr17:3518831 | ENST00000263073 | - | 10 | 19 | 567_625 | 956 | 1420 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SMG6 | chr17:2139786 | chr17:3518831 | ENST00000544865 | - | 10 | 19 | 163_193 | 925 | 1389 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SMG6 | chr17:2139786 | chr17:3518831 | ENST00000544865 | - | 10 | 19 | 567_625 | 925 | 1389 | Coiled coil | Ontology_term=ECO:0000255 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SMG6 | chr17:2139786 | chr17:3518831 | ENST00000263073 | - | 10 | 19 | 1197_1239 | 956 | 1420 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SMG6 | chr17:2139786 | chr17:3518831 | ENST00000354901 | - | 3 | 12 | 1197_1239 | 48 | 512 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SMG6 | chr17:2139786 | chr17:3518831 | ENST00000354901 | - | 3 | 12 | 163_193 | 48 | 512 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SMG6 | chr17:2139786 | chr17:3518831 | ENST00000354901 | - | 3 | 12 | 567_625 | 48 | 512 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SMG6 | chr17:2139786 | chr17:3518831 | ENST00000536871 | - | 2 | 11 | 1197_1239 | 48 | 512 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SMG6 | chr17:2139786 | chr17:3518831 | ENST00000536871 | - | 2 | 11 | 163_193 | 48 | 512 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SMG6 | chr17:2139786 | chr17:3518831 | ENST00000536871 | - | 2 | 11 | 567_625 | 48 | 512 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SMG6 | chr17:2139786 | chr17:3518831 | ENST00000544865 | - | 10 | 19 | 1197_1239 | 925 | 1389 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SMG6 | chr17:2139786 | chr17:3518831 | ENST00000263073 | - | 10 | 19 | 1246_1397 | 956 | 1420 | Domain | Note=PINc |
| Hgene | >SMG6 | chr17:2139786 | chr17:3518831 | ENST00000354901 | - | 3 | 12 | 1246_1397 | 48 | 512 | Domain | Note=PINc |
| Hgene | >SMG6 | chr17:2139786 | chr17:3518831 | ENST00000536871 | - | 2 | 11 | 1246_1397 | 48 | 512 | Domain | Note=PINc |
| Hgene | >SMG6 | chr17:2139786 | chr17:3518831 | ENST00000544865 | - | 10 | 19 | 1246_1397 | 925 | 1389 | Domain | Note=PINc |
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FusionGeneSequence for SMG6_SHPK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SMG6_ENST00000544865_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_1130aa MKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSAVENGTQPVKDVCKELNNQEQNGPIDPENNRGQESF PRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEVANKPDRAEIEKSPGGGRVGA AKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSST DSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMNKESPMVRSARDDMDRGKPDKGLSSGGKGSEK QESKNPKQELRGRGRGILILPAHTTLSVNSAGSPESAPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDTDD EVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYPGPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQ HMRNLQQQELHRLLRVADNQELQLSNLLSRDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVKD PNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRCMICQGDIARYREQASDTANYGKA RSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKKS TFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSP SPIGSTRMLQLMTINMFAVHNSQLKVLNISTSVQLAASMPSGFQPAQTPDPTAPVAYFPYFNRTYLGVAASLNGGNVLATFVHMLVQWMA DLGLEVEESTVYSRMIQAAVQQRDTHLTITPTVLGERHLPDQLASVTRISSSDLSLGHVTRALCRGIVQNLHSMLPIQQLQDWGVERVMG >In-frame_SMG6_ENST00000263073_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_1161aa MAEGLERVRISASELRGILATLAPQAGSRENMKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSAVENG TQPVKDVCKELNNQEQNGPIDPENNRGQESFPRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEED ECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEG AGLTDNGCRRRRQDRTKERPRLKKQVSVSSTDSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMN KESPMVRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQELRGRGRGILILPAHTTLSVNSAGSPESAPLGPRLLFGSGSKGSRSWGRGG TTRRLWDPNNPDQKPALKTQTPQLHFLDTDDEVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYP GPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQHMRNLQQQELHRLLRVADNQELQLSNLLSRDRISPEGLEKMAQLRAELLQLYERCILLD IEFSDNQNVDQILWKNAFYQVIEKFRQLVKDPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKY ALISAQRCMICQGDIARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLF EETKRKAEQMEKKQHEEFDLSPDQWRKGKKSTFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAH GKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKVLNISTSVQLAASMPSGFQPAQTPDPTAPVAYFP YFNRTYLGVAASLNGGNVLATFVHMLVQWMADLGLEVEESTVYSRMIQAAVQQRDTHLTITPTVLGERHLPDQLASVTRISSSDLSLGHV >In-frame_SMG6_ENST00000354901_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_253aa METFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKVLNISTSVQLAASMPSGFQPAQTPDPTAPVAYFPYFNRTYLG VAASLNGGNVLATFVHMLVQWMADLGLEVEESTVYSRMIQAAVQQRDTHLTITPTVLGERHLPDQLASVTRISSSDLSLGHVTRALCRGI >In-frame_SMG6_ENST00000536871_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_253aa METFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKVLNISTSVQLAASMPSGFQPAQTPDPTAPVAYFPYFNRTYLG VAASLNGGNVLATFVHMLVQWMADLGLEVEESTVYSRMIQAAVQQRDTHLTITPTVLGERHLPDQLASVTRISSSDLSLGHVTRALCRGI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SMG6_ENST00000544865_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_3390nt ATGAAGGAATTAAAGGAGGCCAGGCCGCGCAAAGATAACAGGCGTCCAGATCTGGAAATCTATAAGCCTGGCCTTTCTCGGCTAAGGAAC AAGCCCAAAATCAAGGAACCCCCTGGGAGTGAGGAATTCAAAGATGAAATTGTTAATGACCGAGATTGCTCTGCTGTTGAAAATGGTACA CAGCCCGTTAAAGATGTCTGCAAGGAACTGAACAACCAAGAGCAGAATGGTCCTATAGACCCAGAAAATAATCGGGGACAAGAATCCTTT CCTAGGACTGCTGGACAAGAGGATCGTAGTCTAAAAATTATCAAAAGAACAAAGAAACCCGACCTGCAGATCTATCAGCCTGGACGACGT TTGCAGACTGTTAGCAAAGAATCCGCCAGTCGGGTGGAGGAGGAAGAAGTCCTCAACCAGGTAGAACAACTGAGAGTAGAGGAAGATGAG TGTAGGGGAAATGTTGCGAAGGAGGAAGTTGCGAATAAACCAGACAGGGCTGAGATAGAAAAGAGCCCAGGTGGTGGGAGAGTAGGGGCT GCAAAAGGAGAAAAAGGAAAGAGGATGGGAAAAGGGGAGGGGGTGAGGGAAACCCACGACGACCCAGCCCGCGGGAGGCCGGGCTCCGCA AAGCGCTACTCCCGCTCAGACAAACGAAGGAATCGCTACCGCACGCGCAGCACCAGCTCAGCTGGCAGCAACAACAGCGCTGAGGGAGCT GGCCTGACGGATAATGGATGTCGCCGCCGCCGACAGGATAGGACCAAGGAGAGGCCACGACTGAAGAAGCAAGTGTCTGTGTCCTCAACC GATTCCTTAGACGAGGACAGAATTGATGAGCCTGATGGATTAGGACCCAGGAGAAGTTCAGAAAGGAAGAGACATTTAGAAAGAAACTGG TCTGGCCGTGGGGAGGGTGAGCAGAAAAACAGTGCTAAAGAATATCGAGGCACTCTTCGTGTCACTTTCGATGCAGAAGCCATGAACAAA GAGTCTCCCATGGTGAGGTCAGCCAGGGATGATATGGATAGAGGAAAGCCTGACAAAGGCTTGAGCAGTGGGGGCAAAGGCTCTGAGAAG CAGGAGTCCAAAAACCCGAAACAAGAACTTCGGGGTCGTGGTCGTGGCATTCTGATTTTGCCTGCCCATACCACCCTATCTGTCAATTCA GCAGGTTCTCCAGAGTCCGCGCCTTTGGGACCTCGGCTTTTGTTTGGATCTGGTAGTAAGGGATCTCGGAGTTGGGGCCGTGGAGGCACC ACACGCCGATTGTGGGACCCAAACAATCCTGATCAGAAACCTGCTCTAAAGACTCAGACGCCCCAGCTACATTTCTTGGACACTGATGAT GAAGTCAGCCCTACATCTTGGGGTGACTCACGCCAGGCTCAGGCATCTTACTATAAGTTTCAAAACTCTGACAACCCCTATTATTACCCC CGGACACCAGGCCCTGCCTCCCAGTATCCCTATACGGGCTATAACCCTCTACAGTACCCAGTGGGCCCTACGAATGGTGTGTACCCAGGG CCTTACTACCCAGGCTACCCGACTCCGTCAGGACAGTATGTGTGTAGCCCTCTACCTACCAGCACCATGAGTCCCGAGGAGGTAGAGCAG CACATGAGGAACCTGCAGCAACAGGAGCTGCACAGGCTTCTCCGGGTGGCTGACAACCAGGAACTGCAGCTCAGCAACCTGCTCTCCAGG GACCGCATCAGTCCGGAGGGCCTGGAGAAGATGGCGCAACTCAGAGCTGAACTGCTGCAGCTATATGAGCGCTGTATTCTATTAGATATT GAGTTCTCTGATAATCAGAATGTGGATCAGATCCTGTGGAAGAATGCTTTCTATCAGGTGATTGAGAAGTTCAGGCAACTTGTCAAGGAT CCGAATGTTGAGAACCCAGAACAGATTCGGAACAGACTTTTGGAGCTCTTGGATGAGGGTAGTGACTTCTTTGATAGTTTGCTTCAGAAG CTGCAGGTTACTTACAAGTTCAAACTGGAAGACTACATGGATGGTCTTGCCATTCGCAGCAAGCCATTACGCAAGACAGTAAAATATGCC TTGATCAGTGCCCAGCGATGCATGATATGCCAAGGAGATATTGCTAGGTACCGGGAGCAAGCCAGTGATACAGCGAATTATGGGAAAGCA CGCAGTTGGTACCTGAAGGCCCAGCACATTGCTCCCAAGAATGGGCGCCCCTATAACCAGTTGGCTTTGCTGGCAGTGTATACGAGGAGG AAGCTTGACGCTGTCTATTACTATATGCGCAGTTTAGCTGCCAGCAACCCTATCCTGACTGCCAAGGAGAGTCTCATGAGCTTGTTTGAA GAGACCAAGCGGAAGGCAGAACAGATGGAAAAGAAGCAACATGAGGAATTTGACCTGAGCCCTGACCAGTGGCGGAAAGGAAAGAAGTCT ACTTTCCGGCATGTTGGAGATGACACCACTCGCCTGGAGATCTGGATTCATCCATCCCATCCACGGTCTTCCCAGGGCACTGAGTCTGGG AAGGATTCTGAGCAAGAGAATGGGCTGGGCAGCCTGAGTCCCAGTGATCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCATGGG AAGCTGTTTACCCGGATTGGGATGGAGACATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCC TCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGTTCTCAACATCAGC ACCTCGGTTCAGCTGGCAGCCTCCATGCCTTCAGGATTCCAGCCTGCACAGACTCCAGACCCTACGGCCCCAGTCGCCTACTTCCCATAC TTCAACAGGACCTACCTGGGGGTGGCCGCGTCACTCAACGGGGGCAATGTGCTGGCCACGTTCGTCCACATGCTGGTTCAGTGGATGGCA GATCTAGGCCTGGAGGTTGAAGAATCCACTGTGTATTCACGCATGATTCAGGCAGCTGTGCAGCAGAGAGATACCCACCTGACCATCACC CCGACAGTGCTGGGGGAGAGGCACCTGCCGGACCAGCTGGCCTCAGTGACCAGAATCTCCTCCTCCGACCTCTCCCTGGGGCACGTGACC CGGGCTCTGTGCCGAGGCATTGTTCAGAACCTGCACTCCATGCTTCCGATTCAGCAGCTCCAGGACTGGGGCGTGGAGAGGGTGATGGGC AGTGGGAGTGCGCTGTCCAGGAATGACGTGCTGAAGCAGGAGGTGCAGAGGGCTTTCCCTTTGCCCATGTCCTTTGGGCAGGATGTGGAT >In-frame_SMG6_ENST00000263073_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_3483nt ATGGCGGAAGGGCTGGAGCGTGTGCGGATCTCCGCGTCGGAGCTGCGCGGGATCCTGGCTACTCTGGCCCCGCAGGCCGGGAGCAGAGAA AACATGAAGGAATTAAAGGAGGCCAGGCCGCGCAAAGATAACAGGCGTCCAGATCTGGAAATCTATAAGCCTGGCCTTTCTCGGCTAAGG AACAAGCCCAAAATCAAGGAACCCCCTGGGAGTGAGGAATTCAAAGATGAAATTGTTAATGACCGAGATTGCTCTGCTGTTGAAAATGGT ACACAGCCCGTTAAAGATGTCTGCAAGGAACTGAACAACCAAGAGCAGAATGGTCCTATAGACCCAGAAAATAATCGGGGACAAGAATCC TTTCCTAGGACTGCTGGACAAGAGGATCGTAGTCTAAAAATTATCAAAAGAACAAAGAAACCCGACCTGCAGATCTATCAGCCTGGACGA CGTTTGCAGACTGTTAGCAAAGAATCCGCCAGTCGGGTGGAGGAGGAAGAAGTCCTCAACCAGGTAGAACAACTGAGAGTAGAGGAAGAT GAGTGTAGGGGAAATGTTGCGAAGGAGGAAGTTGCGAATAAACCAGACAGGGCTGAGATAGAAAAGAGCCCAGGTGGTGGGAGAGTAGGG GCTGCAAAAGGAGAAAAAGGAAAGAGGATGGGAAAAGGGGAGGGGGTGAGGGAAACCCACGACGACCCAGCCCGCGGGAGGCCGGGCTCC GCAAAGCGCTACTCCCGCTCAGACAAACGAAGGAATCGCTACCGCACGCGCAGCACCAGCTCAGCTGGCAGCAACAACAGCGCTGAGGGA GCTGGCCTGACGGATAATGGATGTCGCCGCCGCCGACAGGATAGGACCAAGGAGAGGCCACGACTGAAGAAGCAAGTGTCTGTGTCCTCA ACCGATTCCTTAGACGAGGACAGAATTGATGAGCCTGATGGATTAGGACCCAGGAGAAGTTCAGAAAGGAAGAGACATTTAGAAAGAAAC TGGTCTGGCCGTGGGGAGGGTGAGCAGAAAAACAGTGCTAAAGAATATCGAGGCACTCTTCGTGTCACTTTCGATGCAGAAGCCATGAAC AAAGAGTCTCCCATGGTGAGGTCAGCCAGGGATGATATGGATAGAGGAAAGCCTGACAAAGGCTTGAGCAGTGGGGGCAAAGGCTCTGAG AAGCAGGAGTCCAAAAACCCGAAACAAGAACTTCGGGGTCGTGGTCGTGGCATTCTGATTTTGCCTGCCCATACCACCCTATCTGTCAAT TCAGCAGGTTCTCCAGAGTCCGCGCCTTTGGGACCTCGGCTTTTGTTTGGATCTGGTAGTAAGGGATCTCGGAGTTGGGGCCGTGGAGGC ACCACACGCCGATTGTGGGACCCAAACAATCCTGATCAGAAACCTGCTCTAAAGACTCAGACGCCCCAGCTACATTTCTTGGACACTGAT GATGAAGTCAGCCCTACATCTTGGGGTGACTCACGCCAGGCTCAGGCATCTTACTATAAGTTTCAAAACTCTGACAACCCCTATTATTAC CCCCGGACACCAGGCCCTGCCTCCCAGTATCCCTATACGGGCTATAACCCTCTACAGTACCCAGTGGGCCCTACGAATGGTGTGTACCCA GGGCCTTACTACCCAGGCTACCCGACTCCGTCAGGACAGTATGTGTGTAGCCCTCTACCTACCAGCACCATGAGTCCCGAGGAGGTAGAG CAGCACATGAGGAACCTGCAGCAACAGGAGCTGCACAGGCTTCTCCGGGTGGCTGACAACCAGGAACTGCAGCTCAGCAACCTGCTCTCC AGGGACCGCATCAGTCCGGAGGGCCTGGAGAAGATGGCGCAACTCAGAGCTGAACTGCTGCAGCTATATGAGCGCTGTATTCTATTAGAT ATTGAGTTCTCTGATAATCAGAATGTGGATCAGATCCTGTGGAAGAATGCTTTCTATCAGGTGATTGAGAAGTTCAGGCAACTTGTCAAG GATCCGAATGTTGAGAACCCAGAACAGATTCGGAACAGACTTTTGGAGCTCTTGGATGAGGGTAGTGACTTCTTTGATAGTTTGCTTCAG AAGCTGCAGGTTACTTACAAGTTCAAACTGGAAGACTACATGGATGGTCTTGCCATTCGCAGCAAGCCATTACGCAAGACAGTAAAATAT GCCTTGATCAGTGCCCAGCGATGCATGATATGCCAAGGAGATATTGCTAGGTACCGGGAGCAAGCCAGTGATACAGCGAATTATGGGAAA GCACGCAGTTGGTACCTGAAGGCCCAGCACATTGCTCCCAAGAATGGGCGCCCCTATAACCAGTTGGCTTTGCTGGCAGTGTATACGAGG AGGAAGCTTGACGCTGTCTATTACTATATGCGCAGTTTAGCTGCCAGCAACCCTATCCTGACTGCCAAGGAGAGTCTCATGAGCTTGTTT GAAGAGACCAAGCGGAAGGCAGAACAGATGGAAAAGAAGCAACATGAGGAATTTGACCTGAGCCCTGACCAGTGGCGGAAAGGAAAGAAG TCTACTTTCCGGCATGTTGGAGATGACACCACTCGCCTGGAGATCTGGATTCATCCATCCCATCCACGGTCTTCCCAGGGCACTGAGTCT GGGAAGGATTCTGAGCAAGAGAATGGGCTGGGCAGCCTGAGTCCCAGTGATCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCAT GGGAAGCTGTTTACCCGGATTGGGATGGAGACATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGC CCCTCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGTTCTCAACATC AGCACCTCGGTTCAGCTGGCAGCCTCCATGCCTTCAGGATTCCAGCCTGCACAGACTCCAGACCCTACGGCCCCAGTCGCCTACTTCCCA TACTTCAACAGGACCTACCTGGGGGTGGCCGCGTCACTCAACGGGGGCAATGTGCTGGCCACGTTCGTCCACATGCTGGTTCAGTGGATG GCAGATCTAGGCCTGGAGGTTGAAGAATCCACTGTGTATTCACGCATGATTCAGGCAGCTGTGCAGCAGAGAGATACCCACCTGACCATC ACCCCGACAGTGCTGGGGGAGAGGCACCTGCCGGACCAGCTGGCCTCAGTGACCAGAATCTCCTCCTCCGACCTCTCCCTGGGGCACGTG ACCCGGGCTCTGTGCCGAGGCATTGTTCAGAACCTGCACTCCATGCTTCCGATTCAGCAGCTCCAGGACTGGGGCGTGGAGAGGGTGATG GGCAGTGGGAGTGCGCTGTCCAGGAATGACGTGCTGAAGCAGGAGGTGCAGAGGGCTTTCCCTTTGCCCATGTCCTTTGGGCAGGATGTG >In-frame_SMG6_ENST00000354901_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_759nt ATGGAGACATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGC ATGCTGCAGCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGTTCTCAACATCAGCACCTCGGTTCAGCTGGCAGCC TCCATGCCTTCAGGATTCCAGCCTGCACAGACTCCAGACCCTACGGCCCCAGTCGCCTACTTCCCATACTTCAACAGGACCTACCTGGGG GTGGCCGCGTCACTCAACGGGGGCAATGTGCTGGCCACGTTCGTCCACATGCTGGTTCAGTGGATGGCAGATCTAGGCCTGGAGGTTGAA GAATCCACTGTGTATTCACGCATGATTCAGGCAGCTGTGCAGCAGAGAGATACCCACCTGACCATCACCCCGACAGTGCTGGGGGAGAGG CACCTGCCGGACCAGCTGGCCTCAGTGACCAGAATCTCCTCCTCCGACCTCTCCCTGGGGCACGTGACCCGGGCTCTGTGCCGAGGCATT GTTCAGAACCTGCACTCCATGCTTCCGATTCAGCAGCTCCAGGACTGGGGCGTGGAGAGGGTGATGGGCAGTGGGAGTGCGCTGTCCAGG AATGACGTGCTGAAGCAGGAGGTGCAGAGGGCTTTCCCTTTGCCCATGTCCTTTGGGCAGGATGTGGATGCAGCTGTCGGGGCAGCTCTG >In-frame_SMG6_ENST00000536871_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_759nt ATGGAGACATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGC ATGCTGCAGCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGTTCTCAACATCAGCACCTCGGTTCAGCTGGCAGCC TCCATGCCTTCAGGATTCCAGCCTGCACAGACTCCAGACCCTACGGCCCCAGTCGCCTACTTCCCATACTTCAACAGGACCTACCTGGGG GTGGCCGCGTCACTCAACGGGGGCAATGTGCTGGCCACGTTCGTCCACATGCTGGTTCAGTGGATGGCAGATCTAGGCCTGGAGGTTGAA GAATCCACTGTGTATTCACGCATGATTCAGGCAGCTGTGCAGCAGAGAGATACCCACCTGACCATCACCCCGACAGTGCTGGGGGAGAGG CACCTGCCGGACCAGCTGGCCTCAGTGACCAGAATCTCCTCCTCCGACCTCTCCCTGGGGCACGTGACCCGGGCTCTGTGCCGAGGCATT GTTCAGAACCTGCACTCCATGCTTCCGATTCAGCAGCTCCAGGACTGGGGCGTGGAGAGGGTGATGGGCAGTGGGAGTGCGCTGTCCAGG AATGACGTGCTGAAGCAGGAGGTGCAGAGGGCTTTCCCTTTGCCCATGTCCTTTGGGCAGGATGTGGATGCAGCTGTCGGGGCAGCTCTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SMG6_ENST00000544865_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_6199nt AGCAGTAGGCGCTGGGGCCGCGGCGGACCCTCGCTGCCCTACCTCTCTCGCGGGTTAGTGCGGGGTCGGGCTCGGCCAGTCCTGGCCAGC TCCGGGAGAGCCTGGCCCGAATTCCTGCCTCCACCCTCTTTCTCGCCGCGAAGGTGACTGTTCCTTTTGCCCCAGCCCTCTCAGACCCGC CCCGGATTCCCAGGCATCGGGAGACGCGGAAAGGAGTGGGGTCTGGTGGAGGCCCCGGGCGTATCGCTCTCCAGGCCGCCCTCCGCGGGC CTGCCCCGGCCACCGCTTTAACGTCGGAGAGAAGGAATTGGGGAGAAAGGTTTAAGAGCCTGCGACTTCGTTGCTGAACTTTTCCCCCCC AAGACAGGCTTCCGAAAGCTGCGCCACTGGAGGGATCCGGGACCTCAGACTACTCGGGTTTGGCCCTGGCATGTGTGGGAGCAGTTTTTA TTAGAGAGAATGCTCAATTTGCAAGTTAATTTCAAGTCTCCAGCCACGTCAGGAAAAAAACATGAAGGAATTAAAGGAGGCCAGGCCGCG CAAAGATAACAGGCGTCCAGATCTGGAAATCTATAAGCCTGGCCTTTCTCGGCTAAGGAACAAGCCCAAAATCAAGGAACCCCCTGGGAG TGAGGAATTCAAAGATGAAATTGTTAATGACCGAGATTGCTCTGCTGTTGAAAATGGTACACAGCCCGTTAAAGATGTCTGCAAGGAACT GAACAACCAAGAGCAGAATGGTCCTATAGACCCAGAAAATAATCGGGGACAAGAATCCTTTCCTAGGACTGCTGGACAAGAGGATCGTAG TCTAAAAATTATCAAAAGAACAAAGAAACCCGACCTGCAGATCTATCAGCCTGGACGACGTTTGCAGACTGTTAGCAAAGAATCCGCCAG TCGGGTGGAGGAGGAAGAAGTCCTCAACCAGGTAGAACAACTGAGAGTAGAGGAAGATGAGTGTAGGGGAAATGTTGCGAAGGAGGAAGT TGCGAATAAACCAGACAGGGCTGAGATAGAAAAGAGCCCAGGTGGTGGGAGAGTAGGGGCTGCAAAAGGAGAAAAAGGAAAGAGGATGGG AAAAGGGGAGGGGGTGAGGGAAACCCACGACGACCCAGCCCGCGGGAGGCCGGGCTCCGCAAAGCGCTACTCCCGCTCAGACAAACGAAG GAATCGCTACCGCACGCGCAGCACCAGCTCAGCTGGCAGCAACAACAGCGCTGAGGGAGCTGGCCTGACGGATAATGGATGTCGCCGCCG CCGACAGGATAGGACCAAGGAGAGGCCACGACTGAAGAAGCAAGTGTCTGTGTCCTCAACCGATTCCTTAGACGAGGACAGAATTGATGA GCCTGATGGATTAGGACCCAGGAGAAGTTCAGAAAGGAAGAGACATTTAGAAAGAAACTGGTCTGGCCGTGGGGAGGGTGAGCAGAAAAA CAGTGCTAAAGAATATCGAGGCACTCTTCGTGTCACTTTCGATGCAGAAGCCATGAACAAAGAGTCTCCCATGGTGAGGTCAGCCAGGGA TGATATGGATAGAGGAAAGCCTGACAAAGGCTTGAGCAGTGGGGGCAAAGGCTCTGAGAAGCAGGAGTCCAAAAACCCGAAACAAGAACT TCGGGGTCGTGGTCGTGGCATTCTGATTTTGCCTGCCCATACCACCCTATCTGTCAATTCAGCAGGTTCTCCAGAGTCCGCGCCTTTGGG ACCTCGGCTTTTGTTTGGATCTGGTAGTAAGGGATCTCGGAGTTGGGGCCGTGGAGGCACCACACGCCGATTGTGGGACCCAAACAATCC TGATCAGAAACCTGCTCTAAAGACTCAGACGCCCCAGCTACATTTCTTGGACACTGATGATGAAGTCAGCCCTACATCTTGGGGTGACTC ACGCCAGGCTCAGGCATCTTACTATAAGTTTCAAAACTCTGACAACCCCTATTATTACCCCCGGACACCAGGCCCTGCCTCCCAGTATCC CTATACGGGCTATAACCCTCTACAGTACCCAGTGGGCCCTACGAATGGTGTGTACCCAGGGCCTTACTACCCAGGCTACCCGACTCCGTC AGGACAGTATGTGTGTAGCCCTCTACCTACCAGCACCATGAGTCCCGAGGAGGTAGAGCAGCACATGAGGAACCTGCAGCAACAGGAGCT GCACAGGCTTCTCCGGGTGGCTGACAACCAGGAACTGCAGCTCAGCAACCTGCTCTCCAGGGACCGCATCAGTCCGGAGGGCCTGGAGAA GATGGCGCAACTCAGAGCTGAACTGCTGCAGCTATATGAGCGCTGTATTCTATTAGATATTGAGTTCTCTGATAATCAGAATGTGGATCA GATCCTGTGGAAGAATGCTTTCTATCAGGTGATTGAGAAGTTCAGGCAACTTGTCAAGGATCCGAATGTTGAGAACCCAGAACAGATTCG GAACAGACTTTTGGAGCTCTTGGATGAGGGTAGTGACTTCTTTGATAGTTTGCTTCAGAAGCTGCAGGTTACTTACAAGTTCAAACTGGA AGACTACATGGATGGTCTTGCCATTCGCAGCAAGCCATTACGCAAGACAGTAAAATATGCCTTGATCAGTGCCCAGCGATGCATGATATG CCAAGGAGATATTGCTAGGTACCGGGAGCAAGCCAGTGATACAGCGAATTATGGGAAAGCACGCAGTTGGTACCTGAAGGCCCAGCACAT TGCTCCCAAGAATGGGCGCCCCTATAACCAGTTGGCTTTGCTGGCAGTGTATACGAGGAGGAAGCTTGACGCTGTCTATTACTATATGCG CAGTTTAGCTGCCAGCAACCCTATCCTGACTGCCAAGGAGAGTCTCATGAGCTTGTTTGAAGAGACCAAGCGGAAGGCAGAACAGATGGA AAAGAAGCAACATGAGGAATTTGACCTGAGCCCTGACCAGTGGCGGAAAGGAAAGAAGTCTACTTTCCGGCATGTTGGAGATGACACCAC TCGCCTGGAGATCTGGATTCATCCATCCCATCCACGGTCTTCCCAGGGCACTGAGTCTGGGAAGGATTCTGAGCAAGAGAATGGGCTGGG CAGCCTGAGTCCCAGTGATCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCATGGGAAGCTGTTTACCCGGATTGGGATGGAGAC ATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGCATGCTGCA GCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGTTCTCAACATCAGCACCTCGGTTCAGCTGGCAGCCTCCATGCC TTCAGGATTCCAGCCTGCACAGACTCCAGACCCTACGGCCCCAGTCGCCTACTTCCCATACTTCAACAGGACCTACCTGGGGGTGGCCGC GTCACTCAACGGGGGCAATGTGCTGGCCACGTTCGTCCACATGCTGGTTCAGTGGATGGCAGATCTAGGCCTGGAGGTTGAAGAATCCAC TGTGTATTCACGCATGATTCAGGCAGCTGTGCAGCAGAGAGATACCCACCTGACCATCACCCCGACAGTGCTGGGGGAGAGGCACCTGCC GGACCAGCTGGCCTCAGTGACCAGAATCTCCTCCTCCGACCTCTCCCTGGGGCACGTGACCCGGGCTCTGTGCCGAGGCATTGTTCAGAA CCTGCACTCCATGCTTCCGATTCAGCAGCTCCAGGACTGGGGCGTGGAGAGGGTGATGGGCAGTGGGAGTGCGCTGTCCAGGAATGACGT GCTGAAGCAGGAGGTGCAGAGGGCTTTCCCTTTGCCCATGTCCTTTGGGCAGGATGTGGATGCAGCTGTCGGGGCAGCTCTGGTCATGCT CCGGAGACACCTCAACCAGAAGGAATCTTAGACAGCAAACTCTTTCGCCAAACGACTGCTGTGAATTTTACCTGATTAACATTCCTGACA CCATCTGTGGGTCATCCTTTCCCTGGACCGTTCAGTGGACAGCTTTCAAGCAGTGCTTGTTGTGAGGTCCCATCTCGGCCAAGAACTTAC CTTCAGAACATACTCTAATAATGCAGCCAGGAGCCGTCAGCCAGATCCCAAATGAGTGCCTTCCGAAATTGACCCACCTGGGAGCTATTT ACAAATGTCCATGTGGGAGAGAGAGAGCATGAGAGCACAGTAGCCCAGCCTGCTGGTCAGCAGGCTCATCTGTGGTTCACCTGTAGACAG AGAGCAGATCAATGTGTACTTCAGACACCAGAAAGTCTGGTGGCTTTGGTCCCAAGTGGGAAAAGAGAACTGCCCCATGCCCAGCTTGTG ATTATCGTTTTTGGAGACCTGAAGCCCACACTCGGGTCGTATGGACTTCTGGAAAAGTTCTTGTCTCCTGGACTGAACCATGTGACCGGA GGCCCCTTTCCTAGTCTCATCCTCCCCTGGCTGCAGATGCTTAGCTGGGCCAGGGATTGACCCAAGCGCGATGCAGCAGGCAGGCTCAGA AGACGATGCGGGGCTGTGTGCCGGCCTTCTTGCTGCATGTACTCAGCCTCAGGAGAGCTTGCTGCACCCAGGCCGCCCAGGTCTTCACAG CACAACTGCCTGGAAGGCAGGTTGCGAGAAGGAGAGGCGGATGGCATGAGCAGCAAGGGGGACCGATGCTGTGCAGCTCACACCACTCCA GAACCTGACAAGGCACCAGCAGGACCCCTTGCCAGGAGCATGTCTGTGCAGCAGTGTTTTTGCCCCTGCACATTCCAGAAGCCCTCATGG GAAGGGATGCAGCCAGGCAGACTCCTGCCAGATGGGGCAGGTAGTTTATTCAAAGAGAACTCTGTATCCCATAGGCCCAGGCTCTCCTTT CGCTTGGCGTGGGCTTTGCTGGCCCAGTGTGTGCTCCTGGCTCAGCAGAAACATCCATTTGAGTTGGCATCCCTGTAGGGATCCCAGAGC GTTGTAAGCCTTCTTGTGATTGGTAGGGATGGCTGTGGGGTGGCTTCCAGGAGGGGGCCACCATTGCCGCATCTACTTCTAGACTCCCAA AGGAGCCCAGGCTCAGGCAGGCCTGGCCCAGAGTCACGCTGGCAACCACGAGTTTGGGAAGCAGTCGTATTCTCTCTCTCTCTCTCTCTC TCTCTCTCAGTATCCATGACAGGTATGAAACATATTGTCTCTTTATAAATGTCATTTTACAAATTATGTGATTATCTGGAAGCTCTAAGA TGAGAGCAAATGCCTGATCACTCTGGCCAAATGTCAGATACTAAAGCCCATTCTTGGCCGGGCATGTTGGCTCCCGCCTGTAATCCCAGC ACTTTGGGAAGCCCAAGTGGGTGAATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGGGATACCCCGTCTCTACTAAAAA TACAAGCCGGGCGTGGTGGCGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAAAATCACTTGAACTCGGGAGGCAGAGGTT GCAGTGAGCTGAGATCGCGCCATTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCATAAATAAATACAAAGCCCATTCTTCCAG AGTCTTGTGCCTTAAATAAAACACACCTCTCTGCTGTGGGAAGACTGTGCAATGGCACAGCCGCAGAGCTTGGTTTGGGAGGTTGAAGTG CTCTGGGGAGAATTCGTAGATCATCCTCAGAAAAGCCTTGCCCTGGTGTTCTACCAGAAAAACGTCTCCCAATCACCCAGGAAAGCTGTC CACAGTAGTCCCCCCTTATCCACGGTGTCACTTTCCATGGGTTCAGTTATCTGCGGTCAACCACGGTCTGACAATATTAAATGGAAAATT CTTCAAACAGTTCCCAAGTTTTCCCTTGTGCATTGTTCTGAGCAGTGTGATGGAGAGTCTCTGCCGTGCCATCTGGGATGCAAACCGTCC CTGTGTTCCCCACGTCCAGGCCGTAGATGCTCCCCGCCGGTCAGTCACTTAGTCGTCAGATCGCCCGTCCTGGTATCACAGTGCTTCTGT TCAGGTCAGTCTTTTTTTACTTCATTAGGGCCCCAAAGCACCAGAGTAGTGATGCTGGTAGTGATGCTGGCTGTTCGGATATGCCAAAGA >In-frame_SMG6_ENST00000263073_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_5832nt GCTGCGCGCGGCGGTGGCGGAGCCGCTACGGCTGTAGCAGCAGCCGCGAAGATGGCGGAAGGGCTGGAGCGTGTGCGGATCTCCGCGTCG GAGCTGCGCGGGATCCTGGCTACTCTGGCCCCGCAGGCCGGGAGCAGAGAAAACATGAAGGAATTAAAGGAGGCCAGGCCGCGCAAAGAT AACAGGCGTCCAGATCTGGAAATCTATAAGCCTGGCCTTTCTCGGCTAAGGAACAAGCCCAAAATCAAGGAACCCCCTGGGAGTGAGGAA TTCAAAGATGAAATTGTTAATGACCGAGATTGCTCTGCTGTTGAAAATGGTACACAGCCCGTTAAAGATGTCTGCAAGGAACTGAACAAC CAAGAGCAGAATGGTCCTATAGACCCAGAAAATAATCGGGGACAAGAATCCTTTCCTAGGACTGCTGGACAAGAGGATCGTAGTCTAAAA ATTATCAAAAGAACAAAGAAACCCGACCTGCAGATCTATCAGCCTGGACGACGTTTGCAGACTGTTAGCAAAGAATCCGCCAGTCGGGTG GAGGAGGAAGAAGTCCTCAACCAGGTAGAACAACTGAGAGTAGAGGAAGATGAGTGTAGGGGAAATGTTGCGAAGGAGGAAGTTGCGAAT AAACCAGACAGGGCTGAGATAGAAAAGAGCCCAGGTGGTGGGAGAGTAGGGGCTGCAAAAGGAGAAAAAGGAAAGAGGATGGGAAAAGGG GAGGGGGTGAGGGAAACCCACGACGACCCAGCCCGCGGGAGGCCGGGCTCCGCAAAGCGCTACTCCCGCTCAGACAAACGAAGGAATCGC TACCGCACGCGCAGCACCAGCTCAGCTGGCAGCAACAACAGCGCTGAGGGAGCTGGCCTGACGGATAATGGATGTCGCCGCCGCCGACAG GATAGGACCAAGGAGAGGCCACGACTGAAGAAGCAAGTGTCTGTGTCCTCAACCGATTCCTTAGACGAGGACAGAATTGATGAGCCTGAT GGATTAGGACCCAGGAGAAGTTCAGAAAGGAAGAGACATTTAGAAAGAAACTGGTCTGGCCGTGGGGAGGGTGAGCAGAAAAACAGTGCT AAAGAATATCGAGGCACTCTTCGTGTCACTTTCGATGCAGAAGCCATGAACAAAGAGTCTCCCATGGTGAGGTCAGCCAGGGATGATATG GATAGAGGAAAGCCTGACAAAGGCTTGAGCAGTGGGGGCAAAGGCTCTGAGAAGCAGGAGTCCAAAAACCCGAAACAAGAACTTCGGGGT CGTGGTCGTGGCATTCTGATTTTGCCTGCCCATACCACCCTATCTGTCAATTCAGCAGGTTCTCCAGAGTCCGCGCCTTTGGGACCTCGG CTTTTGTTTGGATCTGGTAGTAAGGGATCTCGGAGTTGGGGCCGTGGAGGCACCACACGCCGATTGTGGGACCCAAACAATCCTGATCAG AAACCTGCTCTAAAGACTCAGACGCCCCAGCTACATTTCTTGGACACTGATGATGAAGTCAGCCCTACATCTTGGGGTGACTCACGCCAG GCTCAGGCATCTTACTATAAGTTTCAAAACTCTGACAACCCCTATTATTACCCCCGGACACCAGGCCCTGCCTCCCAGTATCCCTATACG GGCTATAACCCTCTACAGTACCCAGTGGGCCCTACGAATGGTGTGTACCCAGGGCCTTACTACCCAGGCTACCCGACTCCGTCAGGACAG TATGTGTGTAGCCCTCTACCTACCAGCACCATGAGTCCCGAGGAGGTAGAGCAGCACATGAGGAACCTGCAGCAACAGGAGCTGCACAGG CTTCTCCGGGTGGCTGACAACCAGGAACTGCAGCTCAGCAACCTGCTCTCCAGGGACCGCATCAGTCCGGAGGGCCTGGAGAAGATGGCG CAACTCAGAGCTGAACTGCTGCAGCTATATGAGCGCTGTATTCTATTAGATATTGAGTTCTCTGATAATCAGAATGTGGATCAGATCCTG TGGAAGAATGCTTTCTATCAGGTGATTGAGAAGTTCAGGCAACTTGTCAAGGATCCGAATGTTGAGAACCCAGAACAGATTCGGAACAGA CTTTTGGAGCTCTTGGATGAGGGTAGTGACTTCTTTGATAGTTTGCTTCAGAAGCTGCAGGTTACTTACAAGTTCAAACTGGAAGACTAC ATGGATGGTCTTGCCATTCGCAGCAAGCCATTACGCAAGACAGTAAAATATGCCTTGATCAGTGCCCAGCGATGCATGATATGCCAAGGA GATATTGCTAGGTACCGGGAGCAAGCCAGTGATACAGCGAATTATGGGAAAGCACGCAGTTGGTACCTGAAGGCCCAGCACATTGCTCCC AAGAATGGGCGCCCCTATAACCAGTTGGCTTTGCTGGCAGTGTATACGAGGAGGAAGCTTGACGCTGTCTATTACTATATGCGCAGTTTA GCTGCCAGCAACCCTATCCTGACTGCCAAGGAGAGTCTCATGAGCTTGTTTGAAGAGACCAAGCGGAAGGCAGAACAGATGGAAAAGAAG CAACATGAGGAATTTGACCTGAGCCCTGACCAGTGGCGGAAAGGAAAGAAGTCTACTTTCCGGCATGTTGGAGATGACACCACTCGCCTG GAGATCTGGATTCATCCATCCCATCCACGGTCTTCCCAGGGCACTGAGTCTGGGAAGGATTCTGAGCAAGAGAATGGGCTGGGCAGCCTG AGTCCCAGTGATCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCATGGGAAGCTGTTTACCCGGATTGGGATGGAGACATTCCCT GCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATG ACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGTTCTCAACATCAGCACCTCGGTTCAGCTGGCAGCCTCCATGCCTTCAGGA TTCCAGCCTGCACAGACTCCAGACCCTACGGCCCCAGTCGCCTACTTCCCATACTTCAACAGGACCTACCTGGGGGTGGCCGCGTCACTC AACGGGGGCAATGTGCTGGCCACGTTCGTCCACATGCTGGTTCAGTGGATGGCAGATCTAGGCCTGGAGGTTGAAGAATCCACTGTGTAT TCACGCATGATTCAGGCAGCTGTGCAGCAGAGAGATACCCACCTGACCATCACCCCGACAGTGCTGGGGGAGAGGCACCTGCCGGACCAG CTGGCCTCAGTGACCAGAATCTCCTCCTCCGACCTCTCCCTGGGGCACGTGACCCGGGCTCTGTGCCGAGGCATTGTTCAGAACCTGCAC TCCATGCTTCCGATTCAGCAGCTCCAGGACTGGGGCGTGGAGAGGGTGATGGGCAGTGGGAGTGCGCTGTCCAGGAATGACGTGCTGAAG CAGGAGGTGCAGAGGGCTTTCCCTTTGCCCATGTCCTTTGGGCAGGATGTGGATGCAGCTGTCGGGGCAGCTCTGGTCATGCTCCGGAGA CACCTCAACCAGAAGGAATCTTAGACAGCAAACTCTTTCGCCAAACGACTGCTGTGAATTTTACCTGATTAACATTCCTGACACCATCTG TGGGTCATCCTTTCCCTGGACCGTTCAGTGGACAGCTTTCAAGCAGTGCTTGTTGTGAGGTCCCATCTCGGCCAAGAACTTACCTTCAGA ACATACTCTAATAATGCAGCCAGGAGCCGTCAGCCAGATCCCAAATGAGTGCCTTCCGAAATTGACCCACCTGGGAGCTATTTACAAATG TCCATGTGGGAGAGAGAGAGCATGAGAGCACAGTAGCCCAGCCTGCTGGTCAGCAGGCTCATCTGTGGTTCACCTGTAGACAGAGAGCAG ATCAATGTGTACTTCAGACACCAGAAAGTCTGGTGGCTTTGGTCCCAAGTGGGAAAAGAGAACTGCCCCATGCCCAGCTTGTGATTATCG TTTTTGGAGACCTGAAGCCCACACTCGGGTCGTATGGACTTCTGGAAAAGTTCTTGTCTCCTGGACTGAACCATGTGACCGGAGGCCCCT TTCCTAGTCTCATCCTCCCCTGGCTGCAGATGCTTAGCTGGGCCAGGGATTGACCCAAGCGCGATGCAGCAGGCAGGCTCAGAAGACGAT GCGGGGCTGTGTGCCGGCCTTCTTGCTGCATGTACTCAGCCTCAGGAGAGCTTGCTGCACCCAGGCCGCCCAGGTCTTCACAGCACAACT GCCTGGAAGGCAGGTTGCGAGAAGGAGAGGCGGATGGCATGAGCAGCAAGGGGGACCGATGCTGTGCAGCTCACACCACTCCAGAACCTG ACAAGGCACCAGCAGGACCCCTTGCCAGGAGCATGTCTGTGCAGCAGTGTTTTTGCCCCTGCACATTCCAGAAGCCCTCATGGGAAGGGA TGCAGCCAGGCAGACTCCTGCCAGATGGGGCAGGTAGTTTATTCAAAGAGAACTCTGTATCCCATAGGCCCAGGCTCTCCTTTCGCTTGG CGTGGGCTTTGCTGGCCCAGTGTGTGCTCCTGGCTCAGCAGAAACATCCATTTGAGTTGGCATCCCTGTAGGGATCCCAGAGCGTTGTAA GCCTTCTTGTGATTGGTAGGGATGGCTGTGGGGTGGCTTCCAGGAGGGGGCCACCATTGCCGCATCTACTTCTAGACTCCCAAAGGAGCC CAGGCTCAGGCAGGCCTGGCCCAGAGTCACGCTGGCAACCACGAGTTTGGGAAGCAGTCGTATTCTCTCTCTCTCTCTCTCTCTCTCTCT CAGTATCCATGACAGGTATGAAACATATTGTCTCTTTATAAATGTCATTTTACAAATTATGTGATTATCTGGAAGCTCTAAGATGAGAGC AAATGCCTGATCACTCTGGCCAAATGTCAGATACTAAAGCCCATTCTTGGCCGGGCATGTTGGCTCCCGCCTGTAATCCCAGCACTTTGG GAAGCCCAAGTGGGTGAATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGGGATACCCCGTCTCTACTAAAAATACAAGC CGGGCGTGGTGGCGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAAAATCACTTGAACTCGGGAGGCAGAGGTTGCAGTGA GCTGAGATCGCGCCATTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCATAAATAAATACAAAGCCCATTCTTCCAGAGTCTTG TGCCTTAAATAAAACACACCTCTCTGCTGTGGGAAGACTGTGCAATGGCACAGCCGCAGAGCTTGGTTTGGGAGGTTGAAGTGCTCTGGG GAGAATTCGTAGATCATCCTCAGAAAAGCCTTGCCCTGGTGTTCTACCAGAAAAACGTCTCCCAATCACCCAGGAAAGCTGTCCACAGTA GTCCCCCCTTATCCACGGTGTCACTTTCCATGGGTTCAGTTATCTGCGGTCAACCACGGTCTGACAATATTAAATGGAAAATTCTTCAAA CAGTTCCCAAGTTTTCCCTTGTGCATTGTTCTGAGCAGTGTGATGGAGAGTCTCTGCCGTGCCATCTGGGATGCAAACCGTCCCTGTGTT CCCCACGTCCAGGCCGTAGATGCTCCCCGCCGGTCAGTCACTTAGTCGTCAGATCGCCCGTCCTGGTATCACAGTGCTTCTGTTCAGGTC AGTCTTTTTTTACTTCATTAGGGCCCCAAAGCACCAGAGTAGTGATGCTGGTAGTGATGCTGGCTGTTCGGATATGCCAAAGAGAAACCG >In-frame_SMG6_ENST00000354901_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_3352nt GGACCCAGATACCCGTCAGAATTTCCAGGCCTTGGTTTGGTTTAGACATTTTAGAAGATGTTAACAGCAATAATTGTAAAAGACTTTGAG TGGCACGCATGGTGAACAGAAAGTACTAGATCCTGAAGAGGGGGGAAAGGCATTTCTGTGCTCTTCCTGGTAAAGTGTTTGAAAATGAAC ATTCAGAAGAAAACCTAAAGCACCTGAAATGCACAGGGGACGAGAATGAGAGCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCA TGGGAAGCTGTTTACCCGGATTGGGATGGAGACATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAG CCCCTCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGTTCTCAACAT CAGCACCTCGGTTCAGCTGGCAGCCTCCATGCCTTCAGGATTCCAGCCTGCACAGACTCCAGACCCTACGGCCCCAGTCGCCTACTTCCC ATACTTCAACAGGACCTACCTGGGGGTGGCCGCGTCACTCAACGGGGGCAATGTGCTGGCCACGTTCGTCCACATGCTGGTTCAGTGGAT GGCAGATCTAGGCCTGGAGGTTGAAGAATCCACTGTGTATTCACGCATGATTCAGGCAGCTGTGCAGCAGAGAGATACCCACCTGACCAT CACCCCGACAGTGCTGGGGGAGAGGCACCTGCCGGACCAGCTGGCCTCAGTGACCAGAATCTCCTCCTCCGACCTCTCCCTGGGGCACGT GACCCGGGCTCTGTGCCGAGGCATTGTTCAGAACCTGCACTCCATGCTTCCGATTCAGCAGCTCCAGGACTGGGGCGTGGAGAGGGTGAT GGGCAGTGGGAGTGCGCTGTCCAGGAATGACGTGCTGAAGCAGGAGGTGCAGAGGGCTTTCCCTTTGCCCATGTCCTTTGGGCAGGATGT GGATGCAGCTGTCGGGGCAGCTCTGGTCATGCTCCGGAGACACCTCAACCAGAAGGAATCTTAGACAGCAAACTCTTTCGCCAAACGACT GCTGTGAATTTTACCTGATTAACATTCCTGACACCATCTGTGGGTCATCCTTTCCCTGGACCGTTCAGTGGACAGCTTTCAAGCAGTGCT TGTTGTGAGGTCCCATCTCGGCCAAGAACTTACCTTCAGAACATACTCTAATAATGCAGCCAGGAGCCGTCAGCCAGATCCCAAATGAGT GCCTTCCGAAATTGACCCACCTGGGAGCTATTTACAAATGTCCATGTGGGAGAGAGAGAGCATGAGAGCACAGTAGCCCAGCCTGCTGGT CAGCAGGCTCATCTGTGGTTCACCTGTAGACAGAGAGCAGATCAATGTGTACTTCAGACACCAGAAAGTCTGGTGGCTTTGGTCCCAAGT GGGAAAAGAGAACTGCCCCATGCCCAGCTTGTGATTATCGTTTTTGGAGACCTGAAGCCCACACTCGGGTCGTATGGACTTCTGGAAAAG TTCTTGTCTCCTGGACTGAACCATGTGACCGGAGGCCCCTTTCCTAGTCTCATCCTCCCCTGGCTGCAGATGCTTAGCTGGGCCAGGGAT TGACCCAAGCGCGATGCAGCAGGCAGGCTCAGAAGACGATGCGGGGCTGTGTGCCGGCCTTCTTGCTGCATGTACTCAGCCTCAGGAGAG CTTGCTGCACCCAGGCCGCCCAGGTCTTCACAGCACAACTGCCTGGAAGGCAGGTTGCGAGAAGGAGAGGCGGATGGCATGAGCAGCAAG GGGGACCGATGCTGTGCAGCTCACACCACTCCAGAACCTGACAAGGCACCAGCAGGACCCCTTGCCAGGAGCATGTCTGTGCAGCAGTGT TTTTGCCCCTGCACATTCCAGAAGCCCTCATGGGAAGGGATGCAGCCAGGCAGACTCCTGCCAGATGGGGCAGGTAGTTTATTCAAAGAG AACTCTGTATCCCATAGGCCCAGGCTCTCCTTTCGCTTGGCGTGGGCTTTGCTGGCCCAGTGTGTGCTCCTGGCTCAGCAGAAACATCCA TTTGAGTTGGCATCCCTGTAGGGATCCCAGAGCGTTGTAAGCCTTCTTGTGATTGGTAGGGATGGCTGTGGGGTGGCTTCCAGGAGGGGG CCACCATTGCCGCATCTACTTCTAGACTCCCAAAGGAGCCCAGGCTCAGGCAGGCCTGGCCCAGAGTCACGCTGGCAACCACGAGTTTGG GAAGCAGTCGTATTCTCTCTCTCTCTCTCTCTCTCTCTCTCAGTATCCATGACAGGTATGAAACATATTGTCTCTTTATAAATGTCATTT TACAAATTATGTGATTATCTGGAAGCTCTAAGATGAGAGCAAATGCCTGATCACTCTGGCCAAATGTCAGATACTAAAGCCCATTCTTGG CCGGGCATGTTGGCTCCCGCCTGTAATCCCAGCACTTTGGGAAGCCCAAGTGGGTGAATCACCTGAGGTCAGGAGTTCAAGACCAGCCTG ACCAACATGGGGATACCCCGTCTCTACTAAAAATACAAGCCGGGCGTGGTGGCGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGC AGGAAAATCACTTGAACTCGGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCGCCATTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTG TCTCATAAATAAATACAAAGCCCATTCTTCCAGAGTCTTGTGCCTTAAATAAAACACACCTCTCTGCTGTGGGAAGACTGTGCAATGGCA CAGCCGCAGAGCTTGGTTTGGGAGGTTGAAGTGCTCTGGGGAGAATTCGTAGATCATCCTCAGAAAAGCCTTGCCCTGGTGTTCTACCAG AAAAACGTCTCCCAATCACCCAGGAAAGCTGTCCACAGTAGTCCCCCCTTATCCACGGTGTCACTTTCCATGGGTTCAGTTATCTGCGGT CAACCACGGTCTGACAATATTAAATGGAAAATTCTTCAAACAGTTCCCAAGTTTTCCCTTGTGCATTGTTCTGAGCAGTGTGATGGAGAG TCTCTGCCGTGCCATCTGGGATGCAAACCGTCCCTGTGTTCCCCACGTCCAGGCCGTAGATGCTCCCCGCCGGTCAGTCACTTAGTCGTC AGATCGCCCGTCCTGGTATCACAGTGCTTCTGTTCAGGTCAGTCTTTTTTTACTTCATTAGGGCCCCAAAGCACCAGAGTAGTGATGCTG GTAGTGATGCTGGCTGTTCGGATATGCCAAAGAGAAACCGTAAGGTGCTTCCTTTAAGTGAAAAGATGGGAAGAAAACAGTCATATGCTG >In-frame_SMG6_ENST00000536871_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_3299nt ATACCAGAGAGTTTAGGGACTGTGAAGGTTTCAGGAAATTTGTTGAGTATTTAGAAAAGCCGATGGTTTCAGAGAGAAACTTTGATATTA GCTTGAACACAGTTATTGCCAGGGGTGAGGAAATAGCATACCAAAGCATAATAACTCATAGTGATTTATCCAAAACTTGAGTTGTTTGCA TCTCTGGACCCTGAAAACTCCTTTATCTTGAATTTGTTCAAAATTGCAGGATACCGGGAAGGATGGAGACATTCCCTGCAGTGGCTGAGA AGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATGACCATCAATATGT TTGCAGTACACAACTCCCAGCTGAAAGTTCTCAACATCAGCACCTCGGTTCAGCTGGCAGCCTCCATGCCTTCAGGATTCCAGCCTGCAC AGACTCCAGACCCTACGGCCCCAGTCGCCTACTTCCCATACTTCAACAGGACCTACCTGGGGGTGGCCGCGTCACTCAACGGGGGCAATG TGCTGGCCACGTTCGTCCACATGCTGGTTCAGTGGATGGCAGATCTAGGCCTGGAGGTTGAAGAATCCACTGTGTATTCACGCATGATTC AGGCAGCTGTGCAGCAGAGAGATACCCACCTGACCATCACCCCGACAGTGCTGGGGGAGAGGCACCTGCCGGACCAGCTGGCCTCAGTGA CCAGAATCTCCTCCTCCGACCTCTCCCTGGGGCACGTGACCCGGGCTCTGTGCCGAGGCATTGTTCAGAACCTGCACTCCATGCTTCCGA TTCAGCAGCTCCAGGACTGGGGCGTGGAGAGGGTGATGGGCAGTGGGAGTGCGCTGTCCAGGAATGACGTGCTGAAGCAGGAGGTGCAGA GGGCTTTCCCTTTGCCCATGTCCTTTGGGCAGGATGTGGATGCAGCTGTCGGGGCAGCTCTGGTCATGCTCCGGAGACACCTCAACCAGA AGGAATCTTAGACAGCAAACTCTTTCGCCAAACGACTGCTGTGAATTTTACCTGATTAACATTCCTGACACCATCTGTGGGTCATCCTTT CCCTGGACCGTTCAGTGGACAGCTTTCAAGCAGTGCTTGTTGTGAGGTCCCATCTCGGCCAAGAACTTACCTTCAGAACATACTCTAATA ATGCAGCCAGGAGCCGTCAGCCAGATCCCAAATGAGTGCCTTCCGAAATTGACCCACCTGGGAGCTATTTACAAATGTCCATGTGGGAGA GAGAGAGCATGAGAGCACAGTAGCCCAGCCTGCTGGTCAGCAGGCTCATCTGTGGTTCACCTGTAGACAGAGAGCAGATCAATGTGTACT TCAGACACCAGAAAGTCTGGTGGCTTTGGTCCCAAGTGGGAAAAGAGAACTGCCCCATGCCCAGCTTGTGATTATCGTTTTTGGAGACCT GAAGCCCACACTCGGGTCGTATGGACTTCTGGAAAAGTTCTTGTCTCCTGGACTGAACCATGTGACCGGAGGCCCCTTTCCTAGTCTCAT CCTCCCCTGGCTGCAGATGCTTAGCTGGGCCAGGGATTGACCCAAGCGCGATGCAGCAGGCAGGCTCAGAAGACGATGCGGGGCTGTGTG CCGGCCTTCTTGCTGCATGTACTCAGCCTCAGGAGAGCTTGCTGCACCCAGGCCGCCCAGGTCTTCACAGCACAACTGCCTGGAAGGCAG GTTGCGAGAAGGAGAGGCGGATGGCATGAGCAGCAAGGGGGACCGATGCTGTGCAGCTCACACCACTCCAGAACCTGACAAGGCACCAGC AGGACCCCTTGCCAGGAGCATGTCTGTGCAGCAGTGTTTTTGCCCCTGCACATTCCAGAAGCCCTCATGGGAAGGGATGCAGCCAGGCAG ACTCCTGCCAGATGGGGCAGGTAGTTTATTCAAAGAGAACTCTGTATCCCATAGGCCCAGGCTCTCCTTTCGCTTGGCGTGGGCTTTGCT GGCCCAGTGTGTGCTCCTGGCTCAGCAGAAACATCCATTTGAGTTGGCATCCCTGTAGGGATCCCAGAGCGTTGTAAGCCTTCTTGTGAT TGGTAGGGATGGCTGTGGGGTGGCTTCCAGGAGGGGGCCACCATTGCCGCATCTACTTCTAGACTCCCAAAGGAGCCCAGGCTCAGGCAG GCCTGGCCCAGAGTCACGCTGGCAACCACGAGTTTGGGAAGCAGTCGTATTCTCTCTCTCTCTCTCTCTCTCTCTCTCAGTATCCATGAC AGGTATGAAACATATTGTCTCTTTATAAATGTCATTTTACAAATTATGTGATTATCTGGAAGCTCTAAGATGAGAGCAAATGCCTGATCA CTCTGGCCAAATGTCAGATACTAAAGCCCATTCTTGGCCGGGCATGTTGGCTCCCGCCTGTAATCCCAGCACTTTGGGAAGCCCAAGTGG GTGAATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGGGATACCCCGTCTCTACTAAAAATACAAGCCGGGCGTGGTGGC GCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAAAATCACTTGAACTCGGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCGC CATTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCATAAATAAATACAAAGCCCATTCTTCCAGAGTCTTGTGCCTTAAATAAA ACACACCTCTCTGCTGTGGGAAGACTGTGCAATGGCACAGCCGCAGAGCTTGGTTTGGGAGGTTGAAGTGCTCTGGGGAGAATTCGTAGA TCATCCTCAGAAAAGCCTTGCCCTGGTGTTCTACCAGAAAAACGTCTCCCAATCACCCAGGAAAGCTGTCCACAGTAGTCCCCCCTTATC CACGGTGTCACTTTCCATGGGTTCAGTTATCTGCGGTCAACCACGGTCTGACAATATTAAATGGAAAATTCTTCAAACAGTTCCCAAGTT TTCCCTTGTGCATTGTTCTGAGCAGTGTGATGGAGAGTCTCTGCCGTGCCATCTGGGATGCAAACCGTCCCTGTGTTCCCCACGTCCAGG CCGTAGATGCTCCCCGCCGGTCAGTCACTTAGTCGTCAGATCGCCCGTCCTGGTATCACAGTGCTTCTGTTCAGGTCAGTCTTTTTTTAC TTCATTAGGGCCCCAAAGCACCAGAGTAGTGATGCTGGTAGTGATGCTGGCTGTTCGGATATGCCAAAGAGAAACCGTAAGGTGCTTCCT |
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FusionGenePPI for SMG6_SHPK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SMG6 | TERT, HDAC8, UPF1, HBB, PPP1CC, SOX2, RBM8A, MAGOH, PABPC1, SMG6, UPF3B, SMG5, SMG7, PSG1, C2orf68, FAM221B, SPATA1, HAO2, LPIN3, TRIM25 | SHPK | MDM2, ARFGAP3, EID2B, C10orf55, FAM219A, TRAF3, TCF25, NR2F2, FAM126A, THYN1, LINC01587, PDDC1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | SMG6 | chr17:2139786 | chr17:3518831 | ENST00000263073 | - | 10 | 19 | 114_503 | 956 | 1420 | telomeric DNA |
| Hgene | SMG6 | chr17:2139786 | chr17:3518831 | ENST00000544865 | - | 10 | 19 | 114_503 | 925 | 1389 | telomeric DNA |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | SMG6 | chr17:2139786 | chr17:3518831 | ENST00000354901 | - | 3 | 12 | 114_503 | 48 | 512 | telomeric DNA |
| Hgene | SMG6 | chr17:2139786 | chr17:3518831 | ENST00000536871 | - | 2 | 11 | 114_503 | 48 | 512 | telomeric DNA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SMG6_SHPK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SMG6_SHPK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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