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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 34912

FusionGeneSummary for SMG6_SHPK

check button Fusion gene summary
Fusion gene informationFusion gene name: SMG6_SHPK
Fusion gene ID: 34912
HgeneTgene
Gene symbol

SMG6

SHPK

Gene ID

23293

23729

Gene nameSMG6, nonsense mediated mRNA decay factorsedoheptulokinase
SynonymsC17orf31|EST1A|SMG-6|hSMG5/7aCARKL|SHK
Cytomap

17p13.3

17p13.2

Type of geneprotein-codingprotein-coding
Descriptiontelomerase-binding protein EST1AEST1 telomerase component homolog Aever shorter telomeres 1Asmg-6 homolog, nonsense mediated mRNA decay factortelomerase subunit EST1Asedoheptulokinasecarbohydrate kinase-like protein
Modification date2018052320180523
UniProtAcc

Q86US8

Q9UHJ6

Ensembl transtripts involved in fusion geneENST00000544865, ENST00000263073, 
ENST00000354901, ENST00000536871, 
ENST00000573166, 
ENST00000225519, 
ENST00000572705, 
Fusion gene scores* DoF score12 X 8 X 5=4802 X 2 X 2=8
# samples 122
** MAII scorelog2(12/480*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: SMG6 [Title/Abstract] AND SHPK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSMG6

GO:1904354

negative regulation of telomere capping

12676087

TgeneSHPK

GO:0005975

carbohydrate metabolic process

19413330

TgeneSHPK

GO:0016310

phosphorylation

19413330

TgeneSHPK

GO:0071222

cellular response to lipopolysaccharide

22682222


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-HC-8265-01BSMG6chr17

2139786

-SHPKchr17

3518831

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000544865ENST00000225519SMG6chr17

2139786

-SHPKchr17

3518831

-
5CDS-intronENST00000544865ENST00000572705SMG6chr17

2139786

-SHPKchr17

3518831

-
In-frameENST00000263073ENST00000225519SMG6chr17

2139786

-SHPKchr17

3518831

-
5CDS-intronENST00000263073ENST00000572705SMG6chr17

2139786

-SHPKchr17

3518831

-
In-frameENST00000354901ENST00000225519SMG6chr17

2139786

-SHPKchr17

3518831

-
5CDS-intronENST00000354901ENST00000572705SMG6chr17

2139786

-SHPKchr17

3518831

-
In-frameENST00000536871ENST00000225519SMG6chr17

2139786

-SHPKchr17

3518831

-
5CDS-intronENST00000536871ENST00000572705SMG6chr17

2139786

-SHPKchr17

3518831

-
intron-3CDSENST00000573166ENST00000225519SMG6chr17

2139786

-SHPKchr17

3518831

-
intron-intronENST00000573166ENST00000572705SMG6chr17

2139786

-SHPKchr17

3518831

-

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FusionProtFeatures for SMG6_SHPK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SMG6

Q86US8

SHPK

Q9UHJ6

Component of the telomerase ribonucleoprotein (RNP)complex that is essential for the replication of chromosometermini. May have a general role in telomere regulation. Promotesin vitro the ability of TERT to elongate telomeres. Overexpressioninduces telomere uncapping, chromosomal end-to-end fusions(telomeric DNA persists at the fusion points) and did not perturbTRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNAtemplate component (TER). Plays a role in nonsense-mediated mRNA decay. Is thoughtto provide a link to the mRNA degradation machinery as it hasendonuclease activity required to initiate NMD, and to serve as anadapter for UPF1 to protein phosphatase 2A (PP2A), therebytriggering UPF1 dephosphorylation. Degrades single-stranded RNA(ssRNA), but not ssDNA or dsRNA. Acts as a modulator of macrophage activation throughcontrol of glucose metabolism. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMG6chr17:2139786chr17:3518831ENST00000263073-1019163_1939561420Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr17:3518831ENST00000263073-1019567_6259561420Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr17:3518831ENST00000544865-1019163_1939251389Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr17:3518831ENST00000544865-1019567_6259251389Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMG6chr17:2139786chr17:3518831ENST00000263073-10191197_12399561420Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr17:3518831ENST00000354901-3121197_123948512Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr17:3518831ENST00000354901-312163_19348512Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr17:3518831ENST00000354901-312567_62548512Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr17:3518831ENST00000536871-2111197_123948512Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr17:3518831ENST00000536871-211163_19348512Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr17:3518831ENST00000536871-211567_62548512Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr17:3518831ENST00000544865-10191197_12399251389Coiled coilOntology_term=ECO:0000255
HgeneSMG6chr17:2139786chr17:3518831ENST00000263073-10191246_13979561420DomainNote=PINc
HgeneSMG6chr17:2139786chr17:3518831ENST00000354901-3121246_139748512DomainNote=PINc
HgeneSMG6chr17:2139786chr17:3518831ENST00000536871-2111246_139748512DomainNote=PINc
HgeneSMG6chr17:2139786chr17:3518831ENST00000544865-10191246_13979251389DomainNote=PINc


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FusionGeneSequence for SMG6_SHPK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SMG6_ENST00000544865_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_1130aa
MKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSAVENGTQPVKDVCKELNNQEQNGPIDPENNRGQESF
PRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEVANKPDRAEIEKSPGGGRVGA
AKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSST
DSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMNKESPMVRSARDDMDRGKPDKGLSSGGKGSEK
QESKNPKQELRGRGRGILILPAHTTLSVNSAGSPESAPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDTDD
EVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYPGPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQ
HMRNLQQQELHRLLRVADNQELQLSNLLSRDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVKD
PNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRCMICQGDIARYREQASDTANYGKA
RSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKKS
TFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSP
SPIGSTRMLQLMTINMFAVHNSQLKVLNISTSVQLAASMPSGFQPAQTPDPTAPVAYFPYFNRTYLGVAASLNGGNVLATFVHMLVQWMA
DLGLEVEESTVYSRMIQAAVQQRDTHLTITPTVLGERHLPDQLASVTRISSSDLSLGHVTRALCRGIVQNLHSMLPIQQLQDWGVERVMG

>In-frame_SMG6_ENST00000263073_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_1161aa
MAEGLERVRISASELRGILATLAPQAGSRENMKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSAVENG
TQPVKDVCKELNNQEQNGPIDPENNRGQESFPRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEED
ECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEG
AGLTDNGCRRRRQDRTKERPRLKKQVSVSSTDSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMN
KESPMVRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQELRGRGRGILILPAHTTLSVNSAGSPESAPLGPRLLFGSGSKGSRSWGRGG
TTRRLWDPNNPDQKPALKTQTPQLHFLDTDDEVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYP
GPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQHMRNLQQQELHRLLRVADNQELQLSNLLSRDRISPEGLEKMAQLRAELLQLYERCILLD
IEFSDNQNVDQILWKNAFYQVIEKFRQLVKDPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKY
ALISAQRCMICQGDIARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLF
EETKRKAEQMEKKQHEEFDLSPDQWRKGKKSTFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAH
GKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKVLNISTSVQLAASMPSGFQPAQTPDPTAPVAYFP
YFNRTYLGVAASLNGGNVLATFVHMLVQWMADLGLEVEESTVYSRMIQAAVQQRDTHLTITPTVLGERHLPDQLASVTRISSSDLSLGHV

>In-frame_SMG6_ENST00000354901_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_253aa
METFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKVLNISTSVQLAASMPSGFQPAQTPDPTAPVAYFPYFNRTYLG
VAASLNGGNVLATFVHMLVQWMADLGLEVEESTVYSRMIQAAVQQRDTHLTITPTVLGERHLPDQLASVTRISSSDLSLGHVTRALCRGI

>In-frame_SMG6_ENST00000536871_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_253aa
METFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKVLNISTSVQLAASMPSGFQPAQTPDPTAPVAYFPYFNRTYLG
VAASLNGGNVLATFVHMLVQWMADLGLEVEESTVYSRMIQAAVQQRDTHLTITPTVLGERHLPDQLASVTRISSSDLSLGHVTRALCRGI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SMG6_ENST00000544865_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_3390nt
ATGAAGGAATTAAAGGAGGCCAGGCCGCGCAAAGATAACAGGCGTCCAGATCTGGAAATCTATAAGCCTGGCCTTTCTCGGCTAAGGAAC
AAGCCCAAAATCAAGGAACCCCCTGGGAGTGAGGAATTCAAAGATGAAATTGTTAATGACCGAGATTGCTCTGCTGTTGAAAATGGTACA
CAGCCCGTTAAAGATGTCTGCAAGGAACTGAACAACCAAGAGCAGAATGGTCCTATAGACCCAGAAAATAATCGGGGACAAGAATCCTTT
CCTAGGACTGCTGGACAAGAGGATCGTAGTCTAAAAATTATCAAAAGAACAAAGAAACCCGACCTGCAGATCTATCAGCCTGGACGACGT
TTGCAGACTGTTAGCAAAGAATCCGCCAGTCGGGTGGAGGAGGAAGAAGTCCTCAACCAGGTAGAACAACTGAGAGTAGAGGAAGATGAG
TGTAGGGGAAATGTTGCGAAGGAGGAAGTTGCGAATAAACCAGACAGGGCTGAGATAGAAAAGAGCCCAGGTGGTGGGAGAGTAGGGGCT
GCAAAAGGAGAAAAAGGAAAGAGGATGGGAAAAGGGGAGGGGGTGAGGGAAACCCACGACGACCCAGCCCGCGGGAGGCCGGGCTCCGCA
AAGCGCTACTCCCGCTCAGACAAACGAAGGAATCGCTACCGCACGCGCAGCACCAGCTCAGCTGGCAGCAACAACAGCGCTGAGGGAGCT
GGCCTGACGGATAATGGATGTCGCCGCCGCCGACAGGATAGGACCAAGGAGAGGCCACGACTGAAGAAGCAAGTGTCTGTGTCCTCAACC
GATTCCTTAGACGAGGACAGAATTGATGAGCCTGATGGATTAGGACCCAGGAGAAGTTCAGAAAGGAAGAGACATTTAGAAAGAAACTGG
TCTGGCCGTGGGGAGGGTGAGCAGAAAAACAGTGCTAAAGAATATCGAGGCACTCTTCGTGTCACTTTCGATGCAGAAGCCATGAACAAA
GAGTCTCCCATGGTGAGGTCAGCCAGGGATGATATGGATAGAGGAAAGCCTGACAAAGGCTTGAGCAGTGGGGGCAAAGGCTCTGAGAAG
CAGGAGTCCAAAAACCCGAAACAAGAACTTCGGGGTCGTGGTCGTGGCATTCTGATTTTGCCTGCCCATACCACCCTATCTGTCAATTCA
GCAGGTTCTCCAGAGTCCGCGCCTTTGGGACCTCGGCTTTTGTTTGGATCTGGTAGTAAGGGATCTCGGAGTTGGGGCCGTGGAGGCACC
ACACGCCGATTGTGGGACCCAAACAATCCTGATCAGAAACCTGCTCTAAAGACTCAGACGCCCCAGCTACATTTCTTGGACACTGATGAT
GAAGTCAGCCCTACATCTTGGGGTGACTCACGCCAGGCTCAGGCATCTTACTATAAGTTTCAAAACTCTGACAACCCCTATTATTACCCC
CGGACACCAGGCCCTGCCTCCCAGTATCCCTATACGGGCTATAACCCTCTACAGTACCCAGTGGGCCCTACGAATGGTGTGTACCCAGGG
CCTTACTACCCAGGCTACCCGACTCCGTCAGGACAGTATGTGTGTAGCCCTCTACCTACCAGCACCATGAGTCCCGAGGAGGTAGAGCAG
CACATGAGGAACCTGCAGCAACAGGAGCTGCACAGGCTTCTCCGGGTGGCTGACAACCAGGAACTGCAGCTCAGCAACCTGCTCTCCAGG
GACCGCATCAGTCCGGAGGGCCTGGAGAAGATGGCGCAACTCAGAGCTGAACTGCTGCAGCTATATGAGCGCTGTATTCTATTAGATATT
GAGTTCTCTGATAATCAGAATGTGGATCAGATCCTGTGGAAGAATGCTTTCTATCAGGTGATTGAGAAGTTCAGGCAACTTGTCAAGGAT
CCGAATGTTGAGAACCCAGAACAGATTCGGAACAGACTTTTGGAGCTCTTGGATGAGGGTAGTGACTTCTTTGATAGTTTGCTTCAGAAG
CTGCAGGTTACTTACAAGTTCAAACTGGAAGACTACATGGATGGTCTTGCCATTCGCAGCAAGCCATTACGCAAGACAGTAAAATATGCC
TTGATCAGTGCCCAGCGATGCATGATATGCCAAGGAGATATTGCTAGGTACCGGGAGCAAGCCAGTGATACAGCGAATTATGGGAAAGCA
CGCAGTTGGTACCTGAAGGCCCAGCACATTGCTCCCAAGAATGGGCGCCCCTATAACCAGTTGGCTTTGCTGGCAGTGTATACGAGGAGG
AAGCTTGACGCTGTCTATTACTATATGCGCAGTTTAGCTGCCAGCAACCCTATCCTGACTGCCAAGGAGAGTCTCATGAGCTTGTTTGAA
GAGACCAAGCGGAAGGCAGAACAGATGGAAAAGAAGCAACATGAGGAATTTGACCTGAGCCCTGACCAGTGGCGGAAAGGAAAGAAGTCT
ACTTTCCGGCATGTTGGAGATGACACCACTCGCCTGGAGATCTGGATTCATCCATCCCATCCACGGTCTTCCCAGGGCACTGAGTCTGGG
AAGGATTCTGAGCAAGAGAATGGGCTGGGCAGCCTGAGTCCCAGTGATCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCATGGG
AAGCTGTTTACCCGGATTGGGATGGAGACATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCC
TCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGTTCTCAACATCAGC
ACCTCGGTTCAGCTGGCAGCCTCCATGCCTTCAGGATTCCAGCCTGCACAGACTCCAGACCCTACGGCCCCAGTCGCCTACTTCCCATAC
TTCAACAGGACCTACCTGGGGGTGGCCGCGTCACTCAACGGGGGCAATGTGCTGGCCACGTTCGTCCACATGCTGGTTCAGTGGATGGCA
GATCTAGGCCTGGAGGTTGAAGAATCCACTGTGTATTCACGCATGATTCAGGCAGCTGTGCAGCAGAGAGATACCCACCTGACCATCACC
CCGACAGTGCTGGGGGAGAGGCACCTGCCGGACCAGCTGGCCTCAGTGACCAGAATCTCCTCCTCCGACCTCTCCCTGGGGCACGTGACC
CGGGCTCTGTGCCGAGGCATTGTTCAGAACCTGCACTCCATGCTTCCGATTCAGCAGCTCCAGGACTGGGGCGTGGAGAGGGTGATGGGC
AGTGGGAGTGCGCTGTCCAGGAATGACGTGCTGAAGCAGGAGGTGCAGAGGGCTTTCCCTTTGCCCATGTCCTTTGGGCAGGATGTGGAT

>In-frame_SMG6_ENST00000263073_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_3483nt
ATGGCGGAAGGGCTGGAGCGTGTGCGGATCTCCGCGTCGGAGCTGCGCGGGATCCTGGCTACTCTGGCCCCGCAGGCCGGGAGCAGAGAA
AACATGAAGGAATTAAAGGAGGCCAGGCCGCGCAAAGATAACAGGCGTCCAGATCTGGAAATCTATAAGCCTGGCCTTTCTCGGCTAAGG
AACAAGCCCAAAATCAAGGAACCCCCTGGGAGTGAGGAATTCAAAGATGAAATTGTTAATGACCGAGATTGCTCTGCTGTTGAAAATGGT
ACACAGCCCGTTAAAGATGTCTGCAAGGAACTGAACAACCAAGAGCAGAATGGTCCTATAGACCCAGAAAATAATCGGGGACAAGAATCC
TTTCCTAGGACTGCTGGACAAGAGGATCGTAGTCTAAAAATTATCAAAAGAACAAAGAAACCCGACCTGCAGATCTATCAGCCTGGACGA
CGTTTGCAGACTGTTAGCAAAGAATCCGCCAGTCGGGTGGAGGAGGAAGAAGTCCTCAACCAGGTAGAACAACTGAGAGTAGAGGAAGAT
GAGTGTAGGGGAAATGTTGCGAAGGAGGAAGTTGCGAATAAACCAGACAGGGCTGAGATAGAAAAGAGCCCAGGTGGTGGGAGAGTAGGG
GCTGCAAAAGGAGAAAAAGGAAAGAGGATGGGAAAAGGGGAGGGGGTGAGGGAAACCCACGACGACCCAGCCCGCGGGAGGCCGGGCTCC
GCAAAGCGCTACTCCCGCTCAGACAAACGAAGGAATCGCTACCGCACGCGCAGCACCAGCTCAGCTGGCAGCAACAACAGCGCTGAGGGA
GCTGGCCTGACGGATAATGGATGTCGCCGCCGCCGACAGGATAGGACCAAGGAGAGGCCACGACTGAAGAAGCAAGTGTCTGTGTCCTCA
ACCGATTCCTTAGACGAGGACAGAATTGATGAGCCTGATGGATTAGGACCCAGGAGAAGTTCAGAAAGGAAGAGACATTTAGAAAGAAAC
TGGTCTGGCCGTGGGGAGGGTGAGCAGAAAAACAGTGCTAAAGAATATCGAGGCACTCTTCGTGTCACTTTCGATGCAGAAGCCATGAAC
AAAGAGTCTCCCATGGTGAGGTCAGCCAGGGATGATATGGATAGAGGAAAGCCTGACAAAGGCTTGAGCAGTGGGGGCAAAGGCTCTGAG
AAGCAGGAGTCCAAAAACCCGAAACAAGAACTTCGGGGTCGTGGTCGTGGCATTCTGATTTTGCCTGCCCATACCACCCTATCTGTCAAT
TCAGCAGGTTCTCCAGAGTCCGCGCCTTTGGGACCTCGGCTTTTGTTTGGATCTGGTAGTAAGGGATCTCGGAGTTGGGGCCGTGGAGGC
ACCACACGCCGATTGTGGGACCCAAACAATCCTGATCAGAAACCTGCTCTAAAGACTCAGACGCCCCAGCTACATTTCTTGGACACTGAT
GATGAAGTCAGCCCTACATCTTGGGGTGACTCACGCCAGGCTCAGGCATCTTACTATAAGTTTCAAAACTCTGACAACCCCTATTATTAC
CCCCGGACACCAGGCCCTGCCTCCCAGTATCCCTATACGGGCTATAACCCTCTACAGTACCCAGTGGGCCCTACGAATGGTGTGTACCCA
GGGCCTTACTACCCAGGCTACCCGACTCCGTCAGGACAGTATGTGTGTAGCCCTCTACCTACCAGCACCATGAGTCCCGAGGAGGTAGAG
CAGCACATGAGGAACCTGCAGCAACAGGAGCTGCACAGGCTTCTCCGGGTGGCTGACAACCAGGAACTGCAGCTCAGCAACCTGCTCTCC
AGGGACCGCATCAGTCCGGAGGGCCTGGAGAAGATGGCGCAACTCAGAGCTGAACTGCTGCAGCTATATGAGCGCTGTATTCTATTAGAT
ATTGAGTTCTCTGATAATCAGAATGTGGATCAGATCCTGTGGAAGAATGCTTTCTATCAGGTGATTGAGAAGTTCAGGCAACTTGTCAAG
GATCCGAATGTTGAGAACCCAGAACAGATTCGGAACAGACTTTTGGAGCTCTTGGATGAGGGTAGTGACTTCTTTGATAGTTTGCTTCAG
AAGCTGCAGGTTACTTACAAGTTCAAACTGGAAGACTACATGGATGGTCTTGCCATTCGCAGCAAGCCATTACGCAAGACAGTAAAATAT
GCCTTGATCAGTGCCCAGCGATGCATGATATGCCAAGGAGATATTGCTAGGTACCGGGAGCAAGCCAGTGATACAGCGAATTATGGGAAA
GCACGCAGTTGGTACCTGAAGGCCCAGCACATTGCTCCCAAGAATGGGCGCCCCTATAACCAGTTGGCTTTGCTGGCAGTGTATACGAGG
AGGAAGCTTGACGCTGTCTATTACTATATGCGCAGTTTAGCTGCCAGCAACCCTATCCTGACTGCCAAGGAGAGTCTCATGAGCTTGTTT
GAAGAGACCAAGCGGAAGGCAGAACAGATGGAAAAGAAGCAACATGAGGAATTTGACCTGAGCCCTGACCAGTGGCGGAAAGGAAAGAAG
TCTACTTTCCGGCATGTTGGAGATGACACCACTCGCCTGGAGATCTGGATTCATCCATCCCATCCACGGTCTTCCCAGGGCACTGAGTCT
GGGAAGGATTCTGAGCAAGAGAATGGGCTGGGCAGCCTGAGTCCCAGTGATCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCAT
GGGAAGCTGTTTACCCGGATTGGGATGGAGACATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGC
CCCTCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGTTCTCAACATC
AGCACCTCGGTTCAGCTGGCAGCCTCCATGCCTTCAGGATTCCAGCCTGCACAGACTCCAGACCCTACGGCCCCAGTCGCCTACTTCCCA
TACTTCAACAGGACCTACCTGGGGGTGGCCGCGTCACTCAACGGGGGCAATGTGCTGGCCACGTTCGTCCACATGCTGGTTCAGTGGATG
GCAGATCTAGGCCTGGAGGTTGAAGAATCCACTGTGTATTCACGCATGATTCAGGCAGCTGTGCAGCAGAGAGATACCCACCTGACCATC
ACCCCGACAGTGCTGGGGGAGAGGCACCTGCCGGACCAGCTGGCCTCAGTGACCAGAATCTCCTCCTCCGACCTCTCCCTGGGGCACGTG
ACCCGGGCTCTGTGCCGAGGCATTGTTCAGAACCTGCACTCCATGCTTCCGATTCAGCAGCTCCAGGACTGGGGCGTGGAGAGGGTGATG
GGCAGTGGGAGTGCGCTGTCCAGGAATGACGTGCTGAAGCAGGAGGTGCAGAGGGCTTTCCCTTTGCCCATGTCCTTTGGGCAGGATGTG

>In-frame_SMG6_ENST00000354901_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_759nt
ATGGAGACATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGC
ATGCTGCAGCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGTTCTCAACATCAGCACCTCGGTTCAGCTGGCAGCC
TCCATGCCTTCAGGATTCCAGCCTGCACAGACTCCAGACCCTACGGCCCCAGTCGCCTACTTCCCATACTTCAACAGGACCTACCTGGGG
GTGGCCGCGTCACTCAACGGGGGCAATGTGCTGGCCACGTTCGTCCACATGCTGGTTCAGTGGATGGCAGATCTAGGCCTGGAGGTTGAA
GAATCCACTGTGTATTCACGCATGATTCAGGCAGCTGTGCAGCAGAGAGATACCCACCTGACCATCACCCCGACAGTGCTGGGGGAGAGG
CACCTGCCGGACCAGCTGGCCTCAGTGACCAGAATCTCCTCCTCCGACCTCTCCCTGGGGCACGTGACCCGGGCTCTGTGCCGAGGCATT
GTTCAGAACCTGCACTCCATGCTTCCGATTCAGCAGCTCCAGGACTGGGGCGTGGAGAGGGTGATGGGCAGTGGGAGTGCGCTGTCCAGG
AATGACGTGCTGAAGCAGGAGGTGCAGAGGGCTTTCCCTTTGCCCATGTCCTTTGGGCAGGATGTGGATGCAGCTGTCGGGGCAGCTCTG

>In-frame_SMG6_ENST00000536871_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_759nt
ATGGAGACATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGC
ATGCTGCAGCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGTTCTCAACATCAGCACCTCGGTTCAGCTGGCAGCC
TCCATGCCTTCAGGATTCCAGCCTGCACAGACTCCAGACCCTACGGCCCCAGTCGCCTACTTCCCATACTTCAACAGGACCTACCTGGGG
GTGGCCGCGTCACTCAACGGGGGCAATGTGCTGGCCACGTTCGTCCACATGCTGGTTCAGTGGATGGCAGATCTAGGCCTGGAGGTTGAA
GAATCCACTGTGTATTCACGCATGATTCAGGCAGCTGTGCAGCAGAGAGATACCCACCTGACCATCACCCCGACAGTGCTGGGGGAGAGG
CACCTGCCGGACCAGCTGGCCTCAGTGACCAGAATCTCCTCCTCCGACCTCTCCCTGGGGCACGTGACCCGGGCTCTGTGCCGAGGCATT
GTTCAGAACCTGCACTCCATGCTTCCGATTCAGCAGCTCCAGGACTGGGGCGTGGAGAGGGTGATGGGCAGTGGGAGTGCGCTGTCCAGG
AATGACGTGCTGAAGCAGGAGGTGCAGAGGGCTTTCCCTTTGCCCATGTCCTTTGGGCAGGATGTGGATGCAGCTGTCGGGGCAGCTCTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_SMG6_ENST00000544865_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_6199nt
AGCAGTAGGCGCTGGGGCCGCGGCGGACCCTCGCTGCCCTACCTCTCTCGCGGGTTAGTGCGGGGTCGGGCTCGGCCAGTCCTGGCCAGC
TCCGGGAGAGCCTGGCCCGAATTCCTGCCTCCACCCTCTTTCTCGCCGCGAAGGTGACTGTTCCTTTTGCCCCAGCCCTCTCAGACCCGC
CCCGGATTCCCAGGCATCGGGAGACGCGGAAAGGAGTGGGGTCTGGTGGAGGCCCCGGGCGTATCGCTCTCCAGGCCGCCCTCCGCGGGC
CTGCCCCGGCCACCGCTTTAACGTCGGAGAGAAGGAATTGGGGAGAAAGGTTTAAGAGCCTGCGACTTCGTTGCTGAACTTTTCCCCCCC
AAGACAGGCTTCCGAAAGCTGCGCCACTGGAGGGATCCGGGACCTCAGACTACTCGGGTTTGGCCCTGGCATGTGTGGGAGCAGTTTTTA
TTAGAGAGAATGCTCAATTTGCAAGTTAATTTCAAGTCTCCAGCCACGTCAGGAAAAAAACATGAAGGAATTAAAGGAGGCCAGGCCGCG
CAAAGATAACAGGCGTCCAGATCTGGAAATCTATAAGCCTGGCCTTTCTCGGCTAAGGAACAAGCCCAAAATCAAGGAACCCCCTGGGAG
TGAGGAATTCAAAGATGAAATTGTTAATGACCGAGATTGCTCTGCTGTTGAAAATGGTACACAGCCCGTTAAAGATGTCTGCAAGGAACT
GAACAACCAAGAGCAGAATGGTCCTATAGACCCAGAAAATAATCGGGGACAAGAATCCTTTCCTAGGACTGCTGGACAAGAGGATCGTAG
TCTAAAAATTATCAAAAGAACAAAGAAACCCGACCTGCAGATCTATCAGCCTGGACGACGTTTGCAGACTGTTAGCAAAGAATCCGCCAG
TCGGGTGGAGGAGGAAGAAGTCCTCAACCAGGTAGAACAACTGAGAGTAGAGGAAGATGAGTGTAGGGGAAATGTTGCGAAGGAGGAAGT
TGCGAATAAACCAGACAGGGCTGAGATAGAAAAGAGCCCAGGTGGTGGGAGAGTAGGGGCTGCAAAAGGAGAAAAAGGAAAGAGGATGGG
AAAAGGGGAGGGGGTGAGGGAAACCCACGACGACCCAGCCCGCGGGAGGCCGGGCTCCGCAAAGCGCTACTCCCGCTCAGACAAACGAAG
GAATCGCTACCGCACGCGCAGCACCAGCTCAGCTGGCAGCAACAACAGCGCTGAGGGAGCTGGCCTGACGGATAATGGATGTCGCCGCCG
CCGACAGGATAGGACCAAGGAGAGGCCACGACTGAAGAAGCAAGTGTCTGTGTCCTCAACCGATTCCTTAGACGAGGACAGAATTGATGA
GCCTGATGGATTAGGACCCAGGAGAAGTTCAGAAAGGAAGAGACATTTAGAAAGAAACTGGTCTGGCCGTGGGGAGGGTGAGCAGAAAAA
CAGTGCTAAAGAATATCGAGGCACTCTTCGTGTCACTTTCGATGCAGAAGCCATGAACAAAGAGTCTCCCATGGTGAGGTCAGCCAGGGA
TGATATGGATAGAGGAAAGCCTGACAAAGGCTTGAGCAGTGGGGGCAAAGGCTCTGAGAAGCAGGAGTCCAAAAACCCGAAACAAGAACT
TCGGGGTCGTGGTCGTGGCATTCTGATTTTGCCTGCCCATACCACCCTATCTGTCAATTCAGCAGGTTCTCCAGAGTCCGCGCCTTTGGG
ACCTCGGCTTTTGTTTGGATCTGGTAGTAAGGGATCTCGGAGTTGGGGCCGTGGAGGCACCACACGCCGATTGTGGGACCCAAACAATCC
TGATCAGAAACCTGCTCTAAAGACTCAGACGCCCCAGCTACATTTCTTGGACACTGATGATGAAGTCAGCCCTACATCTTGGGGTGACTC
ACGCCAGGCTCAGGCATCTTACTATAAGTTTCAAAACTCTGACAACCCCTATTATTACCCCCGGACACCAGGCCCTGCCTCCCAGTATCC
CTATACGGGCTATAACCCTCTACAGTACCCAGTGGGCCCTACGAATGGTGTGTACCCAGGGCCTTACTACCCAGGCTACCCGACTCCGTC
AGGACAGTATGTGTGTAGCCCTCTACCTACCAGCACCATGAGTCCCGAGGAGGTAGAGCAGCACATGAGGAACCTGCAGCAACAGGAGCT
GCACAGGCTTCTCCGGGTGGCTGACAACCAGGAACTGCAGCTCAGCAACCTGCTCTCCAGGGACCGCATCAGTCCGGAGGGCCTGGAGAA
GATGGCGCAACTCAGAGCTGAACTGCTGCAGCTATATGAGCGCTGTATTCTATTAGATATTGAGTTCTCTGATAATCAGAATGTGGATCA
GATCCTGTGGAAGAATGCTTTCTATCAGGTGATTGAGAAGTTCAGGCAACTTGTCAAGGATCCGAATGTTGAGAACCCAGAACAGATTCG
GAACAGACTTTTGGAGCTCTTGGATGAGGGTAGTGACTTCTTTGATAGTTTGCTTCAGAAGCTGCAGGTTACTTACAAGTTCAAACTGGA
AGACTACATGGATGGTCTTGCCATTCGCAGCAAGCCATTACGCAAGACAGTAAAATATGCCTTGATCAGTGCCCAGCGATGCATGATATG
CCAAGGAGATATTGCTAGGTACCGGGAGCAAGCCAGTGATACAGCGAATTATGGGAAAGCACGCAGTTGGTACCTGAAGGCCCAGCACAT
TGCTCCCAAGAATGGGCGCCCCTATAACCAGTTGGCTTTGCTGGCAGTGTATACGAGGAGGAAGCTTGACGCTGTCTATTACTATATGCG
CAGTTTAGCTGCCAGCAACCCTATCCTGACTGCCAAGGAGAGTCTCATGAGCTTGTTTGAAGAGACCAAGCGGAAGGCAGAACAGATGGA
AAAGAAGCAACATGAGGAATTTGACCTGAGCCCTGACCAGTGGCGGAAAGGAAAGAAGTCTACTTTCCGGCATGTTGGAGATGACACCAC
TCGCCTGGAGATCTGGATTCATCCATCCCATCCACGGTCTTCCCAGGGCACTGAGTCTGGGAAGGATTCTGAGCAAGAGAATGGGCTGGG
CAGCCTGAGTCCCAGTGATCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCATGGGAAGCTGTTTACCCGGATTGGGATGGAGAC
ATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGCATGCTGCA
GCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGTTCTCAACATCAGCACCTCGGTTCAGCTGGCAGCCTCCATGCC
TTCAGGATTCCAGCCTGCACAGACTCCAGACCCTACGGCCCCAGTCGCCTACTTCCCATACTTCAACAGGACCTACCTGGGGGTGGCCGC
GTCACTCAACGGGGGCAATGTGCTGGCCACGTTCGTCCACATGCTGGTTCAGTGGATGGCAGATCTAGGCCTGGAGGTTGAAGAATCCAC
TGTGTATTCACGCATGATTCAGGCAGCTGTGCAGCAGAGAGATACCCACCTGACCATCACCCCGACAGTGCTGGGGGAGAGGCACCTGCC
GGACCAGCTGGCCTCAGTGACCAGAATCTCCTCCTCCGACCTCTCCCTGGGGCACGTGACCCGGGCTCTGTGCCGAGGCATTGTTCAGAA
CCTGCACTCCATGCTTCCGATTCAGCAGCTCCAGGACTGGGGCGTGGAGAGGGTGATGGGCAGTGGGAGTGCGCTGTCCAGGAATGACGT
GCTGAAGCAGGAGGTGCAGAGGGCTTTCCCTTTGCCCATGTCCTTTGGGCAGGATGTGGATGCAGCTGTCGGGGCAGCTCTGGTCATGCT
CCGGAGACACCTCAACCAGAAGGAATCTTAGACAGCAAACTCTTTCGCCAAACGACTGCTGTGAATTTTACCTGATTAACATTCCTGACA
CCATCTGTGGGTCATCCTTTCCCTGGACCGTTCAGTGGACAGCTTTCAAGCAGTGCTTGTTGTGAGGTCCCATCTCGGCCAAGAACTTAC
CTTCAGAACATACTCTAATAATGCAGCCAGGAGCCGTCAGCCAGATCCCAAATGAGTGCCTTCCGAAATTGACCCACCTGGGAGCTATTT
ACAAATGTCCATGTGGGAGAGAGAGAGCATGAGAGCACAGTAGCCCAGCCTGCTGGTCAGCAGGCTCATCTGTGGTTCACCTGTAGACAG
AGAGCAGATCAATGTGTACTTCAGACACCAGAAAGTCTGGTGGCTTTGGTCCCAAGTGGGAAAAGAGAACTGCCCCATGCCCAGCTTGTG
ATTATCGTTTTTGGAGACCTGAAGCCCACACTCGGGTCGTATGGACTTCTGGAAAAGTTCTTGTCTCCTGGACTGAACCATGTGACCGGA
GGCCCCTTTCCTAGTCTCATCCTCCCCTGGCTGCAGATGCTTAGCTGGGCCAGGGATTGACCCAAGCGCGATGCAGCAGGCAGGCTCAGA
AGACGATGCGGGGCTGTGTGCCGGCCTTCTTGCTGCATGTACTCAGCCTCAGGAGAGCTTGCTGCACCCAGGCCGCCCAGGTCTTCACAG
CACAACTGCCTGGAAGGCAGGTTGCGAGAAGGAGAGGCGGATGGCATGAGCAGCAAGGGGGACCGATGCTGTGCAGCTCACACCACTCCA
GAACCTGACAAGGCACCAGCAGGACCCCTTGCCAGGAGCATGTCTGTGCAGCAGTGTTTTTGCCCCTGCACATTCCAGAAGCCCTCATGG
GAAGGGATGCAGCCAGGCAGACTCCTGCCAGATGGGGCAGGTAGTTTATTCAAAGAGAACTCTGTATCCCATAGGCCCAGGCTCTCCTTT
CGCTTGGCGTGGGCTTTGCTGGCCCAGTGTGTGCTCCTGGCTCAGCAGAAACATCCATTTGAGTTGGCATCCCTGTAGGGATCCCAGAGC
GTTGTAAGCCTTCTTGTGATTGGTAGGGATGGCTGTGGGGTGGCTTCCAGGAGGGGGCCACCATTGCCGCATCTACTTCTAGACTCCCAA
AGGAGCCCAGGCTCAGGCAGGCCTGGCCCAGAGTCACGCTGGCAACCACGAGTTTGGGAAGCAGTCGTATTCTCTCTCTCTCTCTCTCTC
TCTCTCTCAGTATCCATGACAGGTATGAAACATATTGTCTCTTTATAAATGTCATTTTACAAATTATGTGATTATCTGGAAGCTCTAAGA
TGAGAGCAAATGCCTGATCACTCTGGCCAAATGTCAGATACTAAAGCCCATTCTTGGCCGGGCATGTTGGCTCCCGCCTGTAATCCCAGC
ACTTTGGGAAGCCCAAGTGGGTGAATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGGGATACCCCGTCTCTACTAAAAA
TACAAGCCGGGCGTGGTGGCGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAAAATCACTTGAACTCGGGAGGCAGAGGTT
GCAGTGAGCTGAGATCGCGCCATTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCATAAATAAATACAAAGCCCATTCTTCCAG
AGTCTTGTGCCTTAAATAAAACACACCTCTCTGCTGTGGGAAGACTGTGCAATGGCACAGCCGCAGAGCTTGGTTTGGGAGGTTGAAGTG
CTCTGGGGAGAATTCGTAGATCATCCTCAGAAAAGCCTTGCCCTGGTGTTCTACCAGAAAAACGTCTCCCAATCACCCAGGAAAGCTGTC
CACAGTAGTCCCCCCTTATCCACGGTGTCACTTTCCATGGGTTCAGTTATCTGCGGTCAACCACGGTCTGACAATATTAAATGGAAAATT
CTTCAAACAGTTCCCAAGTTTTCCCTTGTGCATTGTTCTGAGCAGTGTGATGGAGAGTCTCTGCCGTGCCATCTGGGATGCAAACCGTCC
CTGTGTTCCCCACGTCCAGGCCGTAGATGCTCCCCGCCGGTCAGTCACTTAGTCGTCAGATCGCCCGTCCTGGTATCACAGTGCTTCTGT
TCAGGTCAGTCTTTTTTTACTTCATTAGGGCCCCAAAGCACCAGAGTAGTGATGCTGGTAGTGATGCTGGCTGTTCGGATATGCCAAAGA

>In-frame_SMG6_ENST00000263073_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_5832nt
GCTGCGCGCGGCGGTGGCGGAGCCGCTACGGCTGTAGCAGCAGCCGCGAAGATGGCGGAAGGGCTGGAGCGTGTGCGGATCTCCGCGTCG
GAGCTGCGCGGGATCCTGGCTACTCTGGCCCCGCAGGCCGGGAGCAGAGAAAACATGAAGGAATTAAAGGAGGCCAGGCCGCGCAAAGAT
AACAGGCGTCCAGATCTGGAAATCTATAAGCCTGGCCTTTCTCGGCTAAGGAACAAGCCCAAAATCAAGGAACCCCCTGGGAGTGAGGAA
TTCAAAGATGAAATTGTTAATGACCGAGATTGCTCTGCTGTTGAAAATGGTACACAGCCCGTTAAAGATGTCTGCAAGGAACTGAACAAC
CAAGAGCAGAATGGTCCTATAGACCCAGAAAATAATCGGGGACAAGAATCCTTTCCTAGGACTGCTGGACAAGAGGATCGTAGTCTAAAA
ATTATCAAAAGAACAAAGAAACCCGACCTGCAGATCTATCAGCCTGGACGACGTTTGCAGACTGTTAGCAAAGAATCCGCCAGTCGGGTG
GAGGAGGAAGAAGTCCTCAACCAGGTAGAACAACTGAGAGTAGAGGAAGATGAGTGTAGGGGAAATGTTGCGAAGGAGGAAGTTGCGAAT
AAACCAGACAGGGCTGAGATAGAAAAGAGCCCAGGTGGTGGGAGAGTAGGGGCTGCAAAAGGAGAAAAAGGAAAGAGGATGGGAAAAGGG
GAGGGGGTGAGGGAAACCCACGACGACCCAGCCCGCGGGAGGCCGGGCTCCGCAAAGCGCTACTCCCGCTCAGACAAACGAAGGAATCGC
TACCGCACGCGCAGCACCAGCTCAGCTGGCAGCAACAACAGCGCTGAGGGAGCTGGCCTGACGGATAATGGATGTCGCCGCCGCCGACAG
GATAGGACCAAGGAGAGGCCACGACTGAAGAAGCAAGTGTCTGTGTCCTCAACCGATTCCTTAGACGAGGACAGAATTGATGAGCCTGAT
GGATTAGGACCCAGGAGAAGTTCAGAAAGGAAGAGACATTTAGAAAGAAACTGGTCTGGCCGTGGGGAGGGTGAGCAGAAAAACAGTGCT
AAAGAATATCGAGGCACTCTTCGTGTCACTTTCGATGCAGAAGCCATGAACAAAGAGTCTCCCATGGTGAGGTCAGCCAGGGATGATATG
GATAGAGGAAAGCCTGACAAAGGCTTGAGCAGTGGGGGCAAAGGCTCTGAGAAGCAGGAGTCCAAAAACCCGAAACAAGAACTTCGGGGT
CGTGGTCGTGGCATTCTGATTTTGCCTGCCCATACCACCCTATCTGTCAATTCAGCAGGTTCTCCAGAGTCCGCGCCTTTGGGACCTCGG
CTTTTGTTTGGATCTGGTAGTAAGGGATCTCGGAGTTGGGGCCGTGGAGGCACCACACGCCGATTGTGGGACCCAAACAATCCTGATCAG
AAACCTGCTCTAAAGACTCAGACGCCCCAGCTACATTTCTTGGACACTGATGATGAAGTCAGCCCTACATCTTGGGGTGACTCACGCCAG
GCTCAGGCATCTTACTATAAGTTTCAAAACTCTGACAACCCCTATTATTACCCCCGGACACCAGGCCCTGCCTCCCAGTATCCCTATACG
GGCTATAACCCTCTACAGTACCCAGTGGGCCCTACGAATGGTGTGTACCCAGGGCCTTACTACCCAGGCTACCCGACTCCGTCAGGACAG
TATGTGTGTAGCCCTCTACCTACCAGCACCATGAGTCCCGAGGAGGTAGAGCAGCACATGAGGAACCTGCAGCAACAGGAGCTGCACAGG
CTTCTCCGGGTGGCTGACAACCAGGAACTGCAGCTCAGCAACCTGCTCTCCAGGGACCGCATCAGTCCGGAGGGCCTGGAGAAGATGGCG
CAACTCAGAGCTGAACTGCTGCAGCTATATGAGCGCTGTATTCTATTAGATATTGAGTTCTCTGATAATCAGAATGTGGATCAGATCCTG
TGGAAGAATGCTTTCTATCAGGTGATTGAGAAGTTCAGGCAACTTGTCAAGGATCCGAATGTTGAGAACCCAGAACAGATTCGGAACAGA
CTTTTGGAGCTCTTGGATGAGGGTAGTGACTTCTTTGATAGTTTGCTTCAGAAGCTGCAGGTTACTTACAAGTTCAAACTGGAAGACTAC
ATGGATGGTCTTGCCATTCGCAGCAAGCCATTACGCAAGACAGTAAAATATGCCTTGATCAGTGCCCAGCGATGCATGATATGCCAAGGA
GATATTGCTAGGTACCGGGAGCAAGCCAGTGATACAGCGAATTATGGGAAAGCACGCAGTTGGTACCTGAAGGCCCAGCACATTGCTCCC
AAGAATGGGCGCCCCTATAACCAGTTGGCTTTGCTGGCAGTGTATACGAGGAGGAAGCTTGACGCTGTCTATTACTATATGCGCAGTTTA
GCTGCCAGCAACCCTATCCTGACTGCCAAGGAGAGTCTCATGAGCTTGTTTGAAGAGACCAAGCGGAAGGCAGAACAGATGGAAAAGAAG
CAACATGAGGAATTTGACCTGAGCCCTGACCAGTGGCGGAAAGGAAAGAAGTCTACTTTCCGGCATGTTGGAGATGACACCACTCGCCTG
GAGATCTGGATTCATCCATCCCATCCACGGTCTTCCCAGGGCACTGAGTCTGGGAAGGATTCTGAGCAAGAGAATGGGCTGGGCAGCCTG
AGTCCCAGTGATCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCATGGGAAGCTGTTTACCCGGATTGGGATGGAGACATTCCCT
GCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATG
ACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGTTCTCAACATCAGCACCTCGGTTCAGCTGGCAGCCTCCATGCCTTCAGGA
TTCCAGCCTGCACAGACTCCAGACCCTACGGCCCCAGTCGCCTACTTCCCATACTTCAACAGGACCTACCTGGGGGTGGCCGCGTCACTC
AACGGGGGCAATGTGCTGGCCACGTTCGTCCACATGCTGGTTCAGTGGATGGCAGATCTAGGCCTGGAGGTTGAAGAATCCACTGTGTAT
TCACGCATGATTCAGGCAGCTGTGCAGCAGAGAGATACCCACCTGACCATCACCCCGACAGTGCTGGGGGAGAGGCACCTGCCGGACCAG
CTGGCCTCAGTGACCAGAATCTCCTCCTCCGACCTCTCCCTGGGGCACGTGACCCGGGCTCTGTGCCGAGGCATTGTTCAGAACCTGCAC
TCCATGCTTCCGATTCAGCAGCTCCAGGACTGGGGCGTGGAGAGGGTGATGGGCAGTGGGAGTGCGCTGTCCAGGAATGACGTGCTGAAG
CAGGAGGTGCAGAGGGCTTTCCCTTTGCCCATGTCCTTTGGGCAGGATGTGGATGCAGCTGTCGGGGCAGCTCTGGTCATGCTCCGGAGA
CACCTCAACCAGAAGGAATCTTAGACAGCAAACTCTTTCGCCAAACGACTGCTGTGAATTTTACCTGATTAACATTCCTGACACCATCTG
TGGGTCATCCTTTCCCTGGACCGTTCAGTGGACAGCTTTCAAGCAGTGCTTGTTGTGAGGTCCCATCTCGGCCAAGAACTTACCTTCAGA
ACATACTCTAATAATGCAGCCAGGAGCCGTCAGCCAGATCCCAAATGAGTGCCTTCCGAAATTGACCCACCTGGGAGCTATTTACAAATG
TCCATGTGGGAGAGAGAGAGCATGAGAGCACAGTAGCCCAGCCTGCTGGTCAGCAGGCTCATCTGTGGTTCACCTGTAGACAGAGAGCAG
ATCAATGTGTACTTCAGACACCAGAAAGTCTGGTGGCTTTGGTCCCAAGTGGGAAAAGAGAACTGCCCCATGCCCAGCTTGTGATTATCG
TTTTTGGAGACCTGAAGCCCACACTCGGGTCGTATGGACTTCTGGAAAAGTTCTTGTCTCCTGGACTGAACCATGTGACCGGAGGCCCCT
TTCCTAGTCTCATCCTCCCCTGGCTGCAGATGCTTAGCTGGGCCAGGGATTGACCCAAGCGCGATGCAGCAGGCAGGCTCAGAAGACGAT
GCGGGGCTGTGTGCCGGCCTTCTTGCTGCATGTACTCAGCCTCAGGAGAGCTTGCTGCACCCAGGCCGCCCAGGTCTTCACAGCACAACT
GCCTGGAAGGCAGGTTGCGAGAAGGAGAGGCGGATGGCATGAGCAGCAAGGGGGACCGATGCTGTGCAGCTCACACCACTCCAGAACCTG
ACAAGGCACCAGCAGGACCCCTTGCCAGGAGCATGTCTGTGCAGCAGTGTTTTTGCCCCTGCACATTCCAGAAGCCCTCATGGGAAGGGA
TGCAGCCAGGCAGACTCCTGCCAGATGGGGCAGGTAGTTTATTCAAAGAGAACTCTGTATCCCATAGGCCCAGGCTCTCCTTTCGCTTGG
CGTGGGCTTTGCTGGCCCAGTGTGTGCTCCTGGCTCAGCAGAAACATCCATTTGAGTTGGCATCCCTGTAGGGATCCCAGAGCGTTGTAA
GCCTTCTTGTGATTGGTAGGGATGGCTGTGGGGTGGCTTCCAGGAGGGGGCCACCATTGCCGCATCTACTTCTAGACTCCCAAAGGAGCC
CAGGCTCAGGCAGGCCTGGCCCAGAGTCACGCTGGCAACCACGAGTTTGGGAAGCAGTCGTATTCTCTCTCTCTCTCTCTCTCTCTCTCT
CAGTATCCATGACAGGTATGAAACATATTGTCTCTTTATAAATGTCATTTTACAAATTATGTGATTATCTGGAAGCTCTAAGATGAGAGC
AAATGCCTGATCACTCTGGCCAAATGTCAGATACTAAAGCCCATTCTTGGCCGGGCATGTTGGCTCCCGCCTGTAATCCCAGCACTTTGG
GAAGCCCAAGTGGGTGAATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGGGATACCCCGTCTCTACTAAAAATACAAGC
CGGGCGTGGTGGCGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAAAATCACTTGAACTCGGGAGGCAGAGGTTGCAGTGA
GCTGAGATCGCGCCATTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCATAAATAAATACAAAGCCCATTCTTCCAGAGTCTTG
TGCCTTAAATAAAACACACCTCTCTGCTGTGGGAAGACTGTGCAATGGCACAGCCGCAGAGCTTGGTTTGGGAGGTTGAAGTGCTCTGGG
GAGAATTCGTAGATCATCCTCAGAAAAGCCTTGCCCTGGTGTTCTACCAGAAAAACGTCTCCCAATCACCCAGGAAAGCTGTCCACAGTA
GTCCCCCCTTATCCACGGTGTCACTTTCCATGGGTTCAGTTATCTGCGGTCAACCACGGTCTGACAATATTAAATGGAAAATTCTTCAAA
CAGTTCCCAAGTTTTCCCTTGTGCATTGTTCTGAGCAGTGTGATGGAGAGTCTCTGCCGTGCCATCTGGGATGCAAACCGTCCCTGTGTT
CCCCACGTCCAGGCCGTAGATGCTCCCCGCCGGTCAGTCACTTAGTCGTCAGATCGCCCGTCCTGGTATCACAGTGCTTCTGTTCAGGTC
AGTCTTTTTTTACTTCATTAGGGCCCCAAAGCACCAGAGTAGTGATGCTGGTAGTGATGCTGGCTGTTCGGATATGCCAAAGAGAAACCG

>In-frame_SMG6_ENST00000354901_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_3352nt
GGACCCAGATACCCGTCAGAATTTCCAGGCCTTGGTTTGGTTTAGACATTTTAGAAGATGTTAACAGCAATAATTGTAAAAGACTTTGAG
TGGCACGCATGGTGAACAGAAAGTACTAGATCCTGAAGAGGGGGGAAAGGCATTTCTGTGCTCTTCCTGGTAAAGTGTTTGAAAATGAAC
ATTCAGAAGAAAACCTAAAGCACCTGAAATGCACAGGGGACGAGAATGAGAGCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCA
TGGGAAGCTGTTTACCCGGATTGGGATGGAGACATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAG
CCCCTCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGTTCTCAACAT
CAGCACCTCGGTTCAGCTGGCAGCCTCCATGCCTTCAGGATTCCAGCCTGCACAGACTCCAGACCCTACGGCCCCAGTCGCCTACTTCCC
ATACTTCAACAGGACCTACCTGGGGGTGGCCGCGTCACTCAACGGGGGCAATGTGCTGGCCACGTTCGTCCACATGCTGGTTCAGTGGAT
GGCAGATCTAGGCCTGGAGGTTGAAGAATCCACTGTGTATTCACGCATGATTCAGGCAGCTGTGCAGCAGAGAGATACCCACCTGACCAT
CACCCCGACAGTGCTGGGGGAGAGGCACCTGCCGGACCAGCTGGCCTCAGTGACCAGAATCTCCTCCTCCGACCTCTCCCTGGGGCACGT
GACCCGGGCTCTGTGCCGAGGCATTGTTCAGAACCTGCACTCCATGCTTCCGATTCAGCAGCTCCAGGACTGGGGCGTGGAGAGGGTGAT
GGGCAGTGGGAGTGCGCTGTCCAGGAATGACGTGCTGAAGCAGGAGGTGCAGAGGGCTTTCCCTTTGCCCATGTCCTTTGGGCAGGATGT
GGATGCAGCTGTCGGGGCAGCTCTGGTCATGCTCCGGAGACACCTCAACCAGAAGGAATCTTAGACAGCAAACTCTTTCGCCAAACGACT
GCTGTGAATTTTACCTGATTAACATTCCTGACACCATCTGTGGGTCATCCTTTCCCTGGACCGTTCAGTGGACAGCTTTCAAGCAGTGCT
TGTTGTGAGGTCCCATCTCGGCCAAGAACTTACCTTCAGAACATACTCTAATAATGCAGCCAGGAGCCGTCAGCCAGATCCCAAATGAGT
GCCTTCCGAAATTGACCCACCTGGGAGCTATTTACAAATGTCCATGTGGGAGAGAGAGAGCATGAGAGCACAGTAGCCCAGCCTGCTGGT
CAGCAGGCTCATCTGTGGTTCACCTGTAGACAGAGAGCAGATCAATGTGTACTTCAGACACCAGAAAGTCTGGTGGCTTTGGTCCCAAGT
GGGAAAAGAGAACTGCCCCATGCCCAGCTTGTGATTATCGTTTTTGGAGACCTGAAGCCCACACTCGGGTCGTATGGACTTCTGGAAAAG
TTCTTGTCTCCTGGACTGAACCATGTGACCGGAGGCCCCTTTCCTAGTCTCATCCTCCCCTGGCTGCAGATGCTTAGCTGGGCCAGGGAT
TGACCCAAGCGCGATGCAGCAGGCAGGCTCAGAAGACGATGCGGGGCTGTGTGCCGGCCTTCTTGCTGCATGTACTCAGCCTCAGGAGAG
CTTGCTGCACCCAGGCCGCCCAGGTCTTCACAGCACAACTGCCTGGAAGGCAGGTTGCGAGAAGGAGAGGCGGATGGCATGAGCAGCAAG
GGGGACCGATGCTGTGCAGCTCACACCACTCCAGAACCTGACAAGGCACCAGCAGGACCCCTTGCCAGGAGCATGTCTGTGCAGCAGTGT
TTTTGCCCCTGCACATTCCAGAAGCCCTCATGGGAAGGGATGCAGCCAGGCAGACTCCTGCCAGATGGGGCAGGTAGTTTATTCAAAGAG
AACTCTGTATCCCATAGGCCCAGGCTCTCCTTTCGCTTGGCGTGGGCTTTGCTGGCCCAGTGTGTGCTCCTGGCTCAGCAGAAACATCCA
TTTGAGTTGGCATCCCTGTAGGGATCCCAGAGCGTTGTAAGCCTTCTTGTGATTGGTAGGGATGGCTGTGGGGTGGCTTCCAGGAGGGGG
CCACCATTGCCGCATCTACTTCTAGACTCCCAAAGGAGCCCAGGCTCAGGCAGGCCTGGCCCAGAGTCACGCTGGCAACCACGAGTTTGG
GAAGCAGTCGTATTCTCTCTCTCTCTCTCTCTCTCTCTCTCAGTATCCATGACAGGTATGAAACATATTGTCTCTTTATAAATGTCATTT
TACAAATTATGTGATTATCTGGAAGCTCTAAGATGAGAGCAAATGCCTGATCACTCTGGCCAAATGTCAGATACTAAAGCCCATTCTTGG
CCGGGCATGTTGGCTCCCGCCTGTAATCCCAGCACTTTGGGAAGCCCAAGTGGGTGAATCACCTGAGGTCAGGAGTTCAAGACCAGCCTG
ACCAACATGGGGATACCCCGTCTCTACTAAAAATACAAGCCGGGCGTGGTGGCGCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGC
AGGAAAATCACTTGAACTCGGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCGCCATTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTG
TCTCATAAATAAATACAAAGCCCATTCTTCCAGAGTCTTGTGCCTTAAATAAAACACACCTCTCTGCTGTGGGAAGACTGTGCAATGGCA
CAGCCGCAGAGCTTGGTTTGGGAGGTTGAAGTGCTCTGGGGAGAATTCGTAGATCATCCTCAGAAAAGCCTTGCCCTGGTGTTCTACCAG
AAAAACGTCTCCCAATCACCCAGGAAAGCTGTCCACAGTAGTCCCCCCTTATCCACGGTGTCACTTTCCATGGGTTCAGTTATCTGCGGT
CAACCACGGTCTGACAATATTAAATGGAAAATTCTTCAAACAGTTCCCAAGTTTTCCCTTGTGCATTGTTCTGAGCAGTGTGATGGAGAG
TCTCTGCCGTGCCATCTGGGATGCAAACCGTCCCTGTGTTCCCCACGTCCAGGCCGTAGATGCTCCCCGCCGGTCAGTCACTTAGTCGTC
AGATCGCCCGTCCTGGTATCACAGTGCTTCTGTTCAGGTCAGTCTTTTTTTACTTCATTAGGGCCCCAAAGCACCAGAGTAGTGATGCTG
GTAGTGATGCTGGCTGTTCGGATATGCCAAAGAGAAACCGTAAGGTGCTTCCTTTAAGTGAAAAGATGGGAAGAAAACAGTCATATGCTG

>In-frame_SMG6_ENST00000536871_chr17_2139786_-_SHPK_ENST00000225519_chr17_3518831_-_3299nt
ATACCAGAGAGTTTAGGGACTGTGAAGGTTTCAGGAAATTTGTTGAGTATTTAGAAAAGCCGATGGTTTCAGAGAGAAACTTTGATATTA
GCTTGAACACAGTTATTGCCAGGGGTGAGGAAATAGCATACCAAAGCATAATAACTCATAGTGATTTATCCAAAACTTGAGTTGTTTGCA
TCTCTGGACCCTGAAAACTCCTTTATCTTGAATTTGTTCAAAATTGCAGGATACCGGGAAGGATGGAGACATTCCCTGCAGTGGCTGAGA
AGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATGACCATCAATATGT
TTGCAGTACACAACTCCCAGCTGAAAGTTCTCAACATCAGCACCTCGGTTCAGCTGGCAGCCTCCATGCCTTCAGGATTCCAGCCTGCAC
AGACTCCAGACCCTACGGCCCCAGTCGCCTACTTCCCATACTTCAACAGGACCTACCTGGGGGTGGCCGCGTCACTCAACGGGGGCAATG
TGCTGGCCACGTTCGTCCACATGCTGGTTCAGTGGATGGCAGATCTAGGCCTGGAGGTTGAAGAATCCACTGTGTATTCACGCATGATTC
AGGCAGCTGTGCAGCAGAGAGATACCCACCTGACCATCACCCCGACAGTGCTGGGGGAGAGGCACCTGCCGGACCAGCTGGCCTCAGTGA
CCAGAATCTCCTCCTCCGACCTCTCCCTGGGGCACGTGACCCGGGCTCTGTGCCGAGGCATTGTTCAGAACCTGCACTCCATGCTTCCGA
TTCAGCAGCTCCAGGACTGGGGCGTGGAGAGGGTGATGGGCAGTGGGAGTGCGCTGTCCAGGAATGACGTGCTGAAGCAGGAGGTGCAGA
GGGCTTTCCCTTTGCCCATGTCCTTTGGGCAGGATGTGGATGCAGCTGTCGGGGCAGCTCTGGTCATGCTCCGGAGACACCTCAACCAGA
AGGAATCTTAGACAGCAAACTCTTTCGCCAAACGACTGCTGTGAATTTTACCTGATTAACATTCCTGACACCATCTGTGGGTCATCCTTT
CCCTGGACCGTTCAGTGGACAGCTTTCAAGCAGTGCTTGTTGTGAGGTCCCATCTCGGCCAAGAACTTACCTTCAGAACATACTCTAATA
ATGCAGCCAGGAGCCGTCAGCCAGATCCCAAATGAGTGCCTTCCGAAATTGACCCACCTGGGAGCTATTTACAAATGTCCATGTGGGAGA
GAGAGAGCATGAGAGCACAGTAGCCCAGCCTGCTGGTCAGCAGGCTCATCTGTGGTTCACCTGTAGACAGAGAGCAGATCAATGTGTACT
TCAGACACCAGAAAGTCTGGTGGCTTTGGTCCCAAGTGGGAAAAGAGAACTGCCCCATGCCCAGCTTGTGATTATCGTTTTTGGAGACCT
GAAGCCCACACTCGGGTCGTATGGACTTCTGGAAAAGTTCTTGTCTCCTGGACTGAACCATGTGACCGGAGGCCCCTTTCCTAGTCTCAT
CCTCCCCTGGCTGCAGATGCTTAGCTGGGCCAGGGATTGACCCAAGCGCGATGCAGCAGGCAGGCTCAGAAGACGATGCGGGGCTGTGTG
CCGGCCTTCTTGCTGCATGTACTCAGCCTCAGGAGAGCTTGCTGCACCCAGGCCGCCCAGGTCTTCACAGCACAACTGCCTGGAAGGCAG
GTTGCGAGAAGGAGAGGCGGATGGCATGAGCAGCAAGGGGGACCGATGCTGTGCAGCTCACACCACTCCAGAACCTGACAAGGCACCAGC
AGGACCCCTTGCCAGGAGCATGTCTGTGCAGCAGTGTTTTTGCCCCTGCACATTCCAGAAGCCCTCATGGGAAGGGATGCAGCCAGGCAG
ACTCCTGCCAGATGGGGCAGGTAGTTTATTCAAAGAGAACTCTGTATCCCATAGGCCCAGGCTCTCCTTTCGCTTGGCGTGGGCTTTGCT
GGCCCAGTGTGTGCTCCTGGCTCAGCAGAAACATCCATTTGAGTTGGCATCCCTGTAGGGATCCCAGAGCGTTGTAAGCCTTCTTGTGAT
TGGTAGGGATGGCTGTGGGGTGGCTTCCAGGAGGGGGCCACCATTGCCGCATCTACTTCTAGACTCCCAAAGGAGCCCAGGCTCAGGCAG
GCCTGGCCCAGAGTCACGCTGGCAACCACGAGTTTGGGAAGCAGTCGTATTCTCTCTCTCTCTCTCTCTCTCTCTCTCAGTATCCATGAC
AGGTATGAAACATATTGTCTCTTTATAAATGTCATTTTACAAATTATGTGATTATCTGGAAGCTCTAAGATGAGAGCAAATGCCTGATCA
CTCTGGCCAAATGTCAGATACTAAAGCCCATTCTTGGCCGGGCATGTTGGCTCCCGCCTGTAATCCCAGCACTTTGGGAAGCCCAAGTGG
GTGAATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATGGGGATACCCCGTCTCTACTAAAAATACAAGCCGGGCGTGGTGGC
GCATGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAAAATCACTTGAACTCGGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCGC
CATTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCATAAATAAATACAAAGCCCATTCTTCCAGAGTCTTGTGCCTTAAATAAA
ACACACCTCTCTGCTGTGGGAAGACTGTGCAATGGCACAGCCGCAGAGCTTGGTTTGGGAGGTTGAAGTGCTCTGGGGAGAATTCGTAGA
TCATCCTCAGAAAAGCCTTGCCCTGGTGTTCTACCAGAAAAACGTCTCCCAATCACCCAGGAAAGCTGTCCACAGTAGTCCCCCCTTATC
CACGGTGTCACTTTCCATGGGTTCAGTTATCTGCGGTCAACCACGGTCTGACAATATTAAATGGAAAATTCTTCAAACAGTTCCCAAGTT
TTCCCTTGTGCATTGTTCTGAGCAGTGTGATGGAGAGTCTCTGCCGTGCCATCTGGGATGCAAACCGTCCCTGTGTTCCCCACGTCCAGG
CCGTAGATGCTCCCCGCCGGTCAGTCACTTAGTCGTCAGATCGCCCGTCCTGGTATCACAGTGCTTCTGTTCAGGTCAGTCTTTTTTTAC
TTCATTAGGGCCCCAAAGCACCAGAGTAGTGATGCTGGTAGTGATGCTGGCTGTTCGGATATGCCAAAGAGAAACCGTAAGGTGCTTCCT


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FusionGenePPI for SMG6_SHPK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SMG6TERT, HDAC8, UPF1, HBB, PPP1CC, SOX2, RBM8A, MAGOH, PABPC1, SMG6, UPF3B, SMG5, SMG7, PSG1, C2orf68, FAM221B, SPATA1, HAO2, LPIN3, TRIM25SHPKMDM2, ARFGAP3, EID2B, C10orf55, FAM219A, TRAF3, TCF25, NR2F2, FAM126A, THYN1, LINC01587, PDDC1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneSMG6chr17:2139786chr17:3518831ENST00000263073-1019114_5039561420telomeric DNA
HgeneSMG6chr17:2139786chr17:3518831ENST00000544865-1019114_5039251389telomeric DNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSMG6chr17:2139786chr17:3518831ENST00000354901-312114_50348512telomeric DNA
HgeneSMG6chr17:2139786chr17:3518831ENST00000536871-211114_50348512telomeric DNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SMG6_SHPK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SMG6_SHPK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource