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Fusion gene ID: 34911 |
FusionGeneSummary for SMG6_RECK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SMG6_RECK | Fusion gene ID: 34911 | Hgene | Tgene | Gene symbol | SMG6 | RECK | Gene ID | 23293 | 8434 |
| Gene name | SMG6, nonsense mediated mRNA decay factor | reversion inducing cysteine rich protein with kazal motifs | |
| Synonyms | C17orf31|EST1A|SMG-6|hSMG5/7a | ST15 | |
| Cytomap | 17p13.3 | 9p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | telomerase-binding protein EST1AEST1 telomerase component homolog Aever shorter telomeres 1Asmg-6 homolog, nonsense mediated mRNA decay factortelomerase subunit EST1A | reversion-inducing cysteine-rich protein with Kazal motifsmembrane-anchored glycoprotein (metastasis and invasion)suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs)suppression of tumorigenicity 5 (reversion-in | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q86US8 | O95980 | |
| Ensembl transtripts involved in fusion gene | ENST00000544865, ENST00000263073, ENST00000354901, ENST00000536871, ENST00000573166, | ENST00000377966, ENST00000479053, | |
| Fusion gene scores | * DoF score | 12 X 8 X 5=480 | 4 X 4 X 4=64 |
| # samples | 12 | 4 | |
| ** MAII score | log2(12/480*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SMG6 [Title/Abstract] AND RECK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SMG6 | GO:1904354 | negative regulation of telomere capping | 12676087 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-IE-A3OV-01A | SMG6 | chr17 | 2139786 | - | RECK | chr9 | 36107973 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000544865 | ENST00000377966 | SMG6 | chr17 | 2139786 | - | RECK | chr9 | 36107973 | + |
| 5CDS-intron | ENST00000544865 | ENST00000479053 | SMG6 | chr17 | 2139786 | - | RECK | chr9 | 36107973 | + |
| In-frame | ENST00000263073 | ENST00000377966 | SMG6 | chr17 | 2139786 | - | RECK | chr9 | 36107973 | + |
| 5CDS-intron | ENST00000263073 | ENST00000479053 | SMG6 | chr17 | 2139786 | - | RECK | chr9 | 36107973 | + |
| In-frame | ENST00000354901 | ENST00000377966 | SMG6 | chr17 | 2139786 | - | RECK | chr9 | 36107973 | + |
| 5CDS-intron | ENST00000354901 | ENST00000479053 | SMG6 | chr17 | 2139786 | - | RECK | chr9 | 36107973 | + |
| In-frame | ENST00000536871 | ENST00000377966 | SMG6 | chr17 | 2139786 | - | RECK | chr9 | 36107973 | + |
| 5CDS-intron | ENST00000536871 | ENST00000479053 | SMG6 | chr17 | 2139786 | - | RECK | chr9 | 36107973 | + |
| intron-3CDS | ENST00000573166 | ENST00000377966 | SMG6 | chr17 | 2139786 | - | RECK | chr9 | 36107973 | + |
| intron-intron | ENST00000573166 | ENST00000479053 | SMG6 | chr17 | 2139786 | - | RECK | chr9 | 36107973 | + |
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FusionProtFeatures for SMG6_RECK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SMG6 | RECK |
| Component of the telomerase ribonucleoprotein (RNP)complex that is essential for the replication of chromosometermini. May have a general role in telomere regulation. Promotesin vitro the ability of TERT to elongate telomeres. Overexpressioninduces telomere uncapping, chromosomal end-to-end fusions(telomeric DNA persists at the fusion points) and did not perturbTRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNAtemplate component (TER). Plays a role in nonsense-mediated mRNA decay. Is thoughtto provide a link to the mRNA degradation machinery as it hasendonuclease activity required to initiate NMD, and to serve as anadapter for UPF1 to protein phosphatase 2A (PP2A), therebytriggering UPF1 dephosphorylation. Degrades single-stranded RNA(ssRNA), but not ssDNA or dsRNA. | Negatively regulates matrix metalloproteinase-9 (MMP-9)by suppressing MMP-9 secretion and by direct inhibition of itsenzymatic activity. RECK down-regulation by oncogenic signals mayfacilitate tumor invasion and metastasis. Appears to also regulateMMP-2 and MT1-MMP, which are involved in cancer progression. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SMG6 | chr17:2139786 | chr9:36107973 | ENST00000263073 | - | 10 | 19 | 163_193 | 956 | 1420 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SMG6 | chr17:2139786 | chr9:36107973 | ENST00000263073 | - | 10 | 19 | 567_625 | 956 | 1420 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SMG6 | chr17:2139786 | chr9:36107973 | ENST00000544865 | - | 10 | 19 | 163_193 | 925 | 1389 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SMG6 | chr17:2139786 | chr9:36107973 | ENST00000544865 | - | 10 | 19 | 567_625 | 925 | 1389 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >RECK | chr17:2139786 | chr9:36107973 | ENST00000377966 | + | 12 | 21 | 627_673 | 525 | 972 | Domain | Kazal-like 1 |
| Tgene | >RECK | chr17:2139786 | chr9:36107973 | ENST00000377966 | + | 12 | 21 | 698_752 | 525 | 972 | Domain | Kazal-like 2 |
| Tgene | >RECK | chr17:2139786 | chr9:36107973 | ENST00000377966 | + | 12 | 21 | 753_789 | 525 | 972 | Domain | Kazal-like 3 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SMG6 | chr17:2139786 | chr9:36107973 | ENST00000263073 | - | 10 | 19 | 1197_1239 | 956 | 1420 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SMG6 | chr17:2139786 | chr9:36107973 | ENST00000354901 | - | 3 | 12 | 1197_1239 | 48 | 512 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SMG6 | chr17:2139786 | chr9:36107973 | ENST00000354901 | - | 3 | 12 | 163_193 | 48 | 512 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SMG6 | chr17:2139786 | chr9:36107973 | ENST00000354901 | - | 3 | 12 | 567_625 | 48 | 512 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SMG6 | chr17:2139786 | chr9:36107973 | ENST00000536871 | - | 2 | 11 | 1197_1239 | 48 | 512 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SMG6 | chr17:2139786 | chr9:36107973 | ENST00000536871 | - | 2 | 11 | 163_193 | 48 | 512 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SMG6 | chr17:2139786 | chr9:36107973 | ENST00000536871 | - | 2 | 11 | 567_625 | 48 | 512 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SMG6 | chr17:2139786 | chr9:36107973 | ENST00000544865 | - | 10 | 19 | 1197_1239 | 925 | 1389 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SMG6 | chr17:2139786 | chr9:36107973 | ENST00000263073 | - | 10 | 19 | 1246_1397 | 956 | 1420 | Domain | Note=PINc |
| Hgene | >SMG6 | chr17:2139786 | chr9:36107973 | ENST00000354901 | - | 3 | 12 | 1246_1397 | 48 | 512 | Domain | Note=PINc |
| Hgene | >SMG6 | chr17:2139786 | chr9:36107973 | ENST00000536871 | - | 2 | 11 | 1246_1397 | 48 | 512 | Domain | Note=PINc |
| Hgene | >SMG6 | chr17:2139786 | chr9:36107973 | ENST00000544865 | - | 10 | 19 | 1246_1397 | 925 | 1389 | Domain | Note=PINc |
| Tgene | RECK | chr17:2139786 | chr9:36107973 | ENST00000377966 | + | 12 | 21 | 37_338 | 525 | 972 | Region | Note=5 X Knot repeats |
| Tgene | RECK | chr17:2139786 | chr9:36107973 | ENST00000377966 | + | 12 | 21 | 104_141 | 525 | 972 | Repeat | Note=Knot 2 |
| Tgene | RECK | chr17:2139786 | chr9:36107973 | ENST00000377966 | + | 12 | 21 | 151_197 | 525 | 972 | Repeat | Note=Knot 3 |
| Tgene | RECK | chr17:2139786 | chr9:36107973 | ENST00000377966 | + | 12 | 21 | 216_263 | 525 | 972 | Repeat | Note=Knot 4 |
| Tgene | RECK | chr17:2139786 | chr9:36107973 | ENST00000377966 | + | 12 | 21 | 292_338 | 525 | 972 | Repeat | Note=Knot 5 |
| Tgene | RECK | chr17:2139786 | chr9:36107973 | ENST00000377966 | + | 12 | 21 | 37_84 | 525 | 972 | Repeat | Note=Knot 1 |
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FusionGeneSequence for SMG6_RECK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SMG6_ENST00000544865_chr17_2139786_-_RECK_ENST00000377966_chr9_36107973_+_1372aa MKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSAVENGTQPVKDVCKELNNQEQNGPIDPENNRGQESF PRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEEDECRGNVAKEEVANKPDRAEIEKSPGGGRVGA AKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGCRRRRQDRTKERPRLKKQVSVSST DSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMNKESPMVRSARDDMDRGKPDKGLSSGGKGSEK QESKNPKQELRGRGRGILILPAHTTLSVNSAGSPESAPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKTQTPQLHFLDTDD EVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYPGPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQ HMRNLQQQELHRLLRVADNQELQLSNLLSRDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVKD PNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRCMICQGDIARYREQASDTANYGKA RSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKKS TFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSP SPIGSTRMLQLMTINMFAVHNSQLKGCKLGEASDFIVRQGTLIQVPSSAGEVGCYKICSCGQSGLLENCMEMHCIDLQKSCIVGGKRKSH GTSFSIDCNVCSCFAGNLVCSTRLCLSEHSSEDDRRTFTGLPCNCADQFVPVCGQNGRTYPSACIARCVGLQDHQFEFGSCMSKDPCNPN PCQKNQRCIPKPQVCLTTFDKFGCSQYECVPRQLACDQVQDPVCDTDHMEHNNLCTLYQRGKSLSYKGPCQPFCRATEPVCGHNGETYSS VCAAYSDRVAVDYYGDCQAVGVLSEHSSVAECASVKCPSLLAAGCKPIIPPGACCPLCAGMLRVLFDKEKLDTIAKVTNKKPITVLEILQ KIRMHVSVPQCDVFGYFSIESEIVILIIPVDHYPKALQIEACNKEAEKIESLINSDSPTLASHVPLSALIISQVQVSSSVPSAGVRARPS >In-frame_SMG6_ENST00000263073_chr17_2139786_-_RECK_ENST00000377966_chr9_36107973_+_1403aa MAEGLERVRISASELRGILATLAPQAGSRENMKELKEARPRKDNRRPDLEIYKPGLSRLRNKPKIKEPPGSEEFKDEIVNDRDCSAVENG TQPVKDVCKELNNQEQNGPIDPENNRGQESFPRTAGQEDRSLKIIKRTKKPDLQIYQPGRRLQTVSKESASRVEEEEVLNQVEQLRVEED ECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGKRMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEG AGLTDNGCRRRRQDRTKERPRLKKQVSVSSTDSLDEDRIDEPDGLGPRRSSERKRHLERNWSGRGEGEQKNSAKEYRGTLRVTFDAEAMN KESPMVRSARDDMDRGKPDKGLSSGGKGSEKQESKNPKQELRGRGRGILILPAHTTLSVNSAGSPESAPLGPRLLFGSGSKGSRSWGRGG TTRRLWDPNNPDQKPALKTQTPQLHFLDTDDEVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYP GPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQHMRNLQQQELHRLLRVADNQELQLSNLLSRDRISPEGLEKMAQLRAELLQLYERCILLD IEFSDNQNVDQILWKNAFYQVIEKFRQLVKDPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKY ALISAQRCMICQGDIARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLF EETKRKAEQMEKKQHEEFDLSPDQWRKGKKSTFRHVGDDTTRLEIWIHPSHPRSSQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAH GKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKGCKLGEASDFIVRQGTLIQVPSSAGEVGCYKICS CGQSGLLENCMEMHCIDLQKSCIVGGKRKSHGTSFSIDCNVCSCFAGNLVCSTRLCLSEHSSEDDRRTFTGLPCNCADQFVPVCGQNGRT YPSACIARCVGLQDHQFEFGSCMSKDPCNPNPCQKNQRCIPKPQVCLTTFDKFGCSQYECVPRQLACDQVQDPVCDTDHMEHNNLCTLYQ RGKSLSYKGPCQPFCRATEPVCGHNGETYSSVCAAYSDRVAVDYYGDCQAVGVLSEHSSVAECASVKCPSLLAAGCKPIIPPGACCPLCA GMLRVLFDKEKLDTIAKVTNKKPITVLEILQKIRMHVSVPQCDVFGYFSIESEIVILIIPVDHYPKALQIEACNKEAEKIESLINSDSPT >In-frame_SMG6_ENST00000354901_chr17_2139786_-_RECK_ENST00000377966_chr9_36107973_+_495aa METFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKGCKLGEASDFIVRQGTLIQVPSSAGEVGCYKICSCGQSGLLE NCMEMHCIDLQKSCIVGGKRKSHGTSFSIDCNVCSCFAGNLVCSTRLCLSEHSSEDDRRTFTGLPCNCADQFVPVCGQNGRTYPSACIAR CVGLQDHQFEFGSCMSKDPCNPNPCQKNQRCIPKPQVCLTTFDKFGCSQYECVPRQLACDQVQDPVCDTDHMEHNNLCTLYQRGKSLSYK GPCQPFCRATEPVCGHNGETYSSVCAAYSDRVAVDYYGDCQAVGVLSEHSSVAECASVKCPSLLAAGCKPIIPPGACCPLCAGMLRVLFD KEKLDTIAKVTNKKPITVLEILQKIRMHVSVPQCDVFGYFSIESEIVILIIPVDHYPKALQIEACNKEAEKIESLINSDSPTLASHVPLS >In-frame_SMG6_ENST00000536871_chr17_2139786_-_RECK_ENST00000377966_chr9_36107973_+_495aa METFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKGCKLGEASDFIVRQGTLIQVPSSAGEVGCYKICSCGQSGLLE NCMEMHCIDLQKSCIVGGKRKSHGTSFSIDCNVCSCFAGNLVCSTRLCLSEHSSEDDRRTFTGLPCNCADQFVPVCGQNGRTYPSACIAR CVGLQDHQFEFGSCMSKDPCNPNPCQKNQRCIPKPQVCLTTFDKFGCSQYECVPRQLACDQVQDPVCDTDHMEHNNLCTLYQRGKSLSYK GPCQPFCRATEPVCGHNGETYSSVCAAYSDRVAVDYYGDCQAVGVLSEHSSVAECASVKCPSLLAAGCKPIIPPGACCPLCAGMLRVLFD KEKLDTIAKVTNKKPITVLEILQKIRMHVSVPQCDVFGYFSIESEIVILIIPVDHYPKALQIEACNKEAEKIESLINSDSPTLASHVPLS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SMG6_ENST00000544865_chr17_2139786_-_RECK_ENST00000377966_chr9_36107973_+_4116nt ATGAAGGAATTAAAGGAGGCCAGGCCGCGCAAAGATAACAGGCGTCCAGATCTGGAAATCTATAAGCCTGGCCTTTCTCGGCTAAGGAAC AAGCCCAAAATCAAGGAACCCCCTGGGAGTGAGGAATTCAAAGATGAAATTGTTAATGACCGAGATTGCTCTGCTGTTGAAAATGGTACA CAGCCCGTTAAAGATGTCTGCAAGGAACTGAACAACCAAGAGCAGAATGGTCCTATAGACCCAGAAAATAATCGGGGACAAGAATCCTTT CCTAGGACTGCTGGACAAGAGGATCGTAGTCTAAAAATTATCAAAAGAACAAAGAAACCCGACCTGCAGATCTATCAGCCTGGACGACGT TTGCAGACTGTTAGCAAAGAATCCGCCAGTCGGGTGGAGGAGGAAGAAGTCCTCAACCAGGTAGAACAACTGAGAGTAGAGGAAGATGAG TGTAGGGGAAATGTTGCGAAGGAGGAAGTTGCGAATAAACCAGACAGGGCTGAGATAGAAAAGAGCCCAGGTGGTGGGAGAGTAGGGGCT GCAAAAGGAGAAAAAGGAAAGAGGATGGGAAAAGGGGAGGGGGTGAGGGAAACCCACGACGACCCAGCCCGCGGGAGGCCGGGCTCCGCA AAGCGCTACTCCCGCTCAGACAAACGAAGGAATCGCTACCGCACGCGCAGCACCAGCTCAGCTGGCAGCAACAACAGCGCTGAGGGAGCT GGCCTGACGGATAATGGATGTCGCCGCCGCCGACAGGATAGGACCAAGGAGAGGCCACGACTGAAGAAGCAAGTGTCTGTGTCCTCAACC GATTCCTTAGACGAGGACAGAATTGATGAGCCTGATGGATTAGGACCCAGGAGAAGTTCAGAAAGGAAGAGACATTTAGAAAGAAACTGG TCTGGCCGTGGGGAGGGTGAGCAGAAAAACAGTGCTAAAGAATATCGAGGCACTCTTCGTGTCACTTTCGATGCAGAAGCCATGAACAAA GAGTCTCCCATGGTGAGGTCAGCCAGGGATGATATGGATAGAGGAAAGCCTGACAAAGGCTTGAGCAGTGGGGGCAAAGGCTCTGAGAAG CAGGAGTCCAAAAACCCGAAACAAGAACTTCGGGGTCGTGGTCGTGGCATTCTGATTTTGCCTGCCCATACCACCCTATCTGTCAATTCA GCAGGTTCTCCAGAGTCCGCGCCTTTGGGACCTCGGCTTTTGTTTGGATCTGGTAGTAAGGGATCTCGGAGTTGGGGCCGTGGAGGCACC ACACGCCGATTGTGGGACCCAAACAATCCTGATCAGAAACCTGCTCTAAAGACTCAGACGCCCCAGCTACATTTCTTGGACACTGATGAT GAAGTCAGCCCTACATCTTGGGGTGACTCACGCCAGGCTCAGGCATCTTACTATAAGTTTCAAAACTCTGACAACCCCTATTATTACCCC CGGACACCAGGCCCTGCCTCCCAGTATCCCTATACGGGCTATAACCCTCTACAGTACCCAGTGGGCCCTACGAATGGTGTGTACCCAGGG CCTTACTACCCAGGCTACCCGACTCCGTCAGGACAGTATGTGTGTAGCCCTCTACCTACCAGCACCATGAGTCCCGAGGAGGTAGAGCAG CACATGAGGAACCTGCAGCAACAGGAGCTGCACAGGCTTCTCCGGGTGGCTGACAACCAGGAACTGCAGCTCAGCAACCTGCTCTCCAGG GACCGCATCAGTCCGGAGGGCCTGGAGAAGATGGCGCAACTCAGAGCTGAACTGCTGCAGCTATATGAGCGCTGTATTCTATTAGATATT GAGTTCTCTGATAATCAGAATGTGGATCAGATCCTGTGGAAGAATGCTTTCTATCAGGTGATTGAGAAGTTCAGGCAACTTGTCAAGGAT CCGAATGTTGAGAACCCAGAACAGATTCGGAACAGACTTTTGGAGCTCTTGGATGAGGGTAGTGACTTCTTTGATAGTTTGCTTCAGAAG CTGCAGGTTACTTACAAGTTCAAACTGGAAGACTACATGGATGGTCTTGCCATTCGCAGCAAGCCATTACGCAAGACAGTAAAATATGCC TTGATCAGTGCCCAGCGATGCATGATATGCCAAGGAGATATTGCTAGGTACCGGGAGCAAGCCAGTGATACAGCGAATTATGGGAAAGCA CGCAGTTGGTACCTGAAGGCCCAGCACATTGCTCCCAAGAATGGGCGCCCCTATAACCAGTTGGCTTTGCTGGCAGTGTATACGAGGAGG AAGCTTGACGCTGTCTATTACTATATGCGCAGTTTAGCTGCCAGCAACCCTATCCTGACTGCCAAGGAGAGTCTCATGAGCTTGTTTGAA GAGACCAAGCGGAAGGCAGAACAGATGGAAAAGAAGCAACATGAGGAATTTGACCTGAGCCCTGACCAGTGGCGGAAAGGAAAGAAGTCT ACTTTCCGGCATGTTGGAGATGACACCACTCGCCTGGAGATCTGGATTCATCCATCCCATCCACGGTCTTCCCAGGGCACTGAGTCTGGG AAGGATTCTGAGCAAGAGAATGGGCTGGGCAGCCTGAGTCCCAGTGATCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCATGGG AAGCTGTTTACCCGGATTGGGATGGAGACATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCC TCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGGTTGCAAACTGGGA GAAGCTTCTGATTTCATTGTCCGTCAAGGGACACTAATCCAGGTGCCATCATCTGCAGGGGAAGTTGGTTGTTATAAAATCTGTTCATGT GGACAAAGTGGACTCTTAGAAAACTGTATGGAAATGCACTGTATAGACCTCCAGAAGTCTTGTATTGTTGGAGGAAAAAGAAAAAGTCAT GGAACATCCTTTAGTATTGACTGCAATGTCTGTTCTTGTTTTGCTGGCAATTTGGTGTGCTCTACCCGCCTTTGCCTCAGTGAGCACAGT TCAGAAGATGACCGTCGTACCTTCACAGGTCTGCCCTGTAACTGTGCAGATCAGTTTGTCCCTGTATGTGGGCAGAATGGGCGCACTTAC CCCAGTGCCTGCATTGCTCGCTGTGTGGGCCTCCAAGACCATCAGTTTGAGTTTGGATCATGCATGTCAAAGGATCCATGTAATCCTAAT CCCTGCCAAAAAAACCAAAGGTGCATACCCAAACCACAGGTCTGCCTGACGACTTTTGATAAATTTGGATGTAGCCAGTATGAGTGTGTA CCAAGACAGCTCGCGTGTGACCAGGTCCAAGATCCTGTTTGTGACACAGACCACATGGAGCACAACAATCTCTGCACTTTATACCAAAGA GGAAAAAGCCTCTCTTACAAAGGTCCCTGCCAGCCCTTTTGCAGAGCAACCGAGCCCGTATGTGGGCACAATGGTGAGACCTACAGCAGT GTGTGTGCTGCCTACTCGGATCGCGTGGCAGTCGATTACTATGGGGACTGCCAGGCCGTCGGAGTCCTCTCAGAGCACAGCTCCGTCGCC GAGTGTGCTTCTGTCAAGTGTCCTTCGCTCTTGGCAGCTGGATGCAAACCCATCATCCCACCGGGTGCTTGTTGCCCATTATGTGCTGGG ATGTTAAGAGTTTTATTTGACAAAGAAAAACTGGATACTATTGCTAAGGTAACAAATAAAAAGCCAATAACAGTTCTGGAAATACTTCAG AAAATCCGCATGCACGTGTCTGTCCCACAGTGTGATGTGTTTGGATACTTCAGCATTGAATCAGAAATTGTGATCCTGATCATTCCCGTC GATCACTATCCAAAAGCTCTGCAGATTGAAGCCTGCAATAAAGAAGCAGAGAAGATTGAGTCCCTTATCAACTCTGACAGCCCGACTTTG GCGTCCCATGTCCCTCTCTCTGCCCTCATCATTTCCCAGGTACAGGTCTCCAGCAGTGTGCCATCGGCCGGTGTCAGGGCCAGGCCTTCT >In-frame_SMG6_ENST00000263073_chr17_2139786_-_RECK_ENST00000377966_chr9_36107973_+_4209nt ATGGCGGAAGGGCTGGAGCGTGTGCGGATCTCCGCGTCGGAGCTGCGCGGGATCCTGGCTACTCTGGCCCCGCAGGCCGGGAGCAGAGAA AACATGAAGGAATTAAAGGAGGCCAGGCCGCGCAAAGATAACAGGCGTCCAGATCTGGAAATCTATAAGCCTGGCCTTTCTCGGCTAAGG AACAAGCCCAAAATCAAGGAACCCCCTGGGAGTGAGGAATTCAAAGATGAAATTGTTAATGACCGAGATTGCTCTGCTGTTGAAAATGGT ACACAGCCCGTTAAAGATGTCTGCAAGGAACTGAACAACCAAGAGCAGAATGGTCCTATAGACCCAGAAAATAATCGGGGACAAGAATCC TTTCCTAGGACTGCTGGACAAGAGGATCGTAGTCTAAAAATTATCAAAAGAACAAAGAAACCCGACCTGCAGATCTATCAGCCTGGACGA CGTTTGCAGACTGTTAGCAAAGAATCCGCCAGTCGGGTGGAGGAGGAAGAAGTCCTCAACCAGGTAGAACAACTGAGAGTAGAGGAAGAT GAGTGTAGGGGAAATGTTGCGAAGGAGGAAGTTGCGAATAAACCAGACAGGGCTGAGATAGAAAAGAGCCCAGGTGGTGGGAGAGTAGGG GCTGCAAAAGGAGAAAAAGGAAAGAGGATGGGAAAAGGGGAGGGGGTGAGGGAAACCCACGACGACCCAGCCCGCGGGAGGCCGGGCTCC GCAAAGCGCTACTCCCGCTCAGACAAACGAAGGAATCGCTACCGCACGCGCAGCACCAGCTCAGCTGGCAGCAACAACAGCGCTGAGGGA GCTGGCCTGACGGATAATGGATGTCGCCGCCGCCGACAGGATAGGACCAAGGAGAGGCCACGACTGAAGAAGCAAGTGTCTGTGTCCTCA ACCGATTCCTTAGACGAGGACAGAATTGATGAGCCTGATGGATTAGGACCCAGGAGAAGTTCAGAAAGGAAGAGACATTTAGAAAGAAAC TGGTCTGGCCGTGGGGAGGGTGAGCAGAAAAACAGTGCTAAAGAATATCGAGGCACTCTTCGTGTCACTTTCGATGCAGAAGCCATGAAC AAAGAGTCTCCCATGGTGAGGTCAGCCAGGGATGATATGGATAGAGGAAAGCCTGACAAAGGCTTGAGCAGTGGGGGCAAAGGCTCTGAG AAGCAGGAGTCCAAAAACCCGAAACAAGAACTTCGGGGTCGTGGTCGTGGCATTCTGATTTTGCCTGCCCATACCACCCTATCTGTCAAT TCAGCAGGTTCTCCAGAGTCCGCGCCTTTGGGACCTCGGCTTTTGTTTGGATCTGGTAGTAAGGGATCTCGGAGTTGGGGCCGTGGAGGC ACCACACGCCGATTGTGGGACCCAAACAATCCTGATCAGAAACCTGCTCTAAAGACTCAGACGCCCCAGCTACATTTCTTGGACACTGAT GATGAAGTCAGCCCTACATCTTGGGGTGACTCACGCCAGGCTCAGGCATCTTACTATAAGTTTCAAAACTCTGACAACCCCTATTATTAC CCCCGGACACCAGGCCCTGCCTCCCAGTATCCCTATACGGGCTATAACCCTCTACAGTACCCAGTGGGCCCTACGAATGGTGTGTACCCA GGGCCTTACTACCCAGGCTACCCGACTCCGTCAGGACAGTATGTGTGTAGCCCTCTACCTACCAGCACCATGAGTCCCGAGGAGGTAGAG CAGCACATGAGGAACCTGCAGCAACAGGAGCTGCACAGGCTTCTCCGGGTGGCTGACAACCAGGAACTGCAGCTCAGCAACCTGCTCTCC AGGGACCGCATCAGTCCGGAGGGCCTGGAGAAGATGGCGCAACTCAGAGCTGAACTGCTGCAGCTATATGAGCGCTGTATTCTATTAGAT ATTGAGTTCTCTGATAATCAGAATGTGGATCAGATCCTGTGGAAGAATGCTTTCTATCAGGTGATTGAGAAGTTCAGGCAACTTGTCAAG GATCCGAATGTTGAGAACCCAGAACAGATTCGGAACAGACTTTTGGAGCTCTTGGATGAGGGTAGTGACTTCTTTGATAGTTTGCTTCAG AAGCTGCAGGTTACTTACAAGTTCAAACTGGAAGACTACATGGATGGTCTTGCCATTCGCAGCAAGCCATTACGCAAGACAGTAAAATAT GCCTTGATCAGTGCCCAGCGATGCATGATATGCCAAGGAGATATTGCTAGGTACCGGGAGCAAGCCAGTGATACAGCGAATTATGGGAAA GCACGCAGTTGGTACCTGAAGGCCCAGCACATTGCTCCCAAGAATGGGCGCCCCTATAACCAGTTGGCTTTGCTGGCAGTGTATACGAGG AGGAAGCTTGACGCTGTCTATTACTATATGCGCAGTTTAGCTGCCAGCAACCCTATCCTGACTGCCAAGGAGAGTCTCATGAGCTTGTTT GAAGAGACCAAGCGGAAGGCAGAACAGATGGAAAAGAAGCAACATGAGGAATTTGACCTGAGCCCTGACCAGTGGCGGAAAGGAAAGAAG TCTACTTTCCGGCATGTTGGAGATGACACCACTCGCCTGGAGATCTGGATTCATCCATCCCATCCACGGTCTTCCCAGGGCACTGAGTCT GGGAAGGATTCTGAGCAAGAGAATGGGCTGGGCAGCCTGAGTCCCAGTGATCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCAT GGGAAGCTGTTTACCCGGATTGGGATGGAGACATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGC CCCTCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGGTTGCAAACTG GGAGAAGCTTCTGATTTCATTGTCCGTCAAGGGACACTAATCCAGGTGCCATCATCTGCAGGGGAAGTTGGTTGTTATAAAATCTGTTCA TGTGGACAAAGTGGACTCTTAGAAAACTGTATGGAAATGCACTGTATAGACCTCCAGAAGTCTTGTATTGTTGGAGGAAAAAGAAAAAGT CATGGAACATCCTTTAGTATTGACTGCAATGTCTGTTCTTGTTTTGCTGGCAATTTGGTGTGCTCTACCCGCCTTTGCCTCAGTGAGCAC AGTTCAGAAGATGACCGTCGTACCTTCACAGGTCTGCCCTGTAACTGTGCAGATCAGTTTGTCCCTGTATGTGGGCAGAATGGGCGCACT TACCCCAGTGCCTGCATTGCTCGCTGTGTGGGCCTCCAAGACCATCAGTTTGAGTTTGGATCATGCATGTCAAAGGATCCATGTAATCCT AATCCCTGCCAAAAAAACCAAAGGTGCATACCCAAACCACAGGTCTGCCTGACGACTTTTGATAAATTTGGATGTAGCCAGTATGAGTGT GTACCAAGACAGCTCGCGTGTGACCAGGTCCAAGATCCTGTTTGTGACACAGACCACATGGAGCACAACAATCTCTGCACTTTATACCAA AGAGGAAAAAGCCTCTCTTACAAAGGTCCCTGCCAGCCCTTTTGCAGAGCAACCGAGCCCGTATGTGGGCACAATGGTGAGACCTACAGC AGTGTGTGTGCTGCCTACTCGGATCGCGTGGCAGTCGATTACTATGGGGACTGCCAGGCCGTCGGAGTCCTCTCAGAGCACAGCTCCGTC GCCGAGTGTGCTTCTGTCAAGTGTCCTTCGCTCTTGGCAGCTGGATGCAAACCCATCATCCCACCGGGTGCTTGTTGCCCATTATGTGCT GGGATGTTAAGAGTTTTATTTGACAAAGAAAAACTGGATACTATTGCTAAGGTAACAAATAAAAAGCCAATAACAGTTCTGGAAATACTT CAGAAAATCCGCATGCACGTGTCTGTCCCACAGTGTGATGTGTTTGGATACTTCAGCATTGAATCAGAAATTGTGATCCTGATCATTCCC GTCGATCACTATCCAAAAGCTCTGCAGATTGAAGCCTGCAATAAAGAAGCAGAGAAGATTGAGTCCCTTATCAACTCTGACAGCCCGACT TTGGCGTCCCATGTCCCTCTCTCTGCCCTCATCATTTCCCAGGTACAGGTCTCCAGCAGTGTGCCATCGGCCGGTGTCAGGGCCAGGCCT >In-frame_SMG6_ENST00000354901_chr17_2139786_-_RECK_ENST00000377966_chr9_36107973_+_1485nt ATGGAGACATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGC ATGCTGCAGCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGGTTGCAAACTGGGAGAAGCTTCTGATTTCATTGTC CGTCAAGGGACACTAATCCAGGTGCCATCATCTGCAGGGGAAGTTGGTTGTTATAAAATCTGTTCATGTGGACAAAGTGGACTCTTAGAA AACTGTATGGAAATGCACTGTATAGACCTCCAGAAGTCTTGTATTGTTGGAGGAAAAAGAAAAAGTCATGGAACATCCTTTAGTATTGAC TGCAATGTCTGTTCTTGTTTTGCTGGCAATTTGGTGTGCTCTACCCGCCTTTGCCTCAGTGAGCACAGTTCAGAAGATGACCGTCGTACC TTCACAGGTCTGCCCTGTAACTGTGCAGATCAGTTTGTCCCTGTATGTGGGCAGAATGGGCGCACTTACCCCAGTGCCTGCATTGCTCGC TGTGTGGGCCTCCAAGACCATCAGTTTGAGTTTGGATCATGCATGTCAAAGGATCCATGTAATCCTAATCCCTGCCAAAAAAACCAAAGG TGCATACCCAAACCACAGGTCTGCCTGACGACTTTTGATAAATTTGGATGTAGCCAGTATGAGTGTGTACCAAGACAGCTCGCGTGTGAC CAGGTCCAAGATCCTGTTTGTGACACAGACCACATGGAGCACAACAATCTCTGCACTTTATACCAAAGAGGAAAAAGCCTCTCTTACAAA GGTCCCTGCCAGCCCTTTTGCAGAGCAACCGAGCCCGTATGTGGGCACAATGGTGAGACCTACAGCAGTGTGTGTGCTGCCTACTCGGAT CGCGTGGCAGTCGATTACTATGGGGACTGCCAGGCCGTCGGAGTCCTCTCAGAGCACAGCTCCGTCGCCGAGTGTGCTTCTGTCAAGTGT CCTTCGCTCTTGGCAGCTGGATGCAAACCCATCATCCCACCGGGTGCTTGTTGCCCATTATGTGCTGGGATGTTAAGAGTTTTATTTGAC AAAGAAAAACTGGATACTATTGCTAAGGTAACAAATAAAAAGCCAATAACAGTTCTGGAAATACTTCAGAAAATCCGCATGCACGTGTCT GTCCCACAGTGTGATGTGTTTGGATACTTCAGCATTGAATCAGAAATTGTGATCCTGATCATTCCCGTCGATCACTATCCAAAAGCTCTG CAGATTGAAGCCTGCAATAAAGAAGCAGAGAAGATTGAGTCCCTTATCAACTCTGACAGCCCGACTTTGGCGTCCCATGTCCCTCTCTCT GCCCTCATCATTTCCCAGGTACAGGTCTCCAGCAGTGTGCCATCGGCCGGTGTCAGGGCCAGGCCTTCTTGCCACTCCCTCCTCCTTCCC >In-frame_SMG6_ENST00000536871_chr17_2139786_-_RECK_ENST00000377966_chr9_36107973_+_1485nt ATGGAGACATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGC ATGCTGCAGCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGGTTGCAAACTGGGAGAAGCTTCTGATTTCATTGTC CGTCAAGGGACACTAATCCAGGTGCCATCATCTGCAGGGGAAGTTGGTTGTTATAAAATCTGTTCATGTGGACAAAGTGGACTCTTAGAA AACTGTATGGAAATGCACTGTATAGACCTCCAGAAGTCTTGTATTGTTGGAGGAAAAAGAAAAAGTCATGGAACATCCTTTAGTATTGAC TGCAATGTCTGTTCTTGTTTTGCTGGCAATTTGGTGTGCTCTACCCGCCTTTGCCTCAGTGAGCACAGTTCAGAAGATGACCGTCGTACC TTCACAGGTCTGCCCTGTAACTGTGCAGATCAGTTTGTCCCTGTATGTGGGCAGAATGGGCGCACTTACCCCAGTGCCTGCATTGCTCGC TGTGTGGGCCTCCAAGACCATCAGTTTGAGTTTGGATCATGCATGTCAAAGGATCCATGTAATCCTAATCCCTGCCAAAAAAACCAAAGG TGCATACCCAAACCACAGGTCTGCCTGACGACTTTTGATAAATTTGGATGTAGCCAGTATGAGTGTGTACCAAGACAGCTCGCGTGTGAC CAGGTCCAAGATCCTGTTTGTGACACAGACCACATGGAGCACAACAATCTCTGCACTTTATACCAAAGAGGAAAAAGCCTCTCTTACAAA GGTCCCTGCCAGCCCTTTTGCAGAGCAACCGAGCCCGTATGTGGGCACAATGGTGAGACCTACAGCAGTGTGTGTGCTGCCTACTCGGAT CGCGTGGCAGTCGATTACTATGGGGACTGCCAGGCCGTCGGAGTCCTCTCAGAGCACAGCTCCGTCGCCGAGTGTGCTTCTGTCAAGTGT CCTTCGCTCTTGGCAGCTGGATGCAAACCCATCATCCCACCGGGTGCTTGTTGCCCATTATGTGCTGGGATGTTAAGAGTTTTATTTGAC AAAGAAAAACTGGATACTATTGCTAAGGTAACAAATAAAAAGCCAATAACAGTTCTGGAAATACTTCAGAAAATCCGCATGCACGTGTCT GTCCCACAGTGTGATGTGTTTGGATACTTCAGCATTGAATCAGAAATTGTGATCCTGATCATTCCCGTCGATCACTATCCAAAAGCTCTG CAGATTGAAGCCTGCAATAAAGAAGCAGAGAAGATTGAGTCCCTTATCAACTCTGACAGCCCGACTTTGGCGTCCCATGTCCCTCTCTCT GCCCTCATCATTTCCCAGGTACAGGTCTCCAGCAGTGTGCCATCGGCCGGTGTCAGGGCCAGGCCTTCTTGCCACTCCCTCCTCCTTCCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SMG6_ENST00000544865_chr17_2139786_-_RECK_ENST00000377966_chr9_36107973_+_6033nt AGCAGTAGGCGCTGGGGCCGCGGCGGACCCTCGCTGCCCTACCTCTCTCGCGGGTTAGTGCGGGGTCGGGCTCGGCCAGTCCTGGCCAGC TCCGGGAGAGCCTGGCCCGAATTCCTGCCTCCACCCTCTTTCTCGCCGCGAAGGTGACTGTTCCTTTTGCCCCAGCCCTCTCAGACCCGC CCCGGATTCCCAGGCATCGGGAGACGCGGAAAGGAGTGGGGTCTGGTGGAGGCCCCGGGCGTATCGCTCTCCAGGCCGCCCTCCGCGGGC CTGCCCCGGCCACCGCTTTAACGTCGGAGAGAAGGAATTGGGGAGAAAGGTTTAAGAGCCTGCGACTTCGTTGCTGAACTTTTCCCCCCC AAGACAGGCTTCCGAAAGCTGCGCCACTGGAGGGATCCGGGACCTCAGACTACTCGGGTTTGGCCCTGGCATGTGTGGGAGCAGTTTTTA TTAGAGAGAATGCTCAATTTGCAAGTTAATTTCAAGTCTCCAGCCACGTCAGGAAAAAAACATGAAGGAATTAAAGGAGGCCAGGCCGCG CAAAGATAACAGGCGTCCAGATCTGGAAATCTATAAGCCTGGCCTTTCTCGGCTAAGGAACAAGCCCAAAATCAAGGAACCCCCTGGGAG TGAGGAATTCAAAGATGAAATTGTTAATGACCGAGATTGCTCTGCTGTTGAAAATGGTACACAGCCCGTTAAAGATGTCTGCAAGGAACT GAACAACCAAGAGCAGAATGGTCCTATAGACCCAGAAAATAATCGGGGACAAGAATCCTTTCCTAGGACTGCTGGACAAGAGGATCGTAG TCTAAAAATTATCAAAAGAACAAAGAAACCCGACCTGCAGATCTATCAGCCTGGACGACGTTTGCAGACTGTTAGCAAAGAATCCGCCAG TCGGGTGGAGGAGGAAGAAGTCCTCAACCAGGTAGAACAACTGAGAGTAGAGGAAGATGAGTGTAGGGGAAATGTTGCGAAGGAGGAAGT TGCGAATAAACCAGACAGGGCTGAGATAGAAAAGAGCCCAGGTGGTGGGAGAGTAGGGGCTGCAAAAGGAGAAAAAGGAAAGAGGATGGG AAAAGGGGAGGGGGTGAGGGAAACCCACGACGACCCAGCCCGCGGGAGGCCGGGCTCCGCAAAGCGCTACTCCCGCTCAGACAAACGAAG GAATCGCTACCGCACGCGCAGCACCAGCTCAGCTGGCAGCAACAACAGCGCTGAGGGAGCTGGCCTGACGGATAATGGATGTCGCCGCCG CCGACAGGATAGGACCAAGGAGAGGCCACGACTGAAGAAGCAAGTGTCTGTGTCCTCAACCGATTCCTTAGACGAGGACAGAATTGATGA GCCTGATGGATTAGGACCCAGGAGAAGTTCAGAAAGGAAGAGACATTTAGAAAGAAACTGGTCTGGCCGTGGGGAGGGTGAGCAGAAAAA CAGTGCTAAAGAATATCGAGGCACTCTTCGTGTCACTTTCGATGCAGAAGCCATGAACAAAGAGTCTCCCATGGTGAGGTCAGCCAGGGA TGATATGGATAGAGGAAAGCCTGACAAAGGCTTGAGCAGTGGGGGCAAAGGCTCTGAGAAGCAGGAGTCCAAAAACCCGAAACAAGAACT TCGGGGTCGTGGTCGTGGCATTCTGATTTTGCCTGCCCATACCACCCTATCTGTCAATTCAGCAGGTTCTCCAGAGTCCGCGCCTTTGGG ACCTCGGCTTTTGTTTGGATCTGGTAGTAAGGGATCTCGGAGTTGGGGCCGTGGAGGCACCACACGCCGATTGTGGGACCCAAACAATCC TGATCAGAAACCTGCTCTAAAGACTCAGACGCCCCAGCTACATTTCTTGGACACTGATGATGAAGTCAGCCCTACATCTTGGGGTGACTC ACGCCAGGCTCAGGCATCTTACTATAAGTTTCAAAACTCTGACAACCCCTATTATTACCCCCGGACACCAGGCCCTGCCTCCCAGTATCC CTATACGGGCTATAACCCTCTACAGTACCCAGTGGGCCCTACGAATGGTGTGTACCCAGGGCCTTACTACCCAGGCTACCCGACTCCGTC AGGACAGTATGTGTGTAGCCCTCTACCTACCAGCACCATGAGTCCCGAGGAGGTAGAGCAGCACATGAGGAACCTGCAGCAACAGGAGCT GCACAGGCTTCTCCGGGTGGCTGACAACCAGGAACTGCAGCTCAGCAACCTGCTCTCCAGGGACCGCATCAGTCCGGAGGGCCTGGAGAA GATGGCGCAACTCAGAGCTGAACTGCTGCAGCTATATGAGCGCTGTATTCTATTAGATATTGAGTTCTCTGATAATCAGAATGTGGATCA GATCCTGTGGAAGAATGCTTTCTATCAGGTGATTGAGAAGTTCAGGCAACTTGTCAAGGATCCGAATGTTGAGAACCCAGAACAGATTCG GAACAGACTTTTGGAGCTCTTGGATGAGGGTAGTGACTTCTTTGATAGTTTGCTTCAGAAGCTGCAGGTTACTTACAAGTTCAAACTGGA AGACTACATGGATGGTCTTGCCATTCGCAGCAAGCCATTACGCAAGACAGTAAAATATGCCTTGATCAGTGCCCAGCGATGCATGATATG CCAAGGAGATATTGCTAGGTACCGGGAGCAAGCCAGTGATACAGCGAATTATGGGAAAGCACGCAGTTGGTACCTGAAGGCCCAGCACAT TGCTCCCAAGAATGGGCGCCCCTATAACCAGTTGGCTTTGCTGGCAGTGTATACGAGGAGGAAGCTTGACGCTGTCTATTACTATATGCG CAGTTTAGCTGCCAGCAACCCTATCCTGACTGCCAAGGAGAGTCTCATGAGCTTGTTTGAAGAGACCAAGCGGAAGGCAGAACAGATGGA AAAGAAGCAACATGAGGAATTTGACCTGAGCCCTGACCAGTGGCGGAAAGGAAAGAAGTCTACTTTCCGGCATGTTGGAGATGACACCAC TCGCCTGGAGATCTGGATTCATCCATCCCATCCACGGTCTTCCCAGGGCACTGAGTCTGGGAAGGATTCTGAGCAAGAGAATGGGCTGGG CAGCCTGAGTCCCAGTGATCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCATGGGAAGCTGTTTACCCGGATTGGGATGGAGAC ATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGCATGCTGCA GCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGGTTGCAAACTGGGAGAAGCTTCTGATTTCATTGTCCGTCAAGG GACACTAATCCAGGTGCCATCATCTGCAGGGGAAGTTGGTTGTTATAAAATCTGTTCATGTGGACAAAGTGGACTCTTAGAAAACTGTAT GGAAATGCACTGTATAGACCTCCAGAAGTCTTGTATTGTTGGAGGAAAAAGAAAAAGTCATGGAACATCCTTTAGTATTGACTGCAATGT CTGTTCTTGTTTTGCTGGCAATTTGGTGTGCTCTACCCGCCTTTGCCTCAGTGAGCACAGTTCAGAAGATGACCGTCGTACCTTCACAGG TCTGCCCTGTAACTGTGCAGATCAGTTTGTCCCTGTATGTGGGCAGAATGGGCGCACTTACCCCAGTGCCTGCATTGCTCGCTGTGTGGG CCTCCAAGACCATCAGTTTGAGTTTGGATCATGCATGTCAAAGGATCCATGTAATCCTAATCCCTGCCAAAAAAACCAAAGGTGCATACC CAAACCACAGGTCTGCCTGACGACTTTTGATAAATTTGGATGTAGCCAGTATGAGTGTGTACCAAGACAGCTCGCGTGTGACCAGGTCCA AGATCCTGTTTGTGACACAGACCACATGGAGCACAACAATCTCTGCACTTTATACCAAAGAGGAAAAAGCCTCTCTTACAAAGGTCCCTG CCAGCCCTTTTGCAGAGCAACCGAGCCCGTATGTGGGCACAATGGTGAGACCTACAGCAGTGTGTGTGCTGCCTACTCGGATCGCGTGGC AGTCGATTACTATGGGGACTGCCAGGCCGTCGGAGTCCTCTCAGAGCACAGCTCCGTCGCCGAGTGTGCTTCTGTCAAGTGTCCTTCGCT CTTGGCAGCTGGATGCAAACCCATCATCCCACCGGGTGCTTGTTGCCCATTATGTGCTGGGATGTTAAGAGTTTTATTTGACAAAGAAAA ACTGGATACTATTGCTAAGGTAACAAATAAAAAGCCAATAACAGTTCTGGAAATACTTCAGAAAATCCGCATGCACGTGTCTGTCCCACA GTGTGATGTGTTTGGATACTTCAGCATTGAATCAGAAATTGTGATCCTGATCATTCCCGTCGATCACTATCCAAAAGCTCTGCAGATTGA AGCCTGCAATAAAGAAGCAGAGAAGATTGAGTCCCTTATCAACTCTGACAGCCCGACTTTGGCGTCCCATGTCCCTCTCTCTGCCCTCAT CATTTCCCAGGTACAGGTCTCCAGCAGTGTGCCATCGGCCGGTGTCAGGGCCAGGCCTTCTTGCCACTCCCTCCTCCTTCCCCTCAGCTT GGGCCTTGCCTTGCACTTGCTCTGGACATATAACTGACTGCCCACGGAAAGTGCAGAATGCTCCTCCACCTCACTCTCCTGCCTTGAAAA AGACATTCAGGACTGCTGGTTTGTAGTTGAATATTGGCCAAGGAAAGGCACATGTCACCTCTATTCGCCACACAGTATTTTTTTTTTTAA TCCGCCAATATTAGTAGGATTTTTGTTTTGTTTTTACAAATGTTAAAATGTGTTGTTCCAAATACTAATGAAAACAGAATGTCTCTTCCT GGTAGACCACTGCCATATGATTTACATTTCCTCACCATAAGGGTCCCCCACTCTAAAGCAAATTTATCGCTGGGAAATGAGATGACCACT TTTTAGAAAGATAATTCACTGTACTATCAGGTTCACAAACTTCATTTCAGAGTTCTTTTTGAAGTATTTAAGGTTCCCGTTGCATTTGTT TTGTTTACAGATAATTACCTACTCTGGCTAGAAGCTAGGGGTCCCAGTGAAGAGCCACTGCCATTAAAGAATATGAAACATAGATAAAAC ATCTTTGAAATTATGTAAATTATGTAAATTATCAGGCAAATTTGCATTAAATTACAGAAATTTAATTCAGAACCCCAACTACTGTGTTAT GCAAAAGCAAGCTGATTAAATGACACTCATATAATTATATGTTGTAAGCAACAGGCTCACTGGTCACGGATTTGTGTCTGTGACTTTTGT GAAAGGGAGAAGTGACATTGCATCAAAGCATCTTGCATTATGCAATTTTTATATTAACCAGATATATATTCATCGGTATTCATCCAAGTT AAATGTAGAGTTTTTAAACATCAATCTTTAAACCAATTGCTGCTACTTATATAATTGCCAAAAAGTGAAATAATGTGTAGTTCATGTAAA TAATACATTATATTTCTATTTTATTATGAAGAAGGTGAATAGCCATATTTGTAAAATGACAATCATGTGTGTTAACCCAGTGCTTTCCAT TCGTGAAAACACATTTGCTTTTTGTGATATGCACAATGTAGATAAGTGTTCTGTCTGACTTTCTTTTTTGATATAGAAGTATAAAGAATT GTGGTTTATATATTTAAAAGTGTCAAGCTGAGTATTAAAATGTATGCATGTTGTCTAAGAAATTGAATACTTTGAATGTGTTTCACAGTT TGAAATAAGCTATTTGATGTAATACTTCTTGTGTGTATGCACATGAACTTAGATTTTACATGAAGTATTTTTTCAGTATTATATGTACCC TCTGAAATACATAGGGATATGCGTATTATACCAAAATGTTGCTGAAAAATGGGCACTTAAAGCTTTCAGAATATGTCAGTGCTGATGTAG CATGCTTGTTGCAATTGCCTTTTTTCTGTATAAATGTCTTTAATGCAATATACTGGAAAGCTTTTCTATTTTAATAAAAATAATTTTTAT >In-frame_SMG6_ENST00000263073_chr17_2139786_-_RECK_ENST00000377966_chr9_36107973_+_5666nt GCTGCGCGCGGCGGTGGCGGAGCCGCTACGGCTGTAGCAGCAGCCGCGAAGATGGCGGAAGGGCTGGAGCGTGTGCGGATCTCCGCGTCG GAGCTGCGCGGGATCCTGGCTACTCTGGCCCCGCAGGCCGGGAGCAGAGAAAACATGAAGGAATTAAAGGAGGCCAGGCCGCGCAAAGAT AACAGGCGTCCAGATCTGGAAATCTATAAGCCTGGCCTTTCTCGGCTAAGGAACAAGCCCAAAATCAAGGAACCCCCTGGGAGTGAGGAA TTCAAAGATGAAATTGTTAATGACCGAGATTGCTCTGCTGTTGAAAATGGTACACAGCCCGTTAAAGATGTCTGCAAGGAACTGAACAAC CAAGAGCAGAATGGTCCTATAGACCCAGAAAATAATCGGGGACAAGAATCCTTTCCTAGGACTGCTGGACAAGAGGATCGTAGTCTAAAA ATTATCAAAAGAACAAAGAAACCCGACCTGCAGATCTATCAGCCTGGACGACGTTTGCAGACTGTTAGCAAAGAATCCGCCAGTCGGGTG GAGGAGGAAGAAGTCCTCAACCAGGTAGAACAACTGAGAGTAGAGGAAGATGAGTGTAGGGGAAATGTTGCGAAGGAGGAAGTTGCGAAT AAACCAGACAGGGCTGAGATAGAAAAGAGCCCAGGTGGTGGGAGAGTAGGGGCTGCAAAAGGAGAAAAAGGAAAGAGGATGGGAAAAGGG GAGGGGGTGAGGGAAACCCACGACGACCCAGCCCGCGGGAGGCCGGGCTCCGCAAAGCGCTACTCCCGCTCAGACAAACGAAGGAATCGC TACCGCACGCGCAGCACCAGCTCAGCTGGCAGCAACAACAGCGCTGAGGGAGCTGGCCTGACGGATAATGGATGTCGCCGCCGCCGACAG GATAGGACCAAGGAGAGGCCACGACTGAAGAAGCAAGTGTCTGTGTCCTCAACCGATTCCTTAGACGAGGACAGAATTGATGAGCCTGAT GGATTAGGACCCAGGAGAAGTTCAGAAAGGAAGAGACATTTAGAAAGAAACTGGTCTGGCCGTGGGGAGGGTGAGCAGAAAAACAGTGCT AAAGAATATCGAGGCACTCTTCGTGTCACTTTCGATGCAGAAGCCATGAACAAAGAGTCTCCCATGGTGAGGTCAGCCAGGGATGATATG GATAGAGGAAAGCCTGACAAAGGCTTGAGCAGTGGGGGCAAAGGCTCTGAGAAGCAGGAGTCCAAAAACCCGAAACAAGAACTTCGGGGT CGTGGTCGTGGCATTCTGATTTTGCCTGCCCATACCACCCTATCTGTCAATTCAGCAGGTTCTCCAGAGTCCGCGCCTTTGGGACCTCGG CTTTTGTTTGGATCTGGTAGTAAGGGATCTCGGAGTTGGGGCCGTGGAGGCACCACACGCCGATTGTGGGACCCAAACAATCCTGATCAG AAACCTGCTCTAAAGACTCAGACGCCCCAGCTACATTTCTTGGACACTGATGATGAAGTCAGCCCTACATCTTGGGGTGACTCACGCCAG GCTCAGGCATCTTACTATAAGTTTCAAAACTCTGACAACCCCTATTATTACCCCCGGACACCAGGCCCTGCCTCCCAGTATCCCTATACG GGCTATAACCCTCTACAGTACCCAGTGGGCCCTACGAATGGTGTGTACCCAGGGCCTTACTACCCAGGCTACCCGACTCCGTCAGGACAG TATGTGTGTAGCCCTCTACCTACCAGCACCATGAGTCCCGAGGAGGTAGAGCAGCACATGAGGAACCTGCAGCAACAGGAGCTGCACAGG CTTCTCCGGGTGGCTGACAACCAGGAACTGCAGCTCAGCAACCTGCTCTCCAGGGACCGCATCAGTCCGGAGGGCCTGGAGAAGATGGCG CAACTCAGAGCTGAACTGCTGCAGCTATATGAGCGCTGTATTCTATTAGATATTGAGTTCTCTGATAATCAGAATGTGGATCAGATCCTG TGGAAGAATGCTTTCTATCAGGTGATTGAGAAGTTCAGGCAACTTGTCAAGGATCCGAATGTTGAGAACCCAGAACAGATTCGGAACAGA CTTTTGGAGCTCTTGGATGAGGGTAGTGACTTCTTTGATAGTTTGCTTCAGAAGCTGCAGGTTACTTACAAGTTCAAACTGGAAGACTAC ATGGATGGTCTTGCCATTCGCAGCAAGCCATTACGCAAGACAGTAAAATATGCCTTGATCAGTGCCCAGCGATGCATGATATGCCAAGGA GATATTGCTAGGTACCGGGAGCAAGCCAGTGATACAGCGAATTATGGGAAAGCACGCAGTTGGTACCTGAAGGCCCAGCACATTGCTCCC AAGAATGGGCGCCCCTATAACCAGTTGGCTTTGCTGGCAGTGTATACGAGGAGGAAGCTTGACGCTGTCTATTACTATATGCGCAGTTTA GCTGCCAGCAACCCTATCCTGACTGCCAAGGAGAGTCTCATGAGCTTGTTTGAAGAGACCAAGCGGAAGGCAGAACAGATGGAAAAGAAG CAACATGAGGAATTTGACCTGAGCCCTGACCAGTGGCGGAAAGGAAAGAAGTCTACTTTCCGGCATGTTGGAGATGACACCACTCGCCTG GAGATCTGGATTCATCCATCCCATCCACGGTCTTCCCAGGGCACTGAGTCTGGGAAGGATTCTGAGCAAGAGAATGGGCTGGGCAGCCTG AGTCCCAGTGATCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCATGGGAAGCTGTTTACCCGGATTGGGATGGAGACATTCCCT GCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATG ACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGGTTGCAAACTGGGAGAAGCTTCTGATTTCATTGTCCGTCAAGGGACACTA ATCCAGGTGCCATCATCTGCAGGGGAAGTTGGTTGTTATAAAATCTGTTCATGTGGACAAAGTGGACTCTTAGAAAACTGTATGGAAATG CACTGTATAGACCTCCAGAAGTCTTGTATTGTTGGAGGAAAAAGAAAAAGTCATGGAACATCCTTTAGTATTGACTGCAATGTCTGTTCT TGTTTTGCTGGCAATTTGGTGTGCTCTACCCGCCTTTGCCTCAGTGAGCACAGTTCAGAAGATGACCGTCGTACCTTCACAGGTCTGCCC TGTAACTGTGCAGATCAGTTTGTCCCTGTATGTGGGCAGAATGGGCGCACTTACCCCAGTGCCTGCATTGCTCGCTGTGTGGGCCTCCAA GACCATCAGTTTGAGTTTGGATCATGCATGTCAAAGGATCCATGTAATCCTAATCCCTGCCAAAAAAACCAAAGGTGCATACCCAAACCA CAGGTCTGCCTGACGACTTTTGATAAATTTGGATGTAGCCAGTATGAGTGTGTACCAAGACAGCTCGCGTGTGACCAGGTCCAAGATCCT GTTTGTGACACAGACCACATGGAGCACAACAATCTCTGCACTTTATACCAAAGAGGAAAAAGCCTCTCTTACAAAGGTCCCTGCCAGCCC TTTTGCAGAGCAACCGAGCCCGTATGTGGGCACAATGGTGAGACCTACAGCAGTGTGTGTGCTGCCTACTCGGATCGCGTGGCAGTCGAT TACTATGGGGACTGCCAGGCCGTCGGAGTCCTCTCAGAGCACAGCTCCGTCGCCGAGTGTGCTTCTGTCAAGTGTCCTTCGCTCTTGGCA GCTGGATGCAAACCCATCATCCCACCGGGTGCTTGTTGCCCATTATGTGCTGGGATGTTAAGAGTTTTATTTGACAAAGAAAAACTGGAT ACTATTGCTAAGGTAACAAATAAAAAGCCAATAACAGTTCTGGAAATACTTCAGAAAATCCGCATGCACGTGTCTGTCCCACAGTGTGAT GTGTTTGGATACTTCAGCATTGAATCAGAAATTGTGATCCTGATCATTCCCGTCGATCACTATCCAAAAGCTCTGCAGATTGAAGCCTGC AATAAAGAAGCAGAGAAGATTGAGTCCCTTATCAACTCTGACAGCCCGACTTTGGCGTCCCATGTCCCTCTCTCTGCCCTCATCATTTCC CAGGTACAGGTCTCCAGCAGTGTGCCATCGGCCGGTGTCAGGGCCAGGCCTTCTTGCCACTCCCTCCTCCTTCCCCTCAGCTTGGGCCTT GCCTTGCACTTGCTCTGGACATATAACTGACTGCCCACGGAAAGTGCAGAATGCTCCTCCACCTCACTCTCCTGCCTTGAAAAAGACATT CAGGACTGCTGGTTTGTAGTTGAATATTGGCCAAGGAAAGGCACATGTCACCTCTATTCGCCACACAGTATTTTTTTTTTTAATCCGCCA ATATTAGTAGGATTTTTGTTTTGTTTTTACAAATGTTAAAATGTGTTGTTCCAAATACTAATGAAAACAGAATGTCTCTTCCTGGTAGAC CACTGCCATATGATTTACATTTCCTCACCATAAGGGTCCCCCACTCTAAAGCAAATTTATCGCTGGGAAATGAGATGACCACTTTTTAGA AAGATAATTCACTGTACTATCAGGTTCACAAACTTCATTTCAGAGTTCTTTTTGAAGTATTTAAGGTTCCCGTTGCATTTGTTTTGTTTA CAGATAATTACCTACTCTGGCTAGAAGCTAGGGGTCCCAGTGAAGAGCCACTGCCATTAAAGAATATGAAACATAGATAAAACATCTTTG AAATTATGTAAATTATGTAAATTATCAGGCAAATTTGCATTAAATTACAGAAATTTAATTCAGAACCCCAACTACTGTGTTATGCAAAAG CAAGCTGATTAAATGACACTCATATAATTATATGTTGTAAGCAACAGGCTCACTGGTCACGGATTTGTGTCTGTGACTTTTGTGAAAGGG AGAAGTGACATTGCATCAAAGCATCTTGCATTATGCAATTTTTATATTAACCAGATATATATTCATCGGTATTCATCCAAGTTAAATGTA GAGTTTTTAAACATCAATCTTTAAACCAATTGCTGCTACTTATATAATTGCCAAAAAGTGAAATAATGTGTAGTTCATGTAAATAATACA TTATATTTCTATTTTATTATGAAGAAGGTGAATAGCCATATTTGTAAAATGACAATCATGTGTGTTAACCCAGTGCTTTCCATTCGTGAA AACACATTTGCTTTTTGTGATATGCACAATGTAGATAAGTGTTCTGTCTGACTTTCTTTTTTGATATAGAAGTATAAAGAATTGTGGTTT ATATATTTAAAAGTGTCAAGCTGAGTATTAAAATGTATGCATGTTGTCTAAGAAATTGAATACTTTGAATGTGTTTCACAGTTTGAAATA AGCTATTTGATGTAATACTTCTTGTGTGTATGCACATGAACTTAGATTTTACATGAAGTATTTTTTCAGTATTATATGTACCCTCTGAAA TACATAGGGATATGCGTATTATACCAAAATGTTGCTGAAAAATGGGCACTTAAAGCTTTCAGAATATGTCAGTGCTGATGTAGCATGCTT >In-frame_SMG6_ENST00000354901_chr17_2139786_-_RECK_ENST00000377966_chr9_36107973_+_3186nt GGACCCAGATACCCGTCAGAATTTCCAGGCCTTGGTTTGGTTTAGACATTTTAGAAGATGTTAACAGCAATAATTGTAAAAGACTTTGAG TGGCACGCATGGTGAACAGAAAGTACTAGATCCTGAAGAGGGGGGAAAGGCATTTCTGTGCTCTTCCTGGTAAAGTGTTTGAAAATGAAC ATTCAGAAGAAAACCTAAAGCACCTGAAATGCACAGGGGACGAGAATGAGAGCTGAACAAAAGGTTCATCCTCAGTTTTCTCCATGCCCA TGGGAAGCTGTTTACCCGGATTGGGATGGAGACATTCCCTGCAGTGGCTGAGAAGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAG CCCCTCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATGACCATCAATATGTTTGCAGTACACAACTCCCAGCTGAAAGGTTGCAAACT GGGAGAAGCTTCTGATTTCATTGTCCGTCAAGGGACACTAATCCAGGTGCCATCATCTGCAGGGGAAGTTGGTTGTTATAAAATCTGTTC ATGTGGACAAAGTGGACTCTTAGAAAACTGTATGGAAATGCACTGTATAGACCTCCAGAAGTCTTGTATTGTTGGAGGAAAAAGAAAAAG TCATGGAACATCCTTTAGTATTGACTGCAATGTCTGTTCTTGTTTTGCTGGCAATTTGGTGTGCTCTACCCGCCTTTGCCTCAGTGAGCA CAGTTCAGAAGATGACCGTCGTACCTTCACAGGTCTGCCCTGTAACTGTGCAGATCAGTTTGTCCCTGTATGTGGGCAGAATGGGCGCAC TTACCCCAGTGCCTGCATTGCTCGCTGTGTGGGCCTCCAAGACCATCAGTTTGAGTTTGGATCATGCATGTCAAAGGATCCATGTAATCC TAATCCCTGCCAAAAAAACCAAAGGTGCATACCCAAACCACAGGTCTGCCTGACGACTTTTGATAAATTTGGATGTAGCCAGTATGAGTG TGTACCAAGACAGCTCGCGTGTGACCAGGTCCAAGATCCTGTTTGTGACACAGACCACATGGAGCACAACAATCTCTGCACTTTATACCA AAGAGGAAAAAGCCTCTCTTACAAAGGTCCCTGCCAGCCCTTTTGCAGAGCAACCGAGCCCGTATGTGGGCACAATGGTGAGACCTACAG CAGTGTGTGTGCTGCCTACTCGGATCGCGTGGCAGTCGATTACTATGGGGACTGCCAGGCCGTCGGAGTCCTCTCAGAGCACAGCTCCGT CGCCGAGTGTGCTTCTGTCAAGTGTCCTTCGCTCTTGGCAGCTGGATGCAAACCCATCATCCCACCGGGTGCTTGTTGCCCATTATGTGC TGGGATGTTAAGAGTTTTATTTGACAAAGAAAAACTGGATACTATTGCTAAGGTAACAAATAAAAAGCCAATAACAGTTCTGGAAATACT TCAGAAAATCCGCATGCACGTGTCTGTCCCACAGTGTGATGTGTTTGGATACTTCAGCATTGAATCAGAAATTGTGATCCTGATCATTCC CGTCGATCACTATCCAAAAGCTCTGCAGATTGAAGCCTGCAATAAAGAAGCAGAGAAGATTGAGTCCCTTATCAACTCTGACAGCCCGAC TTTGGCGTCCCATGTCCCTCTCTCTGCCCTCATCATTTCCCAGGTACAGGTCTCCAGCAGTGTGCCATCGGCCGGTGTCAGGGCCAGGCC TTCTTGCCACTCCCTCCTCCTTCCCCTCAGCTTGGGCCTTGCCTTGCACTTGCTCTGGACATATAACTGACTGCCCACGGAAAGTGCAGA ATGCTCCTCCACCTCACTCTCCTGCCTTGAAAAAGACATTCAGGACTGCTGGTTTGTAGTTGAATATTGGCCAAGGAAAGGCACATGTCA CCTCTATTCGCCACACAGTATTTTTTTTTTTAATCCGCCAATATTAGTAGGATTTTTGTTTTGTTTTTACAAATGTTAAAATGTGTTGTT CCAAATACTAATGAAAACAGAATGTCTCTTCCTGGTAGACCACTGCCATATGATTTACATTTCCTCACCATAAGGGTCCCCCACTCTAAA GCAAATTTATCGCTGGGAAATGAGATGACCACTTTTTAGAAAGATAATTCACTGTACTATCAGGTTCACAAACTTCATTTCAGAGTTCTT TTTGAAGTATTTAAGGTTCCCGTTGCATTTGTTTTGTTTACAGATAATTACCTACTCTGGCTAGAAGCTAGGGGTCCCAGTGAAGAGCCA CTGCCATTAAAGAATATGAAACATAGATAAAACATCTTTGAAATTATGTAAATTATGTAAATTATCAGGCAAATTTGCATTAAATTACAG AAATTTAATTCAGAACCCCAACTACTGTGTTATGCAAAAGCAAGCTGATTAAATGACACTCATATAATTATATGTTGTAAGCAACAGGCT CACTGGTCACGGATTTGTGTCTGTGACTTTTGTGAAAGGGAGAAGTGACATTGCATCAAAGCATCTTGCATTATGCAATTTTTATATTAA CCAGATATATATTCATCGGTATTCATCCAAGTTAAATGTAGAGTTTTTAAACATCAATCTTTAAACCAATTGCTGCTACTTATATAATTG CCAAAAAGTGAAATAATGTGTAGTTCATGTAAATAATACATTATATTTCTATTTTATTATGAAGAAGGTGAATAGCCATATTTGTAAAAT GACAATCATGTGTGTTAACCCAGTGCTTTCCATTCGTGAAAACACATTTGCTTTTTGTGATATGCACAATGTAGATAAGTGTTCTGTCTG ACTTTCTTTTTTGATATAGAAGTATAAAGAATTGTGGTTTATATATTTAAAAGTGTCAAGCTGAGTATTAAAATGTATGCATGTTGTCTA AGAAATTGAATACTTTGAATGTGTTTCACAGTTTGAAATAAGCTATTTGATGTAATACTTCTTGTGTGTATGCACATGAACTTAGATTTT ACATGAAGTATTTTTTCAGTATTATATGTACCCTCTGAAATACATAGGGATATGCGTATTATACCAAAATGTTGCTGAAAAATGGGCACT TAAAGCTTTCAGAATATGTCAGTGCTGATGTAGCATGCTTGTTGCAATTGCCTTTTTTCTGTATAAATGTCTTTAATGCAATATACTGGA >In-frame_SMG6_ENST00000536871_chr17_2139786_-_RECK_ENST00000377966_chr9_36107973_+_3133nt ATACCAGAGAGTTTAGGGACTGTGAAGGTTTCAGGAAATTTGTTGAGTATTTAGAAAAGCCGATGGTTTCAGAGAGAAACTTTGATATTA GCTTGAACACAGTTATTGCCAGGGGTGAGGAAATAGCATACCAAAGCATAATAACTCATAGTGATTTATCCAAAACTTGAGTTGTTTGCA TCTCTGGACCCTGAAAACTCCTTTATCTTGAATTTGTTCAAAATTGCAGGATACCGGGAAGGATGGAGACATTCCCTGCAGTGGCTGAGA AGGTCCTCAAGGAGTTCCAGGTGTTACTGCAGCACAGCCCCTCTCCCATTGGAAGTACCCGCATGCTGCAGCTTATGACCATCAATATGT TTGCAGTACACAACTCCCAGCTGAAAGGTTGCAAACTGGGAGAAGCTTCTGATTTCATTGTCCGTCAAGGGACACTAATCCAGGTGCCAT CATCTGCAGGGGAAGTTGGTTGTTATAAAATCTGTTCATGTGGACAAAGTGGACTCTTAGAAAACTGTATGGAAATGCACTGTATAGACC TCCAGAAGTCTTGTATTGTTGGAGGAAAAAGAAAAAGTCATGGAACATCCTTTAGTATTGACTGCAATGTCTGTTCTTGTTTTGCTGGCA ATTTGGTGTGCTCTACCCGCCTTTGCCTCAGTGAGCACAGTTCAGAAGATGACCGTCGTACCTTCACAGGTCTGCCCTGTAACTGTGCAG ATCAGTTTGTCCCTGTATGTGGGCAGAATGGGCGCACTTACCCCAGTGCCTGCATTGCTCGCTGTGTGGGCCTCCAAGACCATCAGTTTG AGTTTGGATCATGCATGTCAAAGGATCCATGTAATCCTAATCCCTGCCAAAAAAACCAAAGGTGCATACCCAAACCACAGGTCTGCCTGA CGACTTTTGATAAATTTGGATGTAGCCAGTATGAGTGTGTACCAAGACAGCTCGCGTGTGACCAGGTCCAAGATCCTGTTTGTGACACAG ACCACATGGAGCACAACAATCTCTGCACTTTATACCAAAGAGGAAAAAGCCTCTCTTACAAAGGTCCCTGCCAGCCCTTTTGCAGAGCAA CCGAGCCCGTATGTGGGCACAATGGTGAGACCTACAGCAGTGTGTGTGCTGCCTACTCGGATCGCGTGGCAGTCGATTACTATGGGGACT GCCAGGCCGTCGGAGTCCTCTCAGAGCACAGCTCCGTCGCCGAGTGTGCTTCTGTCAAGTGTCCTTCGCTCTTGGCAGCTGGATGCAAAC CCATCATCCCACCGGGTGCTTGTTGCCCATTATGTGCTGGGATGTTAAGAGTTTTATTTGACAAAGAAAAACTGGATACTATTGCTAAGG TAACAAATAAAAAGCCAATAACAGTTCTGGAAATACTTCAGAAAATCCGCATGCACGTGTCTGTCCCACAGTGTGATGTGTTTGGATACT TCAGCATTGAATCAGAAATTGTGATCCTGATCATTCCCGTCGATCACTATCCAAAAGCTCTGCAGATTGAAGCCTGCAATAAAGAAGCAG AGAAGATTGAGTCCCTTATCAACTCTGACAGCCCGACTTTGGCGTCCCATGTCCCTCTCTCTGCCCTCATCATTTCCCAGGTACAGGTCT CCAGCAGTGTGCCATCGGCCGGTGTCAGGGCCAGGCCTTCTTGCCACTCCCTCCTCCTTCCCCTCAGCTTGGGCCTTGCCTTGCACTTGC TCTGGACATATAACTGACTGCCCACGGAAAGTGCAGAATGCTCCTCCACCTCACTCTCCTGCCTTGAAAAAGACATTCAGGACTGCTGGT TTGTAGTTGAATATTGGCCAAGGAAAGGCACATGTCACCTCTATTCGCCACACAGTATTTTTTTTTTTAATCCGCCAATATTAGTAGGAT TTTTGTTTTGTTTTTACAAATGTTAAAATGTGTTGTTCCAAATACTAATGAAAACAGAATGTCTCTTCCTGGTAGACCACTGCCATATGA TTTACATTTCCTCACCATAAGGGTCCCCCACTCTAAAGCAAATTTATCGCTGGGAAATGAGATGACCACTTTTTAGAAAGATAATTCACT GTACTATCAGGTTCACAAACTTCATTTCAGAGTTCTTTTTGAAGTATTTAAGGTTCCCGTTGCATTTGTTTTGTTTACAGATAATTACCT ACTCTGGCTAGAAGCTAGGGGTCCCAGTGAAGAGCCACTGCCATTAAAGAATATGAAACATAGATAAAACATCTTTGAAATTATGTAAAT TATGTAAATTATCAGGCAAATTTGCATTAAATTACAGAAATTTAATTCAGAACCCCAACTACTGTGTTATGCAAAAGCAAGCTGATTAAA TGACACTCATATAATTATATGTTGTAAGCAACAGGCTCACTGGTCACGGATTTGTGTCTGTGACTTTTGTGAAAGGGAGAAGTGACATTG CATCAAAGCATCTTGCATTATGCAATTTTTATATTAACCAGATATATATTCATCGGTATTCATCCAAGTTAAATGTAGAGTTTTTAAACA TCAATCTTTAAACCAATTGCTGCTACTTATATAATTGCCAAAAAGTGAAATAATGTGTAGTTCATGTAAATAATACATTATATTTCTATT TTATTATGAAGAAGGTGAATAGCCATATTTGTAAAATGACAATCATGTGTGTTAACCCAGTGCTTTCCATTCGTGAAAACACATTTGCTT TTTGTGATATGCACAATGTAGATAAGTGTTCTGTCTGACTTTCTTTTTTGATATAGAAGTATAAAGAATTGTGGTTTATATATTTAAAAG TGTCAAGCTGAGTATTAAAATGTATGCATGTTGTCTAAGAAATTGAATACTTTGAATGTGTTTCACAGTTTGAAATAAGCTATTTGATGT AATACTTCTTGTGTGTATGCACATGAACTTAGATTTTACATGAAGTATTTTTTCAGTATTATATGTACCCTCTGAAATACATAGGGATAT GCGTATTATACCAAAATGTTGCTGAAAAATGGGCACTTAAAGCTTTCAGAATATGTCAGTGCTGATGTAGCATGCTTGTTGCAATTGCCT |
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FusionGenePPI for SMG6_RECK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SMG6 | TERT, HDAC8, UPF1, HBB, PPP1CC, SOX2, RBM8A, MAGOH, PABPC1, SMG6, UPF3B, SMG5, SMG7, PSG1, C2orf68, FAM221B, SPATA1, HAO2, LPIN3, TRIM25 | RECK | CTH, MEOX2, REL, TCF4, KEAP1, TRIM39, USHBP1, KRT40, TRIM69, TEKT4, NOTCH2NL, CEP44, MCCC2, IFNA4, ACOX1, MTNR1B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | SMG6 | chr17:2139786 | chr9:36107973 | ENST00000263073 | - | 10 | 19 | 114_503 | 956 | 1420 | telomeric DNA |
| Hgene | SMG6 | chr17:2139786 | chr9:36107973 | ENST00000544865 | - | 10 | 19 | 114_503 | 925 | 1389 | telomeric DNA |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | SMG6 | chr17:2139786 | chr9:36107973 | ENST00000354901 | - | 3 | 12 | 114_503 | 48 | 512 | telomeric DNA |
| Hgene | SMG6 | chr17:2139786 | chr9:36107973 | ENST00000536871 | - | 2 | 11 | 114_503 | 48 | 512 | telomeric DNA |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SMG6_RECK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SMG6_RECK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | RECK | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Tgene | RECK | C0009171 | Cocaine Abuse | 1 | PSYGENET |
| Tgene | RECK | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| Tgene | RECK | C0017636 | Glioblastoma | 1 | CTD_human |
| Tgene | RECK | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | RECK | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Tgene | RECK | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
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