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Fusion gene ID: 34898 |
FusionGeneSummary for SMG1_SULT1A2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SMG1_SULT1A2 | Fusion gene ID: 34898 | Hgene | Tgene | Gene symbol | SMG1 | SULT1A2 | Gene ID | 23049 | 6799 |
| Gene name | SMG1, nonsense mediated mRNA decay associated PI3K related kinase | sulfotransferase family 1A member 2 | |
| Synonyms | 61E3.4|ATX|LIP | HAST4|P-PST|ST1A2|STP2|TSPST2 | |
| Cytomap | 16p12.3 | 16p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase SMG1PI-3-kinase-related kinase SMG-1SMG1 phosphatidylinositol 3-kinase-related kinaselambda-interacting proteinlambda/iota protein kinase C-interacting proteinsmg-1 homolog, phosphatidylinositol 3-kinase-related kinase | sulfotransferase 1A2P-PST 2aryl sulfotransferase 2arylamine sulfotransferasephenol sulfotransferase 2phenol-preferring phenol sulfotransferase2phenol-sulfating phenol sulfotransferase 2phenolic-metabolizing (P) form of PSTsulfotransferase family, | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q96Q15 | P50226 | |
| Ensembl transtripts involved in fusion gene | ENST00000389467, ENST00000446231, ENST00000565224, ENST00000567737, | ENST00000533150, ENST00000335715, ENST00000395630, | |
| Fusion gene scores | * DoF score | 14 X 10 X 7=980 | 1 X 1 X 1=1 |
| # samples | 16 | 1 | |
| ** MAII score | log2(16/980*10)=-2.61470984411521 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: SMG1 [Title/Abstract] AND SULT1A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SMG1 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 11544179 |
| Hgene | SMG1 | GO:0018105 | peptidyl-serine phosphorylation | 11544179|15175154 |
| Hgene | SMG1 | GO:0046777 | protein autophosphorylation | 11331269|11544179 |
| Hgene | SMG1 | GO:0046854 | phosphatidylinositol phosphorylation | 11331269 |
| Hgene | SMG1 | GO:2001020 | regulation of response to DNA damage stimulus | 15175154 |
| Tgene | SULT1A2 | GO:0006068 | ethanol catabolic process | 23207770 |
| Tgene | SULT1A2 | GO:0006805 | xenobiotic metabolic process | 20417180 |
| Tgene | SULT1A2 | GO:0018958 | phenol-containing compound metabolic process | 20417180 |
| Tgene | SULT1A2 | GO:0050427 | 3'-phosphoadenosine 5'-phosphosulfate metabolic process | 23207770 |
| Tgene | SULT1A2 | GO:0051923 | sulfation | 20056724|23207770 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-XF-AAMY-01A | SMG1 | chr16 | 18907374 | - | SULT1A2 | chr16 | 28606996 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000389467 | ENST00000533150 | SMG1 | chr16 | 18907374 | - | SULT1A2 | chr16 | 28606996 | - |
| In-frame | ENST00000389467 | ENST00000335715 | SMG1 | chr16 | 18907374 | - | SULT1A2 | chr16 | 28606996 | - |
| In-frame | ENST00000389467 | ENST00000395630 | SMG1 | chr16 | 18907374 | - | SULT1A2 | chr16 | 28606996 | - |
| In-frame | ENST00000446231 | ENST00000533150 | SMG1 | chr16 | 18907374 | - | SULT1A2 | chr16 | 28606996 | - |
| In-frame | ENST00000446231 | ENST00000335715 | SMG1 | chr16 | 18907374 | - | SULT1A2 | chr16 | 28606996 | - |
| In-frame | ENST00000446231 | ENST00000395630 | SMG1 | chr16 | 18907374 | - | SULT1A2 | chr16 | 28606996 | - |
| In-frame | ENST00000565224 | ENST00000533150 | SMG1 | chr16 | 18907374 | - | SULT1A2 | chr16 | 28606996 | - |
| In-frame | ENST00000565224 | ENST00000335715 | SMG1 | chr16 | 18907374 | - | SULT1A2 | chr16 | 28606996 | - |
| In-frame | ENST00000565224 | ENST00000395630 | SMG1 | chr16 | 18907374 | - | SULT1A2 | chr16 | 28606996 | - |
| intron-3CDS | ENST00000567737 | ENST00000533150 | SMG1 | chr16 | 18907374 | - | SULT1A2 | chr16 | 28606996 | - |
| intron-3CDS | ENST00000567737 | ENST00000335715 | SMG1 | chr16 | 18907374 | - | SULT1A2 | chr16 | 28606996 | - |
| intron-3CDS | ENST00000567737 | ENST00000395630 | SMG1 | chr16 | 18907374 | - | SULT1A2 | chr16 | 28606996 | - |
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FusionProtFeatures for SMG1_SULT1A2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SMG1 | SULT1A2 |
| Serine/threonine protein kinase involved in both mRNAsurveillance and genotoxic stress response pathways. Recognizesthe substrate consensus sequence [ST]-Q. Plays a central role innonsense-mediated decay (NMD) of mRNAs containing premature stopcodons by phosphorylating UPF1/RENT1. Recruited by release factorsto stalled ribosomes together with SMG8 and SMG9 (forming theSMG1C protein kinase complex), and UPF1 to form the transient SURF(SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURFcomplex associates with the exon junction complex (EJC) throughUPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillancecomplex which is believed to activate NMD. Also acts as agenotoxic stress-activated protein kinase that displays somefunctional overlap with ATM. Can phosphorylate p53/TP53 and isrequired for optimal p53/TP53 activation after cellular exposureto genotoxic stress. Its depletion leads to spontaneous DNA damageand increased sensitivity to ionizing radiation (IR). May activatePRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269,ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154,ECO:0000269|PubMed:16452507}. | Sulfotransferase that utilizes 3'-phospho-5'-adenylylsulfate (PAPS) as sulfonate donor to catalyze the sulfateconjugation of catecholamines, phenolic drugs andneurotransmitters. Is also responsible for the sulfonation andactivation of minoxidil. Mediates the metabolic activation ofcarcinogenic N-hydroxyarylamines to DNA binding products and couldso participate as modulating factor of cancer risk. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >SULT1A2 | chr16:18907374 | chr16:28606996 | ENST00000335715 | - | 1 | 8 | 227_232 | 49 | 296 | Nucleotide binding | Note=PAPS |
| Tgene | >SULT1A2 | chr16:18907374 | chr16:28606996 | ENST00000335715 | - | 1 | 8 | 255_259 | 49 | 296 | Nucleotide binding | Note=PAPS |
| Tgene | >SULT1A2 | chr16:18907374 | chr16:28606996 | ENST00000335715 | - | 1 | 8 | 48_53 | 49 | 296 | Nucleotide binding | Note=PAPS |
| Tgene | >SULT1A2 | chr16:18907374 | chr16:28606996 | ENST00000395630 | - | 1 | 8 | 227_232 | 49 | 296 | Nucleotide binding | Note=PAPS |
| Tgene | >SULT1A2 | chr16:18907374 | chr16:28606996 | ENST00000395630 | - | 1 | 8 | 255_259 | 49 | 296 | Nucleotide binding | Note=PAPS |
| Tgene | >SULT1A2 | chr16:18907374 | chr16:28606996 | ENST00000395630 | - | 1 | 8 | 48_53 | 49 | 296 | Nucleotide binding | Note=PAPS |
| Tgene | >SULT1A2 | chr16:18907374 | chr16:28606996 | ENST00000335715 | - | 1 | 8 | 106_108 | 49 | 296 | Region | Substrate binding |
| Tgene | >SULT1A2 | chr16:18907374 | chr16:28606996 | ENST00000395630 | - | 1 | 8 | 106_108 | 49 | 296 | Region | Substrate binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SMG1 | chr16:18907374 | chr16:28606996 | ENST00000446231 | - | 3 | 63 | 1131_1866 | 137 | 3662 | Domain | FAT |
| Hgene | >SMG1 | chr16:18907374 | chr16:28606996 | ENST00000446231 | - | 3 | 63 | 2150_2478 | 137 | 3662 | Domain | PI3K/PI4K |
| Hgene | >SMG1 | chr16:18907374 | chr16:28606996 | ENST00000446231 | - | 3 | 63 | 3629_3661 | 137 | 3662 | Domain | FATC |
| Hgene | >SMG1 | chr16:18907374 | chr16:28606996 | ENST00000446231 | - | 3 | 63 | 1817_1852 | 137 | 3662 | Repeat | Note=HEAT |
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FusionGeneSequence for SMG1_SULT1A2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SMG1_ENST00000389467_chr16_18907374_-_SULT1A2_ENST00000533150_chr16_28606996_-_351aa MSRRAPGSRLSSGGGGGGTKYPRSWNDWQPRTDSASADPDNLKYSSSRDRGGSSSYGLQPSNSAVVSRQRHDDTRVHADIQNDEKGGYSV NGGSGENTYGRKSLGQELRVNNVTSPEFTSVQHGSRALATKDMRKSQGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSG VCVLGARGVEEDRAGASAHQTFPDPLLRDGDSEKHTSPTTPEDTPAPGSAPPDSVGSEGQAIQASTEEPSAAQNPKREIQKILEFVGRSL >In-frame_SMG1_ENST00000389467_chr16_18907374_-_SULT1A2_ENST00000335715_chr16_28606996_-_384aa MSRRAPGSRLSSGGGGGGTKYPRSWNDWQPRTDSASADPDNLKYSSSRDRGGSSSYGLQPSNSAVVSRQRHDDTRVHADIQNDEKGGYSV NGGSGENTYGRKSLGQELRVNNVTSPEFTSVQHGSRALATKDMRKSQGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSG METLKNTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWWEL SRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNYTTVRREFMDHSISPFMRKGMAGDWKTTFTVAQ >In-frame_SMG1_ENST00000389467_chr16_18907374_-_SULT1A2_ENST00000395630_chr16_28606996_-_384aa MSRRAPGSRLSSGGGGGGTKYPRSWNDWQPRTDSASADPDNLKYSSSRDRGGSSSYGLQPSNSAVVSRQRHDDTRVHADIQNDEKGGYSV NGGSGENTYGRKSLGQELRVNNVTSPEFTSVQHGSRALATKDMRKSQGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSG METLKNTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWWEL SRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNYTTVRREFMDHSISPFMRKGMAGDWKTTFTVAQ >In-frame_SMG1_ENST00000446231_chr16_18907374_-_SULT1A2_ENST00000533150_chr16_28606996_-_351aa MSRRAPGSRLSSGGGGGGTKYPRSWNDWQPRTDSASADPDNLKYSSSRDRGGSSSYGLQPSNSAVVSRQRHDDTRVHADIQNDEKGGYSV NGGSGENTYGRKSLGQELRVNNVTSPEFTSVQHGSRALATKDMRKSQGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSG VCVLGARGVEEDRAGASAHQTFPDPLLRDGDSEKHTSPTTPEDTPAPGSAPPDSVGSEGQAIQASTEEPSAAQNPKREIQKILEFVGRSL >In-frame_SMG1_ENST00000446231_chr16_18907374_-_SULT1A2_ENST00000335715_chr16_28606996_-_384aa MSRRAPGSRLSSGGGGGGTKYPRSWNDWQPRTDSASADPDNLKYSSSRDRGGSSSYGLQPSNSAVVSRQRHDDTRVHADIQNDEKGGYSV NGGSGENTYGRKSLGQELRVNNVTSPEFTSVQHGSRALATKDMRKSQGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSG METLKNTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWWEL SRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNYTTVRREFMDHSISPFMRKGMAGDWKTTFTVAQ >In-frame_SMG1_ENST00000446231_chr16_18907374_-_SULT1A2_ENST00000395630_chr16_28606996_-_384aa MSRRAPGSRLSSGGGGGGTKYPRSWNDWQPRTDSASADPDNLKYSSSRDRGGSSSYGLQPSNSAVVSRQRHDDTRVHADIQNDEKGGYSV NGGSGENTYGRKSLGQELRVNNVTSPEFTSVQHGSRALATKDMRKSQGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSG METLKNTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWWEL SRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNYTTVRREFMDHSISPFMRKGMAGDWKTTFTVAQ >In-frame_SMG1_ENST00000565224_chr16_18907374_-_SULT1A2_ENST00000533150_chr16_28606996_-_325aa MRFLRTDSASADPDNLKYSSSRDRGGSSSYGLQPSNSAVVSRQRHDDTRVHADIQNDEKGGYSVNGGSGENTYGRKSLGQELRVNNVTSP EFTSVQHGSRALATKDMRKSQGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSGVCVLGARGVEEDRAGASAHQTFPDPL LRDGDSEKHTSPTTPEDTPAPGSAPPDSVGSEGQAIQASTEEPSAAQNPKREIQKILEFVGRSLPEETVDLMVEHTSFKEMKKNPMTNYT >In-frame_SMG1_ENST00000565224_chr16_18907374_-_SULT1A2_ENST00000335715_chr16_28606996_-_358aa MRFLRTDSASADPDNLKYSSSRDRGGSSSYGLQPSNSAVVSRQRHDDTRVHADIQNDEKGGYSVNGGSGENTYGRKSLGQELRVNNVTSP EFTSVQHGSRALATKDMRKSQGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSGMETLKNTPAPRLLKTHLPLALLPQTL LDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKIL >In-frame_SMG1_ENST00000565224_chr16_18907374_-_SULT1A2_ENST00000395630_chr16_28606996_-_358aa MRFLRTDSASADPDNLKYSSSRDRGGSSSYGLQPSNSAVVSRQRHDDTRVHADIQNDEKGGYSVNGGSGENTYGRKSLGQELRVNNVTSP EFTSVQHGSRALATKDMRKSQGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKVPGIPSGMETLKNTPAPRLLKTHLPLALLPQTL LDQKVKVVYVARNAKDVAVSYYHFYHMAKVYPHPGTWESFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKIL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SMG1_ENST00000389467_chr16_18907374_-_SULT1A2_ENST00000533150_chr16_28606996_-_1053nt ATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAACCC AGAACTGATAGTGCATCAGCCGACCCAGATAATTTAAAATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAACCT TCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACGATGATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGTGTC AATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGTCGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACCAGT GTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAGACATGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATCTAC CAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTCCCATCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCAGGT GTGTGTGTCCTGGGTGCAAGGGGAGTGGAGGAAGACAGGGCTGGGGCTTCAGCTCACCAGACCTTCCCTGACCCACTGCTCAGGGATGGA GACTCTGAAAAACACACCAGCCCCACGACTCCTGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAGAAGGTCAA GCAATCCAAGCCTCCACTGAGGAGCCCTCTGCTGCTCAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGGCGCTCCCTG CCAGAGGAGACTGTGGACCTCATGGTTGAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACCACCGTCCGCCGG GAGTTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAGAATGAGCGC >In-frame_SMG1_ENST00000389467_chr16_18907374_-_SULT1A2_ENST00000335715_chr16_28606996_-_1152nt ATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAACCC AGAACTGATAGTGCATCAGCCGACCCAGATAATTTAAAATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAACCT TCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACGATGATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGTGTC AATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGTCGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACCAGT GTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAGACATGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATCTAC CAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTCCCATCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCAGGG ATGGAGACTCTGAAAAACACACCAGCCCCACGACTCCTGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAGAAG GTCAAGGTGGTCTATGTTGCCCGCAACGCAAAGGATGTGGCGGTTTCCTACTACCACTTCTACCACATGGCCAAAGTGTACCCTCACCCT GGGACCTGGGAAAGCTTCCTGGAGAAGTTCATGGCTGGAGAAGTGTCCTATGGGTCCTGGTACCAGCACGTGCAAGAGTGGTGGGAGCTG AGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAGACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGG CGCTCCCTGCCAGAGGAGACTGTGGACCTCATGGTTGAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACCACC GTCCGCCGGGAGTTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAG >In-frame_SMG1_ENST00000389467_chr16_18907374_-_SULT1A2_ENST00000395630_chr16_28606996_-_1152nt ATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAACCC AGAACTGATAGTGCATCAGCCGACCCAGATAATTTAAAATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAACCT TCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACGATGATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGTGTC AATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGTCGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACCAGT GTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAGACATGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATCTAC CAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTCCCATCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCAGGG ATGGAGACTCTGAAAAACACACCAGCCCCACGACTCCTGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAGAAG GTCAAGGTGGTCTATGTTGCCCGCAACGCAAAGGATGTGGCGGTTTCCTACTACCACTTCTACCACATGGCCAAAGTGTACCCTCACCCT GGGACCTGGGAAAGCTTCCTGGAGAAGTTCATGGCTGGAGAAGTGTCCTATGGGTCCTGGTACCAGCACGTGCAAGAGTGGTGGGAGCTG AGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAGACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGG CGCTCCCTGCCAGAGGAGACTGTGGACCTCATGGTTGAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACCACC GTCCGCCGGGAGTTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAG >In-frame_SMG1_ENST00000446231_chr16_18907374_-_SULT1A2_ENST00000533150_chr16_28606996_-_1053nt ATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAACCC AGAACTGATAGTGCATCAGCCGACCCAGATAATTTAAAATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAACCT TCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACGATGATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGTGTC AATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGTCGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACCAGT GTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAGACATGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATCTAC CAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTCCCATCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCAGGT GTGTGTGTCCTGGGTGCAAGGGGAGTGGAGGAAGACAGGGCTGGGGCTTCAGCTCACCAGACCTTCCCTGACCCACTGCTCAGGGATGGA GACTCTGAAAAACACACCAGCCCCACGACTCCTGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAGAAGGTCAA GCAATCCAAGCCTCCACTGAGGAGCCCTCTGCTGCTCAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGGCGCTCCCTG CCAGAGGAGACTGTGGACCTCATGGTTGAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACCACCGTCCGCCGG GAGTTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAGAATGAGCGC >In-frame_SMG1_ENST00000446231_chr16_18907374_-_SULT1A2_ENST00000335715_chr16_28606996_-_1152nt ATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAACCC AGAACTGATAGTGCATCAGCCGACCCAGATAATTTAAAATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAACCT TCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACGATGATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGTGTC AATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGTCGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACCAGT GTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAGACATGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATCTAC CAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTCCCATCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCAGGG ATGGAGACTCTGAAAAACACACCAGCCCCACGACTCCTGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAGAAG GTCAAGGTGGTCTATGTTGCCCGCAACGCAAAGGATGTGGCGGTTTCCTACTACCACTTCTACCACATGGCCAAAGTGTACCCTCACCCT GGGACCTGGGAAAGCTTCCTGGAGAAGTTCATGGCTGGAGAAGTGTCCTATGGGTCCTGGTACCAGCACGTGCAAGAGTGGTGGGAGCTG AGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAGACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGG CGCTCCCTGCCAGAGGAGACTGTGGACCTCATGGTTGAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACCACC GTCCGCCGGGAGTTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAG >In-frame_SMG1_ENST00000446231_chr16_18907374_-_SULT1A2_ENST00000395630_chr16_28606996_-_1152nt ATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAACCC AGAACTGATAGTGCATCAGCCGACCCAGATAATTTAAAATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAACCT TCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACGATGATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGTGTC AATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGTCGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACCAGT GTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAGACATGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATCTAC CAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTCCCATCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCAGGG ATGGAGACTCTGAAAAACACACCAGCCCCACGACTCCTGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAGAAG GTCAAGGTGGTCTATGTTGCCCGCAACGCAAAGGATGTGGCGGTTTCCTACTACCACTTCTACCACATGGCCAAAGTGTACCCTCACCCT GGGACCTGGGAAAGCTTCCTGGAGAAGTTCATGGCTGGAGAAGTGTCCTATGGGTCCTGGTACCAGCACGTGCAAGAGTGGTGGGAGCTG AGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAGACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGG CGCTCCCTGCCAGAGGAGACTGTGGACCTCATGGTTGAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACCACC GTCCGCCGGGAGTTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAG >In-frame_SMG1_ENST00000565224_chr16_18907374_-_SULT1A2_ENST00000533150_chr16_28606996_-_975nt ATGCGATTTTTGAGAACTGATAGTGCATCAGCCGACCCAGATAATTTAAAATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTAT GGACTGCAACCTTCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACGATGATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGT GGCTACAGTGTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGTCGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCT GAGTTCACCAGTGTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAGACATGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTG GACATGATCTACCAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTCCCATCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGG ATTCCCTCAGGTGTGTGTGTCCTGGGTGCAAGGGGAGTGGAGGAAGACAGGGCTGGGGCTTCAGCTCACCAGACCTTCCCTGACCCACTG CTCAGGGATGGAGACTCTGAAAAACACACCAGCCCCACGACTCCTGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGA TCAGAAGGTCAAGCAATCCAAGCCTCCACTGAGGAGCCCTCTGCTGCTCAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTG GGGCGCTCCCTGCCAGAGGAGACTGTGGACCTCATGGTTGAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACC ACCGTCCGCCGGGAGTTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCG >In-frame_SMG1_ENST00000565224_chr16_18907374_-_SULT1A2_ENST00000335715_chr16_28606996_-_1074nt ATGCGATTTTTGAGAACTGATAGTGCATCAGCCGACCCAGATAATTTAAAATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTAT GGACTGCAACCTTCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACGATGATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGT GGCTACAGTGTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGTCGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCT GAGTTCACCAGTGTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAGACATGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTG GACATGATCTACCAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTCCCATCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGG ATTCCCTCAGGGATGGAGACTCTGAAAAACACACCAGCCCCACGACTCCTGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTG TTGGATCAGAAGGTCAAGGTGGTCTATGTTGCCCGCAACGCAAAGGATGTGGCGGTTTCCTACTACCACTTCTACCACATGGCCAAAGTG TACCCTCACCCTGGGACCTGGGAAAGCTTCCTGGAGAAGTTCATGGCTGGAGAAGTGTCCTATGGGTCCTGGTACCAGCACGTGCAAGAG TGGTGGGAGCTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAGACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTG GAGTTTGTGGGGCGCTCCCTGCCAGAGGAGACTGTGGACCTCATGGTTGAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACC AACTACACCACCGTCCGCCGGGAGTTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTC >In-frame_SMG1_ENST00000565224_chr16_18907374_-_SULT1A2_ENST00000395630_chr16_28606996_-_1074nt ATGCGATTTTTGAGAACTGATAGTGCATCAGCCGACCCAGATAATTTAAAATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTAT GGACTGCAACCTTCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACGATGATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGT GGCTACAGTGTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGTCGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCT GAGTTCACCAGTGTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAGACATGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTG GACATGATCTACCAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTCCCATCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGG ATTCCCTCAGGGATGGAGACTCTGAAAAACACACCAGCCCCACGACTCCTGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTG TTGGATCAGAAGGTCAAGGTGGTCTATGTTGCCCGCAACGCAAAGGATGTGGCGGTTTCCTACTACCACTTCTACCACATGGCCAAAGTG TACCCTCACCCTGGGACCTGGGAAAGCTTCCTGGAGAAGTTCATGGCTGGAGAAGTGTCCTATGGGTCCTGGTACCAGCACGTGCAAGAG TGGTGGGAGCTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAGACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTG GAGTTTGTGGGGCGCTCCCTGCCAGAGGAGACTGTGGACCTCATGGTTGAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACC AACTACACCACCGTCCGCCGGGAGTTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SMG1_ENST00000389467_chr16_18907374_-_SULT1A2_ENST00000533150_chr16_28606996_-_1501nt GCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCTCGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCT GGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCACCGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCG GAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCCTTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCC GGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGCGACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAG GTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAA CCCAGAACTGATAGTGCATCAGCCGACCCAGATAATTTAAAATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAA CCTTCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACGATGATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGT GTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGTCGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACC AGTGTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAGACATGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATC TACCAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTCCCATCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCA GGTGTGTGTGTCCTGGGTGCAAGGGGAGTGGAGGAAGACAGGGCTGGGGCTTCAGCTCACCAGACCTTCCCTGACCCACTGCTCAGGGAT GGAGACTCTGAAAAACACACCAGCCCCACGACTCCTGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAGAAGGT CAAGCAATCCAAGCCTCCACTGAGGAGCCCTCTGCTGCTCAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGGCGCTCC CTGCCAGAGGAGACTGTGGACCTCATGGTTGAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACCACCGTCCGC CGGGAGTTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAGAATGAG CGCTTCGATGCGGACTATGCGAAGAAGATGGCAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGTTCCTGGAGTCACTGCAG >In-frame_SMG1_ENST00000389467_chr16_18907374_-_SULT1A2_ENST00000335715_chr16_28606996_-_1600nt GCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCTCGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCT GGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCACCGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCG GAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCCTTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCC GGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGCGACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAG GTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAA CCCAGAACTGATAGTGCATCAGCCGACCCAGATAATTTAAAATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAA CCTTCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACGATGATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGT GTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGTCGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACC AGTGTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAGACATGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATC TACCAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTCCCATCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCA GGGATGGAGACTCTGAAAAACACACCAGCCCCACGACTCCTGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAG AAGGTCAAGGTGGTCTATGTTGCCCGCAACGCAAAGGATGTGGCGGTTTCCTACTACCACTTCTACCACATGGCCAAAGTGTACCCTCAC CCTGGGACCTGGGAAAGCTTCCTGGAGAAGTTCATGGCTGGAGAAGTGTCCTATGGGTCCTGGTACCAGCACGTGCAAGAGTGGTGGGAG CTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAGACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTG GGGCGCTCCCTGCCAGAGGAGACTGTGGACCTCATGGTTGAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACC ACCGTCCGCCGGGAGTTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCG CAGAATGAGCGCTTCGATGCGGACTATGCGAAGAAGATGGCAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGTTCCTGGAG >In-frame_SMG1_ENST00000389467_chr16_18907374_-_SULT1A2_ENST00000395630_chr16_28606996_-_1598nt GCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCTCGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCT GGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCACCGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCG GAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCCTTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCC GGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGCGACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAG GTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAA CCCAGAACTGATAGTGCATCAGCCGACCCAGATAATTTAAAATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAA CCTTCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACGATGATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGT GTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGTCGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACC AGTGTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAGACATGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATC TACCAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTCCCATCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCA GGGATGGAGACTCTGAAAAACACACCAGCCCCACGACTCCTGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAG AAGGTCAAGGTGGTCTATGTTGCCCGCAACGCAAAGGATGTGGCGGTTTCCTACTACCACTTCTACCACATGGCCAAAGTGTACCCTCAC CCTGGGACCTGGGAAAGCTTCCTGGAGAAGTTCATGGCTGGAGAAGTGTCCTATGGGTCCTGGTACCAGCACGTGCAAGAGTGGTGGGAG CTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAGACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTG GGGCGCTCCCTGCCAGAGGAGACTGTGGACCTCATGGTTGAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACC ACCGTCCGCCGGGAGTTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCG CAGAATGAGCGCTTCGATGCGGACTATGCGAAGAAGATGGCAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGTTCCTGGAG >In-frame_SMG1_ENST00000446231_chr16_18907374_-_SULT1A2_ENST00000533150_chr16_28606996_-_1551nt GTGCGACAGCGGCGGCGCGGCGGGCGGAGCCGGGAGGCGGGGAAGCAGTGGCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCT CGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCTGGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCAC CGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCGGAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCC TTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCCGGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGC GACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAGGTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCG GCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAACCCAGAACTGATAGTGCATCAGCCGACCCAGATAATTTAA AATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAACCTTCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACGATG ATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGTGTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGT CGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACCAGTGTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAGACA TGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATCTACCAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTCCCA TCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCAGGTGTGTGTGTCCTGGGTGCAAGGGGAGTGGAGGAAGACA GGGCTGGGGCTTCAGCTCACCAGACCTTCCCTGACCCACTGCTCAGGGATGGAGACTCTGAAAAACACACCAGCCCCACGACTCCTGAAG ACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAGAAGGTCAAGCAATCCAAGCCTCCACTGAGGAGCCCTCTGCTGCTC AGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGGCGCTCCCTGCCAGAGGAGACTGTGGACCTCATGGTTGAGCACACGT CGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACCACCGTCCGCCGGGAGTTCATGGACCACAGCATCTCCCCCTTCATGAGGA AAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAGAATGAGCGCTTCGATGCGGACTATGCGAAGAAGATGGCAGGCTGCA GCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGTTCCTGGAGTCACTGCAGAGGGAGTGTGCGAATCAAGCCTGACCAAGAGGCTCCAGAA >In-frame_SMG1_ENST00000446231_chr16_18907374_-_SULT1A2_ENST00000335715_chr16_28606996_-_1650nt GTGCGACAGCGGCGGCGCGGCGGGCGGAGCCGGGAGGCGGGGAAGCAGTGGCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCT CGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCTGGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCAC CGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCGGAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCC TTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCCGGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGC GACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAGGTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCG GCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAACCCAGAACTGATAGTGCATCAGCCGACCCAGATAATTTAA AATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAACCTTCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACGATG ATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGTGTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGT CGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACCAGTGTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAGACA TGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATCTACCAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTCCCA TCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCAGGGATGGAGACTCTGAAAAACACACCAGCCCCACGACTCC TGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAGAAGGTCAAGGTGGTCTATGTTGCCCGCAACGCAAAGGATG TGGCGGTTTCCTACTACCACTTCTACCACATGGCCAAAGTGTACCCTCACCCTGGGACCTGGGAAAGCTTCCTGGAGAAGTTCATGGCTG GAGAAGTGTCCTATGGGTCCTGGTACCAGCACGTGCAAGAGTGGTGGGAGCTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAG ACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGGCGCTCCCTGCCAGAGGAGACTGTGGACCTCATGGTTG AGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACCACCGTCCGCCGGGAGTTCATGGACCACAGCATCTCCCCCT TCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAGAATGAGCGCTTCGATGCGGACTATGCGAAGAAGATGG CAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGTTCCTGGAGTCACTGCAGAGGGAGTGTGCGAATCAAGCCTGACCAAGAG >In-frame_SMG1_ENST00000446231_chr16_18907374_-_SULT1A2_ENST00000395630_chr16_28606996_-_1648nt GTGCGACAGCGGCGGCGCGGCGGGCGGAGCCGGGAGGCGGGGAAGCAGTGGCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCT CGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCTGGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCAC CGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCGGAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCC TTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCCGGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGC GACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAGGTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCG GCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAACCCAGAACTGATAGTGCATCAGCCGACCCAGATAATTTAA AATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAACCTTCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACGATG ATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGTGTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGT CGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACCAGTGTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAGACA TGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATCTACCAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTCCCA TCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCAGGGATGGAGACTCTGAAAAACACACCAGCCCCACGACTCC TGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAGAAGGTCAAGGTGGTCTATGTTGCCCGCAACGCAAAGGATG TGGCGGTTTCCTACTACCACTTCTACCACATGGCCAAAGTGTACCCTCACCCTGGGACCTGGGAAAGCTTCCTGGAGAAGTTCATGGCTG GAGAAGTGTCCTATGGGTCCTGGTACCAGCACGTGCAAGAGTGGTGGGAGCTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAG ACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGGCGCTCCCTGCCAGAGGAGACTGTGGACCTCATGGTTG AGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACCACCGTCCGCCGGGAGTTCATGGACCACAGCATCTCCCCCT TCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAGAATGAGCGCTTCGATGCGGACTATGCGAAGAAGATGG CAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGTTCCTGGAGTCACTGCAGAGGGAGTGTGCGAATCAAGCCTGACCAAGAG >In-frame_SMG1_ENST00000565224_chr16_18907374_-_SULT1A2_ENST00000533150_chr16_28606996_-_1104nt ATTGACTTGATGCAAAACATCACAAAGGCTCCATATTATACAGTATGCGATTTTTGAGAACTGATAGTGCATCAGCCGACCCAGATAATT TAAAATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAACCTTCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACG ATGATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGTGTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGA AGTCGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACCAGTGTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAG ACATGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATCTACCAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTC CCATCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCAGGTGTGTGTGTCCTGGGTGCAAGGGGAGTGGAGGAAG ACAGGGCTGGGGCTTCAGCTCACCAGACCTTCCCTGACCCACTGCTCAGGGATGGAGACTCTGAAAAACACACCAGCCCCACGACTCCTG AAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAGAAGGTCAAGCAATCCAAGCCTCCACTGAGGAGCCCTCTGCTG CTCAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGGCGCTCCCTGCCAGAGGAGACTGTGGACCTCATGGTTGAGCACA CGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACCACCGTCCGCCGGGAGTTCATGGACCACAGCATCTCCCCCTTCATGA GGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAGAATGAGCGCTTCGATGCGGACTATGCGAAGAAGATGGCAGGCT GCAGCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGTTCCTGGAGTCACTGCAGAGGGAGTGTGCGAATCAAGCCTGACCAAGAGGCTCCA >In-frame_SMG1_ENST00000565224_chr16_18907374_-_SULT1A2_ENST00000335715_chr16_28606996_-_1203nt ATTGACTTGATGCAAAACATCACAAAGGCTCCATATTATACAGTATGCGATTTTTGAGAACTGATAGTGCATCAGCCGACCCAGATAATT TAAAATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAACCTTCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACG ATGATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGTGTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGA AGTCGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACCAGTGTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAG ACATGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATCTACCAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTC CCATCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCAGGGATGGAGACTCTGAAAAACACACCAGCCCCACGAC TCCTGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAGAAGGTCAAGGTGGTCTATGTTGCCCGCAACGCAAAGG ATGTGGCGGTTTCCTACTACCACTTCTACCACATGGCCAAAGTGTACCCTCACCCTGGGACCTGGGAAAGCTTCCTGGAGAAGTTCATGG CTGGAGAAGTGTCCTATGGGTCCTGGTACCAGCACGTGCAAGAGTGGTGGGAGCTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATG AAGACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGGCGCTCCCTGCCAGAGGAGACTGTGGACCTCATGG TTGAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACCACCGTCCGCCGGGAGTTCATGGACCACAGCATCTCCC CCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAGAATGAGCGCTTCGATGCGGACTATGCGAAGAAGA TGGCAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGTTCCTGGAGTCACTGCAGAGGGAGTGTGCGAATCAAGCCTGACCAA >In-frame_SMG1_ENST00000565224_chr16_18907374_-_SULT1A2_ENST00000395630_chr16_28606996_-_1201nt ATTGACTTGATGCAAAACATCACAAAGGCTCCATATTATACAGTATGCGATTTTTGAGAACTGATAGTGCATCAGCCGACCCAGATAATT TAAAATATTCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTATGGACTGCAACCTTCAAATTCAGCTGTGGTGTCTCGGCAAAGGCACG ATGATACCAGAGTCCACGCTGACATACAGAATGACGAAAAGGGTGGCTACAGTGTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGA AGTCGTTGGGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACCAGTGTTCAGCATGGCAGTCGTGCTTTAGCCACCAAAG ACATGAGGAAATCACAGGGCACCACCTGGGTGAGCCAGATTCTGGACATGATCTACCAGGGCGGTGACCTGGAAAAGTGTCACCGAGCTC CCATCTTCATGCGGGTGCCCTTCCTTGAGTTCAAAGTCCCAGGGATTCCCTCAGGGATGGAGACTCTGAAAAACACACCAGCCCCACGAC TCCTGAAGACACACCTGCCCCTGGCTCTGCTCCCCCAGACTCTGTTGGATCAGAAGGTCAAGGTGGTCTATGTTGCCCGCAACGCAAAGG ATGTGGCGGTTTCCTACTACCACTTCTACCACATGGCCAAAGTGTACCCTCACCCTGGGACCTGGGAAAGCTTCCTGGAGAAGTTCATGG CTGGAGAAGTGTCCTATGGGTCCTGGTACCAGCACGTGCAAGAGTGGTGGGAGCTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATG AAGACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAGTTTGTGGGGCGCTCCCTGCCAGAGGAGACTGTGGACCTCATGG TTGAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAACTACACCACCGTCCGCCGGGAGTTCATGGACCACAGCATCTCCC CCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACCGTGGCGCAGAATGAGCGCTTCGATGCGGACTATGCGAAGAAGA TGGCAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGTTCCTGGAGTCACTGCAGAGGGAGTGTGCGAATCAAGCCTGACCAA |
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FusionGenePPI for SMG1_SULT1A2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SMG1 | PRKCI, SMG1, UPF1, UPF2, UPF3A, TTI1, TELO2, ELAVL1, SMG8, SMG9, RBM8A, UPF3B, NCBP2, PABPC1, SMG7, EIF4A3, MAGOH, GSPT2, GSPT1, EEF2, HSP90AA1, HSPA4, RUVBL1, RUVBL2, POLR2E, TUBA1A, TUBG1, HAUS2, HTR6, HSP90B1, EGFR, EPHA1 | SULT1A2 | MYC, NIF3L1, PHF11, STX19, SULT1A1, SULT1A3, TRAPPC3, TRAPPC9, CALCOCO2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | SMG1 | chr16:18907374 | chr16:28606996 | ENST00000446231 | - | 3 | 63 | 1_1977 | 137 | 3662 | SMG8 and SMG9 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SMG1_SULT1A2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SMG1_SULT1A2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SULT1A2 | C0008625 | Chromosome Aberrations | 1 | CTD_human |
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