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Fusion gene ID: 34897 |
FusionGeneSummary for SMG1_SNF8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SMG1_SNF8 | Fusion gene ID: 34897 | Hgene | Tgene | Gene symbol | SMG1 | SNF8 | Gene ID | 23049 | 11267 |
| Gene name | SMG1, nonsense mediated mRNA decay associated PI3K related kinase | SNF8, ESCRT-II complex subunit | |
| Synonyms | 61E3.4|ATX|LIP | Dot3|EAP30|VPS22 | |
| Cytomap | 16p12.3 | 17q21.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase SMG1PI-3-kinase-related kinase SMG-1SMG1 phosphatidylinositol 3-kinase-related kinaselambda-interacting proteinlambda/iota protein kinase C-interacting proteinsmg-1 homolog, phosphatidylinositol 3-kinase-related kinase | vacuolar-sorting protein SNF8EAP30 subunit of ELL complexELL-associated protein of 30 kDaESCRT-II complex subunit VPS22SNF8, ESCRT-II complex subunit, homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96Q15 | Q96H20 | |
| Ensembl transtripts involved in fusion gene | ENST00000389467, ENST00000446231, ENST00000565224, ENST00000567737, | ENST00000502492, ENST00000290330, ENST00000514089, | |
| Fusion gene scores | * DoF score | 14 X 10 X 7=980 | 5 X 4 X 5=100 |
| # samples | 16 | 5 | |
| ** MAII score | log2(16/980*10)=-2.61470984411521 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SMG1 [Title/Abstract] AND SNF8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SMG1 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 11544179 |
| Hgene | SMG1 | GO:0018105 | peptidyl-serine phosphorylation | 11544179|15175154 |
| Hgene | SMG1 | GO:0046777 | protein autophosphorylation | 11331269|11544179 |
| Hgene | SMG1 | GO:0046854 | phosphatidylinositol phosphorylation | 11331269 |
| Hgene | SMG1 | GO:2001020 | regulation of response to DNA damage stimulus | 15175154 |
| Tgene | SNF8 | GO:0006357 | regulation of transcription by RNA polymerase II | 10419521 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-XJ-A9DK-01A | SMG1 | chr16 | 18937272 | - | SNF8 | chr17 | 47018424 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000389467 | ENST00000502492 | SMG1 | chr16 | 18937272 | - | SNF8 | chr17 | 47018424 | - |
| In-frame | ENST00000389467 | ENST00000290330 | SMG1 | chr16 | 18937272 | - | SNF8 | chr17 | 47018424 | - |
| 5CDS-intron | ENST00000389467 | ENST00000514089 | SMG1 | chr16 | 18937272 | - | SNF8 | chr17 | 47018424 | - |
| In-frame | ENST00000446231 | ENST00000502492 | SMG1 | chr16 | 18937272 | - | SNF8 | chr17 | 47018424 | - |
| In-frame | ENST00000446231 | ENST00000290330 | SMG1 | chr16 | 18937272 | - | SNF8 | chr17 | 47018424 | - |
| 5CDS-intron | ENST00000446231 | ENST00000514089 | SMG1 | chr16 | 18937272 | - | SNF8 | chr17 | 47018424 | - |
| intron-3CDS | ENST00000565224 | ENST00000502492 | SMG1 | chr16 | 18937272 | - | SNF8 | chr17 | 47018424 | - |
| intron-3CDS | ENST00000565224 | ENST00000290330 | SMG1 | chr16 | 18937272 | - | SNF8 | chr17 | 47018424 | - |
| intron-intron | ENST00000565224 | ENST00000514089 | SMG1 | chr16 | 18937272 | - | SNF8 | chr17 | 47018424 | - |
| 5UTR-3CDS | ENST00000567737 | ENST00000502492 | SMG1 | chr16 | 18937272 | - | SNF8 | chr17 | 47018424 | - |
| 5UTR-3CDS | ENST00000567737 | ENST00000290330 | SMG1 | chr16 | 18937272 | - | SNF8 | chr17 | 47018424 | - |
| 5UTR-intron | ENST00000567737 | ENST00000514089 | SMG1 | chr16 | 18937272 | - | SNF8 | chr17 | 47018424 | - |
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FusionProtFeatures for SMG1_SNF8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SMG1 | SNF8 |
| Serine/threonine protein kinase involved in both mRNAsurveillance and genotoxic stress response pathways. Recognizesthe substrate consensus sequence [ST]-Q. Plays a central role innonsense-mediated decay (NMD) of mRNAs containing premature stopcodons by phosphorylating UPF1/RENT1. Recruited by release factorsto stalled ribosomes together with SMG8 and SMG9 (forming theSMG1C protein kinase complex), and UPF1 to form the transient SURF(SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURFcomplex associates with the exon junction complex (EJC) throughUPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillancecomplex which is believed to activate NMD. Also acts as agenotoxic stress-activated protein kinase that displays somefunctional overlap with ATM. Can phosphorylate p53/TP53 and isrequired for optimal p53/TP53 activation after cellular exposureto genotoxic stress. Its depletion leads to spontaneous DNA damageand increased sensitivity to ionizing radiation (IR). May activatePRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269,ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154,ECO:0000269|PubMed:16452507}. | Component of the endosomal sorting complex required fortransport II (ESCRT-II), which is required for multivesicular body(MVB) formation and sorting of endosomal cargo proteins into MVBs.The MVB pathway mediates delivery of transmembrane proteins intothe lumen of the lysosome for degradation. The ESCRT-II complex isprobably involved in the recruitment of the ESCRT-III complex. TheESCRT-II complex may also play a role in transcription regulationby participating in derepression of transcription by RNApolymerase II, possibly via its interaction with ELL. Required fordegradation of both endocytosed EGF and EGFR, but not for the EGFRligand-mediated internalization. It is also required for thedegradation of CXCR4. Required for the exosomal release of SDCBP,CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:17714434,ECO:0000269|PubMed:17959629, ECO:0000269|PubMed:18031739,ECO:0000269|PubMed:22660413}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SMG1 | chr16:18937272 | chr17:47018424 | ENST00000446231 | - | 1 | 63 | 1131_1866 | 30 | 3662 | Domain | FAT |
| Hgene | >SMG1 | chr16:18937272 | chr17:47018424 | ENST00000446231 | - | 1 | 63 | 2150_2478 | 30 | 3662 | Domain | PI3K/PI4K |
| Hgene | >SMG1 | chr16:18937272 | chr17:47018424 | ENST00000446231 | - | 1 | 63 | 3629_3661 | 30 | 3662 | Domain | FATC |
| Hgene | >SMG1 | chr16:18937272 | chr17:47018424 | ENST00000446231 | - | 1 | 63 | 1817_1852 | 30 | 3662 | Repeat | Note=HEAT |
| Tgene | SNF8 | chr16:18937272 | chr17:47018424 | ENST00000290330 | - | 1 | 8 | 27_53 | 35 | 258 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | SNF8 | chr16:18937272 | chr17:47018424 | ENST00000502492 | - | 1 | 8 | 27_53 | 35 | 259 | Coiled coil | Ontology_term=ECO:0000255 |
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FusionGeneSequence for SMG1_SNF8 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SMG1_ENST00000389467_chr16_18937272_-_SNF8_ENST00000502492_chr17_47018424_-_254aa MSRRAPGSRLSSGGGGGGTKYPRSWNDWQPRCQSSWTCSRPTWRNLPANTSRRSGRILSSVCSSRTCVQPLAWIRWPLEKDFGLRCWAWG TSITNXVSKLSKCAWRXSIGMEVXXLWRNYINRCXREGASSPRMSVKMTXSEPSRNXRHLALASASSLWAALTSFSLFQLSSIWITPWCC >In-frame_SMG1_ENST00000389467_chr16_18937272_-_SNF8_ENST00000290330_chr17_47018424_-_253aa MSRRAPGSRLSSGGGGGGTKYPRSWNDWQPRCQSSWTCSRPTWRNLPANTSRRSGRILSSVCSSRTCVQPLAWIRWPLEKDFGLRCWAWG TSITNXVSKLSKCAWRXSIGMEVXXLWRNYINRCXREGASSPRMSVKMTXSEPSRNXRHLALASASSLWAALTSFSLFQLSSIWITPWCC >In-frame_SMG1_ENST00000446231_chr16_18937272_-_SNF8_ENST00000502492_chr17_47018424_-_254aa MSRRAPGSRLSSGGGGGGTKYPRSWNDWQPRCQSSWTCSRPTWRNLPANTSRRSGRILSSVCSSRTCVQPLAWIRWPLEKDFGLRCWAWG TSITNXVSKLSKCAWRXSIGMEVXXLWRNYINRCXREGASSPRMSVKMTXSEPSRNXRHLALASASSLWAALTSFSLFQLSSIWITPWCC >In-frame_SMG1_ENST00000446231_chr16_18937272_-_SNF8_ENST00000290330_chr17_47018424_-_253aa MSRRAPGSRLSSGGGGGGTKYPRSWNDWQPRCQSSWTCSRPTWRNLPANTSRRSGRILSSVCSSRTCVQPLAWIRWPLEKDFGLRCWAWG TSITNXVSKLSKCAWRXSIGMEVXXLWRNYINRCXREGASSPRMSVKMTXSEPSRNXRHLALASASSLWAALTSFSLFQLSSIWITPWCC |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SMG1_ENST00000389467_chr16_18937272_-_SNF8_ENST00000502492_chr17_47018424_-_764nt ATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAACCC AGATGTCAAAGCAGTTGGACATGTTCAAGACCAACCTGGAGGAATTTGCCAGCAAACACAAGCAGGAGATCCGGAAGAATCCTGAGTTCC GTGTGCAGTTCCAGGACATGTGTGCAACCATTGGCGTGGATCCGCTGGCCTCTGGAAAAGGATTTTGGTCTGAGATGCTGGGCGTGGGGG ACTTCTATTACGAACTAGGTGTCCAAATTATCGAAGTGTGCCTGGCGCTGAAGCATCGGAATGGAGGTCTGATAACTTTGGAGGAACTAC ATCAACAGGTGTTGAAGGGAAGGGGCAAGTTCGCCCAGGATGTCAGTCAAGATGACCTGATCAGAGCCATCAAGAAACTAAAGGCACTTG GCACTGGCTTCGGCATCATCCCTGTGGGCGGCACTTACCTCATTCAGTCTGTTCCAGCTGAGCTCAATATGGATCACACCGTGGTGCTGC AGCTGGCAGAGAAGAATGGCTACGTGACTGTCAGTGAGATCAAAGCCAGTCTTAAATGGGAGACCGAGCGAGCGCGGCAAGTGCTGGAAC ACCTGCTGAAGGAAGGGTTGGCGTGGCTGGACTTACAGGCCCCAGGGGAGGCCCACTACTGGCTGCCAGCTCTCTTCACTGACCTCTACT >In-frame_SMG1_ENST00000389467_chr16_18937272_-_SNF8_ENST00000290330_chr17_47018424_-_761nt ATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAACCC AGATGTCAAAGCAGTTGGACATGTTCAAGACCAACCTGGAGGAATTTGCCAGCAAACACAAGCAGGAGATCCGGAAGAATCCTGAGTTCC GTGTGCAGTTCCAGGACATGTGTGCAACCATTGGCGTGGATCCGCTGGCCTCTGGAAAAGGATTTTGGTCTGAGATGCTGGGCGTGGGGG ACTTCTATTACGAACTAGGTGTCCAAATTATCGAAGTGTGCCTGGCGCTGAAGCATCGGAATGGAGGTCTGATAACTTTGGAGGAACTAC ATCAACAGGTGTTGAAGGGAAGGGGCAAGTTCGCCCAGGATGTCAGTCAAGATGACCTGATCAGAGCCATCAAGAAACTAAAGGCACTTG GCACTGGCTTCGGCATCATCCCTGTGGGCGGCACTTACCTCATTCAGTCTGTTCCAGCTGAGCTCAATATGGATCACACCGTGGTGCTGC AGCTGGCAGAGAATGGCTACGTGACTGTCAGTGAGATCAAAGCCAGTCTTAAATGGGAGACCGAGCGAGCGCGGCAAGTGCTGGAACACC TGCTGAAGGAAGGGTTGGCGTGGCTGGACTTACAGGCCCCAGGGGAGGCCCACTACTGGCTGCCAGCTCTCTTCACTGACCTCTACTCCC >In-frame_SMG1_ENST00000446231_chr16_18937272_-_SNF8_ENST00000502492_chr17_47018424_-_764nt ATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAACCC AGATGTCAAAGCAGTTGGACATGTTCAAGACCAACCTGGAGGAATTTGCCAGCAAACACAAGCAGGAGATCCGGAAGAATCCTGAGTTCC GTGTGCAGTTCCAGGACATGTGTGCAACCATTGGCGTGGATCCGCTGGCCTCTGGAAAAGGATTTTGGTCTGAGATGCTGGGCGTGGGGG ACTTCTATTACGAACTAGGTGTCCAAATTATCGAAGTGTGCCTGGCGCTGAAGCATCGGAATGGAGGTCTGATAACTTTGGAGGAACTAC ATCAACAGGTGTTGAAGGGAAGGGGCAAGTTCGCCCAGGATGTCAGTCAAGATGACCTGATCAGAGCCATCAAGAAACTAAAGGCACTTG GCACTGGCTTCGGCATCATCCCTGTGGGCGGCACTTACCTCATTCAGTCTGTTCCAGCTGAGCTCAATATGGATCACACCGTGGTGCTGC AGCTGGCAGAGAAGAATGGCTACGTGACTGTCAGTGAGATCAAAGCCAGTCTTAAATGGGAGACCGAGCGAGCGCGGCAAGTGCTGGAAC ACCTGCTGAAGGAAGGGTTGGCGTGGCTGGACTTACAGGCCCCAGGGGAGGCCCACTACTGGCTGCCAGCTCTCTTCACTGACCTCTACT >In-frame_SMG1_ENST00000446231_chr16_18937272_-_SNF8_ENST00000290330_chr17_47018424_-_761nt ATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAACCC AGATGTCAAAGCAGTTGGACATGTTCAAGACCAACCTGGAGGAATTTGCCAGCAAACACAAGCAGGAGATCCGGAAGAATCCTGAGTTCC GTGTGCAGTTCCAGGACATGTGTGCAACCATTGGCGTGGATCCGCTGGCCTCTGGAAAAGGATTTTGGTCTGAGATGCTGGGCGTGGGGG ACTTCTATTACGAACTAGGTGTCCAAATTATCGAAGTGTGCCTGGCGCTGAAGCATCGGAATGGAGGTCTGATAACTTTGGAGGAACTAC ATCAACAGGTGTTGAAGGGAAGGGGCAAGTTCGCCCAGGATGTCAGTCAAGATGACCTGATCAGAGCCATCAAGAAACTAAAGGCACTTG GCACTGGCTTCGGCATCATCCCTGTGGGCGGCACTTACCTCATTCAGTCTGTTCCAGCTGAGCTCAATATGGATCACACCGTGGTGCTGC AGCTGGCAGAGAATGGCTACGTGACTGTCAGTGAGATCAAAGCCAGTCTTAAATGGGAGACCGAGCGAGCGCGGCAAGTGCTGGAACACC TGCTGAAGGAAGGGTTGGCGTGGCTGGACTTACAGGCCCCAGGGGAGGCCCACTACTGGCTGCCAGCTCTCTTCACTGACCTCTACTCCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SMG1_ENST00000389467_chr16_18937272_-_SNF8_ENST00000502492_chr17_47018424_-_2286nt GCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCTCGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCT GGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCACCGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCG GAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCCTTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCC GGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGCGACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAG GTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAA CCCAGATGTCAAAGCAGTTGGACATGTTCAAGACCAACCTGGAGGAATTTGCCAGCAAACACAAGCAGGAGATCCGGAAGAATCCTGAGT TCCGTGTGCAGTTCCAGGACATGTGTGCAACCATTGGCGTGGATCCGCTGGCCTCTGGAAAAGGATTTTGGTCTGAGATGCTGGGCGTGG GGGACTTCTATTACGAACTAGGTGTCCAAATTATCGAAGTGTGCCTGGCGCTGAAGCATCGGAATGGAGGTCTGATAACTTTGGAGGAAC TACATCAACAGGTGTTGAAGGGAAGGGGCAAGTTCGCCCAGGATGTCAGTCAAGATGACCTGATCAGAGCCATCAAGAAACTAAAGGCAC TTGGCACTGGCTTCGGCATCATCCCTGTGGGCGGCACTTACCTCATTCAGTCTGTTCCAGCTGAGCTCAATATGGATCACACCGTGGTGC TGCAGCTGGCAGAGAAGAATGGCTACGTGACTGTCAGTGAGATCAAAGCCAGTCTTAAATGGGAGACCGAGCGAGCGCGGCAAGTGCTGG AACACCTGCTGAAGGAAGGGTTGGCGTGGCTGGACTTACAGGCCCCAGGGGAGGCCCACTACTGGCTGCCAGCTCTCTTCACTGACCTCT ACTCCCAGGAGATTACAGCTGAGGAGGCCAGAGAAGCCCTCCCCTGACTGCATGTGGAAGGGCACACAGCAGCAGGCAGGGAGGAGGCGG AGGTGGCAAATAAACCTGGGCAATTTTGTTTATACAAAAAATAGAAAAAAAGTTCCAAGTTTTTCTTTCTTCCCTCATTCTTTTATTTTT GAAAAGTGCCTTCACGTTGCATTTTTATTGGAGGAAAACCTCGCTCGTTCAGTAAGCATAATCTGATTAACACAGAGAACGGCAAGCACA TATAAAATGATTTTTGTAGGTCATCTGCAAGTTCATGGAAGAGCTGGGCCTAGAATGTGGGTTGTTTCCTGGCCTGTCTAGTCTTTGTAG CTGTGAGACATAGATTACAGCCTATGCTAATTCAAACCTTTTAAATAAAATGTTCCTTATCTCAAACTAGCTGGTCCTAATGGACCAGTA AATAATATTCACTTTCAGTCTCTTCTGGCTTCCTCTGTAGAGGCTCTAGGTTATGACAGAGTTAGCTGTGAGTATGAAGGAAATAGAAGT CAATGTCCAATCGTGGCTAAATTGGAGGAAAGAAAACAATGGAATCTGAGGGGAATCAAACAATAGTTAGGGAATGTTCTATTTTCTTAA ATTCCCTACTAGCTTTCTCACCCTCCTGTAGTGATTGCCAGGTCCCTCTAGCCTCAGTAGTGGGAAAGGGAGTCATTTACTGAACACCTA CCCTGTGCCATTTTACATACAGCTCACTTAAATTTCACCAAGTAGGCAGCCTTCAACATCACAGGTGATTCAATCAAAGTAATTTGCCAG GGGCCGCCAGCTTCAGCCGAGCTAAAGCTGGTGCCTAGGCCTATTAACCCGAGCCCATGCCTTCATGTATCACTGCATAGTACAGAATGG CAGCACATACTGTGTGTAGACATTTTTCTACACACGTGGTCAGCCAAGAGTAAAAGCCTCTGCATCAGAAAGCAAGAATCTCCTATAGCA AGTAGAAGTGGTGATGAGGGAAGAGGCCAGAGTTGTTTAAGGCTCCCAAAGTCCTTATGGTCTAAAGGCTAAGATCCTAAAAGTGCTAGT TTAGTACTGGAAATCTGAAAACTCAATGGTTTTTCCATACTGAGACCCTTCCTTTAGCAGGATATAGCCTGGGCCCATCTCTTCCTCTGC >In-frame_SMG1_ENST00000389467_chr16_18937272_-_SNF8_ENST00000290330_chr17_47018424_-_1225nt GCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCTCGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCT GGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCACCGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCG GAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCCTTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCC GGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGCGACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAG GTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAA CCCAGATGTCAAAGCAGTTGGACATGTTCAAGACCAACCTGGAGGAATTTGCCAGCAAACACAAGCAGGAGATCCGGAAGAATCCTGAGT TCCGTGTGCAGTTCCAGGACATGTGTGCAACCATTGGCGTGGATCCGCTGGCCTCTGGAAAAGGATTTTGGTCTGAGATGCTGGGCGTGG GGGACTTCTATTACGAACTAGGTGTCCAAATTATCGAAGTGTGCCTGGCGCTGAAGCATCGGAATGGAGGTCTGATAACTTTGGAGGAAC TACATCAACAGGTGTTGAAGGGAAGGGGCAAGTTCGCCCAGGATGTCAGTCAAGATGACCTGATCAGAGCCATCAAGAAACTAAAGGCAC TTGGCACTGGCTTCGGCATCATCCCTGTGGGCGGCACTTACCTCATTCAGTCTGTTCCAGCTGAGCTCAATATGGATCACACCGTGGTGC TGCAGCTGGCAGAGAATGGCTACGTGACTGTCAGTGAGATCAAAGCCAGTCTTAAATGGGAGACCGAGCGAGCGCGGCAAGTGCTGGAAC ACCTGCTGAAGGAAGGGTTGGCGTGGCTGGACTTACAGGCCCCAGGGGAGGCCCACTACTGGCTGCCAGCTCTCTTCACTGACCTCTACT CCCAGGAGATTACAGCTGAGGAGGCCAGAGAAGCCCTCCCCTGACTGCATGTGGAAGGGCACACAGCAGCAGGCAGGGAGGAGGCGGAGG >In-frame_SMG1_ENST00000446231_chr16_18937272_-_SNF8_ENST00000502492_chr17_47018424_-_2336nt GTGCGACAGCGGCGGCGCGGCGGGCGGAGCCGGGAGGCGGGGAAGCAGTGGCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCT CGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCTGGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCAC CGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCGGAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCC TTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCCGGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGC GACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAGGTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCG GCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAACCCAGATGTCAAAGCAGTTGGACATGTTCAAGACCAACCT GGAGGAATTTGCCAGCAAACACAAGCAGGAGATCCGGAAGAATCCTGAGTTCCGTGTGCAGTTCCAGGACATGTGTGCAACCATTGGCGT GGATCCGCTGGCCTCTGGAAAAGGATTTTGGTCTGAGATGCTGGGCGTGGGGGACTTCTATTACGAACTAGGTGTCCAAATTATCGAAGT GTGCCTGGCGCTGAAGCATCGGAATGGAGGTCTGATAACTTTGGAGGAACTACATCAACAGGTGTTGAAGGGAAGGGGCAAGTTCGCCCA GGATGTCAGTCAAGATGACCTGATCAGAGCCATCAAGAAACTAAAGGCACTTGGCACTGGCTTCGGCATCATCCCTGTGGGCGGCACTTA CCTCATTCAGTCTGTTCCAGCTGAGCTCAATATGGATCACACCGTGGTGCTGCAGCTGGCAGAGAAGAATGGCTACGTGACTGTCAGTGA GATCAAAGCCAGTCTTAAATGGGAGACCGAGCGAGCGCGGCAAGTGCTGGAACACCTGCTGAAGGAAGGGTTGGCGTGGCTGGACTTACA GGCCCCAGGGGAGGCCCACTACTGGCTGCCAGCTCTCTTCACTGACCTCTACTCCCAGGAGATTACAGCTGAGGAGGCCAGAGAAGCCCT CCCCTGACTGCATGTGGAAGGGCACACAGCAGCAGGCAGGGAGGAGGCGGAGGTGGCAAATAAACCTGGGCAATTTTGTTTATACAAAAA ATAGAAAAAAAGTTCCAAGTTTTTCTTTCTTCCCTCATTCTTTTATTTTTGAAAAGTGCCTTCACGTTGCATTTTTATTGGAGGAAAACC TCGCTCGTTCAGTAAGCATAATCTGATTAACACAGAGAACGGCAAGCACATATAAAATGATTTTTGTAGGTCATCTGCAAGTTCATGGAA GAGCTGGGCCTAGAATGTGGGTTGTTTCCTGGCCTGTCTAGTCTTTGTAGCTGTGAGACATAGATTACAGCCTATGCTAATTCAAACCTT TTAAATAAAATGTTCCTTATCTCAAACTAGCTGGTCCTAATGGACCAGTAAATAATATTCACTTTCAGTCTCTTCTGGCTTCCTCTGTAG AGGCTCTAGGTTATGACAGAGTTAGCTGTGAGTATGAAGGAAATAGAAGTCAATGTCCAATCGTGGCTAAATTGGAGGAAAGAAAACAAT GGAATCTGAGGGGAATCAAACAATAGTTAGGGAATGTTCTATTTTCTTAAATTCCCTACTAGCTTTCTCACCCTCCTGTAGTGATTGCCA GGTCCCTCTAGCCTCAGTAGTGGGAAAGGGAGTCATTTACTGAACACCTACCCTGTGCCATTTTACATACAGCTCACTTAAATTTCACCA AGTAGGCAGCCTTCAACATCACAGGTGATTCAATCAAAGTAATTTGCCAGGGGCCGCCAGCTTCAGCCGAGCTAAAGCTGGTGCCTAGGC CTATTAACCCGAGCCCATGCCTTCATGTATCACTGCATAGTACAGAATGGCAGCACATACTGTGTGTAGACATTTTTCTACACACGTGGT CAGCCAAGAGTAAAAGCCTCTGCATCAGAAAGCAAGAATCTCCTATAGCAAGTAGAAGTGGTGATGAGGGAAGAGGCCAGAGTTGTTTAA GGCTCCCAAAGTCCTTATGGTCTAAAGGCTAAGATCCTAAAAGTGCTAGTTTAGTACTGGAAATCTGAAAACTCAATGGTTTTTCCATAC >In-frame_SMG1_ENST00000446231_chr16_18937272_-_SNF8_ENST00000290330_chr17_47018424_-_1275nt GTGCGACAGCGGCGGCGCGGCGGGCGGAGCCGGGAGGCGGGGAAGCAGTGGCCGTGTGAGCGTGAGGAGCTGCCGCCACCGCCTGCTCCT CGTCGTCCTCGTCCTCCGGGGCCCCGGCGACGTGGGCCGCGCACGGCCCTGGAAAAGACGTCGCCTCCCCTTCATCCGCCTCTCTCTCAC CGCGCCGCTCCCGCCTCCTCGTCCTGCGCTGCGGGCTCAGGCGGAACCCGGAACGGCCGTCCTCTTCCCCCGCCCTCCGCCGCCTCCTCC TTCTCCTCCTCCTCCTCCTCCTCCTCCTTCTCGGCTTCCTCCTCAGCCCCGGGCCGGAGCGGGGTGTCGGCGGCGGCCGGTTCGGGCGGC GACTCGCGCTTCTTTGGGCGGCGGCGCTTGGCCATGTCGTGTCGGGGAAGGTAATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCG GCGGCGGCGGCGGCGGCACCAAGTATCCGCGGAGCTGGAATGACTGGCAACCCAGATGTCAAAGCAGTTGGACATGTTCAAGACCAACCT GGAGGAATTTGCCAGCAAACACAAGCAGGAGATCCGGAAGAATCCTGAGTTCCGTGTGCAGTTCCAGGACATGTGTGCAACCATTGGCGT GGATCCGCTGGCCTCTGGAAAAGGATTTTGGTCTGAGATGCTGGGCGTGGGGGACTTCTATTACGAACTAGGTGTCCAAATTATCGAAGT GTGCCTGGCGCTGAAGCATCGGAATGGAGGTCTGATAACTTTGGAGGAACTACATCAACAGGTGTTGAAGGGAAGGGGCAAGTTCGCCCA GGATGTCAGTCAAGATGACCTGATCAGAGCCATCAAGAAACTAAAGGCACTTGGCACTGGCTTCGGCATCATCCCTGTGGGCGGCACTTA CCTCATTCAGTCTGTTCCAGCTGAGCTCAATATGGATCACACCGTGGTGCTGCAGCTGGCAGAGAATGGCTACGTGACTGTCAGTGAGAT CAAAGCCAGTCTTAAATGGGAGACCGAGCGAGCGCGGCAAGTGCTGGAACACCTGCTGAAGGAAGGGTTGGCGTGGCTGGACTTACAGGC CCCAGGGGAGGCCCACTACTGGCTGCCAGCTCTCTTCACTGACCTCTACTCCCAGGAGATTACAGCTGAGGAGGCCAGAGAAGCCCTCCC CTGACTGCATGTGGAAGGGCACACAGCAGCAGGCAGGGAGGAGGCGGAGGTGGCAAATAAACCTGGGCAATTTTGTTTATACAAAAAATA |
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FusionGenePPI for SMG1_SNF8 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SMG1 | PRKCI, SMG1, UPF1, UPF2, UPF3A, TTI1, TELO2, ELAVL1, SMG8, SMG9, RBM8A, UPF3B, NCBP2, PABPC1, SMG7, EIF4A3, MAGOH, GSPT2, GSPT1, EEF2, HSP90AA1, HSPA4, RUVBL1, RUVBL2, POLR2E, TUBA1A, TUBG1, HAUS2, HTR6, HSP90B1, EGFR, EPHA1 | SNF8 | VPS25, DVL2, NIF3L1, ELL, SNF8, VPS36, CHMP6, VPS28, TSG101, RILP, METTL14, NUDCD3, MCM2, RBP1, KDM1A, PRMT6, ADORA1, SUV39H2, GTF2F1, ACBD3, BCAT1, DUS3L, EFTUD2, GTF2E1, HARS, RPUSD2, TTC1, WDR12, GOLGA2, VAC14, TRIM54, HAT1, PSMD3, UBA6, UBL7, TLN2, YWHAE |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | SMG1 | chr16:18937272 | chr17:47018424 | ENST00000446231 | - | 1 | 63 | 1_1977 | 30 | 3662 | SMG8 and SMG9 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SMG1_SNF8 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SMG1_SNF8 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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