![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 34896 |
FusionGeneSummary for SMG1_RPS15A |
![]() |
Fusion gene information | Fusion gene name: SMG1_RPS15A | Fusion gene ID: 34896 | Hgene | Tgene | Gene symbol | SMG1 | RPS15A | Gene ID | 23049 | 6210 |
Gene name | SMG1, nonsense mediated mRNA decay associated PI3K related kinase | ribosomal protein S15a | |
Synonyms | 61E3.4|ATX|LIP | S15a | |
Cytomap | 16p12.3 | 16p12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase SMG1PI-3-kinase-related kinase SMG-1SMG1 phosphatidylinositol 3-kinase-related kinaselambda-interacting proteinlambda/iota protein kinase C-interacting proteinsmg-1 homolog, phosphatidylinositol 3-kinase-related kinase | 40S ribosomal protein S15asmall ribosomal subunit protein uS8up-regulated by HBV X protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q96Q15 | P62244 | |
Ensembl transtripts involved in fusion gene | ENST00000389467, ENST00000446231, ENST00000565224, ENST00000567737, | ENST00000322989, ENST00000563390, ENST00000575669, ENST00000576436, ENST00000565420, ENST00000569083, | |
Fusion gene scores | * DoF score | 14 X 10 X 7=980 | 4 X 4 X 4=64 |
# samples | 16 | 4 | |
** MAII score | log2(16/980*10)=-2.61470984411521 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SMG1 [Title/Abstract] AND RPS15A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SMG1 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 11544179 |
Hgene | SMG1 | GO:0018105 | peptidyl-serine phosphorylation | 11544179|15175154 |
Hgene | SMG1 | GO:0046777 | protein autophosphorylation | 11331269|11544179 |
Hgene | SMG1 | GO:0046854 | phosphatidylinositol phosphorylation | 11331269 |
Hgene | SMG1 | GO:2001020 | regulation of response to DNA damage stimulus | 15175154 |
Tgene | RPS15A | GO:0008284 | positive regulation of cell proliferation | 15108328 |
Tgene | RPS15A | GO:0009615 | response to virus | 15108328 |
Tgene | RPS15A | GO:0045787 | positive regulation of cell cycle | 15108328 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A2-A0CM-01A | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000389467 | ENST00000322989 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
5CDS-5UTR | ENST00000389467 | ENST00000563390 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
5CDS-intron | ENST00000389467 | ENST00000575669 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
5CDS-5UTR | ENST00000389467 | ENST00000576436 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
5CDS-5UTR | ENST00000389467 | ENST00000565420 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
5CDS-5UTR | ENST00000389467 | ENST00000569083 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
5CDS-5UTR | ENST00000446231 | ENST00000322989 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
5CDS-5UTR | ENST00000446231 | ENST00000563390 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
5CDS-intron | ENST00000446231 | ENST00000575669 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
5CDS-5UTR | ENST00000446231 | ENST00000576436 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
5CDS-5UTR | ENST00000446231 | ENST00000565420 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
5CDS-5UTR | ENST00000446231 | ENST00000569083 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
intron-5UTR | ENST00000565224 | ENST00000322989 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
intron-5UTR | ENST00000565224 | ENST00000563390 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
intron-intron | ENST00000565224 | ENST00000575669 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
intron-5UTR | ENST00000565224 | ENST00000576436 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
intron-5UTR | ENST00000565224 | ENST00000565420 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
intron-5UTR | ENST00000565224 | ENST00000569083 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
5UTR-5UTR | ENST00000567737 | ENST00000322989 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
5UTR-5UTR | ENST00000567737 | ENST00000563390 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
5UTR-intron | ENST00000567737 | ENST00000575669 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
5UTR-5UTR | ENST00000567737 | ENST00000576436 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
5UTR-5UTR | ENST00000567737 | ENST00000565420 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
5UTR-5UTR | ENST00000567737 | ENST00000569083 | SMG1 | chr16 | 18937272 | - | RPS15A | chr16 | 18800440 | - |
Top |
FusionProtFeatures for SMG1_RPS15A |
![]() |
Hgene | Tgene |
SMG1 | RPS15A |
Serine/threonine protein kinase involved in both mRNAsurveillance and genotoxic stress response pathways. Recognizesthe substrate consensus sequence [ST]-Q. Plays a central role innonsense-mediated decay (NMD) of mRNAs containing premature stopcodons by phosphorylating UPF1/RENT1. Recruited by release factorsto stalled ribosomes together with SMG8 and SMG9 (forming theSMG1C protein kinase complex), and UPF1 to form the transient SURF(SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURFcomplex associates with the exon junction complex (EJC) throughUPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillancecomplex which is believed to activate NMD. Also acts as agenotoxic stress-activated protein kinase that displays somefunctional overlap with ATM. Can phosphorylate p53/TP53 and isrequired for optimal p53/TP53 activation after cellular exposureto genotoxic stress. Its depletion leads to spontaneous DNA damageand increased sensitivity to ionizing radiation (IR). May activatePRKCI but not PRKCZ. {ECO:0000269|PubMed:11331269,ECO:0000269|PubMed:11544179, ECO:0000269|PubMed:15175154,ECO:0000269|PubMed:16452507}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for SMG1_RPS15A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for SMG1_RPS15A |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SMG1 | PRKCI, SMG1, UPF1, UPF2, UPF3A, TTI1, TELO2, ELAVL1, SMG8, SMG9, RBM8A, UPF3B, NCBP2, PABPC1, SMG7, EIF4A3, MAGOH, GSPT2, GSPT1, EEF2, HSP90AA1, HSPA4, RUVBL1, RUVBL2, POLR2E, TUBA1A, TUBG1, HAUS2, HTR6, HSP90B1, EGFR, EPHA1 | RPS15A | EWSR1, ELF5, MGMT, CALM1, CDC37, PCK1, VHL, RAD21, HDGF, CUL3, CUL4A, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, CAND1, NEDD8, RPL10A, RPL10, RPL11, RPL12, RPL14, RPL15, RPL18A, RPL18, RPL19, RPL21, RPL23, RPL24, RPL27, RPL30, RPL31, RPL37A, RPL4, RPL5, RPL6, RPL7A, RPL7, RPL9, RPS10, RPS11, RPS12, RPS13, RPS14, RPS19, RPS26, RPS3A, RPS3, RPS4X, RPS5, RPS6, RPS7, RPS8, RPSA, RPS23, RPS16, RPS17, RPLP1, RPS24, RPLP2, RPL23A, RPS2, RPLP0, RPS20, RPS15, RPL3, RPL13, RPL38, RPL29, RPS21, RPL17, RPL32, RPS27A, EEF1A1, EEF2, NOP56, FBL, HNRNPU, GNL3, SLC25A5, ILF3, ILF2, NOP58, MOV10, TUFM, NHP2L1, HNRNPM, ACTA2, EIF6, HSP90AA1, RPLP0P6, RPL10L, GALNT2, NOP2, NIFK, MRPS14, UBA2, GNL1, HIST1H2AD, HSPA8, ATP5A1, HNRNPA0, PSMB1, ESR1, SMURF1, FN1, VCAM1, UBL4A, ITGA4, PAN2, PSMC1, PSMC6, PSMD11, PSMD3, FAU, PNO1, PSMD1, RPS18, RPS25, RPS27, RPS27L, RPS29, RPS9, WDR26, WIBG, RPS28, TSR1, ZBTB1, CEP250, CEP57, CEP76, TUBG1, HUWE1, RNF2, EGFR, DIMT1, IMP3, MPHOSPH10, MRPL14, MRPL16, MRPL22, MRPS7, RPL13A, RPL27A, RPL28, RPL34, RPL35, RPL37, DDX18, RPL22, RPL35A, RPL36, RPL8, VAPA, LOC101929876, TUBB, TUBB2B, TUBB4B, UBA52, SFN, PTEN, AHSA1, EXOSC1, UBE3A, MCM2, RHOU, RC3H1, ZNF746, HNRNPA1, CYLD, TRIM25, UBE2A, HEY1, BRCA1, HDAC6 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SMG1_RPS15A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SMG1_RPS15A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |