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Fusion gene ID: 34881 |
FusionGeneSummary for SMEK2_ALK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SMEK2_ALK | Fusion gene ID: 34881 | Hgene | Tgene | Gene symbol | SMEK2 | ALK | Gene ID | 57223 | 238 |
| Gene name | protein phosphatase 4 regulatory subunit 3B | ALK receptor tyrosine kinase | |
| Synonyms | FLFL2|PP4R3B|PSY2|SMEK2|smk1 | CD246|NBLST3 | |
| Cytomap | 2p16.1 | 2p23.2-p23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein phosphatase 4 regulatory subunit 3BSMEK homolog 2, suppressor of mek1 | ALK tyrosine kinase receptorCD246 antigenanaplastic lymphoma receptor tyrosine kinasemutant anaplastic lymphoma kinase | |
| Modification date | 20180522 | 20180527 | |
| UniProtAcc | Q9UM73 | ||
| Ensembl transtripts involved in fusion gene | ENST00000272313, ENST00000407823, ENST00000345102, ENST00000477749, | ENST00000389048, ENST00000431873, ENST00000498037, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 24 X 23 X 10=5520 |
| # samples | 4 | 46 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(46/5520*10)=-3.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SMEK2 [Title/Abstract] AND ALK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ALK | GO:0016310 | phosphorylation | 9174053 |
| Tgene | ALK | GO:0046777 | protein autophosphorylation | 9174053 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | READ | TCGA-F5-6864-01A | SMEK2 | chr2 | 55804451 | - | ALK | chr2 | 29940563 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000272313 | ENST00000389048 | SMEK2 | chr2 | 55804451 | - | ALK | chr2 | 29940563 | - |
| In-frame | ENST00000272313 | ENST00000431873 | SMEK2 | chr2 | 55804451 | - | ALK | chr2 | 29940563 | - |
| 5CDS-intron | ENST00000272313 | ENST00000498037 | SMEK2 | chr2 | 55804451 | - | ALK | chr2 | 29940563 | - |
| In-frame | ENST00000407823 | ENST00000389048 | SMEK2 | chr2 | 55804451 | - | ALK | chr2 | 29940563 | - |
| In-frame | ENST00000407823 | ENST00000431873 | SMEK2 | chr2 | 55804451 | - | ALK | chr2 | 29940563 | - |
| 5CDS-intron | ENST00000407823 | ENST00000498037 | SMEK2 | chr2 | 55804451 | - | ALK | chr2 | 29940563 | - |
| In-frame | ENST00000345102 | ENST00000389048 | SMEK2 | chr2 | 55804451 | - | ALK | chr2 | 29940563 | - |
| In-frame | ENST00000345102 | ENST00000431873 | SMEK2 | chr2 | 55804451 | - | ALK | chr2 | 29940563 | - |
| 5CDS-intron | ENST00000345102 | ENST00000498037 | SMEK2 | chr2 | 55804451 | - | ALK | chr2 | 29940563 | - |
| intron-3CDS | ENST00000477749 | ENST00000389048 | SMEK2 | chr2 | 55804451 | - | ALK | chr2 | 29940563 | - |
| intron-3CDS | ENST00000477749 | ENST00000431873 | SMEK2 | chr2 | 55804451 | - | ALK | chr2 | 29940563 | - |
| intron-intron | ENST00000477749 | ENST00000498037 | SMEK2 | chr2 | 55804451 | - | ALK | chr2 | 29940563 | - |
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FusionProtFeatures for SMEK2_ALK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SMEK2 | ALK |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Neuronal receptor tyrosine kinase that is essentiallyand transiently expressed in specific regions of the central andperipheral nervous systems and plays an important role in thegenesis and differentiation of the nervous system. Transducessignals from ligands at the cell surface, through specificactivation of the mitogen-activated protein kinase (MAPK) pathway.Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK inducestyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well asof the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptorfor ligands pleiotrophin (PTN), a secreted growth factor, andmidkine (MDK), a PTN-related factor, thus participating in PTN andMDK signal transduction. PTN-binding induces MAPK pathwayactivation, which is important for the anti-apoptotic signaling ofPTN and regulation of cell proliferation. MDK-binding inducesphosphorylation of the ALK target insulin receptor substrate(IRS1), activates mitogen-activated protein kinases (MAPKs) andPI3-kinase, resulting also in cell proliferation induction. DrivesNF-kappa-B activation, probably through IRS1 and the activation ofthe AKT serine/threonine kinase. Recruitment of IRS1 to activatedALK and the activation of NF-kappa-B are essential for theautocrine growth and survival signaling of MDK.{ECO:0000269|PubMed:11121404, ECO:0000269|PubMed:11278720,ECO:0000269|PubMed:11387242, ECO:0000269|PubMed:11809760,ECO:0000269|PubMed:12107166, ECO:0000269|PubMed:12122009,ECO:0000269|PubMed:15226403, ECO:0000269|PubMed:15908427,ECO:0000269|PubMed:16317043, ECO:0000269|PubMed:16878150,ECO:0000269|PubMed:17274988}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SMEK2 | chr2:55804451 | chr2:29940563 | ENST00000272313 | - | 10 | 15 | 1_100 | 503 | 765 | Domain | Note=WH1 |
| Hgene | SMEK2 | chr2:55804451 | chr2:29940563 | ENST00000345102 | - | 11 | 17 | 1_100 | 535 | 850 | Domain | Note=WH1 |
| Hgene | SMEK2 | chr2:55804451 | chr2:29940563 | ENST00000407823 | - | 10 | 16 | 1_100 | 503 | 818 | Domain | Note=WH1 |
| Tgene | >ALK | chr2:55804451 | chr2:29940563 | ENST00000389048 | - | 0 | 29 | 816_940 | 222 | 1621 | Compositional bias | Note=Gly-rich |
| Tgene | >ALK | chr2:55804451 | chr2:29940563 | ENST00000389048 | - | 0 | 29 | 1116_1392 | 222 | 1621 | Domain | Protein kinase |
| Tgene | >ALK | chr2:55804451 | chr2:29940563 | ENST00000389048 | - | 0 | 29 | 264_427 | 222 | 1621 | Domain | MAM 1 |
| Tgene | >ALK | chr2:55804451 | chr2:29940563 | ENST00000389048 | - | 0 | 29 | 437_473 | 222 | 1621 | Domain | Note=LDL-receptor class A |
| Tgene | >ALK | chr2:55804451 | chr2:29940563 | ENST00000389048 | - | 0 | 29 | 478_636 | 222 | 1621 | Domain | MAM 2 |
| Tgene | >ALK | chr2:55804451 | chr2:29940563 | ENST00000389048 | - | 0 | 29 | 1197_1199 | 222 | 1621 | Region | Note=Inhibitor binding |
| Tgene | >ALK | chr2:55804451 | chr2:29940563 | ENST00000389048 | - | 0 | 29 | 1060_1620 | 222 | 1621 | Topological domain | Cytoplasmic |
| Tgene | >ALK | chr2:55804451 | chr2:29940563 | ENST00000389048 | - | 0 | 29 | 1039_1059 | 222 | 1621 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SMEK2 | chr2:55804451 | chr2:29940563 | ENST00000272313 | - | 10 | 15 | 719_724 | 503 | 765 | Compositional bias | Note=Poly-Glu |
| Hgene | >SMEK2 | chr2:55804451 | chr2:29940563 | ENST00000272313 | - | 10 | 15 | 831_838 | 503 | 765 | Compositional bias | Note=Poly-Glu |
| Hgene | >SMEK2 | chr2:55804451 | chr2:29940563 | ENST00000345102 | - | 11 | 17 | 719_724 | 535 | 850 | Compositional bias | Note=Poly-Glu |
| Hgene | >SMEK2 | chr2:55804451 | chr2:29940563 | ENST00000345102 | - | 11 | 17 | 831_838 | 535 | 850 | Compositional bias | Note=Poly-Glu |
| Hgene | >SMEK2 | chr2:55804451 | chr2:29940563 | ENST00000407823 | - | 10 | 16 | 719_724 | 503 | 818 | Compositional bias | Note=Poly-Glu |
| Hgene | >SMEK2 | chr2:55804451 | chr2:29940563 | ENST00000407823 | - | 10 | 16 | 831_838 | 503 | 818 | Compositional bias | Note=Poly-Glu |
| Tgene | ALK | chr2:55804451 | chr2:29940563 | ENST00000389048 | - | 0 | 29 | 19_1038 | 222 | 1621 | Topological domain | Extracellular |
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FusionGeneSequence for SMEK2_ALK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SMEK2_ENST00000272313_chr2_55804451_-_ALK_ENST00000389048_chr2_29940563_-_1902aa MSDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVEELKGMSLLVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGC DEIWEKICQVQGKDPSVEVTQDLIDESEEERFEEMPETSHLIDLPTCELNKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQ ACENLENTEGLHHLYEIIRGILFLNKATLFEVMFSDECIMDVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQ YIQDIILPTPSVFEENFLSTLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLA KLGILPALEIVMGMDDLQVRSAATDIFSYLVEFSPSMVREFVMQEAQQSDDDILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENM LATTNKTEKSEFLNFFYNHCMHVLTAPLLTNTSEDKCEKDNIVGSNKNNTICPGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHR SRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAV SVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQS SFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPAS ESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGS RAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSN LSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENN VIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSL LWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEV NIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAM QMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQ DELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRD IAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVL EFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQ AKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKN NPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTIL >In-frame_SMEK2_ENST00000272313_chr2_55804451_-_ALK_ENST00000431873_chr2_29940563_-_732aa MSDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVEELKGMSLLVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGC DEIWEKICQVQGKDPSVEVTQDLIDESEEERFEEMPETSHLIDLPTCELNKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQ ACENLENTEGLHHLYEIIRGILFLNKATLFEVMFSDECIMDVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQ YIQDIILPTPSVFEENFLSTLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLA KLGILPALEIVMGMDDLQVRSAATDIFSYLVEFSPSMVREFVMQEAQQSDDDILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENM LATTNKTEKSEFLNFFYNHCMHVLTAPLLTNTSEDKCEKDNIVGSNKNNTICPGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHR SRYGKERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKN NPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTIL >In-frame_SMEK2_ENST00000407823_chr2_55804451_-_ALK_ENST00000389048_chr2_29940563_-_1902aa MSDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVEELKGMSLLVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGC DEIWEKICQVQGKDPSVEVTQDLIDESEEERFEEMPETSHLIDLPTCELNKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQ ACENLENTEGLHHLYEIIRGILFLNKATLFEVMFSDECIMDVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQ YIQDIILPTPSVFEENFLSTLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLA KLGILPALEIVMGMDDLQVRSAATDIFSYLVEFSPSMVREFVMQEAQQSDDDILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENM LATTNKTEKSEFLNFFYNHCMHVLTAPLLTNTSEDKCEKDNIVGSNKNNTICPGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHR SRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAV SVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQS SFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKDARFQDHQDHALLLSTTDVPAS ESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGS RAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSN LSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGENN VIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFHPERLENNSSVLGLNGNSGAAGGGGGWNDNTSL LWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKVMEGHGEV NIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAM QMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQ DELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRD IAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVL EFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQ AKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKN NPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTIL >In-frame_SMEK2_ENST00000407823_chr2_55804451_-_ALK_ENST00000431873_chr2_29940563_-_732aa MSDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVEELKGMSLLVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGC DEIWEKICQVQGKDPSVEVTQDLIDESEEERFEEMPETSHLIDLPTCELNKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQ ACENLENTEGLHHLYEIIRGILFLNKATLFEVMFSDECIMDVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQ YIQDIILPTPSVFEENFLSTLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLA KLGILPALEIVMGMDDLQVRSAATDIFSYLVEFSPSMVREFVMQEAQQSDDDILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENM LATTNKTEKSEFLNFFYNHCMHVLTAPLLTNTSEDKCEKDNIVGSNKNNTICPGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHR SRYGKERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKN NPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTIL >In-frame_SMEK2_ENST00000345102_chr2_55804451_-_ALK_ENST00000389048_chr2_29940563_-_1934aa MSDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVEELKGMSLLVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGC DEIWEKICQVQGKDPSVEVTQDLIDESEEERFEEMPETSHLIDLPTCELNKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQ ACENLENTEGLHHLYEIIRGILFLNKATLFEVMFSDECIMDVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQ YIQDIILPTPSVFEENFLSTLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLA KLGILPALEIVMGMDDLQVRSAATDIFSYLVEFSPSMVREFVMQEAQQSDDDILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENM LATTNKTEKSEFLNFFYNHCMHVLTAPLLTNTSEDKCEKDFFLKHYRYSWSFICTPSHSHSHSTPSSSISQDNIVGSNKNNTICPGHSSL ESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPR GSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYI SSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPH TPQWQVRTLKDARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSLVLVENKTGKEQGRMVWHVAAY EGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVAFDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIF DPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYGAAGGKGGKNTMMRSHGVSVLGIFNLEK DDMLYILVGQQGEDACPSTNQLIQKVCIGENNVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTFH PERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWGWETRGGFGGGGGGCSSGGGGGGYIGGNAASNND PEMDGEDGVSFISPLGILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPHLPLSLIL SVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAF GEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQ PSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFT SKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTAL PIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPS ELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHF >In-frame_SMEK2_ENST00000345102_chr2_55804451_-_ALK_ENST00000431873_chr2_29940563_-_764aa MSDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVEELKGMSLLVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGC DEIWEKICQVQGKDPSVEVTQDLIDESEEERFEEMPETSHLIDLPTCELNKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQ ACENLENTEGLHHLYEIIRGILFLNKATLFEVMFSDECIMDVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQ YIQDIILPTPSVFEENFLSTLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLA KLGILPALEIVMGMDDLQVRSAATDIFSYLVEFSPSMVREFVMQEAQQSDDDILLINVVIEQMICDTDPELGGAVQLMGLLRTLIDPENM LATTNKTEKSEFLNFFYNHCMHVLTAPLLTNTSEDKCEKDFFLKHYRYSWSFICTPSHSHSHSTPSSSISQDNIVGSNKNNTICPGHSSL ESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGKERSPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPS ELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHF |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SMEK2_ENST00000272313_chr2_55804451_-_ALK_ENST00000389048_chr2_29940563_-_5706nt ATGTCGGATACGCGGCGGCGAGTGAAGGTCTATACCCTGAACGAAGACCGGCAATGGGACGACCGAGGCACCGGGCACGTCTCCTCCACT TACGTGGAGGAGCTCAAGGGGATGTCGCTGCTGGTTCGGGCAGAGTCCGACGGATCACTACTCTTGGAATCAAAGATAAATCCAAATACT GCATATCAGAAACAACAGGATACATTAATTGTTTGGTCAGAAGCAGAGAACTATGATTTGGCTCTGAGTTTTCAGGAGAAAGCTGGCTGT GATGAGATCTGGGAAAAAATTTGTCAGGTTCAAGGTAAAGACCCATCAGTGGAAGTCACACAGGACCTCATTGATGAATCTGAAGAAGAA CGATTTGAAGAAATGCCTGAAACTAGTCATCTGATTGACCTGCCCACATGTGAACTCAATAAACTTGAAGAGATTGCTGACTTAGTTACC TCAGTGCTCTCCTCACCTATCCGTAGGGAAAAGCTGGCTCTCGCCTTGGAAAATGAAGGCTATATTAAAAAACTATTGCAGCTGTTCCAA GCTTGCGAGAACCTAGAAAACACTGAAGGCTTACACCATTTGTATGAAATTATTAGAGGAATCTTATTCCTAAATAAGGCAACTCTTTTT GAGGTAATGTTTTCTGATGAGTGTATCATGGATGTCGTGGGATGCCTTGAATATGACCCTGCTTTGGCTCAGCCAAAAAGACATAGAGAA TTCTTGACCAAAACTGCAAAGTTCAAGGAAGTTATACCAATAACAGACTCTGAACTAAGGCAAAAAATACATCAGACTTACAGGGTACAG TACATTCAGGACATCATTTTGCCCACACCATCTGTTTTTGAAGAGAATTTTCTTTCTACTCTTACGTCTTTTATTTTCTTCAACAAAGTT GAGATAGTCAGCATGTTGCAGGAAGATGAGAAGTTTTTGTCTGAAGTTTTTGCACAATTAACAGATGAGGCTACAGATGATGATAAACGG CGTGAATTGGTTAATTTTTTCAAGGAGTTTTGTGCATTTTCTCAGACATTACAACCTCAAAACAGGGATGCATTTTTCAAAACATTGGCA AAATTGGGAATTCTTCCTGCTCTTGAAATTGTAATGGGCATGGATGATTTGCAAGTCAGATCAGCTGCTACAGATATATTTTCTTATCTA GTAGAATTTAGTCCATCTATGGTCCGAGAGTTTGTAATGCAAGAAGCTCAGCAGAGTGATGACGATATTCTTCTTATTAATGTGGTAATT GAACAAATGATCTGTGATACTGATCCTGAGCTAGGAGGCGCTGTTCAGTTAATGGGACTTCTTCGTACTCTAATTGATCCAGAGAACATG CTGGCTACAACTAATAAAACCGAAAAAAGTGAATTTCTAAATTTTTTCTACAACCATTGTATGCATGTTCTCACAGCACCACTTTTGACC AATACTTCAGAAGACAAATGTGAAAAGGATAATATAGTTGGATCAAACAAAAACAACACAATTTGTCCCGGTCATAGCTCCTTGGAATCA CCAACAAACATGCCTTCTCCTTCTCCTGATTATTTTACATGGAATCTCACCTGGATAATGAAAGACTCCTTCCCTTTCCTGTCTCATCGC AGCCGATATGGTCTGGAGTGCAGCTTTGACTTCCCCTGTGAGCTGGAGTATTCCCCTCCACTGCATGACCTCAGGAACCAGAGCTGGTCC TGGCGCCGCATCCCCTCCGAGGAGGCCTCCCAGATGGACTTGCTGGATGGGCCTGGGGCAGAGCGTTCTAAGGAGATGCCCAGAGGCTCC TTTCTCCTTCTCAACACCTCAGCTGACTCCAAGCACACCATCCTGAGTCCGTGGATGAGGAGCAGCAGTGAGCACTGCACACTGGCCGTC TCGGTGCACAGGCACCTGCAGCCCTCTGGAAGGTACATTGCCCAGCTGCTGCCCCACAACGAGGCTGCAAGAGAGATCCTCCTGATGCCC ACTCCAGGGAAGCATGGTTGGACAGTGCTCCAGGGAAGAATCGGGCGTCCAGACAACCCATTTCGAGTGGCCCTGGAATACATCTCCAGT GGAAACCGCAGCTTGTCTGCAGTGGACTTCTTTGCCCTGAAGAACTGCAGTGAAGGAACATCCCCAGGCTCCAAGATGGCCCTGCAGAGC TCCTTCACTTGTTGGAATGGGACAGTCCTCCAGCTTGGGCAGGCCTGTGACTTCCACCAGGACTGTGCCCAGGGAGAAGATGAGAGCCAG ATGTGCCGGAAACTGCCTGTGGGTTTTTACTGCAACTTTGAAGATGGCTTCTGTGGCTGGACCCAAGGCACACTGTCACCCCACACTCCT CAATGGCAGGTCAGGACCCTAAAGGATGCCCGGTTCCAGGACCACCAAGACCATGCTCTATTGCTCAGTACCACTGATGTCCCCGCTTCT GAAAGTGCTACAGTGACCAGTGCTACGTTTCCTGCACCGATCAAGAGCTCTCCATGTGAGCTCCGAATGTCCTGGCTCATTCGTGGAGTC TTGAGGGGAAACGTGTCCTTGGTGCTAGTGGAGAACAAAACCGGGAAGGAGCAAGGCAGGATGGTCTGGCATGTCGCCGCCTATGAAGGC TTGAGCCTGTGGCAGTGGATGGTGTTGCCTCTCCTCGATGTGTCTGACAGGTTCTGGCTGCAGATGGTCGCATGGTGGGGACAAGGATCC AGAGCCATCGTGGCTTTTGACAATATCTCCATCAGCCTGGACTGCTACCTCACCATTAGCGGAGAGGACAAGATCCTGCAGAATACAGCA CCCAAATCAAGAAACCTGTTTGAGAGAAACCCAAACAAGGAGCTGAAACCCGGGGAAAATTCACCAAGACAGACCCCCATCTTTGACCCT ACAGTTCATTGGCTGTTCACCACATGTGGGGCCAGCGGGCCCCATGGCCCCACCCAGGCACAGTGCAACAACGCCTACCAGAACTCCAAC CTGAGCGTGGAGGTGGGGAGCGAGGGCCCCCTGAAAGGCATCCAGATCTGGAAGGTGCCAGCCACCGACACCTACAGCATCTCGGGCTAC GGAGCTGCTGGCGGGAAAGGCGGGAAGAACACCATGATGCGGTCCCACGGCGTGTCTGTGCTGGGCATCTTCAACCTGGAGAAGGATGAC ATGCTGTACATCCTGGTTGGGCAGCAGGGAGAGGACGCCTGCCCCAGTACAAACCAGTTAATCCAGAAAGTCTGCATTGGAGAGAACAAT GTGATAGAAGAAGAAATCCGTGTGAACAGAAGCGTGCATGAGTGGGCAGGAGGCGGAGGAGGAGGGGGTGGAGCCACCTACGTATTTAAG ATGAAGGATGGAGTGCCGGTGCCCCTGATCATTGCAGCCGGAGGTGGTGGCAGGGCCTACGGGGCCAAGACAGACACGTTCCACCCAGAG AGACTGGAGAATAACTCCTCGGTTCTAGGGCTAAACGGCAATTCCGGAGCCGCAGGTGGTGGAGGTGGCTGGAATGATAACACTTCCTTG CTCTGGGCCGGAAAATCTTTGCAGGAGGGTGCCACCGGAGGACATTCCTGCCCCCAGGCCATGAAGAAGTGGGGGTGGGAGACAAGAGGG GGTTTCGGAGGGGGTGGAGGGGGGTGCTCCTCAGGTGGAGGAGGCGGAGGATATATAGGCGGCAATGCAGCCTCAAACAATGACCCCGAA ATGGATGGGGAAGATGGGGTTTCCTTCATCAGTCCACTGGGCATCCTGTACACCCCAGCTTTAAAAGTGATGGAAGGCCACGGGGAAGTG AATATTAAGCATTATCTAAACTGCAGTCACTGTGAGGTAGACGAATGTCACATGGACCCTGAAAGCCACAAGGTCATCTGCTTCTGTGAC CACGGGACGGTGCTGGCTGAGGATGGCGTCTCCTGCATTGTGTCACCCACCCCGGAGCCACACCTGCCACTCTCGCTGATCCTCTCTGTG GTGACCTCTGCCCTCGTGGCCGCCCTGGTCCTGGCTTTCTCCGGCATCATGATTGTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATG CAGATGGAGCTGCAGAGCCCTGAGTACAAGCTGAGCAAGCTCCGCACCTCGACCATCATGACCGACTACAACCCCAACTACTGCTTTGCT GGCAAGACCTCCTCCATCAGTGACCTGAAGGAGGTGCCGCGGAAAAACATCACCCTCATTCGGGGTCTGGGCCATGGCGCCTTTGGGGAG GTGTATGAAGGCCAGGTGTCCGGAATGCCCAACGACCCAAGCCCCCTGCAAGTGGCTGTGAAGACGCTGCCTGAAGTGTGCTCTGAACAG GACGAACTGGATTTCCTCATGGAAGCCCTGATCATCAGCAAATTCAACCACCAGAACATTGTTCGCTGCATTGGGGTGAGCCTGCAATCC CTGCCCCGGTTCATCCTGCTGGAGCTCATGGCGGGGGGAGACCTCAAGTCCTTCCTCCGAGAGACCCGCCCTCGCCCGAGCCAGCCCTCC TCCCTGGCCATGCTGGACCTTCTGCACGTGGCTCGGGACATTGCCTGTGGCTGTCAGTATTTGGAGGAAAACCACTTCATCCACCGAGAC ATTGCTGCCAGAAACTGCCTCTTGACCTGTCCAGGCCCTGGAAGAGTGGCCAAGATTGGAGACTTCGGGATGGCCCGAGACATCTACAGG GCGAGCTACTATAGAAAGGGAGGCTGTGCCATGCTGCCAGTTAAGTGGATGCCCCCAGAGGCCTTCATGGAAGGAATATTCACTTCTAAA ACAGACACATGGTCCTTTGGAGTGCTGCTATGGGAAATCTTTTCTCTTGGATATATGCCATACCCCAGCAAAAGCAACCAGGAAGTTCTG GAGTTTGTCACCAGTGGAGGCCGGATGGACCCACCCAAGAACTGCCCTGGGCCTGTATACCGGATAATGACTCAGTGCTGGCAACATCAG CCTGAAGACAGGCCCAACTTTGCCATCATTTTGGAGAGGATTGAATACTGCACCCAGGACCCGGATGTAATCAACACCGCTTTGCCGATA GAATATGGTCCACTTGTGGAAGAGGAAGAGAAAGTGCCTGTGAGGCCCAAGGACCCTGAGGGGGTTCCTCCTCTCCTGGTCTCTCAACAG GCAAAACGGGAGGAGGAGCGCAGCCCAGCTGCCCCACCACCTCTGCCTACCACCTCCTCTGGCAAGGCTGCAAAGAAACCCACAGCTGCA GAGATCTCTGTTCGAGTCCCTAGAGGGCCGGCCGTGGAAGGGGGACACGTGAATATGGCATTCTCTCAGTCCAACCCTCCTTCGGAGTTG CACAAGGTCCACGGATCCAGAAACAAGCCCACCAGCTTGTGGAACCCAACGTACGGCTCCTGGTTTACAGAGAAACCCACCAAAAAGAAT AATCCTATAGCAAAGAAGGAGCCACACGACAGGGGTAACCTGGGGCTGGAGGGAAGCTGTACTGTCCCACCTAACGTTGCAACTGGGAGA CTTCCGGGGGCCTCACTGCTCCTAGAGCCCTCTTCGCTGACTGCCAATATGAAGGAGGTACCTCTGTTCAGGCTACGTCACTTCCCTTGT GGGAATGTCAATTACGGCTACCAGCAACAGGGCTTGCCCTTAGAAGCCGCTACTGCCCCTGGAGCTGGTCATTACGAGGATACCATTCTG >In-frame_SMEK2_ENST00000272313_chr2_55804451_-_ALK_ENST00000431873_chr2_29940563_-_2196nt ATGTCGGATACGCGGCGGCGAGTGAAGGTCTATACCCTGAACGAAGACCGGCAATGGGACGACCGAGGCACCGGGCACGTCTCCTCCACT TACGTGGAGGAGCTCAAGGGGATGTCGCTGCTGGTTCGGGCAGAGTCCGACGGATCACTACTCTTGGAATCAAAGATAAATCCAAATACT GCATATCAGAAACAACAGGATACATTAATTGTTTGGTCAGAAGCAGAGAACTATGATTTGGCTCTGAGTTTTCAGGAGAAAGCTGGCTGT GATGAGATCTGGGAAAAAATTTGTCAGGTTCAAGGTAAAGACCCATCAGTGGAAGTCACACAGGACCTCATTGATGAATCTGAAGAAGAA CGATTTGAAGAAATGCCTGAAACTAGTCATCTGATTGACCTGCCCACATGTGAACTCAATAAACTTGAAGAGATTGCTGACTTAGTTACC TCAGTGCTCTCCTCACCTATCCGTAGGGAAAAGCTGGCTCTCGCCTTGGAAAATGAAGGCTATATTAAAAAACTATTGCAGCTGTTCCAA GCTTGCGAGAACCTAGAAAACACTGAAGGCTTACACCATTTGTATGAAATTATTAGAGGAATCTTATTCCTAAATAAGGCAACTCTTTTT GAGGTAATGTTTTCTGATGAGTGTATCATGGATGTCGTGGGATGCCTTGAATATGACCCTGCTTTGGCTCAGCCAAAAAGACATAGAGAA TTCTTGACCAAAACTGCAAAGTTCAAGGAAGTTATACCAATAACAGACTCTGAACTAAGGCAAAAAATACATCAGACTTACAGGGTACAG TACATTCAGGACATCATTTTGCCCACACCATCTGTTTTTGAAGAGAATTTTCTTTCTACTCTTACGTCTTTTATTTTCTTCAACAAAGTT GAGATAGTCAGCATGTTGCAGGAAGATGAGAAGTTTTTGTCTGAAGTTTTTGCACAATTAACAGATGAGGCTACAGATGATGATAAACGG CGTGAATTGGTTAATTTTTTCAAGGAGTTTTGTGCATTTTCTCAGACATTACAACCTCAAAACAGGGATGCATTTTTCAAAACATTGGCA AAATTGGGAATTCTTCCTGCTCTTGAAATTGTAATGGGCATGGATGATTTGCAAGTCAGATCAGCTGCTACAGATATATTTTCTTATCTA GTAGAATTTAGTCCATCTATGGTCCGAGAGTTTGTAATGCAAGAAGCTCAGCAGAGTGATGACGATATTCTTCTTATTAATGTGGTAATT GAACAAATGATCTGTGATACTGATCCTGAGCTAGGAGGCGCTGTTCAGTTAATGGGACTTCTTCGTACTCTAATTGATCCAGAGAACATG CTGGCTACAACTAATAAAACCGAAAAAAGTGAATTTCTAAATTTTTTCTACAACCATTGTATGCATGTTCTCACAGCACCACTTTTGACC AATACTTCAGAAGACAAATGTGAAAAGGATAATATAGTTGGATCAAACAAAAACAACACAATTTGTCCCGGTCATAGCTCCTTGGAATCA CCAACAAACATGCCTTCTCCTTCTCCTGATTATTTTACATGGAATCTCACCTGGATAATGAAAGACTCCTTCCCTTTCCTGTCTCATCGC AGCCGATATGGTAAAGAGCGCAGCCCAGCTGCCCCACCACCTCTGCCTACCACCTCCTCTGGCAAGGCTGCAAAGAAACCCACAGCTGCA GAGATCTCTGTTCGAGTCCCTAGAGGGCCGGCCGTGGAAGGGGGACACGTGAATATGGCATTCTCTCAGTCCAACCCTCCTTCGGAGTTG CACAAGGTCCACGGATCCAGAAACAAGCCCACCAGCTTGTGGAACCCAACGTACGGCTCCTGGTTTACAGAGAAACCCACCAAAAAGAAT AATCCTATAGCAAAGAAGGAGCCACACGACAGGGGTAACCTGGGGCTGGAGGGAAGCTGTACTGTCCCACCTAACGTTGCAACTGGGAGA CTTCCGGGGGCCTCACTGCTCCTAGAGCCCTCTTCGCTGACTGCCAATATGAAGGAGGTACCTCTGTTCAGGCTACGTCACTTCCCTTGT GGGAATGTCAATTACGGCTACCAGCAACAGGGCTTGCCCTTAGAAGCCGCTACTGCCCCTGGAGCTGGTCATTACGAGGATACCATTCTG >In-frame_SMEK2_ENST00000407823_chr2_55804451_-_ALK_ENST00000389048_chr2_29940563_-_5706nt ATGTCGGATACGCGGCGGCGAGTGAAGGTCTATACCCTGAACGAAGACCGGCAATGGGACGACCGAGGCACCGGGCACGTCTCCTCCACT TACGTGGAGGAGCTCAAGGGGATGTCGCTGCTGGTTCGGGCAGAGTCCGACGGATCACTACTCTTGGAATCAAAGATAAATCCAAATACT GCATATCAGAAACAACAGGATACATTAATTGTTTGGTCAGAAGCAGAGAACTATGATTTGGCTCTGAGTTTTCAGGAGAAAGCTGGCTGT GATGAGATCTGGGAAAAAATTTGTCAGGTTCAAGGTAAAGACCCATCAGTGGAAGTCACACAGGACCTCATTGATGAATCTGAAGAAGAA CGATTTGAAGAAATGCCTGAAACTAGTCATCTGATTGACCTGCCCACATGTGAACTCAATAAACTTGAAGAGATTGCTGACTTAGTTACC TCAGTGCTCTCCTCACCTATCCGTAGGGAAAAGCTGGCTCTCGCCTTGGAAAATGAAGGCTATATTAAAAAACTATTGCAGCTGTTCCAA GCTTGCGAGAACCTAGAAAACACTGAAGGCTTACACCATTTGTATGAAATTATTAGAGGAATCTTATTCCTAAATAAGGCAACTCTTTTT GAGGTAATGTTTTCTGATGAGTGTATCATGGATGTCGTGGGATGCCTTGAATATGACCCTGCTTTGGCTCAGCCAAAAAGACATAGAGAA TTCTTGACCAAAACTGCAAAGTTCAAGGAAGTTATACCAATAACAGACTCTGAACTAAGGCAAAAAATACATCAGACTTACAGGGTACAG TACATTCAGGACATCATTTTGCCCACACCATCTGTTTTTGAAGAGAATTTTCTTTCTACTCTTACGTCTTTTATTTTCTTCAACAAAGTT GAGATAGTCAGCATGTTGCAGGAAGATGAGAAGTTTTTGTCTGAAGTTTTTGCACAATTAACAGATGAGGCTACAGATGATGATAAACGG CGTGAATTGGTTAATTTTTTCAAGGAGTTTTGTGCATTTTCTCAGACATTACAACCTCAAAACAGGGATGCATTTTTCAAAACATTGGCA AAATTGGGAATTCTTCCTGCTCTTGAAATTGTAATGGGCATGGATGATTTGCAAGTCAGATCAGCTGCTACAGATATATTTTCTTATCTA GTAGAATTTAGTCCATCTATGGTCCGAGAGTTTGTAATGCAAGAAGCTCAGCAGAGTGATGACGATATTCTTCTTATTAATGTGGTAATT GAACAAATGATCTGTGATACTGATCCTGAGCTAGGAGGCGCTGTTCAGTTAATGGGACTTCTTCGTACTCTAATTGATCCAGAGAACATG CTGGCTACAACTAATAAAACCGAAAAAAGTGAATTTCTAAATTTTTTCTACAACCATTGTATGCATGTTCTCACAGCACCACTTTTGACC AATACTTCAGAAGACAAATGTGAAAAGGATAATATAGTTGGATCAAACAAAAACAACACAATTTGTCCCGGTCATAGCTCCTTGGAATCA CCAACAAACATGCCTTCTCCTTCTCCTGATTATTTTACATGGAATCTCACCTGGATAATGAAAGACTCCTTCCCTTTCCTGTCTCATCGC AGCCGATATGGTCTGGAGTGCAGCTTTGACTTCCCCTGTGAGCTGGAGTATTCCCCTCCACTGCATGACCTCAGGAACCAGAGCTGGTCC TGGCGCCGCATCCCCTCCGAGGAGGCCTCCCAGATGGACTTGCTGGATGGGCCTGGGGCAGAGCGTTCTAAGGAGATGCCCAGAGGCTCC TTTCTCCTTCTCAACACCTCAGCTGACTCCAAGCACACCATCCTGAGTCCGTGGATGAGGAGCAGCAGTGAGCACTGCACACTGGCCGTC TCGGTGCACAGGCACCTGCAGCCCTCTGGAAGGTACATTGCCCAGCTGCTGCCCCACAACGAGGCTGCAAGAGAGATCCTCCTGATGCCC ACTCCAGGGAAGCATGGTTGGACAGTGCTCCAGGGAAGAATCGGGCGTCCAGACAACCCATTTCGAGTGGCCCTGGAATACATCTCCAGT GGAAACCGCAGCTTGTCTGCAGTGGACTTCTTTGCCCTGAAGAACTGCAGTGAAGGAACATCCCCAGGCTCCAAGATGGCCCTGCAGAGC TCCTTCACTTGTTGGAATGGGACAGTCCTCCAGCTTGGGCAGGCCTGTGACTTCCACCAGGACTGTGCCCAGGGAGAAGATGAGAGCCAG ATGTGCCGGAAACTGCCTGTGGGTTTTTACTGCAACTTTGAAGATGGCTTCTGTGGCTGGACCCAAGGCACACTGTCACCCCACACTCCT CAATGGCAGGTCAGGACCCTAAAGGATGCCCGGTTCCAGGACCACCAAGACCATGCTCTATTGCTCAGTACCACTGATGTCCCCGCTTCT GAAAGTGCTACAGTGACCAGTGCTACGTTTCCTGCACCGATCAAGAGCTCTCCATGTGAGCTCCGAATGTCCTGGCTCATTCGTGGAGTC TTGAGGGGAAACGTGTCCTTGGTGCTAGTGGAGAACAAAACCGGGAAGGAGCAAGGCAGGATGGTCTGGCATGTCGCCGCCTATGAAGGC TTGAGCCTGTGGCAGTGGATGGTGTTGCCTCTCCTCGATGTGTCTGACAGGTTCTGGCTGCAGATGGTCGCATGGTGGGGACAAGGATCC AGAGCCATCGTGGCTTTTGACAATATCTCCATCAGCCTGGACTGCTACCTCACCATTAGCGGAGAGGACAAGATCCTGCAGAATACAGCA CCCAAATCAAGAAACCTGTTTGAGAGAAACCCAAACAAGGAGCTGAAACCCGGGGAAAATTCACCAAGACAGACCCCCATCTTTGACCCT ACAGTTCATTGGCTGTTCACCACATGTGGGGCCAGCGGGCCCCATGGCCCCACCCAGGCACAGTGCAACAACGCCTACCAGAACTCCAAC CTGAGCGTGGAGGTGGGGAGCGAGGGCCCCCTGAAAGGCATCCAGATCTGGAAGGTGCCAGCCACCGACACCTACAGCATCTCGGGCTAC GGAGCTGCTGGCGGGAAAGGCGGGAAGAACACCATGATGCGGTCCCACGGCGTGTCTGTGCTGGGCATCTTCAACCTGGAGAAGGATGAC ATGCTGTACATCCTGGTTGGGCAGCAGGGAGAGGACGCCTGCCCCAGTACAAACCAGTTAATCCAGAAAGTCTGCATTGGAGAGAACAAT GTGATAGAAGAAGAAATCCGTGTGAACAGAAGCGTGCATGAGTGGGCAGGAGGCGGAGGAGGAGGGGGTGGAGCCACCTACGTATTTAAG ATGAAGGATGGAGTGCCGGTGCCCCTGATCATTGCAGCCGGAGGTGGTGGCAGGGCCTACGGGGCCAAGACAGACACGTTCCACCCAGAG AGACTGGAGAATAACTCCTCGGTTCTAGGGCTAAACGGCAATTCCGGAGCCGCAGGTGGTGGAGGTGGCTGGAATGATAACACTTCCTTG CTCTGGGCCGGAAAATCTTTGCAGGAGGGTGCCACCGGAGGACATTCCTGCCCCCAGGCCATGAAGAAGTGGGGGTGGGAGACAAGAGGG GGTTTCGGAGGGGGTGGAGGGGGGTGCTCCTCAGGTGGAGGAGGCGGAGGATATATAGGCGGCAATGCAGCCTCAAACAATGACCCCGAA ATGGATGGGGAAGATGGGGTTTCCTTCATCAGTCCACTGGGCATCCTGTACACCCCAGCTTTAAAAGTGATGGAAGGCCACGGGGAAGTG AATATTAAGCATTATCTAAACTGCAGTCACTGTGAGGTAGACGAATGTCACATGGACCCTGAAAGCCACAAGGTCATCTGCTTCTGTGAC CACGGGACGGTGCTGGCTGAGGATGGCGTCTCCTGCATTGTGTCACCCACCCCGGAGCCACACCTGCCACTCTCGCTGATCCTCTCTGTG GTGACCTCTGCCCTCGTGGCCGCCCTGGTCCTGGCTTTCTCCGGCATCATGATTGTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATG CAGATGGAGCTGCAGAGCCCTGAGTACAAGCTGAGCAAGCTCCGCACCTCGACCATCATGACCGACTACAACCCCAACTACTGCTTTGCT GGCAAGACCTCCTCCATCAGTGACCTGAAGGAGGTGCCGCGGAAAAACATCACCCTCATTCGGGGTCTGGGCCATGGCGCCTTTGGGGAG GTGTATGAAGGCCAGGTGTCCGGAATGCCCAACGACCCAAGCCCCCTGCAAGTGGCTGTGAAGACGCTGCCTGAAGTGTGCTCTGAACAG GACGAACTGGATTTCCTCATGGAAGCCCTGATCATCAGCAAATTCAACCACCAGAACATTGTTCGCTGCATTGGGGTGAGCCTGCAATCC CTGCCCCGGTTCATCCTGCTGGAGCTCATGGCGGGGGGAGACCTCAAGTCCTTCCTCCGAGAGACCCGCCCTCGCCCGAGCCAGCCCTCC TCCCTGGCCATGCTGGACCTTCTGCACGTGGCTCGGGACATTGCCTGTGGCTGTCAGTATTTGGAGGAAAACCACTTCATCCACCGAGAC ATTGCTGCCAGAAACTGCCTCTTGACCTGTCCAGGCCCTGGAAGAGTGGCCAAGATTGGAGACTTCGGGATGGCCCGAGACATCTACAGG GCGAGCTACTATAGAAAGGGAGGCTGTGCCATGCTGCCAGTTAAGTGGATGCCCCCAGAGGCCTTCATGGAAGGAATATTCACTTCTAAA ACAGACACATGGTCCTTTGGAGTGCTGCTATGGGAAATCTTTTCTCTTGGATATATGCCATACCCCAGCAAAAGCAACCAGGAAGTTCTG GAGTTTGTCACCAGTGGAGGCCGGATGGACCCACCCAAGAACTGCCCTGGGCCTGTATACCGGATAATGACTCAGTGCTGGCAACATCAG CCTGAAGACAGGCCCAACTTTGCCATCATTTTGGAGAGGATTGAATACTGCACCCAGGACCCGGATGTAATCAACACCGCTTTGCCGATA GAATATGGTCCACTTGTGGAAGAGGAAGAGAAAGTGCCTGTGAGGCCCAAGGACCCTGAGGGGGTTCCTCCTCTCCTGGTCTCTCAACAG GCAAAACGGGAGGAGGAGCGCAGCCCAGCTGCCCCACCACCTCTGCCTACCACCTCCTCTGGCAAGGCTGCAAAGAAACCCACAGCTGCA GAGATCTCTGTTCGAGTCCCTAGAGGGCCGGCCGTGGAAGGGGGACACGTGAATATGGCATTCTCTCAGTCCAACCCTCCTTCGGAGTTG CACAAGGTCCACGGATCCAGAAACAAGCCCACCAGCTTGTGGAACCCAACGTACGGCTCCTGGTTTACAGAGAAACCCACCAAAAAGAAT AATCCTATAGCAAAGAAGGAGCCACACGACAGGGGTAACCTGGGGCTGGAGGGAAGCTGTACTGTCCCACCTAACGTTGCAACTGGGAGA CTTCCGGGGGCCTCACTGCTCCTAGAGCCCTCTTCGCTGACTGCCAATATGAAGGAGGTACCTCTGTTCAGGCTACGTCACTTCCCTTGT GGGAATGTCAATTACGGCTACCAGCAACAGGGCTTGCCCTTAGAAGCCGCTACTGCCCCTGGAGCTGGTCATTACGAGGATACCATTCTG >In-frame_SMEK2_ENST00000407823_chr2_55804451_-_ALK_ENST00000431873_chr2_29940563_-_2196nt ATGTCGGATACGCGGCGGCGAGTGAAGGTCTATACCCTGAACGAAGACCGGCAATGGGACGACCGAGGCACCGGGCACGTCTCCTCCACT TACGTGGAGGAGCTCAAGGGGATGTCGCTGCTGGTTCGGGCAGAGTCCGACGGATCACTACTCTTGGAATCAAAGATAAATCCAAATACT GCATATCAGAAACAACAGGATACATTAATTGTTTGGTCAGAAGCAGAGAACTATGATTTGGCTCTGAGTTTTCAGGAGAAAGCTGGCTGT GATGAGATCTGGGAAAAAATTTGTCAGGTTCAAGGTAAAGACCCATCAGTGGAAGTCACACAGGACCTCATTGATGAATCTGAAGAAGAA CGATTTGAAGAAATGCCTGAAACTAGTCATCTGATTGACCTGCCCACATGTGAACTCAATAAACTTGAAGAGATTGCTGACTTAGTTACC TCAGTGCTCTCCTCACCTATCCGTAGGGAAAAGCTGGCTCTCGCCTTGGAAAATGAAGGCTATATTAAAAAACTATTGCAGCTGTTCCAA GCTTGCGAGAACCTAGAAAACACTGAAGGCTTACACCATTTGTATGAAATTATTAGAGGAATCTTATTCCTAAATAAGGCAACTCTTTTT GAGGTAATGTTTTCTGATGAGTGTATCATGGATGTCGTGGGATGCCTTGAATATGACCCTGCTTTGGCTCAGCCAAAAAGACATAGAGAA TTCTTGACCAAAACTGCAAAGTTCAAGGAAGTTATACCAATAACAGACTCTGAACTAAGGCAAAAAATACATCAGACTTACAGGGTACAG TACATTCAGGACATCATTTTGCCCACACCATCTGTTTTTGAAGAGAATTTTCTTTCTACTCTTACGTCTTTTATTTTCTTCAACAAAGTT GAGATAGTCAGCATGTTGCAGGAAGATGAGAAGTTTTTGTCTGAAGTTTTTGCACAATTAACAGATGAGGCTACAGATGATGATAAACGG CGTGAATTGGTTAATTTTTTCAAGGAGTTTTGTGCATTTTCTCAGACATTACAACCTCAAAACAGGGATGCATTTTTCAAAACATTGGCA AAATTGGGAATTCTTCCTGCTCTTGAAATTGTAATGGGCATGGATGATTTGCAAGTCAGATCAGCTGCTACAGATATATTTTCTTATCTA GTAGAATTTAGTCCATCTATGGTCCGAGAGTTTGTAATGCAAGAAGCTCAGCAGAGTGATGACGATATTCTTCTTATTAATGTGGTAATT GAACAAATGATCTGTGATACTGATCCTGAGCTAGGAGGCGCTGTTCAGTTAATGGGACTTCTTCGTACTCTAATTGATCCAGAGAACATG CTGGCTACAACTAATAAAACCGAAAAAAGTGAATTTCTAAATTTTTTCTACAACCATTGTATGCATGTTCTCACAGCACCACTTTTGACC AATACTTCAGAAGACAAATGTGAAAAGGATAATATAGTTGGATCAAACAAAAACAACACAATTTGTCCCGGTCATAGCTCCTTGGAATCA CCAACAAACATGCCTTCTCCTTCTCCTGATTATTTTACATGGAATCTCACCTGGATAATGAAAGACTCCTTCCCTTTCCTGTCTCATCGC AGCCGATATGGTAAAGAGCGCAGCCCAGCTGCCCCACCACCTCTGCCTACCACCTCCTCTGGCAAGGCTGCAAAGAAACCCACAGCTGCA GAGATCTCTGTTCGAGTCCCTAGAGGGCCGGCCGTGGAAGGGGGACACGTGAATATGGCATTCTCTCAGTCCAACCCTCCTTCGGAGTTG CACAAGGTCCACGGATCCAGAAACAAGCCCACCAGCTTGTGGAACCCAACGTACGGCTCCTGGTTTACAGAGAAACCCACCAAAAAGAAT AATCCTATAGCAAAGAAGGAGCCACACGACAGGGGTAACCTGGGGCTGGAGGGAAGCTGTACTGTCCCACCTAACGTTGCAACTGGGAGA CTTCCGGGGGCCTCACTGCTCCTAGAGCCCTCTTCGCTGACTGCCAATATGAAGGAGGTACCTCTGTTCAGGCTACGTCACTTCCCTTGT GGGAATGTCAATTACGGCTACCAGCAACAGGGCTTGCCCTTAGAAGCCGCTACTGCCCCTGGAGCTGGTCATTACGAGGATACCATTCTG >In-frame_SMEK2_ENST00000345102_chr2_55804451_-_ALK_ENST00000389048_chr2_29940563_-_5802nt ATGTCGGATACGCGGCGGCGAGTGAAGGTCTATACCCTGAACGAAGACCGGCAATGGGACGACCGAGGCACCGGGCACGTCTCCTCCACT TACGTGGAGGAGCTCAAGGGGATGTCGCTGCTGGTTCGGGCAGAGTCCGACGGATCACTACTCTTGGAATCAAAGATAAATCCAAATACT GCATATCAGAAACAACAGGATACATTAATTGTTTGGTCAGAAGCAGAGAACTATGATTTGGCTCTGAGTTTTCAGGAGAAAGCTGGCTGT GATGAGATCTGGGAAAAAATTTGTCAGGTTCAAGGTAAAGACCCATCAGTGGAAGTCACACAGGACCTCATTGATGAATCTGAAGAAGAA CGATTTGAAGAAATGCCTGAAACTAGTCATCTGATTGACCTGCCCACATGTGAACTCAATAAACTTGAAGAGATTGCTGACTTAGTTACC TCAGTGCTCTCCTCACCTATCCGTAGGGAAAAGCTGGCTCTCGCCTTGGAAAATGAAGGCTATATTAAAAAACTATTGCAGCTGTTCCAA GCTTGCGAGAACCTAGAAAACACTGAAGGCTTACACCATTTGTATGAAATTATTAGAGGAATCTTATTCCTAAATAAGGCAACTCTTTTT GAGGTAATGTTTTCTGATGAGTGTATCATGGATGTCGTGGGATGCCTTGAATATGACCCTGCTTTGGCTCAGCCAAAAAGACATAGAGAA TTCTTGACCAAAACTGCAAAGTTCAAGGAAGTTATACCAATAACAGACTCTGAACTAAGGCAAAAAATACATCAGACTTACAGGGTACAG TACATTCAGGACATCATTTTGCCCACACCATCTGTTTTTGAAGAGAATTTTCTTTCTACTCTTACGTCTTTTATTTTCTTCAACAAAGTT GAGATAGTCAGCATGTTGCAGGAAGATGAGAAGTTTTTGTCTGAAGTTTTTGCACAATTAACAGATGAGGCTACAGATGATGATAAACGG CGTGAATTGGTTAATTTTTTCAAGGAGTTTTGTGCATTTTCTCAGACATTACAACCTCAAAACAGGGATGCATTTTTCAAAACATTGGCA AAATTGGGAATTCTTCCTGCTCTTGAAATTGTAATGGGCATGGATGATTTGCAAGTCAGATCAGCTGCTACAGATATATTTTCTTATCTA GTAGAATTTAGTCCATCTATGGTCCGAGAGTTTGTAATGCAAGAAGCTCAGCAGAGTGATGACGATATTCTTCTTATTAATGTGGTAATT GAACAAATGATCTGTGATACTGATCCTGAGCTAGGAGGCGCTGTTCAGTTAATGGGACTTCTTCGTACTCTAATTGATCCAGAGAACATG CTGGCTACAACTAATAAAACCGAAAAAAGTGAATTTCTAAATTTTTTCTACAACCATTGTATGCATGTTCTCACAGCACCACTTTTGACC AATACTTCAGAAGACAAATGTGAAAAGGATTTTTTTTTAAAACATTACAGATATAGTTGGAGTTTCATATGTACCCCTTCACATTCCCAT TCCCATTCTACCCCCTCTTCCTCCATCTCTCAAGATAATATAGTTGGATCAAACAAAAACAACACAATTTGTCCCGGTCATAGCTCCTTG GAATCACCAACAAACATGCCTTCTCCTTCTCCTGATTATTTTACATGGAATCTCACCTGGATAATGAAAGACTCCTTCCCTTTCCTGTCT CATCGCAGCCGATATGGTCTGGAGTGCAGCTTTGACTTCCCCTGTGAGCTGGAGTATTCCCCTCCACTGCATGACCTCAGGAACCAGAGC TGGTCCTGGCGCCGCATCCCCTCCGAGGAGGCCTCCCAGATGGACTTGCTGGATGGGCCTGGGGCAGAGCGTTCTAAGGAGATGCCCAGA GGCTCCTTTCTCCTTCTCAACACCTCAGCTGACTCCAAGCACACCATCCTGAGTCCGTGGATGAGGAGCAGCAGTGAGCACTGCACACTG GCCGTCTCGGTGCACAGGCACCTGCAGCCCTCTGGAAGGTACATTGCCCAGCTGCTGCCCCACAACGAGGCTGCAAGAGAGATCCTCCTG ATGCCCACTCCAGGGAAGCATGGTTGGACAGTGCTCCAGGGAAGAATCGGGCGTCCAGACAACCCATTTCGAGTGGCCCTGGAATACATC TCCAGTGGAAACCGCAGCTTGTCTGCAGTGGACTTCTTTGCCCTGAAGAACTGCAGTGAAGGAACATCCCCAGGCTCCAAGATGGCCCTG CAGAGCTCCTTCACTTGTTGGAATGGGACAGTCCTCCAGCTTGGGCAGGCCTGTGACTTCCACCAGGACTGTGCCCAGGGAGAAGATGAG AGCCAGATGTGCCGGAAACTGCCTGTGGGTTTTTACTGCAACTTTGAAGATGGCTTCTGTGGCTGGACCCAAGGCACACTGTCACCCCAC ACTCCTCAATGGCAGGTCAGGACCCTAAAGGATGCCCGGTTCCAGGACCACCAAGACCATGCTCTATTGCTCAGTACCACTGATGTCCCC GCTTCTGAAAGTGCTACAGTGACCAGTGCTACGTTTCCTGCACCGATCAAGAGCTCTCCATGTGAGCTCCGAATGTCCTGGCTCATTCGT GGAGTCTTGAGGGGAAACGTGTCCTTGGTGCTAGTGGAGAACAAAACCGGGAAGGAGCAAGGCAGGATGGTCTGGCATGTCGCCGCCTAT GAAGGCTTGAGCCTGTGGCAGTGGATGGTGTTGCCTCTCCTCGATGTGTCTGACAGGTTCTGGCTGCAGATGGTCGCATGGTGGGGACAA GGATCCAGAGCCATCGTGGCTTTTGACAATATCTCCATCAGCCTGGACTGCTACCTCACCATTAGCGGAGAGGACAAGATCCTGCAGAAT ACAGCACCCAAATCAAGAAACCTGTTTGAGAGAAACCCAAACAAGGAGCTGAAACCCGGGGAAAATTCACCAAGACAGACCCCCATCTTT GACCCTACAGTTCATTGGCTGTTCACCACATGTGGGGCCAGCGGGCCCCATGGCCCCACCCAGGCACAGTGCAACAACGCCTACCAGAAC TCCAACCTGAGCGTGGAGGTGGGGAGCGAGGGCCCCCTGAAAGGCATCCAGATCTGGAAGGTGCCAGCCACCGACACCTACAGCATCTCG GGCTACGGAGCTGCTGGCGGGAAAGGCGGGAAGAACACCATGATGCGGTCCCACGGCGTGTCTGTGCTGGGCATCTTCAACCTGGAGAAG GATGACATGCTGTACATCCTGGTTGGGCAGCAGGGAGAGGACGCCTGCCCCAGTACAAACCAGTTAATCCAGAAAGTCTGCATTGGAGAG AACAATGTGATAGAAGAAGAAATCCGTGTGAACAGAAGCGTGCATGAGTGGGCAGGAGGCGGAGGAGGAGGGGGTGGAGCCACCTACGTA TTTAAGATGAAGGATGGAGTGCCGGTGCCCCTGATCATTGCAGCCGGAGGTGGTGGCAGGGCCTACGGGGCCAAGACAGACACGTTCCAC CCAGAGAGACTGGAGAATAACTCCTCGGTTCTAGGGCTAAACGGCAATTCCGGAGCCGCAGGTGGTGGAGGTGGCTGGAATGATAACACT TCCTTGCTCTGGGCCGGAAAATCTTTGCAGGAGGGTGCCACCGGAGGACATTCCTGCCCCCAGGCCATGAAGAAGTGGGGGTGGGAGACA AGAGGGGGTTTCGGAGGGGGTGGAGGGGGGTGCTCCTCAGGTGGAGGAGGCGGAGGATATATAGGCGGCAATGCAGCCTCAAACAATGAC CCCGAAATGGATGGGGAAGATGGGGTTTCCTTCATCAGTCCACTGGGCATCCTGTACACCCCAGCTTTAAAAGTGATGGAAGGCCACGGG GAAGTGAATATTAAGCATTATCTAAACTGCAGTCACTGTGAGGTAGACGAATGTCACATGGACCCTGAAAGCCACAAGGTCATCTGCTTC TGTGACCACGGGACGGTGCTGGCTGAGGATGGCGTCTCCTGCATTGTGTCACCCACCCCGGAGCCACACCTGCCACTCTCGCTGATCCTC TCTGTGGTGACCTCTGCCCTCGTGGCCGCCCTGGTCCTGGCTTTCTCCGGCATCATGATTGTGTACCGCCGGAAGCACCAGGAGCTGCAA GCCATGCAGATGGAGCTGCAGAGCCCTGAGTACAAGCTGAGCAAGCTCCGCACCTCGACCATCATGACCGACTACAACCCCAACTACTGC TTTGCTGGCAAGACCTCCTCCATCAGTGACCTGAAGGAGGTGCCGCGGAAAAACATCACCCTCATTCGGGGTCTGGGCCATGGCGCCTTT GGGGAGGTGTATGAAGGCCAGGTGTCCGGAATGCCCAACGACCCAAGCCCCCTGCAAGTGGCTGTGAAGACGCTGCCTGAAGTGTGCTCT GAACAGGACGAACTGGATTTCCTCATGGAAGCCCTGATCATCAGCAAATTCAACCACCAGAACATTGTTCGCTGCATTGGGGTGAGCCTG CAATCCCTGCCCCGGTTCATCCTGCTGGAGCTCATGGCGGGGGGAGACCTCAAGTCCTTCCTCCGAGAGACCCGCCCTCGCCCGAGCCAG CCCTCCTCCCTGGCCATGCTGGACCTTCTGCACGTGGCTCGGGACATTGCCTGTGGCTGTCAGTATTTGGAGGAAAACCACTTCATCCAC CGAGACATTGCTGCCAGAAACTGCCTCTTGACCTGTCCAGGCCCTGGAAGAGTGGCCAAGATTGGAGACTTCGGGATGGCCCGAGACATC TACAGGGCGAGCTACTATAGAAAGGGAGGCTGTGCCATGCTGCCAGTTAAGTGGATGCCCCCAGAGGCCTTCATGGAAGGAATATTCACT TCTAAAACAGACACATGGTCCTTTGGAGTGCTGCTATGGGAAATCTTTTCTCTTGGATATATGCCATACCCCAGCAAAAGCAACCAGGAA GTTCTGGAGTTTGTCACCAGTGGAGGCCGGATGGACCCACCCAAGAACTGCCCTGGGCCTGTATACCGGATAATGACTCAGTGCTGGCAA CATCAGCCTGAAGACAGGCCCAACTTTGCCATCATTTTGGAGAGGATTGAATACTGCACCCAGGACCCGGATGTAATCAACACCGCTTTG CCGATAGAATATGGTCCACTTGTGGAAGAGGAAGAGAAAGTGCCTGTGAGGCCCAAGGACCCTGAGGGGGTTCCTCCTCTCCTGGTCTCT CAACAGGCAAAACGGGAGGAGGAGCGCAGCCCAGCTGCCCCACCACCTCTGCCTACCACCTCCTCTGGCAAGGCTGCAAAGAAACCCACA GCTGCAGAGATCTCTGTTCGAGTCCCTAGAGGGCCGGCCGTGGAAGGGGGACACGTGAATATGGCATTCTCTCAGTCCAACCCTCCTTCG GAGTTGCACAAGGTCCACGGATCCAGAAACAAGCCCACCAGCTTGTGGAACCCAACGTACGGCTCCTGGTTTACAGAGAAACCCACCAAA AAGAATAATCCTATAGCAAAGAAGGAGCCACACGACAGGGGTAACCTGGGGCTGGAGGGAAGCTGTACTGTCCCACCTAACGTTGCAACT GGGAGACTTCCGGGGGCCTCACTGCTCCTAGAGCCCTCTTCGCTGACTGCCAATATGAAGGAGGTACCTCTGTTCAGGCTACGTCACTTC CCTTGTGGGAATGTCAATTACGGCTACCAGCAACAGGGCTTGCCCTTAGAAGCCGCTACTGCCCCTGGAGCTGGTCATTACGAGGATACC >In-frame_SMEK2_ENST00000345102_chr2_55804451_-_ALK_ENST00000431873_chr2_29940563_-_2292nt ATGTCGGATACGCGGCGGCGAGTGAAGGTCTATACCCTGAACGAAGACCGGCAATGGGACGACCGAGGCACCGGGCACGTCTCCTCCACT TACGTGGAGGAGCTCAAGGGGATGTCGCTGCTGGTTCGGGCAGAGTCCGACGGATCACTACTCTTGGAATCAAAGATAAATCCAAATACT GCATATCAGAAACAACAGGATACATTAATTGTTTGGTCAGAAGCAGAGAACTATGATTTGGCTCTGAGTTTTCAGGAGAAAGCTGGCTGT GATGAGATCTGGGAAAAAATTTGTCAGGTTCAAGGTAAAGACCCATCAGTGGAAGTCACACAGGACCTCATTGATGAATCTGAAGAAGAA CGATTTGAAGAAATGCCTGAAACTAGTCATCTGATTGACCTGCCCACATGTGAACTCAATAAACTTGAAGAGATTGCTGACTTAGTTACC TCAGTGCTCTCCTCACCTATCCGTAGGGAAAAGCTGGCTCTCGCCTTGGAAAATGAAGGCTATATTAAAAAACTATTGCAGCTGTTCCAA GCTTGCGAGAACCTAGAAAACACTGAAGGCTTACACCATTTGTATGAAATTATTAGAGGAATCTTATTCCTAAATAAGGCAACTCTTTTT GAGGTAATGTTTTCTGATGAGTGTATCATGGATGTCGTGGGATGCCTTGAATATGACCCTGCTTTGGCTCAGCCAAAAAGACATAGAGAA TTCTTGACCAAAACTGCAAAGTTCAAGGAAGTTATACCAATAACAGACTCTGAACTAAGGCAAAAAATACATCAGACTTACAGGGTACAG TACATTCAGGACATCATTTTGCCCACACCATCTGTTTTTGAAGAGAATTTTCTTTCTACTCTTACGTCTTTTATTTTCTTCAACAAAGTT GAGATAGTCAGCATGTTGCAGGAAGATGAGAAGTTTTTGTCTGAAGTTTTTGCACAATTAACAGATGAGGCTACAGATGATGATAAACGG CGTGAATTGGTTAATTTTTTCAAGGAGTTTTGTGCATTTTCTCAGACATTACAACCTCAAAACAGGGATGCATTTTTCAAAACATTGGCA AAATTGGGAATTCTTCCTGCTCTTGAAATTGTAATGGGCATGGATGATTTGCAAGTCAGATCAGCTGCTACAGATATATTTTCTTATCTA GTAGAATTTAGTCCATCTATGGTCCGAGAGTTTGTAATGCAAGAAGCTCAGCAGAGTGATGACGATATTCTTCTTATTAATGTGGTAATT GAACAAATGATCTGTGATACTGATCCTGAGCTAGGAGGCGCTGTTCAGTTAATGGGACTTCTTCGTACTCTAATTGATCCAGAGAACATG CTGGCTACAACTAATAAAACCGAAAAAAGTGAATTTCTAAATTTTTTCTACAACCATTGTATGCATGTTCTCACAGCACCACTTTTGACC AATACTTCAGAAGACAAATGTGAAAAGGATTTTTTTTTAAAACATTACAGATATAGTTGGAGTTTCATATGTACCCCTTCACATTCCCAT TCCCATTCTACCCCCTCTTCCTCCATCTCTCAAGATAATATAGTTGGATCAAACAAAAACAACACAATTTGTCCCGGTCATAGCTCCTTG GAATCACCAACAAACATGCCTTCTCCTTCTCCTGATTATTTTACATGGAATCTCACCTGGATAATGAAAGACTCCTTCCCTTTCCTGTCT CATCGCAGCCGATATGGTAAAGAGCGCAGCCCAGCTGCCCCACCACCTCTGCCTACCACCTCCTCTGGCAAGGCTGCAAAGAAACCCACA GCTGCAGAGATCTCTGTTCGAGTCCCTAGAGGGCCGGCCGTGGAAGGGGGACACGTGAATATGGCATTCTCTCAGTCCAACCCTCCTTCG GAGTTGCACAAGGTCCACGGATCCAGAAACAAGCCCACCAGCTTGTGGAACCCAACGTACGGCTCCTGGTTTACAGAGAAACCCACCAAA AAGAATAATCCTATAGCAAAGAAGGAGCCACACGACAGGGGTAACCTGGGGCTGGAGGGAAGCTGTACTGTCCCACCTAACGTTGCAACT GGGAGACTTCCGGGGGCCTCACTGCTCCTAGAGCCCTCTTCGCTGACTGCCAATATGAAGGAGGTACCTCTGTTCAGGCTACGTCACTTC CCTTGTGGGAATGTCAATTACGGCTACCAGCAACAGGGCTTGCCCTTAGAAGCCGCTACTGCCCCTGGAGCTGGTCATTACGAGGATACC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SMEK2_ENST00000272313_chr2_55804451_-_ALK_ENST00000389048_chr2_29940563_-_6484nt AGGCAGAGAGAGTCGGGTTACAAGATGGCGGATCTGTAGTAGTTACCGCGGCGGCGGGAGAGCAAGCGAGCCCTGGGGGGCAAAGAGACG GGAGAGTGGGTGTATGCGCGGGTGAAGTGAGAGGTAACGGGGCTCCGGGCGGAGAGGCCTCAGTGGCTCTTGTCACCCCTTCTCGCGGCT GAACCTTTGGAGCCATGGTGAATTCGGGCCTCTCCGAAGCCGCCGCCGCCGCCACCGCCACTACTGCCTTTACCGTCTCCTAAGAGTGAG GAGCGCGGACGAGGTAAGCGAGGAGGCGGCGGCTAGAGCGGTGGAGACAGCAGCCACCATGTCGGATACGCGGCGGCGAGTGAAGGTCTA TACCCTGAACGAAGACCGGCAATGGGACGACCGAGGCACCGGGCACGTCTCCTCCACTTACGTGGAGGAGCTCAAGGGGATGTCGCTGCT GGTTCGGGCAGAGTCCGACGGATCACTACTCTTGGAATCAAAGATAAATCCAAATACTGCATATCAGAAACAACAGGATACATTAATTGT TTGGTCAGAAGCAGAGAACTATGATTTGGCTCTGAGTTTTCAGGAGAAAGCTGGCTGTGATGAGATCTGGGAAAAAATTTGTCAGGTTCA AGGTAAAGACCCATCAGTGGAAGTCACACAGGACCTCATTGATGAATCTGAAGAAGAACGATTTGAAGAAATGCCTGAAACTAGTCATCT GATTGACCTGCCCACATGTGAACTCAATAAACTTGAAGAGATTGCTGACTTAGTTACCTCAGTGCTCTCCTCACCTATCCGTAGGGAAAA GCTGGCTCTCGCCTTGGAAAATGAAGGCTATATTAAAAAACTATTGCAGCTGTTCCAAGCTTGCGAGAACCTAGAAAACACTGAAGGCTT ACACCATTTGTATGAAATTATTAGAGGAATCTTATTCCTAAATAAGGCAACTCTTTTTGAGGTAATGTTTTCTGATGAGTGTATCATGGA TGTCGTGGGATGCCTTGAATATGACCCTGCTTTGGCTCAGCCAAAAAGACATAGAGAATTCTTGACCAAAACTGCAAAGTTCAAGGAAGT TATACCAATAACAGACTCTGAACTAAGGCAAAAAATACATCAGACTTACAGGGTACAGTACATTCAGGACATCATTTTGCCCACACCATC TGTTTTTGAAGAGAATTTTCTTTCTACTCTTACGTCTTTTATTTTCTTCAACAAAGTTGAGATAGTCAGCATGTTGCAGGAAGATGAGAA GTTTTTGTCTGAAGTTTTTGCACAATTAACAGATGAGGCTACAGATGATGATAAACGGCGTGAATTGGTTAATTTTTTCAAGGAGTTTTG TGCATTTTCTCAGACATTACAACCTCAAAACAGGGATGCATTTTTCAAAACATTGGCAAAATTGGGAATTCTTCCTGCTCTTGAAATTGT AATGGGCATGGATGATTTGCAAGTCAGATCAGCTGCTACAGATATATTTTCTTATCTAGTAGAATTTAGTCCATCTATGGTCCGAGAGTT TGTAATGCAAGAAGCTCAGCAGAGTGATGACGATATTCTTCTTATTAATGTGGTAATTGAACAAATGATCTGTGATACTGATCCTGAGCT AGGAGGCGCTGTTCAGTTAATGGGACTTCTTCGTACTCTAATTGATCCAGAGAACATGCTGGCTACAACTAATAAAACCGAAAAAAGTGA ATTTCTAAATTTTTTCTACAACCATTGTATGCATGTTCTCACAGCACCACTTTTGACCAATACTTCAGAAGACAAATGTGAAAAGGATAA TATAGTTGGATCAAACAAAAACAACACAATTTGTCCCGGTCATAGCTCCTTGGAATCACCAACAAACATGCCTTCTCCTTCTCCTGATTA TTTTACATGGAATCTCACCTGGATAATGAAAGACTCCTTCCCTTTCCTGTCTCATCGCAGCCGATATGGTCTGGAGTGCAGCTTTGACTT CCCCTGTGAGCTGGAGTATTCCCCTCCACTGCATGACCTCAGGAACCAGAGCTGGTCCTGGCGCCGCATCCCCTCCGAGGAGGCCTCCCA GATGGACTTGCTGGATGGGCCTGGGGCAGAGCGTTCTAAGGAGATGCCCAGAGGCTCCTTTCTCCTTCTCAACACCTCAGCTGACTCCAA GCACACCATCCTGAGTCCGTGGATGAGGAGCAGCAGTGAGCACTGCACACTGGCCGTCTCGGTGCACAGGCACCTGCAGCCCTCTGGAAG GTACATTGCCCAGCTGCTGCCCCACAACGAGGCTGCAAGAGAGATCCTCCTGATGCCCACTCCAGGGAAGCATGGTTGGACAGTGCTCCA GGGAAGAATCGGGCGTCCAGACAACCCATTTCGAGTGGCCCTGGAATACATCTCCAGTGGAAACCGCAGCTTGTCTGCAGTGGACTTCTT TGCCCTGAAGAACTGCAGTGAAGGAACATCCCCAGGCTCCAAGATGGCCCTGCAGAGCTCCTTCACTTGTTGGAATGGGACAGTCCTCCA GCTTGGGCAGGCCTGTGACTTCCACCAGGACTGTGCCCAGGGAGAAGATGAGAGCCAGATGTGCCGGAAACTGCCTGTGGGTTTTTACTG CAACTTTGAAGATGGCTTCTGTGGCTGGACCCAAGGCACACTGTCACCCCACACTCCTCAATGGCAGGTCAGGACCCTAAAGGATGCCCG GTTCCAGGACCACCAAGACCATGCTCTATTGCTCAGTACCACTGATGTCCCCGCTTCTGAAAGTGCTACAGTGACCAGTGCTACGTTTCC TGCACCGATCAAGAGCTCTCCATGTGAGCTCCGAATGTCCTGGCTCATTCGTGGAGTCTTGAGGGGAAACGTGTCCTTGGTGCTAGTGGA GAACAAAACCGGGAAGGAGCAAGGCAGGATGGTCTGGCATGTCGCCGCCTATGAAGGCTTGAGCCTGTGGCAGTGGATGGTGTTGCCTCT CCTCGATGTGTCTGACAGGTTCTGGCTGCAGATGGTCGCATGGTGGGGACAAGGATCCAGAGCCATCGTGGCTTTTGACAATATCTCCAT CAGCCTGGACTGCTACCTCACCATTAGCGGAGAGGACAAGATCCTGCAGAATACAGCACCCAAATCAAGAAACCTGTTTGAGAGAAACCC AAACAAGGAGCTGAAACCCGGGGAAAATTCACCAAGACAGACCCCCATCTTTGACCCTACAGTTCATTGGCTGTTCACCACATGTGGGGC CAGCGGGCCCCATGGCCCCACCCAGGCACAGTGCAACAACGCCTACCAGAACTCCAACCTGAGCGTGGAGGTGGGGAGCGAGGGCCCCCT GAAAGGCATCCAGATCTGGAAGGTGCCAGCCACCGACACCTACAGCATCTCGGGCTACGGAGCTGCTGGCGGGAAAGGCGGGAAGAACAC CATGATGCGGTCCCACGGCGTGTCTGTGCTGGGCATCTTCAACCTGGAGAAGGATGACATGCTGTACATCCTGGTTGGGCAGCAGGGAGA GGACGCCTGCCCCAGTACAAACCAGTTAATCCAGAAAGTCTGCATTGGAGAGAACAATGTGATAGAAGAAGAAATCCGTGTGAACAGAAG CGTGCATGAGTGGGCAGGAGGCGGAGGAGGAGGGGGTGGAGCCACCTACGTATTTAAGATGAAGGATGGAGTGCCGGTGCCCCTGATCAT TGCAGCCGGAGGTGGTGGCAGGGCCTACGGGGCCAAGACAGACACGTTCCACCCAGAGAGACTGGAGAATAACTCCTCGGTTCTAGGGCT AAACGGCAATTCCGGAGCCGCAGGTGGTGGAGGTGGCTGGAATGATAACACTTCCTTGCTCTGGGCCGGAAAATCTTTGCAGGAGGGTGC CACCGGAGGACATTCCTGCCCCCAGGCCATGAAGAAGTGGGGGTGGGAGACAAGAGGGGGTTTCGGAGGGGGTGGAGGGGGGTGCTCCTC AGGTGGAGGAGGCGGAGGATATATAGGCGGCAATGCAGCCTCAAACAATGACCCCGAAATGGATGGGGAAGATGGGGTTTCCTTCATCAG TCCACTGGGCATCCTGTACACCCCAGCTTTAAAAGTGATGGAAGGCCACGGGGAAGTGAATATTAAGCATTATCTAAACTGCAGTCACTG TGAGGTAGACGAATGTCACATGGACCCTGAAAGCCACAAGGTCATCTGCTTCTGTGACCACGGGACGGTGCTGGCTGAGGATGGCGTCTC CTGCATTGTGTCACCCACCCCGGAGCCACACCTGCCACTCTCGCTGATCCTCTCTGTGGTGACCTCTGCCCTCGTGGCCGCCCTGGTCCT GGCTTTCTCCGGCATCATGATTGTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGCAGATGGAGCTGCAGAGCCCTGAGTACAAGCT GAGCAAGCTCCGCACCTCGACCATCATGACCGACTACAACCCCAACTACTGCTTTGCTGGCAAGACCTCCTCCATCAGTGACCTGAAGGA GGTGCCGCGGAAAAACATCACCCTCATTCGGGGTCTGGGCCATGGCGCCTTTGGGGAGGTGTATGAAGGCCAGGTGTCCGGAATGCCCAA CGACCCAAGCCCCCTGCAAGTGGCTGTGAAGACGCTGCCTGAAGTGTGCTCTGAACAGGACGAACTGGATTTCCTCATGGAAGCCCTGAT CATCAGCAAATTCAACCACCAGAACATTGTTCGCTGCATTGGGGTGAGCCTGCAATCCCTGCCCCGGTTCATCCTGCTGGAGCTCATGGC GGGGGGAGACCTCAAGTCCTTCCTCCGAGAGACCCGCCCTCGCCCGAGCCAGCCCTCCTCCCTGGCCATGCTGGACCTTCTGCACGTGGC TCGGGACATTGCCTGTGGCTGTCAGTATTTGGAGGAAAACCACTTCATCCACCGAGACATTGCTGCCAGAAACTGCCTCTTGACCTGTCC AGGCCCTGGAAGAGTGGCCAAGATTGGAGACTTCGGGATGGCCCGAGACATCTACAGGGCGAGCTACTATAGAAAGGGAGGCTGTGCCAT GCTGCCAGTTAAGTGGATGCCCCCAGAGGCCTTCATGGAAGGAATATTCACTTCTAAAACAGACACATGGTCCTTTGGAGTGCTGCTATG GGAAATCTTTTCTCTTGGATATATGCCATACCCCAGCAAAAGCAACCAGGAAGTTCTGGAGTTTGTCACCAGTGGAGGCCGGATGGACCC ACCCAAGAACTGCCCTGGGCCTGTATACCGGATAATGACTCAGTGCTGGCAACATCAGCCTGAAGACAGGCCCAACTTTGCCATCATTTT GGAGAGGATTGAATACTGCACCCAGGACCCGGATGTAATCAACACCGCTTTGCCGATAGAATATGGTCCACTTGTGGAAGAGGAAGAGAA AGTGCCTGTGAGGCCCAAGGACCCTGAGGGGGTTCCTCCTCTCCTGGTCTCTCAACAGGCAAAACGGGAGGAGGAGCGCAGCCCAGCTGC CCCACCACCTCTGCCTACCACCTCCTCTGGCAAGGCTGCAAAGAAACCCACAGCTGCAGAGATCTCTGTTCGAGTCCCTAGAGGGCCGGC CGTGGAAGGGGGACACGTGAATATGGCATTCTCTCAGTCCAACCCTCCTTCGGAGTTGCACAAGGTCCACGGATCCAGAAACAAGCCCAC CAGCTTGTGGAACCCAACGTACGGCTCCTGGTTTACAGAGAAACCCACCAAAAAGAATAATCCTATAGCAAAGAAGGAGCCACACGACAG GGGTAACCTGGGGCTGGAGGGAAGCTGTACTGTCCCACCTAACGTTGCAACTGGGAGACTTCCGGGGGCCTCACTGCTCCTAGAGCCCTC TTCGCTGACTGCCAATATGAAGGAGGTACCTCTGTTCAGGCTACGTCACTTCCCTTGTGGGAATGTCAATTACGGCTACCAGCAACAGGG CTTGCCCTTAGAAGCCGCTACTGCCCCTGGAGCTGGTCATTACGAGGATACCATTCTGAAAAGCAAGAATAGCATGAACCAGCCTGGGCC CTGAGCTCGGTCGCACACTCACTTCTCTTCCTTGGGATCCCTAAGACCGTGGAGGAGAGAGAGGCAATGGCTCCTTCACAAACCAGAGAC CAAATGTCACGTTTTGTTTTGTGCCAACCTATTTTGAAGTACCACCAAAAAAGCTGTATTTTGAAAATGCTTTAGAAAGGTTTTGAGCAT GGGTTCATCCTATTCTTTCGAAAGAAGAAAATATCATAAAAATGAGTGATAAATACAAGGCCCAGATGTGGTTGCATAAGGTTTTTATGC ATGTTTGTTGTATACTTCCTTATGCTTCTTTCAAATTGTGTGTGCTCTGCTTCAATGTAGTCAGAATTAGCTGCTTCTATGTTTCATAGT TGGGGTCATAGATGTTTCCTTGCCTTGTTGATGTGGACATGAGCCATTTGAGGGGAGAGGGAACGGAAATAAAGGAGTTATTTGTAATGA >In-frame_SMEK2_ENST00000272313_chr2_55804451_-_ALK_ENST00000431873_chr2_29940563_-_2524nt AGGCAGAGAGAGTCGGGTTACAAGATGGCGGATCTGTAGTAGTTACCGCGGCGGCGGGAGAGCAAGCGAGCCCTGGGGGGCAAAGAGACG GGAGAGTGGGTGTATGCGCGGGTGAAGTGAGAGGTAACGGGGCTCCGGGCGGAGAGGCCTCAGTGGCTCTTGTCACCCCTTCTCGCGGCT GAACCTTTGGAGCCATGGTGAATTCGGGCCTCTCCGAAGCCGCCGCCGCCGCCACCGCCACTACTGCCTTTACCGTCTCCTAAGAGTGAG GAGCGCGGACGAGGTAAGCGAGGAGGCGGCGGCTAGAGCGGTGGAGACAGCAGCCACCATGTCGGATACGCGGCGGCGAGTGAAGGTCTA TACCCTGAACGAAGACCGGCAATGGGACGACCGAGGCACCGGGCACGTCTCCTCCACTTACGTGGAGGAGCTCAAGGGGATGTCGCTGCT GGTTCGGGCAGAGTCCGACGGATCACTACTCTTGGAATCAAAGATAAATCCAAATACTGCATATCAGAAACAACAGGATACATTAATTGT TTGGTCAGAAGCAGAGAACTATGATTTGGCTCTGAGTTTTCAGGAGAAAGCTGGCTGTGATGAGATCTGGGAAAAAATTTGTCAGGTTCA AGGTAAAGACCCATCAGTGGAAGTCACACAGGACCTCATTGATGAATCTGAAGAAGAACGATTTGAAGAAATGCCTGAAACTAGTCATCT GATTGACCTGCCCACATGTGAACTCAATAAACTTGAAGAGATTGCTGACTTAGTTACCTCAGTGCTCTCCTCACCTATCCGTAGGGAAAA GCTGGCTCTCGCCTTGGAAAATGAAGGCTATATTAAAAAACTATTGCAGCTGTTCCAAGCTTGCGAGAACCTAGAAAACACTGAAGGCTT ACACCATTTGTATGAAATTATTAGAGGAATCTTATTCCTAAATAAGGCAACTCTTTTTGAGGTAATGTTTTCTGATGAGTGTATCATGGA TGTCGTGGGATGCCTTGAATATGACCCTGCTTTGGCTCAGCCAAAAAGACATAGAGAATTCTTGACCAAAACTGCAAAGTTCAAGGAAGT TATACCAATAACAGACTCTGAACTAAGGCAAAAAATACATCAGACTTACAGGGTACAGTACATTCAGGACATCATTTTGCCCACACCATC TGTTTTTGAAGAGAATTTTCTTTCTACTCTTACGTCTTTTATTTTCTTCAACAAAGTTGAGATAGTCAGCATGTTGCAGGAAGATGAGAA GTTTTTGTCTGAAGTTTTTGCACAATTAACAGATGAGGCTACAGATGATGATAAACGGCGTGAATTGGTTAATTTTTTCAAGGAGTTTTG TGCATTTTCTCAGACATTACAACCTCAAAACAGGGATGCATTTTTCAAAACATTGGCAAAATTGGGAATTCTTCCTGCTCTTGAAATTGT AATGGGCATGGATGATTTGCAAGTCAGATCAGCTGCTACAGATATATTTTCTTATCTAGTAGAATTTAGTCCATCTATGGTCCGAGAGTT TGTAATGCAAGAAGCTCAGCAGAGTGATGACGATATTCTTCTTATTAATGTGGTAATTGAACAAATGATCTGTGATACTGATCCTGAGCT AGGAGGCGCTGTTCAGTTAATGGGACTTCTTCGTACTCTAATTGATCCAGAGAACATGCTGGCTACAACTAATAAAACCGAAAAAAGTGA ATTTCTAAATTTTTTCTACAACCATTGTATGCATGTTCTCACAGCACCACTTTTGACCAATACTTCAGAAGACAAATGTGAAAAGGATAA TATAGTTGGATCAAACAAAAACAACACAATTTGTCCCGGTCATAGCTCCTTGGAATCACCAACAAACATGCCTTCTCCTTCTCCTGATTA TTTTACATGGAATCTCACCTGGATAATGAAAGACTCCTTCCCTTTCCTGTCTCATCGCAGCCGATATGGTAAAGAGCGCAGCCCAGCTGC CCCACCACCTCTGCCTACCACCTCCTCTGGCAAGGCTGCAAAGAAACCCACAGCTGCAGAGATCTCTGTTCGAGTCCCTAGAGGGCCGGC CGTGGAAGGGGGACACGTGAATATGGCATTCTCTCAGTCCAACCCTCCTTCGGAGTTGCACAAGGTCCACGGATCCAGAAACAAGCCCAC CAGCTTGTGGAACCCAACGTACGGCTCCTGGTTTACAGAGAAACCCACCAAAAAGAATAATCCTATAGCAAAGAAGGAGCCACACGACAG GGGTAACCTGGGGCTGGAGGGAAGCTGTACTGTCCCACCTAACGTTGCAACTGGGAGACTTCCGGGGGCCTCACTGCTCCTAGAGCCCTC TTCGCTGACTGCCAATATGAAGGAGGTACCTCTGTTCAGGCTACGTCACTTCCCTTGTGGGAATGTCAATTACGGCTACCAGCAACAGGG CTTGCCCTTAGAAGCCGCTACTGCCCCTGGAGCTGGTCATTACGAGGATACCATTCTGAAAAGCAAGAATAGCATGAACCAGCCTGGGCC >In-frame_SMEK2_ENST00000407823_chr2_55804451_-_ALK_ENST00000389048_chr2_29940563_-_6493nt GGAAGAGAAAGGCAGAGAGAGTCGGGTTACAAGATGGCGGATCTGTAGTAGTTACCGCGGCGGCGGGAGAGCAAGCGAGCCCTGGGGGGC AAAGAGACGGGAGAGTGGGTGTATGCGCGGGTGAAGTGAGAGGTAACGGGGCTCCGGGCGGAGAGGCCTCAGTGGCTCTTGTCACCCCTT CTCGCGGCTGAACCTTTGGAGCCATGGTGAATTCGGGCCTCTCCGAAGCCGCCGCCGCCGCCACCGCCACTACTGCCTTTACCGTCTCCT AAGAGTGAGGAGCGCGGACGAGGTAAGCGAGGAGGCGGCGGCTAGAGCGGTGGAGACAGCAGCCACCATGTCGGATACGCGGCGGCGAGT GAAGGTCTATACCCTGAACGAAGACCGGCAATGGGACGACCGAGGCACCGGGCACGTCTCCTCCACTTACGTGGAGGAGCTCAAGGGGAT GTCGCTGCTGGTTCGGGCAGAGTCCGACGGATCACTACTCTTGGAATCAAAGATAAATCCAAATACTGCATATCAGAAACAACAGGATAC ATTAATTGTTTGGTCAGAAGCAGAGAACTATGATTTGGCTCTGAGTTTTCAGGAGAAAGCTGGCTGTGATGAGATCTGGGAAAAAATTTG TCAGGTTCAAGGTAAAGACCCATCAGTGGAAGTCACACAGGACCTCATTGATGAATCTGAAGAAGAACGATTTGAAGAAATGCCTGAAAC TAGTCATCTGATTGACCTGCCCACATGTGAACTCAATAAACTTGAAGAGATTGCTGACTTAGTTACCTCAGTGCTCTCCTCACCTATCCG TAGGGAAAAGCTGGCTCTCGCCTTGGAAAATGAAGGCTATATTAAAAAACTATTGCAGCTGTTCCAAGCTTGCGAGAACCTAGAAAACAC TGAAGGCTTACACCATTTGTATGAAATTATTAGAGGAATCTTATTCCTAAATAAGGCAACTCTTTTTGAGGTAATGTTTTCTGATGAGTG TATCATGGATGTCGTGGGATGCCTTGAATATGACCCTGCTTTGGCTCAGCCAAAAAGACATAGAGAATTCTTGACCAAAACTGCAAAGTT CAAGGAAGTTATACCAATAACAGACTCTGAACTAAGGCAAAAAATACATCAGACTTACAGGGTACAGTACATTCAGGACATCATTTTGCC CACACCATCTGTTTTTGAAGAGAATTTTCTTTCTACTCTTACGTCTTTTATTTTCTTCAACAAAGTTGAGATAGTCAGCATGTTGCAGGA AGATGAGAAGTTTTTGTCTGAAGTTTTTGCACAATTAACAGATGAGGCTACAGATGATGATAAACGGCGTGAATTGGTTAATTTTTTCAA GGAGTTTTGTGCATTTTCTCAGACATTACAACCTCAAAACAGGGATGCATTTTTCAAAACATTGGCAAAATTGGGAATTCTTCCTGCTCT TGAAATTGTAATGGGCATGGATGATTTGCAAGTCAGATCAGCTGCTACAGATATATTTTCTTATCTAGTAGAATTTAGTCCATCTATGGT CCGAGAGTTTGTAATGCAAGAAGCTCAGCAGAGTGATGACGATATTCTTCTTATTAATGTGGTAATTGAACAAATGATCTGTGATACTGA TCCTGAGCTAGGAGGCGCTGTTCAGTTAATGGGACTTCTTCGTACTCTAATTGATCCAGAGAACATGCTGGCTACAACTAATAAAACCGA AAAAAGTGAATTTCTAAATTTTTTCTACAACCATTGTATGCATGTTCTCACAGCACCACTTTTGACCAATACTTCAGAAGACAAATGTGA AAAGGATAATATAGTTGGATCAAACAAAAACAACACAATTTGTCCCGGTCATAGCTCCTTGGAATCACCAACAAACATGCCTTCTCCTTC TCCTGATTATTTTACATGGAATCTCACCTGGATAATGAAAGACTCCTTCCCTTTCCTGTCTCATCGCAGCCGATATGGTCTGGAGTGCAG CTTTGACTTCCCCTGTGAGCTGGAGTATTCCCCTCCACTGCATGACCTCAGGAACCAGAGCTGGTCCTGGCGCCGCATCCCCTCCGAGGA GGCCTCCCAGATGGACTTGCTGGATGGGCCTGGGGCAGAGCGTTCTAAGGAGATGCCCAGAGGCTCCTTTCTCCTTCTCAACACCTCAGC TGACTCCAAGCACACCATCCTGAGTCCGTGGATGAGGAGCAGCAGTGAGCACTGCACACTGGCCGTCTCGGTGCACAGGCACCTGCAGCC CTCTGGAAGGTACATTGCCCAGCTGCTGCCCCACAACGAGGCTGCAAGAGAGATCCTCCTGATGCCCACTCCAGGGAAGCATGGTTGGAC AGTGCTCCAGGGAAGAATCGGGCGTCCAGACAACCCATTTCGAGTGGCCCTGGAATACATCTCCAGTGGAAACCGCAGCTTGTCTGCAGT GGACTTCTTTGCCCTGAAGAACTGCAGTGAAGGAACATCCCCAGGCTCCAAGATGGCCCTGCAGAGCTCCTTCACTTGTTGGAATGGGAC AGTCCTCCAGCTTGGGCAGGCCTGTGACTTCCACCAGGACTGTGCCCAGGGAGAAGATGAGAGCCAGATGTGCCGGAAACTGCCTGTGGG TTTTTACTGCAACTTTGAAGATGGCTTCTGTGGCTGGACCCAAGGCACACTGTCACCCCACACTCCTCAATGGCAGGTCAGGACCCTAAA GGATGCCCGGTTCCAGGACCACCAAGACCATGCTCTATTGCTCAGTACCACTGATGTCCCCGCTTCTGAAAGTGCTACAGTGACCAGTGC TACGTTTCCTGCACCGATCAAGAGCTCTCCATGTGAGCTCCGAATGTCCTGGCTCATTCGTGGAGTCTTGAGGGGAAACGTGTCCTTGGT GCTAGTGGAGAACAAAACCGGGAAGGAGCAAGGCAGGATGGTCTGGCATGTCGCCGCCTATGAAGGCTTGAGCCTGTGGCAGTGGATGGT GTTGCCTCTCCTCGATGTGTCTGACAGGTTCTGGCTGCAGATGGTCGCATGGTGGGGACAAGGATCCAGAGCCATCGTGGCTTTTGACAA TATCTCCATCAGCCTGGACTGCTACCTCACCATTAGCGGAGAGGACAAGATCCTGCAGAATACAGCACCCAAATCAAGAAACCTGTTTGA GAGAAACCCAAACAAGGAGCTGAAACCCGGGGAAAATTCACCAAGACAGACCCCCATCTTTGACCCTACAGTTCATTGGCTGTTCACCAC ATGTGGGGCCAGCGGGCCCCATGGCCCCACCCAGGCACAGTGCAACAACGCCTACCAGAACTCCAACCTGAGCGTGGAGGTGGGGAGCGA GGGCCCCCTGAAAGGCATCCAGATCTGGAAGGTGCCAGCCACCGACACCTACAGCATCTCGGGCTACGGAGCTGCTGGCGGGAAAGGCGG GAAGAACACCATGATGCGGTCCCACGGCGTGTCTGTGCTGGGCATCTTCAACCTGGAGAAGGATGACATGCTGTACATCCTGGTTGGGCA GCAGGGAGAGGACGCCTGCCCCAGTACAAACCAGTTAATCCAGAAAGTCTGCATTGGAGAGAACAATGTGATAGAAGAAGAAATCCGTGT GAACAGAAGCGTGCATGAGTGGGCAGGAGGCGGAGGAGGAGGGGGTGGAGCCACCTACGTATTTAAGATGAAGGATGGAGTGCCGGTGCC CCTGATCATTGCAGCCGGAGGTGGTGGCAGGGCCTACGGGGCCAAGACAGACACGTTCCACCCAGAGAGACTGGAGAATAACTCCTCGGT TCTAGGGCTAAACGGCAATTCCGGAGCCGCAGGTGGTGGAGGTGGCTGGAATGATAACACTTCCTTGCTCTGGGCCGGAAAATCTTTGCA GGAGGGTGCCACCGGAGGACATTCCTGCCCCCAGGCCATGAAGAAGTGGGGGTGGGAGACAAGAGGGGGTTTCGGAGGGGGTGGAGGGGG GTGCTCCTCAGGTGGAGGAGGCGGAGGATATATAGGCGGCAATGCAGCCTCAAACAATGACCCCGAAATGGATGGGGAAGATGGGGTTTC CTTCATCAGTCCACTGGGCATCCTGTACACCCCAGCTTTAAAAGTGATGGAAGGCCACGGGGAAGTGAATATTAAGCATTATCTAAACTG CAGTCACTGTGAGGTAGACGAATGTCACATGGACCCTGAAAGCCACAAGGTCATCTGCTTCTGTGACCACGGGACGGTGCTGGCTGAGGA TGGCGTCTCCTGCATTGTGTCACCCACCCCGGAGCCACACCTGCCACTCTCGCTGATCCTCTCTGTGGTGACCTCTGCCCTCGTGGCCGC CCTGGTCCTGGCTTTCTCCGGCATCATGATTGTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGCAGATGGAGCTGCAGAGCCCTGA GTACAAGCTGAGCAAGCTCCGCACCTCGACCATCATGACCGACTACAACCCCAACTACTGCTTTGCTGGCAAGACCTCCTCCATCAGTGA CCTGAAGGAGGTGCCGCGGAAAAACATCACCCTCATTCGGGGTCTGGGCCATGGCGCCTTTGGGGAGGTGTATGAAGGCCAGGTGTCCGG AATGCCCAACGACCCAAGCCCCCTGCAAGTGGCTGTGAAGACGCTGCCTGAAGTGTGCTCTGAACAGGACGAACTGGATTTCCTCATGGA AGCCCTGATCATCAGCAAATTCAACCACCAGAACATTGTTCGCTGCATTGGGGTGAGCCTGCAATCCCTGCCCCGGTTCATCCTGCTGGA GCTCATGGCGGGGGGAGACCTCAAGTCCTTCCTCCGAGAGACCCGCCCTCGCCCGAGCCAGCCCTCCTCCCTGGCCATGCTGGACCTTCT GCACGTGGCTCGGGACATTGCCTGTGGCTGTCAGTATTTGGAGGAAAACCACTTCATCCACCGAGACATTGCTGCCAGAAACTGCCTCTT GACCTGTCCAGGCCCTGGAAGAGTGGCCAAGATTGGAGACTTCGGGATGGCCCGAGACATCTACAGGGCGAGCTACTATAGAAAGGGAGG CTGTGCCATGCTGCCAGTTAAGTGGATGCCCCCAGAGGCCTTCATGGAAGGAATATTCACTTCTAAAACAGACACATGGTCCTTTGGAGT GCTGCTATGGGAAATCTTTTCTCTTGGATATATGCCATACCCCAGCAAAAGCAACCAGGAAGTTCTGGAGTTTGTCACCAGTGGAGGCCG GATGGACCCACCCAAGAACTGCCCTGGGCCTGTATACCGGATAATGACTCAGTGCTGGCAACATCAGCCTGAAGACAGGCCCAACTTTGC CATCATTTTGGAGAGGATTGAATACTGCACCCAGGACCCGGATGTAATCAACACCGCTTTGCCGATAGAATATGGTCCACTTGTGGAAGA GGAAGAGAAAGTGCCTGTGAGGCCCAAGGACCCTGAGGGGGTTCCTCCTCTCCTGGTCTCTCAACAGGCAAAACGGGAGGAGGAGCGCAG CCCAGCTGCCCCACCACCTCTGCCTACCACCTCCTCTGGCAAGGCTGCAAAGAAACCCACAGCTGCAGAGATCTCTGTTCGAGTCCCTAG AGGGCCGGCCGTGGAAGGGGGACACGTGAATATGGCATTCTCTCAGTCCAACCCTCCTTCGGAGTTGCACAAGGTCCACGGATCCAGAAA CAAGCCCACCAGCTTGTGGAACCCAACGTACGGCTCCTGGTTTACAGAGAAACCCACCAAAAAGAATAATCCTATAGCAAAGAAGGAGCC ACACGACAGGGGTAACCTGGGGCTGGAGGGAAGCTGTACTGTCCCACCTAACGTTGCAACTGGGAGACTTCCGGGGGCCTCACTGCTCCT AGAGCCCTCTTCGCTGACTGCCAATATGAAGGAGGTACCTCTGTTCAGGCTACGTCACTTCCCTTGTGGGAATGTCAATTACGGCTACCA GCAACAGGGCTTGCCCTTAGAAGCCGCTACTGCCCCTGGAGCTGGTCATTACGAGGATACCATTCTGAAAAGCAAGAATAGCATGAACCA GCCTGGGCCCTGAGCTCGGTCGCACACTCACTTCTCTTCCTTGGGATCCCTAAGACCGTGGAGGAGAGAGAGGCAATGGCTCCTTCACAA ACCAGAGACCAAATGTCACGTTTTGTTTTGTGCCAACCTATTTTGAAGTACCACCAAAAAAGCTGTATTTTGAAAATGCTTTAGAAAGGT TTTGAGCATGGGTTCATCCTATTCTTTCGAAAGAAGAAAATATCATAAAAATGAGTGATAAATACAAGGCCCAGATGTGGTTGCATAAGG TTTTTATGCATGTTTGTTGTATACTTCCTTATGCTTCTTTCAAATTGTGTGTGCTCTGCTTCAATGTAGTCAGAATTAGCTGCTTCTATG TTTCATAGTTGGGGTCATAGATGTTTCCTTGCCTTGTTGATGTGGACATGAGCCATTTGAGGGGAGAGGGAACGGAAATAAAGGAGTTAT >In-frame_SMEK2_ENST00000407823_chr2_55804451_-_ALK_ENST00000431873_chr2_29940563_-_2533nt GGAAGAGAAAGGCAGAGAGAGTCGGGTTACAAGATGGCGGATCTGTAGTAGTTACCGCGGCGGCGGGAGAGCAAGCGAGCCCTGGGGGGC AAAGAGACGGGAGAGTGGGTGTATGCGCGGGTGAAGTGAGAGGTAACGGGGCTCCGGGCGGAGAGGCCTCAGTGGCTCTTGTCACCCCTT CTCGCGGCTGAACCTTTGGAGCCATGGTGAATTCGGGCCTCTCCGAAGCCGCCGCCGCCGCCACCGCCACTACTGCCTTTACCGTCTCCT AAGAGTGAGGAGCGCGGACGAGGTAAGCGAGGAGGCGGCGGCTAGAGCGGTGGAGACAGCAGCCACCATGTCGGATACGCGGCGGCGAGT GAAGGTCTATACCCTGAACGAAGACCGGCAATGGGACGACCGAGGCACCGGGCACGTCTCCTCCACTTACGTGGAGGAGCTCAAGGGGAT GTCGCTGCTGGTTCGGGCAGAGTCCGACGGATCACTACTCTTGGAATCAAAGATAAATCCAAATACTGCATATCAGAAACAACAGGATAC ATTAATTGTTTGGTCAGAAGCAGAGAACTATGATTTGGCTCTGAGTTTTCAGGAGAAAGCTGGCTGTGATGAGATCTGGGAAAAAATTTG TCAGGTTCAAGGTAAAGACCCATCAGTGGAAGTCACACAGGACCTCATTGATGAATCTGAAGAAGAACGATTTGAAGAAATGCCTGAAAC TAGTCATCTGATTGACCTGCCCACATGTGAACTCAATAAACTTGAAGAGATTGCTGACTTAGTTACCTCAGTGCTCTCCTCACCTATCCG TAGGGAAAAGCTGGCTCTCGCCTTGGAAAATGAAGGCTATATTAAAAAACTATTGCAGCTGTTCCAAGCTTGCGAGAACCTAGAAAACAC TGAAGGCTTACACCATTTGTATGAAATTATTAGAGGAATCTTATTCCTAAATAAGGCAACTCTTTTTGAGGTAATGTTTTCTGATGAGTG TATCATGGATGTCGTGGGATGCCTTGAATATGACCCTGCTTTGGCTCAGCCAAAAAGACATAGAGAATTCTTGACCAAAACTGCAAAGTT CAAGGAAGTTATACCAATAACAGACTCTGAACTAAGGCAAAAAATACATCAGACTTACAGGGTACAGTACATTCAGGACATCATTTTGCC CACACCATCTGTTTTTGAAGAGAATTTTCTTTCTACTCTTACGTCTTTTATTTTCTTCAACAAAGTTGAGATAGTCAGCATGTTGCAGGA AGATGAGAAGTTTTTGTCTGAAGTTTTTGCACAATTAACAGATGAGGCTACAGATGATGATAAACGGCGTGAATTGGTTAATTTTTTCAA GGAGTTTTGTGCATTTTCTCAGACATTACAACCTCAAAACAGGGATGCATTTTTCAAAACATTGGCAAAATTGGGAATTCTTCCTGCTCT TGAAATTGTAATGGGCATGGATGATTTGCAAGTCAGATCAGCTGCTACAGATATATTTTCTTATCTAGTAGAATTTAGTCCATCTATGGT CCGAGAGTTTGTAATGCAAGAAGCTCAGCAGAGTGATGACGATATTCTTCTTATTAATGTGGTAATTGAACAAATGATCTGTGATACTGA TCCTGAGCTAGGAGGCGCTGTTCAGTTAATGGGACTTCTTCGTACTCTAATTGATCCAGAGAACATGCTGGCTACAACTAATAAAACCGA AAAAAGTGAATTTCTAAATTTTTTCTACAACCATTGTATGCATGTTCTCACAGCACCACTTTTGACCAATACTTCAGAAGACAAATGTGA AAAGGATAATATAGTTGGATCAAACAAAAACAACACAATTTGTCCCGGTCATAGCTCCTTGGAATCACCAACAAACATGCCTTCTCCTTC TCCTGATTATTTTACATGGAATCTCACCTGGATAATGAAAGACTCCTTCCCTTTCCTGTCTCATCGCAGCCGATATGGTAAAGAGCGCAG CCCAGCTGCCCCACCACCTCTGCCTACCACCTCCTCTGGCAAGGCTGCAAAGAAACCCACAGCTGCAGAGATCTCTGTTCGAGTCCCTAG AGGGCCGGCCGTGGAAGGGGGACACGTGAATATGGCATTCTCTCAGTCCAACCCTCCTTCGGAGTTGCACAAGGTCCACGGATCCAGAAA CAAGCCCACCAGCTTGTGGAACCCAACGTACGGCTCCTGGTTTACAGAGAAACCCACCAAAAAGAATAATCCTATAGCAAAGAAGGAGCC ACACGACAGGGGTAACCTGGGGCTGGAGGGAAGCTGTACTGTCCCACCTAACGTTGCAACTGGGAGACTTCCGGGGGCCTCACTGCTCCT AGAGCCCTCTTCGCTGACTGCCAATATGAAGGAGGTACCTCTGTTCAGGCTACGTCACTTCCCTTGTGGGAATGTCAATTACGGCTACCA GCAACAGGGCTTGCCCTTAGAAGCCGCTACTGCCCCTGGAGCTGGTCATTACGAGGATACCATTCTGAAAAGCAAGAATAGCATGAACCA >In-frame_SMEK2_ENST00000345102_chr2_55804451_-_ALK_ENST00000389048_chr2_29940563_-_6554nt GGCGGATCTGTAGTAGTTACCGCGGCGGCGGGAGAGCAAGCGAGCCCTGGGGGGCAAAGAGACGGGAGAGTGGGTGTATGCGCGGGTGAA GTGAGAGGTAACGGGGCTCCGGGCGGAGAGGCCTCAGTGGCTCTTGTCACCCCTTCTCGCGGCTGAACCTTTGGAGCCATGGTGAATTCG GGCCTCTCCGAAGCCGCCGCCGCCGCCACCGCCACTACTGCCTTTACCGTCTCCTAAGAGTGAGGAGCGCGGACGAGGTAAGCGAGGAGG CGGCGGCTAGAGCGGTGGAGACAGCAGCCACCATGTCGGATACGCGGCGGCGAGTGAAGGTCTATACCCTGAACGAAGACCGGCAATGGG ACGACCGAGGCACCGGGCACGTCTCCTCCACTTACGTGGAGGAGCTCAAGGGGATGTCGCTGCTGGTTCGGGCAGAGTCCGACGGATCAC TACTCTTGGAATCAAAGATAAATCCAAATACTGCATATCAGAAACAACAGGATACATTAATTGTTTGGTCAGAAGCAGAGAACTATGATT TGGCTCTGAGTTTTCAGGAGAAAGCTGGCTGTGATGAGATCTGGGAAAAAATTTGTCAGGTTCAAGGTAAAGACCCATCAGTGGAAGTCA CACAGGACCTCATTGATGAATCTGAAGAAGAACGATTTGAAGAAATGCCTGAAACTAGTCATCTGATTGACCTGCCCACATGTGAACTCA ATAAACTTGAAGAGATTGCTGACTTAGTTACCTCAGTGCTCTCCTCACCTATCCGTAGGGAAAAGCTGGCTCTCGCCTTGGAAAATGAAG GCTATATTAAAAAACTATTGCAGCTGTTCCAAGCTTGCGAGAACCTAGAAAACACTGAAGGCTTACACCATTTGTATGAAATTATTAGAG GAATCTTATTCCTAAATAAGGCAACTCTTTTTGAGGTAATGTTTTCTGATGAGTGTATCATGGATGTCGTGGGATGCCTTGAATATGACC CTGCTTTGGCTCAGCCAAAAAGACATAGAGAATTCTTGACCAAAACTGCAAAGTTCAAGGAAGTTATACCAATAACAGACTCTGAACTAA GGCAAAAAATACATCAGACTTACAGGGTACAGTACATTCAGGACATCATTTTGCCCACACCATCTGTTTTTGAAGAGAATTTTCTTTCTA CTCTTACGTCTTTTATTTTCTTCAACAAAGTTGAGATAGTCAGCATGTTGCAGGAAGATGAGAAGTTTTTGTCTGAAGTTTTTGCACAAT TAACAGATGAGGCTACAGATGATGATAAACGGCGTGAATTGGTTAATTTTTTCAAGGAGTTTTGTGCATTTTCTCAGACATTACAACCTC AAAACAGGGATGCATTTTTCAAAACATTGGCAAAATTGGGAATTCTTCCTGCTCTTGAAATTGTAATGGGCATGGATGATTTGCAAGTCA GATCAGCTGCTACAGATATATTTTCTTATCTAGTAGAATTTAGTCCATCTATGGTCCGAGAGTTTGTAATGCAAGAAGCTCAGCAGAGTG ATGACGATATTCTTCTTATTAATGTGGTAATTGAACAAATGATCTGTGATACTGATCCTGAGCTAGGAGGCGCTGTTCAGTTAATGGGAC TTCTTCGTACTCTAATTGATCCAGAGAACATGCTGGCTACAACTAATAAAACCGAAAAAAGTGAATTTCTAAATTTTTTCTACAACCATT GTATGCATGTTCTCACAGCACCACTTTTGACCAATACTTCAGAAGACAAATGTGAAAAGGATTTTTTTTTAAAACATTACAGATATAGTT GGAGTTTCATATGTACCCCTTCACATTCCCATTCCCATTCTACCCCCTCTTCCTCCATCTCTCAAGATAATATAGTTGGATCAAACAAAA ACAACACAATTTGTCCCGGTCATAGCTCCTTGGAATCACCAACAAACATGCCTTCTCCTTCTCCTGATTATTTTACATGGAATCTCACCT GGATAATGAAAGACTCCTTCCCTTTCCTGTCTCATCGCAGCCGATATGGTCTGGAGTGCAGCTTTGACTTCCCCTGTGAGCTGGAGTATT CCCCTCCACTGCATGACCTCAGGAACCAGAGCTGGTCCTGGCGCCGCATCCCCTCCGAGGAGGCCTCCCAGATGGACTTGCTGGATGGGC CTGGGGCAGAGCGTTCTAAGGAGATGCCCAGAGGCTCCTTTCTCCTTCTCAACACCTCAGCTGACTCCAAGCACACCATCCTGAGTCCGT GGATGAGGAGCAGCAGTGAGCACTGCACACTGGCCGTCTCGGTGCACAGGCACCTGCAGCCCTCTGGAAGGTACATTGCCCAGCTGCTGC CCCACAACGAGGCTGCAAGAGAGATCCTCCTGATGCCCACTCCAGGGAAGCATGGTTGGACAGTGCTCCAGGGAAGAATCGGGCGTCCAG ACAACCCATTTCGAGTGGCCCTGGAATACATCTCCAGTGGAAACCGCAGCTTGTCTGCAGTGGACTTCTTTGCCCTGAAGAACTGCAGTG AAGGAACATCCCCAGGCTCCAAGATGGCCCTGCAGAGCTCCTTCACTTGTTGGAATGGGACAGTCCTCCAGCTTGGGCAGGCCTGTGACT TCCACCAGGACTGTGCCCAGGGAGAAGATGAGAGCCAGATGTGCCGGAAACTGCCTGTGGGTTTTTACTGCAACTTTGAAGATGGCTTCT GTGGCTGGACCCAAGGCACACTGTCACCCCACACTCCTCAATGGCAGGTCAGGACCCTAAAGGATGCCCGGTTCCAGGACCACCAAGACC ATGCTCTATTGCTCAGTACCACTGATGTCCCCGCTTCTGAAAGTGCTACAGTGACCAGTGCTACGTTTCCTGCACCGATCAAGAGCTCTC CATGTGAGCTCCGAATGTCCTGGCTCATTCGTGGAGTCTTGAGGGGAAACGTGTCCTTGGTGCTAGTGGAGAACAAAACCGGGAAGGAGC AAGGCAGGATGGTCTGGCATGTCGCCGCCTATGAAGGCTTGAGCCTGTGGCAGTGGATGGTGTTGCCTCTCCTCGATGTGTCTGACAGGT TCTGGCTGCAGATGGTCGCATGGTGGGGACAAGGATCCAGAGCCATCGTGGCTTTTGACAATATCTCCATCAGCCTGGACTGCTACCTCA CCATTAGCGGAGAGGACAAGATCCTGCAGAATACAGCACCCAAATCAAGAAACCTGTTTGAGAGAAACCCAAACAAGGAGCTGAAACCCG GGGAAAATTCACCAAGACAGACCCCCATCTTTGACCCTACAGTTCATTGGCTGTTCACCACATGTGGGGCCAGCGGGCCCCATGGCCCCA CCCAGGCACAGTGCAACAACGCCTACCAGAACTCCAACCTGAGCGTGGAGGTGGGGAGCGAGGGCCCCCTGAAAGGCATCCAGATCTGGA AGGTGCCAGCCACCGACACCTACAGCATCTCGGGCTACGGAGCTGCTGGCGGGAAAGGCGGGAAGAACACCATGATGCGGTCCCACGGCG TGTCTGTGCTGGGCATCTTCAACCTGGAGAAGGATGACATGCTGTACATCCTGGTTGGGCAGCAGGGAGAGGACGCCTGCCCCAGTACAA ACCAGTTAATCCAGAAAGTCTGCATTGGAGAGAACAATGTGATAGAAGAAGAAATCCGTGTGAACAGAAGCGTGCATGAGTGGGCAGGAG GCGGAGGAGGAGGGGGTGGAGCCACCTACGTATTTAAGATGAAGGATGGAGTGCCGGTGCCCCTGATCATTGCAGCCGGAGGTGGTGGCA GGGCCTACGGGGCCAAGACAGACACGTTCCACCCAGAGAGACTGGAGAATAACTCCTCGGTTCTAGGGCTAAACGGCAATTCCGGAGCCG CAGGTGGTGGAGGTGGCTGGAATGATAACACTTCCTTGCTCTGGGCCGGAAAATCTTTGCAGGAGGGTGCCACCGGAGGACATTCCTGCC CCCAGGCCATGAAGAAGTGGGGGTGGGAGACAAGAGGGGGTTTCGGAGGGGGTGGAGGGGGGTGCTCCTCAGGTGGAGGAGGCGGAGGAT ATATAGGCGGCAATGCAGCCTCAAACAATGACCCCGAAATGGATGGGGAAGATGGGGTTTCCTTCATCAGTCCACTGGGCATCCTGTACA CCCCAGCTTTAAAAGTGATGGAAGGCCACGGGGAAGTGAATATTAAGCATTATCTAAACTGCAGTCACTGTGAGGTAGACGAATGTCACA TGGACCCTGAAAGCCACAAGGTCATCTGCTTCTGTGACCACGGGACGGTGCTGGCTGAGGATGGCGTCTCCTGCATTGTGTCACCCACCC CGGAGCCACACCTGCCACTCTCGCTGATCCTCTCTGTGGTGACCTCTGCCCTCGTGGCCGCCCTGGTCCTGGCTTTCTCCGGCATCATGA TTGTGTACCGCCGGAAGCACCAGGAGCTGCAAGCCATGCAGATGGAGCTGCAGAGCCCTGAGTACAAGCTGAGCAAGCTCCGCACCTCGA CCATCATGACCGACTACAACCCCAACTACTGCTTTGCTGGCAAGACCTCCTCCATCAGTGACCTGAAGGAGGTGCCGCGGAAAAACATCA CCCTCATTCGGGGTCTGGGCCATGGCGCCTTTGGGGAGGTGTATGAAGGCCAGGTGTCCGGAATGCCCAACGACCCAAGCCCCCTGCAAG TGGCTGTGAAGACGCTGCCTGAAGTGTGCTCTGAACAGGACGAACTGGATTTCCTCATGGAAGCCCTGATCATCAGCAAATTCAACCACC AGAACATTGTTCGCTGCATTGGGGTGAGCCTGCAATCCCTGCCCCGGTTCATCCTGCTGGAGCTCATGGCGGGGGGAGACCTCAAGTCCT TCCTCCGAGAGACCCGCCCTCGCCCGAGCCAGCCCTCCTCCCTGGCCATGCTGGACCTTCTGCACGTGGCTCGGGACATTGCCTGTGGCT GTCAGTATTTGGAGGAAAACCACTTCATCCACCGAGACATTGCTGCCAGAAACTGCCTCTTGACCTGTCCAGGCCCTGGAAGAGTGGCCA AGATTGGAGACTTCGGGATGGCCCGAGACATCTACAGGGCGAGCTACTATAGAAAGGGAGGCTGTGCCATGCTGCCAGTTAAGTGGATGC CCCCAGAGGCCTTCATGGAAGGAATATTCACTTCTAAAACAGACACATGGTCCTTTGGAGTGCTGCTATGGGAAATCTTTTCTCTTGGAT ATATGCCATACCCCAGCAAAAGCAACCAGGAAGTTCTGGAGTTTGTCACCAGTGGAGGCCGGATGGACCCACCCAAGAACTGCCCTGGGC CTGTATACCGGATAATGACTCAGTGCTGGCAACATCAGCCTGAAGACAGGCCCAACTTTGCCATCATTTTGGAGAGGATTGAATACTGCA CCCAGGACCCGGATGTAATCAACACCGCTTTGCCGATAGAATATGGTCCACTTGTGGAAGAGGAAGAGAAAGTGCCTGTGAGGCCCAAGG ACCCTGAGGGGGTTCCTCCTCTCCTGGTCTCTCAACAGGCAAAACGGGAGGAGGAGCGCAGCCCAGCTGCCCCACCACCTCTGCCTACCA CCTCCTCTGGCAAGGCTGCAAAGAAACCCACAGCTGCAGAGATCTCTGTTCGAGTCCCTAGAGGGCCGGCCGTGGAAGGGGGACACGTGA ATATGGCATTCTCTCAGTCCAACCCTCCTTCGGAGTTGCACAAGGTCCACGGATCCAGAAACAAGCCCACCAGCTTGTGGAACCCAACGT ACGGCTCCTGGTTTACAGAGAAACCCACCAAAAAGAATAATCCTATAGCAAAGAAGGAGCCACACGACAGGGGTAACCTGGGGCTGGAGG GAAGCTGTACTGTCCCACCTAACGTTGCAACTGGGAGACTTCCGGGGGCCTCACTGCTCCTAGAGCCCTCTTCGCTGACTGCCAATATGA AGGAGGTACCTCTGTTCAGGCTACGTCACTTCCCTTGTGGGAATGTCAATTACGGCTACCAGCAACAGGGCTTGCCCTTAGAAGCCGCTA CTGCCCCTGGAGCTGGTCATTACGAGGATACCATTCTGAAAAGCAAGAATAGCATGAACCAGCCTGGGCCCTGAGCTCGGTCGCACACTC ACTTCTCTTCCTTGGGATCCCTAAGACCGTGGAGGAGAGAGAGGCAATGGCTCCTTCACAAACCAGAGACCAAATGTCACGTTTTGTTTT GTGCCAACCTATTTTGAAGTACCACCAAAAAAGCTGTATTTTGAAAATGCTTTAGAAAGGTTTTGAGCATGGGTTCATCCTATTCTTTCG AAAGAAGAAAATATCATAAAAATGAGTGATAAATACAAGGCCCAGATGTGGTTGCATAAGGTTTTTATGCATGTTTGTTGTATACTTCCT TATGCTTCTTTCAAATTGTGTGTGCTCTGCTTCAATGTAGTCAGAATTAGCTGCTTCTATGTTTCATAGTTGGGGTCATAGATGTTTCCT >In-frame_SMEK2_ENST00000345102_chr2_55804451_-_ALK_ENST00000431873_chr2_29940563_-_2594nt GGCGGATCTGTAGTAGTTACCGCGGCGGCGGGAGAGCAAGCGAGCCCTGGGGGGCAAAGAGACGGGAGAGTGGGTGTATGCGCGGGTGAA GTGAGAGGTAACGGGGCTCCGGGCGGAGAGGCCTCAGTGGCTCTTGTCACCCCTTCTCGCGGCTGAACCTTTGGAGCCATGGTGAATTCG GGCCTCTCCGAAGCCGCCGCCGCCGCCACCGCCACTACTGCCTTTACCGTCTCCTAAGAGTGAGGAGCGCGGACGAGGTAAGCGAGGAGG CGGCGGCTAGAGCGGTGGAGACAGCAGCCACCATGTCGGATACGCGGCGGCGAGTGAAGGTCTATACCCTGAACGAAGACCGGCAATGGG ACGACCGAGGCACCGGGCACGTCTCCTCCACTTACGTGGAGGAGCTCAAGGGGATGTCGCTGCTGGTTCGGGCAGAGTCCGACGGATCAC TACTCTTGGAATCAAAGATAAATCCAAATACTGCATATCAGAAACAACAGGATACATTAATTGTTTGGTCAGAAGCAGAGAACTATGATT TGGCTCTGAGTTTTCAGGAGAAAGCTGGCTGTGATGAGATCTGGGAAAAAATTTGTCAGGTTCAAGGTAAAGACCCATCAGTGGAAGTCA CACAGGACCTCATTGATGAATCTGAAGAAGAACGATTTGAAGAAATGCCTGAAACTAGTCATCTGATTGACCTGCCCACATGTGAACTCA ATAAACTTGAAGAGATTGCTGACTTAGTTACCTCAGTGCTCTCCTCACCTATCCGTAGGGAAAAGCTGGCTCTCGCCTTGGAAAATGAAG GCTATATTAAAAAACTATTGCAGCTGTTCCAAGCTTGCGAGAACCTAGAAAACACTGAAGGCTTACACCATTTGTATGAAATTATTAGAG GAATCTTATTCCTAAATAAGGCAACTCTTTTTGAGGTAATGTTTTCTGATGAGTGTATCATGGATGTCGTGGGATGCCTTGAATATGACC CTGCTTTGGCTCAGCCAAAAAGACATAGAGAATTCTTGACCAAAACTGCAAAGTTCAAGGAAGTTATACCAATAACAGACTCTGAACTAA GGCAAAAAATACATCAGACTTACAGGGTACAGTACATTCAGGACATCATTTTGCCCACACCATCTGTTTTTGAAGAGAATTTTCTTTCTA CTCTTACGTCTTTTATTTTCTTCAACAAAGTTGAGATAGTCAGCATGTTGCAGGAAGATGAGAAGTTTTTGTCTGAAGTTTTTGCACAAT TAACAGATGAGGCTACAGATGATGATAAACGGCGTGAATTGGTTAATTTTTTCAAGGAGTTTTGTGCATTTTCTCAGACATTACAACCTC AAAACAGGGATGCATTTTTCAAAACATTGGCAAAATTGGGAATTCTTCCTGCTCTTGAAATTGTAATGGGCATGGATGATTTGCAAGTCA GATCAGCTGCTACAGATATATTTTCTTATCTAGTAGAATTTAGTCCATCTATGGTCCGAGAGTTTGTAATGCAAGAAGCTCAGCAGAGTG ATGACGATATTCTTCTTATTAATGTGGTAATTGAACAAATGATCTGTGATACTGATCCTGAGCTAGGAGGCGCTGTTCAGTTAATGGGAC TTCTTCGTACTCTAATTGATCCAGAGAACATGCTGGCTACAACTAATAAAACCGAAAAAAGTGAATTTCTAAATTTTTTCTACAACCATT GTATGCATGTTCTCACAGCACCACTTTTGACCAATACTTCAGAAGACAAATGTGAAAAGGATTTTTTTTTAAAACATTACAGATATAGTT GGAGTTTCATATGTACCCCTTCACATTCCCATTCCCATTCTACCCCCTCTTCCTCCATCTCTCAAGATAATATAGTTGGATCAAACAAAA ACAACACAATTTGTCCCGGTCATAGCTCCTTGGAATCACCAACAAACATGCCTTCTCCTTCTCCTGATTATTTTACATGGAATCTCACCT GGATAATGAAAGACTCCTTCCCTTTCCTGTCTCATCGCAGCCGATATGGTAAAGAGCGCAGCCCAGCTGCCCCACCACCTCTGCCTACCA CCTCCTCTGGCAAGGCTGCAAAGAAACCCACAGCTGCAGAGATCTCTGTTCGAGTCCCTAGAGGGCCGGCCGTGGAAGGGGGACACGTGA ATATGGCATTCTCTCAGTCCAACCCTCCTTCGGAGTTGCACAAGGTCCACGGATCCAGAAACAAGCCCACCAGCTTGTGGAACCCAACGT ACGGCTCCTGGTTTACAGAGAAACCCACCAAAAAGAATAATCCTATAGCAAAGAAGGAGCCACACGACAGGGGTAACCTGGGGCTGGAGG GAAGCTGTACTGTCCCACCTAACGTTGCAACTGGGAGACTTCCGGGGGCCTCACTGCTCCTAGAGCCCTCTTCGCTGACTGCCAATATGA AGGAGGTACCTCTGTTCAGGCTACGTCACTTCCCTTGTGGGAATGTCAATTACGGCTACCAGCAACAGGGCTTGCCCTTAGAAGCCGCTA |
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FusionGenePPI for SMEK2_ALK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SMEK2 | PPP4C, FEZ1, PPP4R2, TRIM28, LACTB2, KYNU, CAPN1, CNDP2, NANS, RPL23, SLC9A3R1, DIAPH1, ECHS1, KIF5B, KLC1, KLC2, PTPN23, TGM2, YWHAQ, COMTD1, PNKD, PMPCB, ALDH3A2, HNRNPU, OSBPL8, GCK, NTRK1, HNRNPD, PPP2CB, BAG6, UBXN10, RNGTT, SMEK1, CRAMP1L, CCDC6, ZNF785, SPATA1, FAM19A3, BNIP3 | ALK | PTN, SHC1, PLCG1, JAK3, SHC3, RAB35, HSPD1, MAP3K4, GRB2, SOCS1, PIK3CB, RAD17, IRF7, EPHB2, EIF4B, MAPK8IP3, CENPF, PLCB2, PDX1, STAT3, MAP2K7, JAK2, MAP3K5, MEP1B, GAK, EPHA1, UBASH3A, MTIF2, MYLK, MAP3K1, MAPK1, SOCS5, CDK13, SMC6, IRS4, KRT18, KRT74, IRS1, IKBKG, ZC3HC1, TNK2, ERRFI1, PIK3R1, HSP90AA1, BCAR1, ACTB, PDLIM3, VIM, TUBB4B, MYO6, MYH10, MYH9, TUBGCP2, ACTN4, CORO1C, FLII, BICD2, GNB2L1, SRC, PXN, PRKCQ, MYBPC2, CDK9, PPM1A, DUSP19 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SMEK2_ALK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | ALK | Q9UM73 | DB08865 | Crizotinib | ALK tyrosine kinase receptor | small molecule | approved |
| Tgene | ALK | Q9UM73 | DB09063 | Ceritinib | ALK tyrosine kinase receptor | small molecule | approved |
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RelatedDiseases for SMEK2_ALK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ALK | C0007131 | Non-Small Cell Lung Carcinoma | 28 | CTD_human |
| Tgene | ALK | C0027819 | Neuroblastoma | 12 | CTD_human;ORPHANET |
| Tgene | ALK | C0152013 | Adenocarcinoma of lung (disorder) | 8 | CTD_human |
| Tgene | ALK | C0206180 | Ki-1+ Anaplastic Large Cell Lymphoma | 6 | CTD_human |
| Tgene | ALK | C2751681 | NEUROBLASTOMA, SUSCEPTIBILITY TO, 3 | 4 | UNIPROT |
| Tgene | ALK | C0018199 | Granuloma, Plasma Cell | 3 | CTD_human |
| Tgene | ALK | C0007621 | Neoplastic Cell Transformation | 2 | CTD_human |
| Tgene | ALK | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
| Tgene | ALK | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Tgene | ALK | C0006118 | Brain Neoplasms | 1 | CTD_human |
| Tgene | ALK | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
| Tgene | ALK | C0011570 | Mental Depression | 1 | PSYGENET |
| Tgene | ALK | C0011581 | Depressive disorder | 1 | PSYGENET |
| Tgene | ALK | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
| Tgene | ALK | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | ALK | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human |
| Tgene | ALK | C0085269 | Plasma Cell Granuloma, Pulmonary | 1 | CTD_human |
| Tgene | ALK | C0278601 | Inflammatory Breast Carcinoma | 1 | CTD_human |
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