![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 34875 |
FusionGeneSummary for SMCO4_CHODL |
![]() |
Fusion gene information | Fusion gene name: SMCO4_CHODL | Fusion gene ID: 34875 | Hgene | Tgene | Gene symbol | SMCO4 | CHODL | Gene ID | 56935 | 140578 |
Gene name | single-pass membrane protein with coiled-coil domains 4 | chondrolectin | |
Synonyms | C11orf75|FN5 | C21orf68|MT75|PRED12 | |
Cytomap | 11q21 | 21q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | single-pass membrane and coiled-coil domain-containing protein 4UPF0443 protein C11orf75 | chondrolectintransmembrane protein MT75 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9NRQ5 | Q9H9P2 | |
Ensembl transtripts involved in fusion gene | ENST00000525141, ENST00000298966, ENST00000527149, | ENST00000400128, ENST00000400131, ENST00000400135, ENST00000400127, ENST00000338326, ENST00000299295, ENST00000543733, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 5 X 4 X 4=80 |
# samples | 2 | 4 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(4/80*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SMCO4 [Title/Abstract] AND CHODL [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW511581 | SMCO4 | chr11 | 93211926 | + | CHODL | chr21 | 19437070 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000525141 | ENST00000400128 | SMCO4 | chr11 | 93211926 | + | CHODL | chr21 | 19437070 | + |
intron-intron | ENST00000525141 | ENST00000400131 | SMCO4 | chr11 | 93211926 | + | CHODL | chr21 | 19437070 | + |
intron-intron | ENST00000525141 | ENST00000400135 | SMCO4 | chr11 | 93211926 | + | CHODL | chr21 | 19437070 | + |
intron-intron | ENST00000525141 | ENST00000400127 | SMCO4 | chr11 | 93211926 | + | CHODL | chr21 | 19437070 | + |
intron-intron | ENST00000525141 | ENST00000338326 | SMCO4 | chr11 | 93211926 | + | CHODL | chr21 | 19437070 | + |
intron-intron | ENST00000525141 | ENST00000299295 | SMCO4 | chr11 | 93211926 | + | CHODL | chr21 | 19437070 | + |
intron-intron | ENST00000525141 | ENST00000543733 | SMCO4 | chr11 | 93211926 | + | CHODL | chr21 | 19437070 | + |
intron-intron | ENST00000298966 | ENST00000400128 | SMCO4 | chr11 | 93211926 | + | CHODL | chr21 | 19437070 | + |
intron-intron | ENST00000298966 | ENST00000400131 | SMCO4 | chr11 | 93211926 | + | CHODL | chr21 | 19437070 | + |
intron-intron | ENST00000298966 | ENST00000400135 | SMCO4 | chr11 | 93211926 | + | CHODL | chr21 | 19437070 | + |
intron-intron | ENST00000298966 | ENST00000400127 | SMCO4 | chr11 | 93211926 | + | CHODL | chr21 | 19437070 | + |
intron-intron | ENST00000298966 | ENST00000338326 | SMCO4 | chr11 | 93211926 | + | CHODL | chr21 | 19437070 | + |
intron-intron | ENST00000298966 | ENST00000299295 | SMCO4 | chr11 | 93211926 | + | CHODL | chr21 | 19437070 | + |
intron-intron | ENST00000298966 | ENST00000543733 | SMCO4 | chr11 | 93211926 | + | CHODL | chr21 | 19437070 | + |
intron-intron | ENST00000527149 | ENST00000400128 | SMCO4 | chr11 | 93211926 | + | CHODL | chr21 | 19437070 | + |
intron-intron | ENST00000527149 | ENST00000400131 | SMCO4 | chr11 | 93211926 | + | CHODL | chr21 | 19437070 | + |
intron-intron | ENST00000527149 | ENST00000400135 | SMCO4 | chr11 | 93211926 | + | CHODL | chr21 | 19437070 | + |
intron-intron | ENST00000527149 | ENST00000400127 | SMCO4 | chr11 | 93211926 | + | CHODL | chr21 | 19437070 | + |
intron-intron | ENST00000527149 | ENST00000338326 | SMCO4 | chr11 | 93211926 | + | CHODL | chr21 | 19437070 | + |
intron-intron | ENST00000527149 | ENST00000299295 | SMCO4 | chr11 | 93211926 | + | CHODL | chr21 | 19437070 | + |
intron-intron | ENST00000527149 | ENST00000543733 | SMCO4 | chr11 | 93211926 | + | CHODL | chr21 | 19437070 | + |
Top |
FusionProtFeatures for SMCO4_CHODL |
![]() |
Hgene | Tgene |
SMCO4 | CHODL |
May play a role in the development of the nervous systemsuch as in neurite outgrowth and elongation. May be involved inmotor axon growth and guidance. {ECO:0000250|UniProtKB:Q568T5,ECO:0000250|UniProtKB:Q9CXM0}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for SMCO4_CHODL |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for SMCO4_CHODL |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SMCO4_CHODL |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SMCO4_CHODL |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |