FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 34874

FusionGeneSummary for SMCO4_BCL7B

check button Fusion gene summary
Fusion gene informationFusion gene name: SMCO4_BCL7B
Fusion gene ID: 34874
HgeneTgene
Gene symbol

SMCO4

BCL7B

Gene ID

56935

9275

Gene namesingle-pass membrane protein with coiled-coil domains 4BCL tumor suppressor 7B
SynonymsC11orf75|FN5-
Cytomap

11q21

7q11.23

Type of geneprotein-codingprotein-coding
Descriptionsingle-pass membrane and coiled-coil domain-containing protein 4UPF0443 protein C11orf75B-cell CLL/lymphoma 7 protein family member BB-cell CLL/lymphoma 7B
Modification date2018051920180519
UniProtAcc

Q9NRQ5

Q9BQE9

Ensembl transtripts involved in fusion geneENST00000525141, ENST00000298966, 
ENST00000527149, 
ENST00000223368, 
ENST00000411832, ENST00000482231, 
Fusion gene scores* DoF score2 X 2 X 1=43 X 4 X 4=48
# samples 26
** MAII scorelog2(2/4*10)=2.32192809488736log2(6/48*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SMCO4 [Title/Abstract] AND BCL7B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK098204SMCO4chr11

93212996

-BCL7Bchr7

72954275

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000525141ENST00000223368SMCO4chr11

93212996

-BCL7Bchr7

72954275

-
intron-intronENST00000525141ENST00000411832SMCO4chr11

93212996

-BCL7Bchr7

72954275

-
intron-5UTRENST00000525141ENST00000482231SMCO4chr11

93212996

-BCL7Bchr7

72954275

-
intron-3CDSENST00000298966ENST00000223368SMCO4chr11

93212996

-BCL7Bchr7

72954275

-
intron-intronENST00000298966ENST00000411832SMCO4chr11

93212996

-BCL7Bchr7

72954275

-
intron-5UTRENST00000298966ENST00000482231SMCO4chr11

93212996

-BCL7Bchr7

72954275

-
intron-3CDSENST00000527149ENST00000223368SMCO4chr11

93212996

-BCL7Bchr7

72954275

-
intron-intronENST00000527149ENST00000411832SMCO4chr11

93212996

-BCL7Bchr7

72954275

-
intron-5UTRENST00000527149ENST00000482231SMCO4chr11

93212996

-BCL7Bchr7

72954275

-

Top

FusionProtFeatures for SMCO4_BCL7B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SMCO4

Q9NRQ5

BCL7B

Q9BQE9

Positive regulator of apoptosis. Plays a role in the Wntsignaling pathway, negatively regulating the expression of Wntsignaling components CTNNB1 and HMGA1 (PubMed:25569233). Involvedin cell cycle progression, maintenance of the nuclear structureand stem cell differentiation (PubMed:25569233). May play a rolein lung tumor development or progression (By similarity).{ECO:0000250|UniProtKB:Q921K9, ECO:0000269|PubMed:25569233}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SMCO4_BCL7B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SMCO4_BCL7B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SMCO4_BCL7B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SMCO4_BCL7B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource