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Fusion gene ID: 34860 |
FusionGeneSummary for SMC3_MXI1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SMC3_MXI1 | Fusion gene ID: 34860 | Hgene | Tgene | Gene symbol | SMC3 | MXI1 | Gene ID | 9126 | 4601 |
| Gene name | structural maintenance of chromosomes 3 | MAX interactor 1, dimerization protein | |
| Synonyms | BAM|BMH|CDLS3|CSPG6|HCAP|SMC3L1 | MAD2|MXD2|MXI|bHLHc11 | |
| Cytomap | 10q25.2 | 10q25.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | structural maintenance of chromosomes protein 3SMC protein 3basement membrane-associated chondroitin proteoglycanchondroitin sulfate proteoglycan 6 (bamacan)chromosome-associated polypeptide | max-interacting protein 1MAX dimerization protein 2Max-related transcription factorclass C basic helix-loop-helix protein 11 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q9UQE7 | P50539 | |
| Ensembl transtripts involved in fusion gene | ENST00000361804, ENST00000462899, | ENST00000332674, ENST00000361248, ENST00000239007, ENST00000393134, ENST00000485566, ENST00000369612, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 5 X 5 X 4=100 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SMC3 [Title/Abstract] AND MXI1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SMC3 | GO:0044791 | positive regulation by host of viral release from host cell | 19444697 |
| Hgene | SMC3 | GO:0051321 | meiotic cell cycle | 12498344 |
| Hgene | SMC3 | GO:0051702 | interaction with symbiont | 19444697 |
| Tgene | MXI1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 11875718 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | ESCA | TCGA-L5-A4OQ-01A | SMC3 | chr10 | 112350330 | + | MXI1 | chr10 | 112038938 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000361804 | ENST00000332674 | SMC3 | chr10 | 112350330 | + | MXI1 | chr10 | 112038938 | + |
| In-frame | ENST00000361804 | ENST00000361248 | SMC3 | chr10 | 112350330 | + | MXI1 | chr10 | 112038938 | + |
| In-frame | ENST00000361804 | ENST00000239007 | SMC3 | chr10 | 112350330 | + | MXI1 | chr10 | 112038938 | + |
| In-frame | ENST00000361804 | ENST00000393134 | SMC3 | chr10 | 112350330 | + | MXI1 | chr10 | 112038938 | + |
| 5CDS-3UTR | ENST00000361804 | ENST00000485566 | SMC3 | chr10 | 112350330 | + | MXI1 | chr10 | 112038938 | + |
| 5CDS-3UTR | ENST00000361804 | ENST00000369612 | SMC3 | chr10 | 112350330 | + | MXI1 | chr10 | 112038938 | + |
| intron-3CDS | ENST00000462899 | ENST00000332674 | SMC3 | chr10 | 112350330 | + | MXI1 | chr10 | 112038938 | + |
| intron-3CDS | ENST00000462899 | ENST00000361248 | SMC3 | chr10 | 112350330 | + | MXI1 | chr10 | 112038938 | + |
| intron-3CDS | ENST00000462899 | ENST00000239007 | SMC3 | chr10 | 112350330 | + | MXI1 | chr10 | 112038938 | + |
| intron-3CDS | ENST00000462899 | ENST00000393134 | SMC3 | chr10 | 112350330 | + | MXI1 | chr10 | 112038938 | + |
| intron-3UTR | ENST00000462899 | ENST00000485566 | SMC3 | chr10 | 112350330 | + | MXI1 | chr10 | 112038938 | + |
| intron-3UTR | ENST00000462899 | ENST00000369612 | SMC3 | chr10 | 112350330 | + | MXI1 | chr10 | 112038938 | + |
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FusionProtFeatures for SMC3_MXI1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SMC3 | MXI1 |
| Central component of cohesin, a complex required forchromosome cohesion during the cell cycle. The cohesin complex mayform a large proteinaceous ring within which sister chromatids canbe trapped. At anaphase, the complex is cleaved and dissociatesfrom chromatin, allowing sister chromatids to segregate. Cohesionis coupled to DNA replication and is involved in DNA repair. Thecohesin complex plays also an important role in spindle poleassembly during mitosis and in chromosomes movement.{ECO:0000269|PubMed:11076961, ECO:0000269|PubMed:19907496}. | Transcriptional repressor. MXI1 binds with MAX to form asequence-specific DNA-binding protein complex which recognizes thecore sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYCtranscriptional activity by competing for MAX. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SMC3 | chr10:112350330 | chr10:112038938 | ENST00000361804 | + | 16 | 29 | 179_350 | 556 | 1218 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SMC3 | chr10:112350330 | chr10:112038938 | ENST00000361804 | + | 16 | 29 | 393_503 | 556 | 1218 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SMC3 | chr10:112350330 | chr10:112038938 | ENST00000361804 | + | 16 | 29 | 32_39 | 556 | 1218 | Nucleotide binding | ATP |
| Tgene | >MXI1 | chr10:112350330 | chr10:112038938 | ENST00000361248 | + | 1 | 5 | 67_119 | 32 | 183 | Domain | bHLH |
| Tgene | >MXI1 | chr10:112350330 | chr10:112038938 | ENST00000369612 | + | 2 | 6 | 67_119 | 42 | 193 | Domain | bHLH |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SMC3 | chr10:112350330 | chr10:112038938 | ENST00000361804 | + | 16 | 29 | 669_916 | 556 | 1218 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SMC3 | chr10:112350330 | chr10:112038938 | ENST00000361804 | + | 16 | 29 | 958_989 | 556 | 1218 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SMC3 | chr10:112350330 | chr10:112038938 | ENST00000361804 | + | 16 | 29 | 1115_1150 | 556 | 1218 | Compositional bias | Note=Ala/Asp-rich (DA-box) |
| Hgene | >SMC3 | chr10:112350330 | chr10:112038938 | ENST00000361804 | + | 16 | 29 | 505_667 | 556 | 1218 | Region | Note=Flexible hinge |
| Tgene | MXI1 | chr10:112350330 | chr10:112038938 | ENST00000239007 | + | 2 | 6 | 67_119 | 78 | 229 | Domain | bHLH |
| Tgene | MXI1 | chr10:112350330 | chr10:112038938 | ENST00000332674 | + | 2 | 6 | 67_119 | 145 | 296 | Domain | bHLH |
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FusionGeneSequence for SMC3_MXI1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SMC3_ENST00000361804_chr10_112350330_+_MXI1_ENST00000332674_chr10_112038938_+_707aa MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALLHEGTGPRVISAFVEIIFDNSDNRLP IDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMK ETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDI ERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEER GIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEE LDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNF ECEPAFYTCVEVTAGNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQLENLEREQRFLKWRLEQLQGPQE >In-frame_SMC3_ENST00000361804_chr10_112350330_+_MXI1_ENST00000361248_chr10_112038938_+_707aa MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALLHEGTGPRVISAFVEIIFDNSDNRLP IDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMK ETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDI ERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEER GIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEE LDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNF ECEPAFYTCVEVTAGNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQLENLEREQRFLKWRLEQLQGPQE >In-frame_SMC3_ENST00000361804_chr10_112350330_+_MXI1_ENST00000239007_chr10_112038938_+_707aa MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALLHEGTGPRVISAFVEIIFDNSDNRLP IDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMK ETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDI ERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEER GIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEE LDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNF ECEPAFYTCVEVTAGNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQLENLEREQRFLKWRLEQLQGPQE >In-frame_SMC3_ENST00000361804_chr10_112350330_+_MXI1_ENST00000393134_chr10_112038938_+_707aa MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALLHEGTGPRVISAFVEIIFDNSDNRLP IDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMK ETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDI ERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEER GIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEE LDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNF ECEPAFYTCVEVTAGNRRAHLRLCLERLKVLIPLGPDCTRHTTLGLLNKAKAHIKKLEEAERKSQHQLENLEREQRFLKWRLEQLQGPQE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SMC3_ENST00000361804_chr10_112350330_+_MXI1_ENST00000332674_chr10_112038938_+_2121nt ATGTACATAAAGCAGGTGATTATCCAGGGTTTTCGAAGTTACAGAGATCAAACAATTGTAGATCCCTTCAGTTCAAAACATAATGTGATT GTGGGCAGAAATGGATCTGGAAAAAGTAACTTTTTTTATGCAATTCAGTTTGTTCTCAGTGATGAGTTTAGTCATCTTCGTCCAGAACAG CGGTTGGCTTTATTGCATGAAGGTACTGGTCCTCGTGTTATTTCTGCTTTTGTGGAGATTATTTTTGATAATTCAGACAACCGGTTACCA ATCGATAAAGAGGAAGTTTCACTTCGAAGAGTTATTGGTGCCAAAAAGGATCAGTATTTCTTAGACAAGAAGATGGTCACGAAAAATGAT GTGATGAACCTCCTTGAAAGCGCTGGTTTTTCTCGAAGCAATCCTTATTATATTGTTAAACAAGGAAAGATCAACCAGATGGCAACAGCA CCAGATTCTCAGAGATTAAAGCTATTAAGAGAAGTAGCTGGTACTAGAGTGTATGACGAACGAAAGGAAGAAAGCATCTCCTTAATGAAA GAAACAGAGGGCAAACGGGAAAAAATCAATGAGTTGTTAAAATACATTGAAGAGAGATTACATACTCTAGAGGAAGAAAAGGAAGAACTA GCTCAGTATCAGAAGTGGGATAAAATGAGACGAGCCCTGGAATATACCATTTACAATCAGGAACTTAACGAGACTCGTGCCAAACTTGAT GAGCTTTCTGCTAAGCGAGAGACTAGTGGAGAAAAATCCAGACAATTAAGAGATGCTCAGCAGGATGCAAGAGATAAAATGGAGGATATC GAACGCCAAGTTAGAGAATTGAAAACAAAAATTTCAGCTATGAAAGAAGAAAAAGAACAGCTTAGTGCTGAAAGACAAGAGCAGATTAAG CAGAGGACTAAGTTGGAGCTTAAAGCCAAGGATTTACAAGATGAACTAGCAGGCAATAGTGAACAAAGGAAACGTTTATTAAAAGAGAGG CAGAAGCTGCTTGAAAAAATAGAAGAAAAGCAGAAAGAACTGGCAGAAACAGAACCCAAATTCAACAGTGTGAAAGAGAAAGAAGAACGA GGAATTGCTAGATTGGCTCAAGCTACCCAGGAAAGAACGGATCTTTATGCAAAGCAGGGTCGAGGAAGCCAGTTTACATCAAAAGAAGAA AGGGATAAGTGGATTAAAAAGGAACTCAAGTCTTTAGATCAGGCTATTAATGACAAGAAAAGACAGATTGCTGCTATACATAAGGATTTG GAAGACACTGAAGCAAATAAAGAGAAAAATCTGGAGCAGTATAATAAACTGGACCAGGATCTTAATGAAGTCAAAGCTCGAGTAGAAGAA CTGGACAGAAAATATTACGAAGTAAAAAATAAGAAAGATGAACTACAAAGTGAAAGAAACTACTTGTGGAGAGAAGAGAATGCAGAACAG CAAGCACTTGCTGCTAAAAGAGAAGATCTTGAAAAGAAGCAACAACTTCTTAGAGCAGCAACAGGAAAGGCCATTTTAAATGGAATAGAC AGCATAAACAAAGTGCTAGACCACTTCCGTCGAAAAGGAATAAACCAGCATGTTCAAAATGGCTATCATGGTATTGTAATGAATAACTTT GAATGTGAACCAGCTTTCTACACATGCGTGGAAGTCACTGCTGGAAACAGACGAGCTCATCTGCGCCTTTGTTTAGAACGCTTAAAAGTT CTGATTCCACTAGGACCAGACTGCACCCGGCACACAACACTTGGTTTGCTCAACAAAGCCAAAGCACACATCAAGAAACTTGAAGAAGCT GAAAGAAAAAGCCAGCACCAGCTCGAGAATTTGGAACGAGAACAGAGATTTTTAAAGTGGCGACTGGAACAGCTGCAGGGTCCTCAGGAG ATGGAACGAATACGAATGGACAGCATTGGATCAACTATTTCTTCAGATCGTTCTGATTCAGAGCGAGAGGAGATTGAAGTGGATGTTGAA AGCACAGAGTTCTCCCATGGAGAAGTGGACAATATAAGTACCACCAGCATCAGTGACATTGATGACCACAGCAGCCTGCCGAGTATTGGG >In-frame_SMC3_ENST00000361804_chr10_112350330_+_MXI1_ENST00000361248_chr10_112038938_+_2121nt ATGTACATAAAGCAGGTGATTATCCAGGGTTTTCGAAGTTACAGAGATCAAACAATTGTAGATCCCTTCAGTTCAAAACATAATGTGATT GTGGGCAGAAATGGATCTGGAAAAAGTAACTTTTTTTATGCAATTCAGTTTGTTCTCAGTGATGAGTTTAGTCATCTTCGTCCAGAACAG CGGTTGGCTTTATTGCATGAAGGTACTGGTCCTCGTGTTATTTCTGCTTTTGTGGAGATTATTTTTGATAATTCAGACAACCGGTTACCA ATCGATAAAGAGGAAGTTTCACTTCGAAGAGTTATTGGTGCCAAAAAGGATCAGTATTTCTTAGACAAGAAGATGGTCACGAAAAATGAT GTGATGAACCTCCTTGAAAGCGCTGGTTTTTCTCGAAGCAATCCTTATTATATTGTTAAACAAGGAAAGATCAACCAGATGGCAACAGCA CCAGATTCTCAGAGATTAAAGCTATTAAGAGAAGTAGCTGGTACTAGAGTGTATGACGAACGAAAGGAAGAAAGCATCTCCTTAATGAAA GAAACAGAGGGCAAACGGGAAAAAATCAATGAGTTGTTAAAATACATTGAAGAGAGATTACATACTCTAGAGGAAGAAAAGGAAGAACTA GCTCAGTATCAGAAGTGGGATAAAATGAGACGAGCCCTGGAATATACCATTTACAATCAGGAACTTAACGAGACTCGTGCCAAACTTGAT GAGCTTTCTGCTAAGCGAGAGACTAGTGGAGAAAAATCCAGACAATTAAGAGATGCTCAGCAGGATGCAAGAGATAAAATGGAGGATATC GAACGCCAAGTTAGAGAATTGAAAACAAAAATTTCAGCTATGAAAGAAGAAAAAGAACAGCTTAGTGCTGAAAGACAAGAGCAGATTAAG CAGAGGACTAAGTTGGAGCTTAAAGCCAAGGATTTACAAGATGAACTAGCAGGCAATAGTGAACAAAGGAAACGTTTATTAAAAGAGAGG CAGAAGCTGCTTGAAAAAATAGAAGAAAAGCAGAAAGAACTGGCAGAAACAGAACCCAAATTCAACAGTGTGAAAGAGAAAGAAGAACGA GGAATTGCTAGATTGGCTCAAGCTACCCAGGAAAGAACGGATCTTTATGCAAAGCAGGGTCGAGGAAGCCAGTTTACATCAAAAGAAGAA AGGGATAAGTGGATTAAAAAGGAACTCAAGTCTTTAGATCAGGCTATTAATGACAAGAAAAGACAGATTGCTGCTATACATAAGGATTTG GAAGACACTGAAGCAAATAAAGAGAAAAATCTGGAGCAGTATAATAAACTGGACCAGGATCTTAATGAAGTCAAAGCTCGAGTAGAAGAA CTGGACAGAAAATATTACGAAGTAAAAAATAAGAAAGATGAACTACAAAGTGAAAGAAACTACTTGTGGAGAGAAGAGAATGCAGAACAG CAAGCACTTGCTGCTAAAAGAGAAGATCTTGAAAAGAAGCAACAACTTCTTAGAGCAGCAACAGGAAAGGCCATTTTAAATGGAATAGAC AGCATAAACAAAGTGCTAGACCACTTCCGTCGAAAAGGAATAAACCAGCATGTTCAAAATGGCTATCATGGTATTGTAATGAATAACTTT GAATGTGAACCAGCTTTCTACACATGCGTGGAAGTCACTGCTGGAAACAGACGAGCTCATCTGCGCCTTTGTTTAGAACGCTTAAAAGTT CTGATTCCACTAGGACCAGACTGCACCCGGCACACAACACTTGGTTTGCTCAACAAAGCCAAAGCACACATCAAGAAACTTGAAGAAGCT GAAAGAAAAAGCCAGCACCAGCTCGAGAATTTGGAACGAGAACAGAGATTTTTAAAGTGGCGACTGGAACAGCTGCAGGGTCCTCAGGAG ATGGAACGAATACGAATGGACAGCATTGGATCAACTATTTCTTCAGATCGTTCTGATTCAGAGCGAGAGGAGATTGAAGTGGATGTTGAA AGCACAGAGTTCTCCCATGGAGAAGTGGACAATATAAGTACCACCAGCATCAGTGACATTGATGACCACAGCAGCCTGCCGAGTATTGGG >In-frame_SMC3_ENST00000361804_chr10_112350330_+_MXI1_ENST00000239007_chr10_112038938_+_2121nt ATGTACATAAAGCAGGTGATTATCCAGGGTTTTCGAAGTTACAGAGATCAAACAATTGTAGATCCCTTCAGTTCAAAACATAATGTGATT GTGGGCAGAAATGGATCTGGAAAAAGTAACTTTTTTTATGCAATTCAGTTTGTTCTCAGTGATGAGTTTAGTCATCTTCGTCCAGAACAG CGGTTGGCTTTATTGCATGAAGGTACTGGTCCTCGTGTTATTTCTGCTTTTGTGGAGATTATTTTTGATAATTCAGACAACCGGTTACCA ATCGATAAAGAGGAAGTTTCACTTCGAAGAGTTATTGGTGCCAAAAAGGATCAGTATTTCTTAGACAAGAAGATGGTCACGAAAAATGAT GTGATGAACCTCCTTGAAAGCGCTGGTTTTTCTCGAAGCAATCCTTATTATATTGTTAAACAAGGAAAGATCAACCAGATGGCAACAGCA CCAGATTCTCAGAGATTAAAGCTATTAAGAGAAGTAGCTGGTACTAGAGTGTATGACGAACGAAAGGAAGAAAGCATCTCCTTAATGAAA GAAACAGAGGGCAAACGGGAAAAAATCAATGAGTTGTTAAAATACATTGAAGAGAGATTACATACTCTAGAGGAAGAAAAGGAAGAACTA GCTCAGTATCAGAAGTGGGATAAAATGAGACGAGCCCTGGAATATACCATTTACAATCAGGAACTTAACGAGACTCGTGCCAAACTTGAT GAGCTTTCTGCTAAGCGAGAGACTAGTGGAGAAAAATCCAGACAATTAAGAGATGCTCAGCAGGATGCAAGAGATAAAATGGAGGATATC GAACGCCAAGTTAGAGAATTGAAAACAAAAATTTCAGCTATGAAAGAAGAAAAAGAACAGCTTAGTGCTGAAAGACAAGAGCAGATTAAG CAGAGGACTAAGTTGGAGCTTAAAGCCAAGGATTTACAAGATGAACTAGCAGGCAATAGTGAACAAAGGAAACGTTTATTAAAAGAGAGG CAGAAGCTGCTTGAAAAAATAGAAGAAAAGCAGAAAGAACTGGCAGAAACAGAACCCAAATTCAACAGTGTGAAAGAGAAAGAAGAACGA GGAATTGCTAGATTGGCTCAAGCTACCCAGGAAAGAACGGATCTTTATGCAAAGCAGGGTCGAGGAAGCCAGTTTACATCAAAAGAAGAA AGGGATAAGTGGATTAAAAAGGAACTCAAGTCTTTAGATCAGGCTATTAATGACAAGAAAAGACAGATTGCTGCTATACATAAGGATTTG GAAGACACTGAAGCAAATAAAGAGAAAAATCTGGAGCAGTATAATAAACTGGACCAGGATCTTAATGAAGTCAAAGCTCGAGTAGAAGAA CTGGACAGAAAATATTACGAAGTAAAAAATAAGAAAGATGAACTACAAAGTGAAAGAAACTACTTGTGGAGAGAAGAGAATGCAGAACAG CAAGCACTTGCTGCTAAAAGAGAAGATCTTGAAAAGAAGCAACAACTTCTTAGAGCAGCAACAGGAAAGGCCATTTTAAATGGAATAGAC AGCATAAACAAAGTGCTAGACCACTTCCGTCGAAAAGGAATAAACCAGCATGTTCAAAATGGCTATCATGGTATTGTAATGAATAACTTT GAATGTGAACCAGCTTTCTACACATGCGTGGAAGTCACTGCTGGAAACAGACGAGCTCATCTGCGCCTTTGTTTAGAACGCTTAAAAGTT CTGATTCCACTAGGACCAGACTGCACCCGGCACACAACACTTGGTTTGCTCAACAAAGCCAAAGCACACATCAAGAAACTTGAAGAAGCT GAAAGAAAAAGCCAGCACCAGCTCGAGAATTTGGAACGAGAACAGAGATTTTTAAAGTGGCGACTGGAACAGCTGCAGGGTCCTCAGGAG ATGGAACGAATACGAATGGACAGCATTGGATCAACTATTTCTTCAGATCGTTCTGATTCAGAGCGAGAGGAGATTGAAGTGGATGTTGAA AGCACAGAGTTCTCCCATGGAGAAGTGGACAATATAAGTACCACCAGCATCAGTGACATTGATGACCACAGCAGCCTGCCGAGTATTGGG >In-frame_SMC3_ENST00000361804_chr10_112350330_+_MXI1_ENST00000393134_chr10_112038938_+_2121nt ATGTACATAAAGCAGGTGATTATCCAGGGTTTTCGAAGTTACAGAGATCAAACAATTGTAGATCCCTTCAGTTCAAAACATAATGTGATT GTGGGCAGAAATGGATCTGGAAAAAGTAACTTTTTTTATGCAATTCAGTTTGTTCTCAGTGATGAGTTTAGTCATCTTCGTCCAGAACAG CGGTTGGCTTTATTGCATGAAGGTACTGGTCCTCGTGTTATTTCTGCTTTTGTGGAGATTATTTTTGATAATTCAGACAACCGGTTACCA ATCGATAAAGAGGAAGTTTCACTTCGAAGAGTTATTGGTGCCAAAAAGGATCAGTATTTCTTAGACAAGAAGATGGTCACGAAAAATGAT GTGATGAACCTCCTTGAAAGCGCTGGTTTTTCTCGAAGCAATCCTTATTATATTGTTAAACAAGGAAAGATCAACCAGATGGCAACAGCA CCAGATTCTCAGAGATTAAAGCTATTAAGAGAAGTAGCTGGTACTAGAGTGTATGACGAACGAAAGGAAGAAAGCATCTCCTTAATGAAA GAAACAGAGGGCAAACGGGAAAAAATCAATGAGTTGTTAAAATACATTGAAGAGAGATTACATACTCTAGAGGAAGAAAAGGAAGAACTA GCTCAGTATCAGAAGTGGGATAAAATGAGACGAGCCCTGGAATATACCATTTACAATCAGGAACTTAACGAGACTCGTGCCAAACTTGAT GAGCTTTCTGCTAAGCGAGAGACTAGTGGAGAAAAATCCAGACAATTAAGAGATGCTCAGCAGGATGCAAGAGATAAAATGGAGGATATC GAACGCCAAGTTAGAGAATTGAAAACAAAAATTTCAGCTATGAAAGAAGAAAAAGAACAGCTTAGTGCTGAAAGACAAGAGCAGATTAAG CAGAGGACTAAGTTGGAGCTTAAAGCCAAGGATTTACAAGATGAACTAGCAGGCAATAGTGAACAAAGGAAACGTTTATTAAAAGAGAGG CAGAAGCTGCTTGAAAAAATAGAAGAAAAGCAGAAAGAACTGGCAGAAACAGAACCCAAATTCAACAGTGTGAAAGAGAAAGAAGAACGA GGAATTGCTAGATTGGCTCAAGCTACCCAGGAAAGAACGGATCTTTATGCAAAGCAGGGTCGAGGAAGCCAGTTTACATCAAAAGAAGAA AGGGATAAGTGGATTAAAAAGGAACTCAAGTCTTTAGATCAGGCTATTAATGACAAGAAAAGACAGATTGCTGCTATACATAAGGATTTG GAAGACACTGAAGCAAATAAAGAGAAAAATCTGGAGCAGTATAATAAACTGGACCAGGATCTTAATGAAGTCAAAGCTCGAGTAGAAGAA CTGGACAGAAAATATTACGAAGTAAAAAATAAGAAAGATGAACTACAAAGTGAAAGAAACTACTTGTGGAGAGAAGAGAATGCAGAACAG CAAGCACTTGCTGCTAAAAGAGAAGATCTTGAAAAGAAGCAACAACTTCTTAGAGCAGCAACAGGAAAGGCCATTTTAAATGGAATAGAC AGCATAAACAAAGTGCTAGACCACTTCCGTCGAAAAGGAATAAACCAGCATGTTCAAAATGGCTATCATGGTATTGTAATGAATAACTTT GAATGTGAACCAGCTTTCTACACATGCGTGGAAGTCACTGCTGGAAACAGACGAGCTCATCTGCGCCTTTGTTTAGAACGCTTAAAAGTT CTGATTCCACTAGGACCAGACTGCACCCGGCACACAACACTTGGTTTGCTCAACAAAGCCAAAGCACACATCAAGAAACTTGAAGAAGCT GAAAGAAAAAGCCAGCACCAGCTCGAGAATTTGGAACGAGAACAGAGATTTTTAAAGTGGCGACTGGAACAGCTGCAGGGTCCTCAGGAG ATGGAACGAATACGAATGGACAGCATTGGATCAACTATTTCTTCAGATCGTTCTGATTCAGAGCGAGAGGAGATTGAAGTGGATGTTGAA AGCACAGAGTTCTCCCATGGAGAAGTGGACAATATAAGTACCACCAGCATCAGTGACATTGATGACCACAGCAGCCTGCCGAGTATTGGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SMC3_ENST00000361804_chr10_112350330_+_MXI1_ENST00000332674_chr10_112038938_+_4625nt TTTTGTTTGGCTGAGGGGAGCGAGCGGCGCTTTGGGGGAGGGGTCGCGTAGGCGCCTCACCTGACCCTGCGGCCGTGCGGTTGCTGCTCC GGGGCAGGTCTCCTTCCAGGCCAGGGGCCCGGAATCATGTACATAAAGCAGGTGATTATCCAGGGTTTTCGAAGTTACAGAGATCAAACA ATTGTAGATCCCTTCAGTTCAAAACATAATGTGATTGTGGGCAGAAATGGATCTGGAAAAAGTAACTTTTTTTATGCAATTCAGTTTGTT CTCAGTGATGAGTTTAGTCATCTTCGTCCAGAACAGCGGTTGGCTTTATTGCATGAAGGTACTGGTCCTCGTGTTATTTCTGCTTTTGTG GAGATTATTTTTGATAATTCAGACAACCGGTTACCAATCGATAAAGAGGAAGTTTCACTTCGAAGAGTTATTGGTGCCAAAAAGGATCAG TATTTCTTAGACAAGAAGATGGTCACGAAAAATGATGTGATGAACCTCCTTGAAAGCGCTGGTTTTTCTCGAAGCAATCCTTATTATATT GTTAAACAAGGAAAGATCAACCAGATGGCAACAGCACCAGATTCTCAGAGATTAAAGCTATTAAGAGAAGTAGCTGGTACTAGAGTGTAT GACGAACGAAAGGAAGAAAGCATCTCCTTAATGAAAGAAACAGAGGGCAAACGGGAAAAAATCAATGAGTTGTTAAAATACATTGAAGAG AGATTACATACTCTAGAGGAAGAAAAGGAAGAACTAGCTCAGTATCAGAAGTGGGATAAAATGAGACGAGCCCTGGAATATACCATTTAC AATCAGGAACTTAACGAGACTCGTGCCAAACTTGATGAGCTTTCTGCTAAGCGAGAGACTAGTGGAGAAAAATCCAGACAATTAAGAGAT GCTCAGCAGGATGCAAGAGATAAAATGGAGGATATCGAACGCCAAGTTAGAGAATTGAAAACAAAAATTTCAGCTATGAAAGAAGAAAAA GAACAGCTTAGTGCTGAAAGACAAGAGCAGATTAAGCAGAGGACTAAGTTGGAGCTTAAAGCCAAGGATTTACAAGATGAACTAGCAGGC AATAGTGAACAAAGGAAACGTTTATTAAAAGAGAGGCAGAAGCTGCTTGAAAAAATAGAAGAAAAGCAGAAAGAACTGGCAGAAACAGAA CCCAAATTCAACAGTGTGAAAGAGAAAGAAGAACGAGGAATTGCTAGATTGGCTCAAGCTACCCAGGAAAGAACGGATCTTTATGCAAAG CAGGGTCGAGGAAGCCAGTTTACATCAAAAGAAGAAAGGGATAAGTGGATTAAAAAGGAACTCAAGTCTTTAGATCAGGCTATTAATGAC AAGAAAAGACAGATTGCTGCTATACATAAGGATTTGGAAGACACTGAAGCAAATAAAGAGAAAAATCTGGAGCAGTATAATAAACTGGAC CAGGATCTTAATGAAGTCAAAGCTCGAGTAGAAGAACTGGACAGAAAATATTACGAAGTAAAAAATAAGAAAGATGAACTACAAAGTGAA AGAAACTACTTGTGGAGAGAAGAGAATGCAGAACAGCAAGCACTTGCTGCTAAAAGAGAAGATCTTGAAAAGAAGCAACAACTTCTTAGA GCAGCAACAGGAAAGGCCATTTTAAATGGAATAGACAGCATAAACAAAGTGCTAGACCACTTCCGTCGAAAAGGAATAAACCAGCATGTT CAAAATGGCTATCATGGTATTGTAATGAATAACTTTGAATGTGAACCAGCTTTCTACACATGCGTGGAAGTCACTGCTGGAAACAGACGA GCTCATCTGCGCCTTTGTTTAGAACGCTTAAAAGTTCTGATTCCACTAGGACCAGACTGCACCCGGCACACAACACTTGGTTTGCTCAAC AAAGCCAAAGCACACATCAAGAAACTTGAAGAAGCTGAAAGAAAAAGCCAGCACCAGCTCGAGAATTTGGAACGAGAACAGAGATTTTTA AAGTGGCGACTGGAACAGCTGCAGGGTCCTCAGGAGATGGAACGAATACGAATGGACAGCATTGGATCAACTATTTCTTCAGATCGTTCT GATTCAGAGCGAGAGGAGATTGAAGTGGATGTTGAAAGCACAGAGTTCTCCCATGGAGAAGTGGACAATATAAGTACCACCAGCATCAGT GACATTGATGACCACAGCAGCCTGCCGAGTATTGGGAGTGACGAGGGTTACTCCAGTGCCAGTGTCAAACTTTCATTCACTTCATAGAAC CCAGCATGACATAACAGTGCAGGGCAAAATATTCACTGGGCCAATTCAATACAAACAATCTCTTAAATTGGGTTCATGATGCAGTCTCCT CTTTAAAACAAAACAAAACAAAACAAAACTATACTTGAACAAAAGGGTCAGAGGACCTGTATTTAAGCAAATACTTAGCAAAAAGTGGGG CAGAGCCTCCCAAGGAGAACAAATATTCAGAATATTCATATTGGAAAAATCACAATTTTTAATGGCAGCAGAAAACTTGTGTGAAATTTT CTTGATTTGAGTTGATTGAGAAGAGGACATTGGAGATGCCATCCTCTTTCTCTTTTCTAGTTTGCTCATACTACATTGAGTAGACACATT TAAGGATGGGGTTATGAACCCTTCCTGAGCTTTATGGTCCTAAAAGCAAAATAAAAACTATTCGAATGAAAAGACAAGAAAATCAGGTAT TAATCTTGGATAGCTAATAATGAGCTATTAAAACTCAGCCTGGGACAGTTTATCATGAAGCCTGTGGATGATCAATCCTTTATTATTATT TTTTTTTTTTGAAAAAAGCTCATTTCATGCTCTGCAAAAGGAGAGACTCCCATGAAGCCTTTTGAAAGGGATCATCATGCAGCTCAACTT TCTGTTGGATTCCATGCTAAGCAAGCTAACCTTATCCTGCATTGTTAGCACTAGGCACCCAGCTGCCACCTCTCCATCCTGCTGCCCTTA GGCCACATGGGAGCAGTCCATGCATGACAGCCTCTATCCTACAAGGCCTATGAGTATGGATTGGGGGGGCCAAAAGGAAAAAGCTCCATG TGCCTCTTTGTCTGCGTGGGTCAGAAGAGTTGTGCACGCAGATTAGCAGGCCAAGGTCTGAGCCACAGCAGCATTTTTATTTCAGATTTT GATAACTGTTTATATGTGTTGAAAACCAAAATGACATCTTTTTAAAGCTTATCCATAAAAAAAAATAGATGTCTTTTATAGTGGAAAAAC ACATGGGGAAAAAAATCATCTATTTTGATGCAGCATTTGATAATGATAAAACACCTCACACCTCACTCTTTATAGTGCACAAAATGAATG AGGTCTGGGCTAGGTAGAAAAAGGGTCAATGCTATTTTTGTTTTTAGAATCATTACCTTTTACCAGCTTTTAACCATCTGATATCTATAG TAGACACACTATCATAGTTAACATAGTAAGTTCAGCACTTGTCTCATTTTAATGTAAAGATTTGCTTCCATTTTCCTACAGGCAGTCTCT CTCTTCCTCACAGTCCCACTGTGCAGGTGCTATTGTTACTCTTACGAATATTTTCAGTAATGTTATTTTCTTCTAAGTGAAATTTCTAGC CTGCACTTTGATGTCATGTGTTCCCTTTGTCTTTCAAACTCCAAGGTTCCCTTGTGGCCCTCTCCCTTACCCTGGGAAGGCCTCTTGGAG ACCTTACCCCTGGCTGTTTGGACTTTGTATACTTTAAATAATTTAACTACCCTTAATTACTTAAAAAAAAAAAAAAGCTTTATGATTTTC ATAACTTATTGCTGATTTTAATGGATTGTTAATTTCAGTCCTGTAGTTTTATTTTATGTTTAGATAGGGCTGGGCAAGGAAAAAGAAAAT AAAGACAACCATATTTAGCAGTGCAGTTGAGTTGTGTGTTAATGTTAGACTATCCCTTTGTGAGTGACACTTTAACAGCATTCACTGCTT CTATATATAGTGTACCATCTTGGTCATACATTACGCCTCAACATATACTTGTGCTCTTCCTTTGCCTCCAGAAGAAGTTTTTCCTTGATT GTGCTATGTTTCAGTGGAAGAAATTCTTTGAAGTAGATGTGAGTGAAAAACTGCATGCCTTTAGAAGCCCAGTATCAGAACTTGCTACGT TTCAGGTGCTAGGGACTTAATGAAAAACAGGACAAAACAATTCCTTTTTGTGGCCCAGGTAAATTATTTCTGGTTTCACTTATAATTACT AATGGCTGAGTCAAGATGTTGTCTCTGTGTTTGCTTACTCTTGATCAAGTGTGAGACAGTTTGAAGACTGTGCTACCATACAAAGTGAAT GAAGCCAGTGACTAAGCTTCTGTTTGTTTTGTTATTCTCATGGCCTTCGCTTGCATTATTTGGGCCTTCATTCAGATGAACTTGAGGTGC CATTTTGTTGCATATGTACAGGATTATGGGCTGGAAAGCATTTGTTATAAACCTATAGTGCACATTTTAACTGCCCCCTAAATTACCCTT CCCTGGGTTTGTTTTCCTTGGGGTGGTGTAGATTGTATGAGTAAGAAGTATTAATTTTTTAAAAGACAAATCAACTTTGAAGACACAAAA >In-frame_SMC3_ENST00000361804_chr10_112350330_+_MXI1_ENST00000361248_chr10_112038938_+_3766nt TTTTGTTTGGCTGAGGGGAGCGAGCGGCGCTTTGGGGGAGGGGTCGCGTAGGCGCCTCACCTGACCCTGCGGCCGTGCGGTTGCTGCTCC GGGGCAGGTCTCCTTCCAGGCCAGGGGCCCGGAATCATGTACATAAAGCAGGTGATTATCCAGGGTTTTCGAAGTTACAGAGATCAAACA ATTGTAGATCCCTTCAGTTCAAAACATAATGTGATTGTGGGCAGAAATGGATCTGGAAAAAGTAACTTTTTTTATGCAATTCAGTTTGTT CTCAGTGATGAGTTTAGTCATCTTCGTCCAGAACAGCGGTTGGCTTTATTGCATGAAGGTACTGGTCCTCGTGTTATTTCTGCTTTTGTG GAGATTATTTTTGATAATTCAGACAACCGGTTACCAATCGATAAAGAGGAAGTTTCACTTCGAAGAGTTATTGGTGCCAAAAAGGATCAG TATTTCTTAGACAAGAAGATGGTCACGAAAAATGATGTGATGAACCTCCTTGAAAGCGCTGGTTTTTCTCGAAGCAATCCTTATTATATT GTTAAACAAGGAAAGATCAACCAGATGGCAACAGCACCAGATTCTCAGAGATTAAAGCTATTAAGAGAAGTAGCTGGTACTAGAGTGTAT GACGAACGAAAGGAAGAAAGCATCTCCTTAATGAAAGAAACAGAGGGCAAACGGGAAAAAATCAATGAGTTGTTAAAATACATTGAAGAG AGATTACATACTCTAGAGGAAGAAAAGGAAGAACTAGCTCAGTATCAGAAGTGGGATAAAATGAGACGAGCCCTGGAATATACCATTTAC AATCAGGAACTTAACGAGACTCGTGCCAAACTTGATGAGCTTTCTGCTAAGCGAGAGACTAGTGGAGAAAAATCCAGACAATTAAGAGAT GCTCAGCAGGATGCAAGAGATAAAATGGAGGATATCGAACGCCAAGTTAGAGAATTGAAAACAAAAATTTCAGCTATGAAAGAAGAAAAA GAACAGCTTAGTGCTGAAAGACAAGAGCAGATTAAGCAGAGGACTAAGTTGGAGCTTAAAGCCAAGGATTTACAAGATGAACTAGCAGGC AATAGTGAACAAAGGAAACGTTTATTAAAAGAGAGGCAGAAGCTGCTTGAAAAAATAGAAGAAAAGCAGAAAGAACTGGCAGAAACAGAA CCCAAATTCAACAGTGTGAAAGAGAAAGAAGAACGAGGAATTGCTAGATTGGCTCAAGCTACCCAGGAAAGAACGGATCTTTATGCAAAG CAGGGTCGAGGAAGCCAGTTTACATCAAAAGAAGAAAGGGATAAGTGGATTAAAAAGGAACTCAAGTCTTTAGATCAGGCTATTAATGAC AAGAAAAGACAGATTGCTGCTATACATAAGGATTTGGAAGACACTGAAGCAAATAAAGAGAAAAATCTGGAGCAGTATAATAAACTGGAC CAGGATCTTAATGAAGTCAAAGCTCGAGTAGAAGAACTGGACAGAAAATATTACGAAGTAAAAAATAAGAAAGATGAACTACAAAGTGAA AGAAACTACTTGTGGAGAGAAGAGAATGCAGAACAGCAAGCACTTGCTGCTAAAAGAGAAGATCTTGAAAAGAAGCAACAACTTCTTAGA GCAGCAACAGGAAAGGCCATTTTAAATGGAATAGACAGCATAAACAAAGTGCTAGACCACTTCCGTCGAAAAGGAATAAACCAGCATGTT CAAAATGGCTATCATGGTATTGTAATGAATAACTTTGAATGTGAACCAGCTTTCTACACATGCGTGGAAGTCACTGCTGGAAACAGACGA GCTCATCTGCGCCTTTGTTTAGAACGCTTAAAAGTTCTGATTCCACTAGGACCAGACTGCACCCGGCACACAACACTTGGTTTGCTCAAC AAAGCCAAAGCACACATCAAGAAACTTGAAGAAGCTGAAAGAAAAAGCCAGCACCAGCTCGAGAATTTGGAACGAGAACAGAGATTTTTA AAGTGGCGACTGGAACAGCTGCAGGGTCCTCAGGAGATGGAACGAATACGAATGGACAGCATTGGATCAACTATTTCTTCAGATCGTTCT GATTCAGAGCGAGAGGAGATTGAAGTGGATGTTGAAAGCACAGAGTTCTCCCATGGAGAAGTGGACAATATAAGTACCACCAGCATCAGT GACATTGATGACCACAGCAGCCTGCCGAGTATTGGGAGTGACGAGGGTTACTCCAGTGCCAGTGTCAAACTTTCATTCACTTCATAGAAC CCAGCATGACATAACAGTGCAGGGCAAAATATTCACTGGGCCAATTCAATACAAACAATCTCTTAAATTGGGTTCATGATGCAGTCTCCT CTTTAAAACAAAACAAAACAAAACAAAACTATACTTGAACAAAAGGGTCAGAGGACCTGTATTTAAGCAAATACTTAGCAAAAAGTGGGG CAGAGCCTCCCAAGGAGAACAAATATTCAGAATATTCATATTGGAAAAATCACAATTTTTAATGGCAGCAGAAAACTTGTGTGAAATTTT CTTGATTTGAGTTGATTGAGAAGAGGACATTGGAGATGCCATCCTCTTTCTCTTTTCTAGTTTGCTCATACTACATTGAGTAGACACATT TAAGGATGGGGTTATGAACCCTTCCTGAGCTTTATGGTCCTAAAAGCAAAATAAAAACTATTCGAATGAAAAGACAAGAAAATCAGGTAT TAATCTTGGATAGCTAATAATGAGCTATTAAAACTCAGCCTGGGACAGTTTATCATGAAGCCTGTGGATGATCAATCCTTTATTATTATT TTTTTTTTTTGAAAAAAGCTCATTTCATGCTCTGCAAAAGGAGAGACTCCCATGAAGCCTTTTGAAAGGGATCATCATGCAGCTCAACTT TCTGTTGGATTCCATGCTAAGCAAGCTAACCTTATCCTGCATTGTTAGCACTAGGCACCCAGCTGCCACCTCTCCATCCTGCTGCCCTTA GGCCACATGGGAGCAGTCCATGCATGACAGCCTCTATCCTACAAGGCCTATGAGTATGGATTGGGGGGGCCAAAAGGAAAAAGCTCCATG TGCCTCTTTGTCTGCGTGGGTCAGAAGAGTTGTGCACGCAGATTAGCAGGCCAAGGTCTGAGCCACAGCAGCATTTTTATTTCAGATTTT GATAACTGTTTATATGTGTTGAAAACCAAAATGACATCTTTTTAAAGCTTATCCATAAAAAAAAATAGATGTCTTTTATAGTGGAAAAAC ACATGGGGAAAAAAATCATCTATTTTGATGCAGCATTTGATAATGATAAAACACCTCACACCTCACTCTTTATAGTGCACAAAATGAATG AGGTCTGGGCTAGGTAGAAAAAGGGTCAATGCTATTTTTGTTTTTAGAATCATTACCTTTTACCAGCTTTTAACCATCTGATATCTATAG TAGACACACTATCATAGTTAACATAGTAAGTTCAGCACTTGTCTCATTTTAATGTAAAGATTTGCTTCCATTTTCCTACAGGCAGTCTCT CTCTTCCTCACAGTCCCACTGTGCAGGTGCTATTGTTACTCTTACGAATATTTTCAGTAATGTTATTTTCTTCTAAGTGAAATTTCTAGC CTGCACTTTGATGTCATGTGTTCCCTTTGTCTTTCAAACTCCAAGGTTCCCTTGTGGCCCTCTCCCTTACCCTGGGAAGGCCTCTTGGAG >In-frame_SMC3_ENST00000361804_chr10_112350330_+_MXI1_ENST00000239007_chr10_112038938_+_3766nt TTTTGTTTGGCTGAGGGGAGCGAGCGGCGCTTTGGGGGAGGGGTCGCGTAGGCGCCTCACCTGACCCTGCGGCCGTGCGGTTGCTGCTCC GGGGCAGGTCTCCTTCCAGGCCAGGGGCCCGGAATCATGTACATAAAGCAGGTGATTATCCAGGGTTTTCGAAGTTACAGAGATCAAACA ATTGTAGATCCCTTCAGTTCAAAACATAATGTGATTGTGGGCAGAAATGGATCTGGAAAAAGTAACTTTTTTTATGCAATTCAGTTTGTT CTCAGTGATGAGTTTAGTCATCTTCGTCCAGAACAGCGGTTGGCTTTATTGCATGAAGGTACTGGTCCTCGTGTTATTTCTGCTTTTGTG GAGATTATTTTTGATAATTCAGACAACCGGTTACCAATCGATAAAGAGGAAGTTTCACTTCGAAGAGTTATTGGTGCCAAAAAGGATCAG TATTTCTTAGACAAGAAGATGGTCACGAAAAATGATGTGATGAACCTCCTTGAAAGCGCTGGTTTTTCTCGAAGCAATCCTTATTATATT GTTAAACAAGGAAAGATCAACCAGATGGCAACAGCACCAGATTCTCAGAGATTAAAGCTATTAAGAGAAGTAGCTGGTACTAGAGTGTAT GACGAACGAAAGGAAGAAAGCATCTCCTTAATGAAAGAAACAGAGGGCAAACGGGAAAAAATCAATGAGTTGTTAAAATACATTGAAGAG AGATTACATACTCTAGAGGAAGAAAAGGAAGAACTAGCTCAGTATCAGAAGTGGGATAAAATGAGACGAGCCCTGGAATATACCATTTAC AATCAGGAACTTAACGAGACTCGTGCCAAACTTGATGAGCTTTCTGCTAAGCGAGAGACTAGTGGAGAAAAATCCAGACAATTAAGAGAT GCTCAGCAGGATGCAAGAGATAAAATGGAGGATATCGAACGCCAAGTTAGAGAATTGAAAACAAAAATTTCAGCTATGAAAGAAGAAAAA GAACAGCTTAGTGCTGAAAGACAAGAGCAGATTAAGCAGAGGACTAAGTTGGAGCTTAAAGCCAAGGATTTACAAGATGAACTAGCAGGC AATAGTGAACAAAGGAAACGTTTATTAAAAGAGAGGCAGAAGCTGCTTGAAAAAATAGAAGAAAAGCAGAAAGAACTGGCAGAAACAGAA CCCAAATTCAACAGTGTGAAAGAGAAAGAAGAACGAGGAATTGCTAGATTGGCTCAAGCTACCCAGGAAAGAACGGATCTTTATGCAAAG CAGGGTCGAGGAAGCCAGTTTACATCAAAAGAAGAAAGGGATAAGTGGATTAAAAAGGAACTCAAGTCTTTAGATCAGGCTATTAATGAC AAGAAAAGACAGATTGCTGCTATACATAAGGATTTGGAAGACACTGAAGCAAATAAAGAGAAAAATCTGGAGCAGTATAATAAACTGGAC CAGGATCTTAATGAAGTCAAAGCTCGAGTAGAAGAACTGGACAGAAAATATTACGAAGTAAAAAATAAGAAAGATGAACTACAAAGTGAA AGAAACTACTTGTGGAGAGAAGAGAATGCAGAACAGCAAGCACTTGCTGCTAAAAGAGAAGATCTTGAAAAGAAGCAACAACTTCTTAGA GCAGCAACAGGAAAGGCCATTTTAAATGGAATAGACAGCATAAACAAAGTGCTAGACCACTTCCGTCGAAAAGGAATAAACCAGCATGTT CAAAATGGCTATCATGGTATTGTAATGAATAACTTTGAATGTGAACCAGCTTTCTACACATGCGTGGAAGTCACTGCTGGAAACAGACGA GCTCATCTGCGCCTTTGTTTAGAACGCTTAAAAGTTCTGATTCCACTAGGACCAGACTGCACCCGGCACACAACACTTGGTTTGCTCAAC AAAGCCAAAGCACACATCAAGAAACTTGAAGAAGCTGAAAGAAAAAGCCAGCACCAGCTCGAGAATTTGGAACGAGAACAGAGATTTTTA AAGTGGCGACTGGAACAGCTGCAGGGTCCTCAGGAGATGGAACGAATACGAATGGACAGCATTGGATCAACTATTTCTTCAGATCGTTCT GATTCAGAGCGAGAGGAGATTGAAGTGGATGTTGAAAGCACAGAGTTCTCCCATGGAGAAGTGGACAATATAAGTACCACCAGCATCAGT GACATTGATGACCACAGCAGCCTGCCGAGTATTGGGAGTGACGAGGGTTACTCCAGTGCCAGTGTCAAACTTTCATTCACTTCATAGAAC CCAGCATGACATAACAGTGCAGGGCAAAATATTCACTGGGCCAATTCAATACAAACAATCTCTTAAATTGGGTTCATGATGCAGTCTCCT CTTTAAAACAAAACAAAACAAAACAAAACTATACTTGAACAAAAGGGTCAGAGGACCTGTATTTAAGCAAATACTTAGCAAAAAGTGGGG CAGAGCCTCCCAAGGAGAACAAATATTCAGAATATTCATATTGGAAAAATCACAATTTTTAATGGCAGCAGAAAACTTGTGTGAAATTTT CTTGATTTGAGTTGATTGAGAAGAGGACATTGGAGATGCCATCCTCTTTCTCTTTTCTAGTTTGCTCATACTACATTGAGTAGACACATT TAAGGATGGGGTTATGAACCCTTCCTGAGCTTTATGGTCCTAAAAGCAAAATAAAAACTATTCGAATGAAAAGACAAGAAAATCAGGTAT TAATCTTGGATAGCTAATAATGAGCTATTAAAACTCAGCCTGGGACAGTTTATCATGAAGCCTGTGGATGATCAATCCTTTATTATTATT TTTTTTTTTTGAAAAAAGCTCATTTCATGCTCTGCAAAAGGAGAGACTCCCATGAAGCCTTTTGAAAGGGATCATCATGCAGCTCAACTT TCTGTTGGATTCCATGCTAAGCAAGCTAACCTTATCCTGCATTGTTAGCACTAGGCACCCAGCTGCCACCTCTCCATCCTGCTGCCCTTA GGCCACATGGGAGCAGTCCATGCATGACAGCCTCTATCCTACAAGGCCTATGAGTATGGATTGGGGGGGCCAAAAGGAAAAAGCTCCATG TGCCTCTTTGTCTGCGTGGGTCAGAAGAGTTGTGCACGCAGATTAGCAGGCCAAGGTCTGAGCCACAGCAGCATTTTTATTTCAGATTTT GATAACTGTTTATATGTGTTGAAAACCAAAATGACATCTTTTTAAAGCTTATCCATAAAAAAAAATAGATGTCTTTTATAGTGGAAAAAC ACATGGGGAAAAAAATCATCTATTTTGATGCAGCATTTGATAATGATAAAACACCTCACACCTCACTCTTTATAGTGCACAAAATGAATG AGGTCTGGGCTAGGTAGAAAAAGGGTCAATGCTATTTTTGTTTTTAGAATCATTACCTTTTACCAGCTTTTAACCATCTGATATCTATAG TAGACACACTATCATAGTTAACATAGTAAGTTCAGCACTTGTCTCATTTTAATGTAAAGATTTGCTTCCATTTTCCTACAGGCAGTCTCT CTCTTCCTCACAGTCCCACTGTGCAGGTGCTATTGTTACTCTTACGAATATTTTCAGTAATGTTATTTTCTTCTAAGTGAAATTTCTAGC CTGCACTTTGATGTCATGTGTTCCCTTTGTCTTTCAAACTCCAAGGTTCCCTTGTGGCCCTCTCCCTTACCCTGGGAAGGCCTCTTGGAG >In-frame_SMC3_ENST00000361804_chr10_112350330_+_MXI1_ENST00000393134_chr10_112038938_+_2352nt TTTTGTTTGGCTGAGGGGAGCGAGCGGCGCTTTGGGGGAGGGGTCGCGTAGGCGCCTCACCTGACCCTGCGGCCGTGCGGTTGCTGCTCC GGGGCAGGTCTCCTTCCAGGCCAGGGGCCCGGAATCATGTACATAAAGCAGGTGATTATCCAGGGTTTTCGAAGTTACAGAGATCAAACA ATTGTAGATCCCTTCAGTTCAAAACATAATGTGATTGTGGGCAGAAATGGATCTGGAAAAAGTAACTTTTTTTATGCAATTCAGTTTGTT CTCAGTGATGAGTTTAGTCATCTTCGTCCAGAACAGCGGTTGGCTTTATTGCATGAAGGTACTGGTCCTCGTGTTATTTCTGCTTTTGTG GAGATTATTTTTGATAATTCAGACAACCGGTTACCAATCGATAAAGAGGAAGTTTCACTTCGAAGAGTTATTGGTGCCAAAAAGGATCAG TATTTCTTAGACAAGAAGATGGTCACGAAAAATGATGTGATGAACCTCCTTGAAAGCGCTGGTTTTTCTCGAAGCAATCCTTATTATATT GTTAAACAAGGAAAGATCAACCAGATGGCAACAGCACCAGATTCTCAGAGATTAAAGCTATTAAGAGAAGTAGCTGGTACTAGAGTGTAT GACGAACGAAAGGAAGAAAGCATCTCCTTAATGAAAGAAACAGAGGGCAAACGGGAAAAAATCAATGAGTTGTTAAAATACATTGAAGAG AGATTACATACTCTAGAGGAAGAAAAGGAAGAACTAGCTCAGTATCAGAAGTGGGATAAAATGAGACGAGCCCTGGAATATACCATTTAC AATCAGGAACTTAACGAGACTCGTGCCAAACTTGATGAGCTTTCTGCTAAGCGAGAGACTAGTGGAGAAAAATCCAGACAATTAAGAGAT GCTCAGCAGGATGCAAGAGATAAAATGGAGGATATCGAACGCCAAGTTAGAGAATTGAAAACAAAAATTTCAGCTATGAAAGAAGAAAAA GAACAGCTTAGTGCTGAAAGACAAGAGCAGATTAAGCAGAGGACTAAGTTGGAGCTTAAAGCCAAGGATTTACAAGATGAACTAGCAGGC AATAGTGAACAAAGGAAACGTTTATTAAAAGAGAGGCAGAAGCTGCTTGAAAAAATAGAAGAAAAGCAGAAAGAACTGGCAGAAACAGAA CCCAAATTCAACAGTGTGAAAGAGAAAGAAGAACGAGGAATTGCTAGATTGGCTCAAGCTACCCAGGAAAGAACGGATCTTTATGCAAAG CAGGGTCGAGGAAGCCAGTTTACATCAAAAGAAGAAAGGGATAAGTGGATTAAAAAGGAACTCAAGTCTTTAGATCAGGCTATTAATGAC AAGAAAAGACAGATTGCTGCTATACATAAGGATTTGGAAGACACTGAAGCAAATAAAGAGAAAAATCTGGAGCAGTATAATAAACTGGAC CAGGATCTTAATGAAGTCAAAGCTCGAGTAGAAGAACTGGACAGAAAATATTACGAAGTAAAAAATAAGAAAGATGAACTACAAAGTGAA AGAAACTACTTGTGGAGAGAAGAGAATGCAGAACAGCAAGCACTTGCTGCTAAAAGAGAAGATCTTGAAAAGAAGCAACAACTTCTTAGA GCAGCAACAGGAAAGGCCATTTTAAATGGAATAGACAGCATAAACAAAGTGCTAGACCACTTCCGTCGAAAAGGAATAAACCAGCATGTT CAAAATGGCTATCATGGTATTGTAATGAATAACTTTGAATGTGAACCAGCTTTCTACACATGCGTGGAAGTCACTGCTGGAAACAGACGA GCTCATCTGCGCCTTTGTTTAGAACGCTTAAAAGTTCTGATTCCACTAGGACCAGACTGCACCCGGCACACAACACTTGGTTTGCTCAAC AAAGCCAAAGCACACATCAAGAAACTTGAAGAAGCTGAAAGAAAAAGCCAGCACCAGCTCGAGAATTTGGAACGAGAACAGAGATTTTTA AAGTGGCGACTGGAACAGCTGCAGGGTCCTCAGGAGATGGAACGAATACGAATGGACAGCATTGGATCAACTATTTCTTCAGATCGTTCT GATTCAGAGCGAGAGGAGATTGAAGTGGATGTTGAAAGCACAGAGTTCTCCCATGGAGAAGTGGACAATATAAGTACCACCAGCATCAGT GACATTGATGACCACAGCAGCCTGCCGAGTATTGGGAGTGACGAGGGTTACTCCAGTGCCAGTGTCAAACTTTCATTCACTTCATAGAAC CCAGCATGACATAACAGTGCAGGGCAAAATATTCACTGGGCCAATTCAATACAAACAATCTCTTAAATTGGGTTCATGATGCAGTCTCCT |
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FusionGenePPI for SMC3_MXI1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SMC3 | CASP4, NEK6, CDK4, MAGED1, SMC1A, REC8, SYCP3, SMARCA5, HDAC2, NUMA1, TUBB, STAG1, MXI1, MXD3, MXD4, MXD1, KIFAP3, STAG3, RAE1, USP13, ATM, PMS1, AIRE, BECN1, CAMKK2, APC, WFDC5, PDS5A, CDCA5, FEZ1, FEZ2, SRRM1, RPGR, PAXIP1, TERF2, SSU72, RAD21, STAG2, PDS5B, HDAC5, WAPAL, DISC1, CEP63, TRAF3IP1, SMARCAD1, HDGF, POLR2A, CTCF, SUPT5H, NIPBL, CDK8, MECP2, FBXO25, CUL3, CUL2, CDK2, COPS5, COPS6, NSMCE2, FBXO6, HNRNPM, SFPQ, NOTCH1, METTL21B, MMS19, SOX2, HDAC8, HDAC9, HDAC11, ANKRD28, RPA1, RPA2, RPA3, BRCA1, CUL7, OBSL1, CCDC8, SUZ12, EED, RNF2, EGFR, SIRT6, ESR1, SDF4, PSMC2, BRCA2, COPG1, KPNB1, MAPRE2, MSH6, SMARCA2, SMARCA4, DNAJA2, PLIN4, PLK1, SF3B3, SMC1B, SSB, NTRK1, RPGRIP1L, HIST1H3E, CLTB, RPL37A, IQGAP1, HERC2, CEP170, SMC2, FNDC3A, ARHGEF12, GNL3L, TMEM165, NEURL4, CHMP4B, NFATC1, TEAD2, FOXB1, FOXG1, FOXJ2, FOXL1, FOXP3, NF2, USP37, SNW1, CDC5L, RNF126, NANOG, POU5F1, MCM2, MCM4, SPAG9, USP15, MCM6, EPS15L1, IVNS1ABP, GTF3C4, NCL, MTNR1B, DLD, SDHA | MXI1 | MAX, SMC3, SIN3B, BUB1B, CDC20, APP, ENTPD5, CALCOCO2, RPL23AP32, KRT40, KRTAP10-7, KRTAP10-9, KRTAP10-5, KRTAP10-8, KRTAP10-3, NOTCH2NL, FBXW11, MXD3, BTRC, SMARCB1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SMC3_MXI1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SMC3_MXI1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SMC3 | C0023470 | Myeloid Leukemia | 1 | CTD_human |
| Tgene | MXI1 | C0022658 | Kidney Diseases | 1 | CTD_human |
| Tgene | MXI1 | C0376358 | Malignant neoplasm of prostate | 1 | UNIPROT |
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