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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 34825

FusionGeneSummary for SMARCC1_SHISA5

check button Fusion gene summary
Fusion gene informationFusion gene name: SMARCC1_SHISA5
Fusion gene ID: 34825
HgeneTgene
Gene symbol

SMARCC1

SHISA5

Gene ID

6599

51246

Gene nameSWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1shisa family member 5
SynonymsBAF155|CRACC1|Rsc8|SRG3|SWI3SCOTIN
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
DescriptionSWI/SNF complex subunit SMARCC1BRG1-associated factor 155SWI/SNF complex 155 kDa subunitSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1chromatin remodeling complex BAF155 subunitmammalian chromatin remodeprotein shisa-5putative NF-kappa-B-activating protein 120shisa homolog 5
Modification date2018052320180523
UniProtAcc

Q92922

Q8N114

Ensembl transtripts involved in fusion geneENST00000254480, ENST00000425518, 
ENST00000296444, ENST00000444115, 
ENST00000426002, ENST00000465449, 
ENST00000442747, ENST00000443308, 
Fusion gene scores* DoF score13 X 10 X 9=117013 X 10 X 7=910
# samples 1713
** MAII scorelog2(17/1170*10)=-2.78290187833307
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/910*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SMARCC1 [Title/Abstract] AND SHISA5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSMARCC1

GO:0006337

nucleosome disassembly

8895581

HgeneSMARCC1

GO:0006338

chromatin remodeling

10078207|11018012|11726552

HgeneSMARCC1

GO:0045893

positive regulation of transcription, DNA-templated

11018012


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-BT-A20W-01ASMARCC1chr3

47747899

-SHISA5chr3

48511242

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000254480ENST00000296444SMARCC1chr3

47747899

-SHISA5chr3

48511242

-
In-frameENST00000254480ENST00000444115SMARCC1chr3

47747899

-SHISA5chr3

48511242

-
In-frameENST00000254480ENST00000426002SMARCC1chr3

47747899

-SHISA5chr3

48511242

-
5CDS-5UTRENST00000254480ENST00000465449SMARCC1chr3

47747899

-SHISA5chr3

48511242

-
5CDS-5UTRENST00000254480ENST00000442747SMARCC1chr3

47747899

-SHISA5chr3

48511242

-
5CDS-5UTRENST00000254480ENST00000443308SMARCC1chr3

47747899

-SHISA5chr3

48511242

-
5UTR-3CDSENST00000425518ENST00000296444SMARCC1chr3

47747899

-SHISA5chr3

48511242

-
5UTR-3CDSENST00000425518ENST00000444115SMARCC1chr3

47747899

-SHISA5chr3

48511242

-
5UTR-3CDSENST00000425518ENST00000426002SMARCC1chr3

47747899

-SHISA5chr3

48511242

-
5UTR-5UTRENST00000425518ENST00000465449SMARCC1chr3

47747899

-SHISA5chr3

48511242

-
5UTR-5UTRENST00000425518ENST00000442747SMARCC1chr3

47747899

-SHISA5chr3

48511242

-
5UTR-5UTRENST00000425518ENST00000443308SMARCC1chr3

47747899

-SHISA5chr3

48511242

-

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FusionProtFeatures for SMARCC1_SHISA5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SMARCC1

Q92922

SHISA5

Q8N114

Involved in transcriptional activation and repression ofselect genes by chromatin remodeling (alteration of DNA-nucleosometopology). Component of SWI/SNF chromatin remodeling complexesthat carry out key enzymatic activities, changing chromatinstructure by altering DNA-histone contacts within a nucleosome inan ATP-dependent manner. May stimulate the ATPase activity of thecatalytic subunit of the complex (PubMed:10078207). Belongs to theneural progenitors-specific chromatin remodeling complex (npBAFcomplex) and the neuron-specific chromatin remodeling complex(nBAF complex). During neural development a switch from astem/progenitor to a postmitotic chromatin remodeling mechanismoccurs as neurons exit the cell cycle and become committed totheir adult state. The transition from proliferating neuralstem/progenitor cells to postmitotic neurons requires a switch insubunit composition of the npBAF and nBAF complexes. As neuralprogenitors exit mitosis and differentiate into neurons, npBAFcomplexes which contain ACTL6A/BAF53A and PHF10/BAF45A, areexchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45Bor DPF3/BAF45C subunits in neuron-specific complexes (nBAF). ThenpBAF complex is essential for the self-renewal/proliferativecapacity of the multipotent neural stem cells. The nBAF complexalong with CREST plays a role regulating the activity of genesessential for dendrite growth (By similarity).{ECO:0000250|UniProtKB:P97496, ECO:0000269|PubMed:10078207,ECO:0000269|PubMed:11018012, ECO:0000303|PubMed:22952240,ECO:0000303|PubMed:26601204}. Can induce apoptosis in a caspase-dependent manner andplays a role in p53/TP53-dependent apoptosis.{ECO:0000269|PubMed:12135983}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMARCC1chr3:47747899chr3:48511242ENST00000254480-1028329_3363461106Compositional biasNote=Poly-Pro
TgeneSHISA5chr3:47747899chr3:48511242ENST00000296444-26147_153104241Compositional biasNote=Poly-Thr
TgeneSHISA5chr3:47747899chr3:48511242ENST00000296444-26158_230104241Compositional biasNote=Pro-rich
TgeneSHISA5chr3:47747899chr3:48511242ENST00000426002-04147_1531138Compositional biasNote=Poly-Thr
TgeneSHISA5chr3:47747899chr3:48511242ENST00000426002-04158_2301138Compositional biasNote=Pro-rich
TgeneSHISA5chr3:47747899chr3:48511242ENST00000442747-26147_15373210Compositional biasNote=Poly-Thr
TgeneSHISA5chr3:47747899chr3:48511242ENST00000442747-26158_23073210Compositional biasNote=Pro-rich
TgeneSHISA5chr3:47747899chr3:48511242ENST00000444115-26147_15373210Compositional biasNote=Poly-Thr
TgeneSHISA5chr3:47747899chr3:48511242ENST00000444115-26158_23073210Compositional biasNote=Pro-rich
TgeneSHISA5chr3:47747899chr3:48511242ENST00000296444-26127_240104241Topological domainCytoplasmic
TgeneSHISA5chr3:47747899chr3:48511242ENST00000426002-04127_2401138Topological domainCytoplasmic
TgeneSHISA5chr3:47747899chr3:48511242ENST00000426002-0429_1051138Topological domainExtracellular
TgeneSHISA5chr3:47747899chr3:48511242ENST00000442747-26127_24073210Topological domainCytoplasmic
TgeneSHISA5chr3:47747899chr3:48511242ENST00000444115-26127_24073210Topological domainCytoplasmic
TgeneSHISA5chr3:47747899chr3:48511242ENST00000296444-26106_126104241TransmembraneHelical
TgeneSHISA5chr3:47747899chr3:48511242ENST00000426002-04106_1261138TransmembraneHelical
TgeneSHISA5chr3:47747899chr3:48511242ENST00000442747-26106_12673210TransmembraneHelical
TgeneSHISA5chr3:47747899chr3:48511242ENST00000444115-26106_12673210TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMARCC1chr3:47747899chr3:48511242ENST00000254480-1028914_9463461106Coiled coilOntology_term=ECO:0000255
HgeneSMARCC1chr3:47747899chr3:48511242ENST00000254480-1028769_8633461106Compositional biasNote=Glu-rich
HgeneSMARCC1chr3:47747899chr3:48511242ENST00000254480-1028867_8783461106Compositional biasNote=Poly-Ala
HgeneSMARCC1chr3:47747899chr3:48511242ENST00000254480-1028977_11053461106Compositional biasNote=Pro-rich
HgeneSMARCC1chr3:47747899chr3:48511242ENST00000254480-1028449_5463461106DomainSWIRM
HgeneSMARCC1chr3:47747899chr3:48511242ENST00000254480-1028618_6693461106DomainSANT
TgeneSHISA5chr3:47747899chr3:48511242ENST00000296444-2629_105104241Topological domainExtracellular
TgeneSHISA5chr3:47747899chr3:48511242ENST00000442747-2629_10573210Topological domainExtracellular
TgeneSHISA5chr3:47747899chr3:48511242ENST00000444115-2629_10573210Topological domainExtracellular


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FusionGeneSequence for SMARCC1_SHISA5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SMARCC1_ENST00000254480_chr3_47747899_-_SHISA5_ENST00000296444_chr3_48511242_-_483aa
MAAAAGGGGPGTAVGATGSGIAAAAAGLAVYRRKDGGPATKFWESPETVSQLDSVRVWLGKHYKKYVHADAPTNKTLAGLVVQLLQFQED
AFGKHVTNPAFTKLPAKCFMDFKAGGALCHILGAAYKYKNEQGWRRFDLQNPSRMDRNVEMFMNIEKTLVQNNCLTRPNIYLIPDIDLKL
ANKLKDIIKRHQGTFTDEKSKASHHIYPYSSSQDDEEWLRPVMRKEKQVLVHWGFYPDSYDTWVHSNDVDAEIEDPPIPEKPWKVHVKWI
LDTDIFNEWMNEEDYEVDENRKPVSFRQRISTKNEEPVRSPERRDRKASANARKRKHSPSPPPPTPTESRKKSGKKGFGATLAVGLTIFV
LSVVTIIICFTCSCCCLYKTCRRPRPVVTTTTSTTVVHAPYPQPPSVPPSYPGPSYQGYHTMPPQPGMPAAPYPMQYPPPYPAQPMGPPA

>In-frame_SMARCC1_ENST00000254480_chr3_47747899_-_SHISA5_ENST00000444115_chr3_48511242_-_483aa
MAAAAGGGGPGTAVGATGSGIAAAAAGLAVYRRKDGGPATKFWESPETVSQLDSVRVWLGKHYKKYVHADAPTNKTLAGLVVQLLQFQED
AFGKHVTNPAFTKLPAKCFMDFKAGGALCHILGAAYKYKNEQGWRRFDLQNPSRMDRNVEMFMNIEKTLVQNNCLTRPNIYLIPDIDLKL
ANKLKDIIKRHQGTFTDEKSKASHHIYPYSSSQDDEEWLRPVMRKEKQVLVHWGFYPDSYDTWVHSNDVDAEIEDPPIPEKPWKVHVKWI
LDTDIFNEWMNEEDYEVDENRKPVSFRQRISTKNEEPVRSPERRDRKASANARKRKHSPSPPPPTPTESRKKSGKKGFGATLAVGLTIFV
LSVVTIIICFTCSCCCLYKTCRRPRPVVTTTTSTTVVHAPYPQPPSVPPSYPGPSYQGYHTMPPQPGMPAAPYPMQYPPPYPAQPMGPPA

>In-frame_SMARCC1_ENST00000254480_chr3_47747899_-_SHISA5_ENST00000426002_chr3_48511242_-_483aa
MAAAAGGGGPGTAVGATGSGIAAAAAGLAVYRRKDGGPATKFWESPETVSQLDSVRVWLGKHYKKYVHADAPTNKTLAGLVVQLLQFQED
AFGKHVTNPAFTKLPAKCFMDFKAGGALCHILGAAYKYKNEQGWRRFDLQNPSRMDRNVEMFMNIEKTLVQNNCLTRPNIYLIPDIDLKL
ANKLKDIIKRHQGTFTDEKSKASHHIYPYSSSQDDEEWLRPVMRKEKQVLVHWGFYPDSYDTWVHSNDVDAEIEDPPIPEKPWKVHVKWI
LDTDIFNEWMNEEDYEVDENRKPVSFRQRISTKNEEPVRSPERRDRKASANARKRKHSPSPPPPTPTESRKKSGKKGFGATLAVGLTIFV
LSVVTIIICFTCSCCCLYKTCRRPRPVVTTTTSTTVVHAPYPQPPSVPPSYPGPSYQGYHTMPPQPGMPAAPYPMQYPPPYPAQPMGPPA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SMARCC1_ENST00000254480_chr3_47747899_-_SHISA5_ENST00000296444_chr3_48511242_-_1449nt
ATGGCCGCAGCGGCGGGCGGCGGCGGGCCGGGGACAGCGGTAGGCGCCACGGGCTCGGGGATTGCGGCGGCAGCCGCAGGCCTAGCTGTT
TATCGACGGAAGGATGGGGGCCCGGCCACCAAGTTTTGGGAGAGCCCGGAGACGGTGTCCCAGCTGGATTCGGTGCGGGTCTGGCTGGGC
AAGCACTACAAGAAGTATGTTCATGCGGATGCTCCTACCAATAAAACACTGGCTGGGCTGGTGGTGCAGCTTCTTCAGTTCCAGGAAGAT
GCCTTTGGGAAGCATGTCACCAACCCGGCCTTCACCAAACTCCCTGCAAAGTGTTTCATGGATTTCAAAGCTGGAGGCGCCTTATGTCAC
ATTCTTGGGGCTGCTTACAAGTATAAAAATGAACAGGGATGGCGGAGGTTTGACCTACAGAACCCATCTCGAATGGATCGTAATGTGGAA
ATGTTTATGAACATTGAAAAAACATTGGTGCAGAACAATTGTTTGACCAGACCCAACATCTACCTCATTCCAGACATTGATCTGAAGTTG
GCTAACAAATTGAAAGATATCATCAAACGACATCAGGGAACATTTACGGATGAGAAGTCAAAAGCTTCCCACCACATTTACCCATATTCT
TCCTCACAAGACGATGAAGAATGGTTGAGACCGGTGATGAGAAAAGAGAAGCAAGTGTTAGTGCATTGGGGCTTTTACCCAGACAGCTAT
GATACTTGGGTCCATAGTAATGATGTTGATGCTGAAATTGAAGATCCACCAATTCCAGAAAAACCATGGAAGGTTCATGTGAAATGGATT
TTGGACACTGATATTTTCAATGAATGGATGAATGAGGAGGATTATGAGGTGGATGAAAATAGGAAGCCTGTGAGTTTTCGTCAGCGGATT
TCAACCAAGAATGAAGAGCCAGTCAGAAGTCCAGAAAGAAGAGATAGAAAAGCATCAGCTAATGCTCGAAAGAGGAAACATTCGCCTTCG
CCTCCCCCTCCGACACCAACAGAATCACGGAAGAAGAGTGGGAAGAAAGGGTTCGGAGCGACCTTGGCCGTTGGCCTGACCATCTTTGTG
CTGTCTGTCGTCACTATCATCATCTGCTTCACCTGCTCCTGCTGCTGCCTTTACAAGACGTGCCGCCGACCACGTCCGGTTGTCACCACC
ACCACATCCACCACTGTGGTGCATGCCCCTTATCCTCAGCCTCCAAGTGTGCCGCCCAGCTACCCTGGACCAAGCTACCAGGGCTACCAC
ACCATGCCGCCTCAGCCAGGGATGCCAGCAGCACCCTACCCAATGCAGTACCCACCACCTTACCCAGCCCAGCCCATGGGCCCACCGGCC
TACCACGAGACCCTGGCTGGAGGAGCAGCCGCGCCCTACCCCGCCAGCCAGCCTCCTTACAACCCGGCCTACATGGATGCCCCGAAGGCG

>In-frame_SMARCC1_ENST00000254480_chr3_47747899_-_SHISA5_ENST00000444115_chr3_48511242_-_1449nt
ATGGCCGCAGCGGCGGGCGGCGGCGGGCCGGGGACAGCGGTAGGCGCCACGGGCTCGGGGATTGCGGCGGCAGCCGCAGGCCTAGCTGTT
TATCGACGGAAGGATGGGGGCCCGGCCACCAAGTTTTGGGAGAGCCCGGAGACGGTGTCCCAGCTGGATTCGGTGCGGGTCTGGCTGGGC
AAGCACTACAAGAAGTATGTTCATGCGGATGCTCCTACCAATAAAACACTGGCTGGGCTGGTGGTGCAGCTTCTTCAGTTCCAGGAAGAT
GCCTTTGGGAAGCATGTCACCAACCCGGCCTTCACCAAACTCCCTGCAAAGTGTTTCATGGATTTCAAAGCTGGAGGCGCCTTATGTCAC
ATTCTTGGGGCTGCTTACAAGTATAAAAATGAACAGGGATGGCGGAGGTTTGACCTACAGAACCCATCTCGAATGGATCGTAATGTGGAA
ATGTTTATGAACATTGAAAAAACATTGGTGCAGAACAATTGTTTGACCAGACCCAACATCTACCTCATTCCAGACATTGATCTGAAGTTG
GCTAACAAATTGAAAGATATCATCAAACGACATCAGGGAACATTTACGGATGAGAAGTCAAAAGCTTCCCACCACATTTACCCATATTCT
TCCTCACAAGACGATGAAGAATGGTTGAGACCGGTGATGAGAAAAGAGAAGCAAGTGTTAGTGCATTGGGGCTTTTACCCAGACAGCTAT
GATACTTGGGTCCATAGTAATGATGTTGATGCTGAAATTGAAGATCCACCAATTCCAGAAAAACCATGGAAGGTTCATGTGAAATGGATT
TTGGACACTGATATTTTCAATGAATGGATGAATGAGGAGGATTATGAGGTGGATGAAAATAGGAAGCCTGTGAGTTTTCGTCAGCGGATT
TCAACCAAGAATGAAGAGCCAGTCAGAAGTCCAGAAAGAAGAGATAGAAAAGCATCAGCTAATGCTCGAAAGAGGAAACATTCGCCTTCG
CCTCCCCCTCCGACACCAACAGAATCACGGAAGAAGAGTGGGAAGAAAGGGTTCGGAGCGACCTTGGCCGTTGGCCTGACCATCTTTGTG
CTGTCTGTCGTCACTATCATCATCTGCTTCACCTGCTCCTGCTGCTGCCTTTACAAGACGTGCCGCCGACCACGTCCGGTTGTCACCACC
ACCACATCCACCACTGTGGTGCATGCCCCTTATCCTCAGCCTCCAAGTGTGCCGCCCAGCTACCCTGGACCAAGCTACCAGGGCTACCAC
ACCATGCCGCCTCAGCCAGGGATGCCAGCAGCACCCTACCCAATGCAGTACCCACCACCTTACCCAGCCCAGCCCATGGGCCCACCGGCC
TACCACGAGACCCTGGCTGGAGGAGCAGCCGCGCCCTACCCCGCCAGCCAGCCTCCTTACAACCCGGCCTACATGGATGCCCCGAAGGCG

>In-frame_SMARCC1_ENST00000254480_chr3_47747899_-_SHISA5_ENST00000426002_chr3_48511242_-_1449nt
ATGGCCGCAGCGGCGGGCGGCGGCGGGCCGGGGACAGCGGTAGGCGCCACGGGCTCGGGGATTGCGGCGGCAGCCGCAGGCCTAGCTGTT
TATCGACGGAAGGATGGGGGCCCGGCCACCAAGTTTTGGGAGAGCCCGGAGACGGTGTCCCAGCTGGATTCGGTGCGGGTCTGGCTGGGC
AAGCACTACAAGAAGTATGTTCATGCGGATGCTCCTACCAATAAAACACTGGCTGGGCTGGTGGTGCAGCTTCTTCAGTTCCAGGAAGAT
GCCTTTGGGAAGCATGTCACCAACCCGGCCTTCACCAAACTCCCTGCAAAGTGTTTCATGGATTTCAAAGCTGGAGGCGCCTTATGTCAC
ATTCTTGGGGCTGCTTACAAGTATAAAAATGAACAGGGATGGCGGAGGTTTGACCTACAGAACCCATCTCGAATGGATCGTAATGTGGAA
ATGTTTATGAACATTGAAAAAACATTGGTGCAGAACAATTGTTTGACCAGACCCAACATCTACCTCATTCCAGACATTGATCTGAAGTTG
GCTAACAAATTGAAAGATATCATCAAACGACATCAGGGAACATTTACGGATGAGAAGTCAAAAGCTTCCCACCACATTTACCCATATTCT
TCCTCACAAGACGATGAAGAATGGTTGAGACCGGTGATGAGAAAAGAGAAGCAAGTGTTAGTGCATTGGGGCTTTTACCCAGACAGCTAT
GATACTTGGGTCCATAGTAATGATGTTGATGCTGAAATTGAAGATCCACCAATTCCAGAAAAACCATGGAAGGTTCATGTGAAATGGATT
TTGGACACTGATATTTTCAATGAATGGATGAATGAGGAGGATTATGAGGTGGATGAAAATAGGAAGCCTGTGAGTTTTCGTCAGCGGATT
TCAACCAAGAATGAAGAGCCAGTCAGAAGTCCAGAAAGAAGAGATAGAAAAGCATCAGCTAATGCTCGAAAGAGGAAACATTCGCCTTCG
CCTCCCCCTCCGACACCAACAGAATCACGGAAGAAGAGTGGGAAGAAAGGGTTCGGAGCGACCTTGGCCGTTGGCCTGACCATCTTTGTG
CTGTCTGTCGTCACTATCATCATCTGCTTCACCTGCTCCTGCTGCTGCCTTTACAAGACGTGCCGCCGACCACGTCCGGTTGTCACCACC
ACCACATCCACCACTGTGGTGCATGCCCCTTATCCTCAGCCTCCAAGTGTGCCGCCCAGCTACCCTGGACCAAGCTACCAGGGCTACCAC
ACCATGCCGCCTCAGCCAGGGATGCCAGCAGCACCCTACCCAATGCAGTACCCACCACCTTACCCAGCCCAGCCCATGGGCCCACCGGCC
TACCACGAGACCCTGGCTGGAGGAGCAGCCGCGCCCTACCCCGCCAGCCAGCCTCCTTACAACCCGGCCTACATGGATGCCCCGAAGGCG


* Fusion transcript sequences (Full-length transcript).
>In-frame_SMARCC1_ENST00000254480_chr3_47747899_-_SHISA5_ENST00000296444_chr3_48511242_-_2878nt
GGCTGGGCGGGGCCGGGAAGCGGCAGTGGCGGCTACGCGCGCGGGGGTGCGCGCGGGAACGACCGGGAAACACCGCGAGGGCCGGGGTGG
GCCAGGCTGTGGGGACGACGGGCTGCGACGATGGCCGCAGCGGCGGGCGGCGGCGGGCCGGGGACAGCGGTAGGCGCCACGGGCTCGGGG
ATTGCGGCGGCAGCCGCAGGCCTAGCTGTTTATCGACGGAAGGATGGGGGCCCGGCCACCAAGTTTTGGGAGAGCCCGGAGACGGTGTCC
CAGCTGGATTCGGTGCGGGTCTGGCTGGGCAAGCACTACAAGAAGTATGTTCATGCGGATGCTCCTACCAATAAAACACTGGCTGGGCTG
GTGGTGCAGCTTCTTCAGTTCCAGGAAGATGCCTTTGGGAAGCATGTCACCAACCCGGCCTTCACCAAACTCCCTGCAAAGTGTTTCATG
GATTTCAAAGCTGGAGGCGCCTTATGTCACATTCTTGGGGCTGCTTACAAGTATAAAAATGAACAGGGATGGCGGAGGTTTGACCTACAG
AACCCATCTCGAATGGATCGTAATGTGGAAATGTTTATGAACATTGAAAAAACATTGGTGCAGAACAATTGTTTGACCAGACCCAACATC
TACCTCATTCCAGACATTGATCTGAAGTTGGCTAACAAATTGAAAGATATCATCAAACGACATCAGGGAACATTTACGGATGAGAAGTCA
AAAGCTTCCCACCACATTTACCCATATTCTTCCTCACAAGACGATGAAGAATGGTTGAGACCGGTGATGAGAAAAGAGAAGCAAGTGTTA
GTGCATTGGGGCTTTTACCCAGACAGCTATGATACTTGGGTCCATAGTAATGATGTTGATGCTGAAATTGAAGATCCACCAATTCCAGAA
AAACCATGGAAGGTTCATGTGAAATGGATTTTGGACACTGATATTTTCAATGAATGGATGAATGAGGAGGATTATGAGGTGGATGAAAAT
AGGAAGCCTGTGAGTTTTCGTCAGCGGATTTCAACCAAGAATGAAGAGCCAGTCAGAAGTCCAGAAAGAAGAGATAGAAAAGCATCAGCT
AATGCTCGAAAGAGGAAACATTCGCCTTCGCCTCCCCCTCCGACACCAACAGAATCACGGAAGAAGAGTGGGAAGAAAGGGTTCGGAGCG
ACCTTGGCCGTTGGCCTGACCATCTTTGTGCTGTCTGTCGTCACTATCATCATCTGCTTCACCTGCTCCTGCTGCTGCCTTTACAAGACG
TGCCGCCGACCACGTCCGGTTGTCACCACCACCACATCCACCACTGTGGTGCATGCCCCTTATCCTCAGCCTCCAAGTGTGCCGCCCAGC
TACCCTGGACCAAGCTACCAGGGCTACCACACCATGCCGCCTCAGCCAGGGATGCCAGCAGCACCCTACCCAATGCAGTACCCACCACCT
TACCCAGCCCAGCCCATGGGCCCACCGGCCTACCACGAGACCCTGGCTGGAGGAGCAGCCGCGCCCTACCCCGCCAGCCAGCCTCCTTAC
AACCCGGCCTACATGGATGCCCCGAAGGCGGCCCTCTGAGCATTCCCTGGCCTCTCTGGCTGCCACTTGGTTATGTTGTGTGTGTGCGTG
AGTGGTGTGCAGGCGCGGTTCCTTACGCCCCATGTGTGCTGTGTGTGTCCAGGCACGGTTCCTTACGCCCCATGTGTGCTGTGTGTGTCC
TGCCTGTATATGTGGCTTCCTCTGATGCTGACAAGGTGGGGAACAATCCTTGCCAGAGTGGGCTGGGACCAGACTTTGTTCTCTTCCTCA
CCTGAAATTATGCTTCCTAAAATCTCAAGCCAAACTCAAAGAATGGGGTGGTGGGGGGCACCCTGTGAGGTGGCCCCTGAGAGGTGGGGG
CCTCTCCAGGGCACATCTGGAGTTCTTCTCCAGCTTACCCTAGGGTGACCAAGTAGGGCCTGTCACACCAGGGTGGCGCAGCTTTCTGTG
TGATGCAGATGTGTCCTGGTTTCGGCAGCGTAGCCAGCTGCTGCTTGAGGCCATGGCTCGTCCCCGGAGTTGGGGGTACCCGTTGCAGAG
CCAGGGACATGATGCAGGCGAAGCTTGGGATCTGGCCAAGTTGGACTTTGATCCTTTGGGCAGATGTCCCATTGCTCCCTGGAGCCTGTC
ATGCCTGTTGGGGATCAGGCAGCCTCCTGATGCCAGAACACCTCAGGCAGAGCCCTACTCAGCTGTACCTGTCTGCCTGGACTGTCCCCT
GTCCCCGCATCTCCCCTGGGACCAGCTGGAGGGCCACATGCACACACAGCCTAGCTGCCCCCAGGGAGCTCTGCTGCCCTTGCTGGCCCT
GCCCTTCCCACAGGTGAGCAGGGCTCCTGTCCACCAGCACACTCAGTTCTCTTCCCTGCAGTGTTTTCATTTTATTTTAGCCAAACATTT
TGCCTGTTTTCTGTTTCAAACATGATAGTTGATATGAGACTGAAACCCCTGGGTTGTGGAGGGAAATTGGCTCAGAGATGGACAACCTGG
CAACTGTGAGTCCCTGCTTCCCGACACCAGCCTCATGGAATATGCAACAACTCCTGTACCCCAGTCCACGGTGTTCTGGCAGCAGGGACA
CCTGGGCCAATGGGCCATCTGGACCAAAGGTGGGGTGTGGGGCCCTGGATGGCAGCTCTGGCCCAGACATGAATACCTCGTGTTCCTCCT
CCCTCTATTACTGTTTCACCAGAGCTGTCTTAGCTCAAATCTGTTGTGTTTCTGAGTCTAGGGTCTGTACACTTGTTTATAATAAATGCA

>In-frame_SMARCC1_ENST00000254480_chr3_47747899_-_SHISA5_ENST00000444115_chr3_48511242_-_2806nt
GGCTGGGCGGGGCCGGGAAGCGGCAGTGGCGGCTACGCGCGCGGGGGTGCGCGCGGGAACGACCGGGAAACACCGCGAGGGCCGGGGTGG
GCCAGGCTGTGGGGACGACGGGCTGCGACGATGGCCGCAGCGGCGGGCGGCGGCGGGCCGGGGACAGCGGTAGGCGCCACGGGCTCGGGG
ATTGCGGCGGCAGCCGCAGGCCTAGCTGTTTATCGACGGAAGGATGGGGGCCCGGCCACCAAGTTTTGGGAGAGCCCGGAGACGGTGTCC
CAGCTGGATTCGGTGCGGGTCTGGCTGGGCAAGCACTACAAGAAGTATGTTCATGCGGATGCTCCTACCAATAAAACACTGGCTGGGCTG
GTGGTGCAGCTTCTTCAGTTCCAGGAAGATGCCTTTGGGAAGCATGTCACCAACCCGGCCTTCACCAAACTCCCTGCAAAGTGTTTCATG
GATTTCAAAGCTGGAGGCGCCTTATGTCACATTCTTGGGGCTGCTTACAAGTATAAAAATGAACAGGGATGGCGGAGGTTTGACCTACAG
AACCCATCTCGAATGGATCGTAATGTGGAAATGTTTATGAACATTGAAAAAACATTGGTGCAGAACAATTGTTTGACCAGACCCAACATC
TACCTCATTCCAGACATTGATCTGAAGTTGGCTAACAAATTGAAAGATATCATCAAACGACATCAGGGAACATTTACGGATGAGAAGTCA
AAAGCTTCCCACCACATTTACCCATATTCTTCCTCACAAGACGATGAAGAATGGTTGAGACCGGTGATGAGAAAAGAGAAGCAAGTGTTA
GTGCATTGGGGCTTTTACCCAGACAGCTATGATACTTGGGTCCATAGTAATGATGTTGATGCTGAAATTGAAGATCCACCAATTCCAGAA
AAACCATGGAAGGTTCATGTGAAATGGATTTTGGACACTGATATTTTCAATGAATGGATGAATGAGGAGGATTATGAGGTGGATGAAAAT
AGGAAGCCTGTGAGTTTTCGTCAGCGGATTTCAACCAAGAATGAAGAGCCAGTCAGAAGTCCAGAAAGAAGAGATAGAAAAGCATCAGCT
AATGCTCGAAAGAGGAAACATTCGCCTTCGCCTCCCCCTCCGACACCAACAGAATCACGGAAGAAGAGTGGGAAGAAAGGGTTCGGAGCG
ACCTTGGCCGTTGGCCTGACCATCTTTGTGCTGTCTGTCGTCACTATCATCATCTGCTTCACCTGCTCCTGCTGCTGCCTTTACAAGACG
TGCCGCCGACCACGTCCGGTTGTCACCACCACCACATCCACCACTGTGGTGCATGCCCCTTATCCTCAGCCTCCAAGTGTGCCGCCCAGC
TACCCTGGACCAAGCTACCAGGGCTACCACACCATGCCGCCTCAGCCAGGGATGCCAGCAGCACCCTACCCAATGCAGTACCCACCACCT
TACCCAGCCCAGCCCATGGGCCCACCGGCCTACCACGAGACCCTGGCTGGAGGAGCAGCCGCGCCCTACCCCGCCAGCCAGCCTCCTTAC
AACCCGGCCTACATGGATGCCCCGAAGGCGGCCCTCTGAGCATTCCCTGGCCTCTCTGGCTGCCACTTGGTTATGTTGTGTGTGTGCGTG
AGTGGTGTGCAGGCGCGGTTCCTTACGCCCCATGTGTGCTGTGTGTGTCCAGGCACGGTTCCTTACGCCCCATGTGTGCTGTGTGTGTCC
TGCCTGTATATGTGGCTTCCTCTGATGCTGACAAGGTGGGGAACAATCCTTGCCAGAGTGGGCTGGGACCAGACTTTGTTCTCTTCCTCA
CCTGAAATTATGCTTCCTAAAATCTCAAGCCAAACTCAAAGAATGGGGTGGTGGGGGGCACCCTGTGAGGTGGCCCCTGAGAGGTGGGGG
CCTCTCCAGGGCACATCTGGAGTTCTTCTCCAGCTTACCCTAGGGTGACCAAGTAGGGCCTGTCACACCAGGGTGGCGCAGCTTTCTGTG
TGATGCAGATGTGTCCTGGTTTCGGCAGCGTAGCCAGCTGCTGCTTGAGGCCATGGCTCGTCCCCGGAGTTGGGGGTACCCGTTGCAGAG
CCAGGGACATGATGCAGGCGAAGCTTGGGATCTGGCCAAGTTGGACTTTGATCCTTTGGGCAGATGTCCCATTGCTCCCTGGAGCCTGTC
ATGCCTGTTGGGGATCAGGCAGCCTCCTGATGCCAGAACACCTCAGGCAGAGCCCTACTCAGCTGTACCTGTCTGCCTGGACTGTCCCCT
GTCCCCGCATCTCCCCTGGGACCAGCTGGAGGGCCACATGCACACACAGCCTAGCTGCCCCCAGGGAGCTCTGCTGCCCTTGCTGGCCCT
GCCCTTCCCACAGGTGAGCAGGGCTCCTGTCCACCAGCACACTCAGTTCTCTTCCCTGCAGTGTTTTCATTTTATTTTAGCCAAACATTT
TGCCTGTTTTCTGTTTCAAACATGATAGTTGATATGAGACTGAAACCCCTGGGTTGTGGAGGGAAATTGGCTCAGAGATGGACAACCTGG
CAACTGTGAGTCCCTGCTTCCCGACACCAGCCTCATGGAATATGCAACAACTCCTGTACCCCAGTCCACGGTGTTCTGGCAGCAGGGACA
CCTGGGCCAATGGGCCATCTGGACCAAAGGTGGGGTGTGGGGCCCTGGATGGCAGCTCTGGCCCAGACATGAATACCTCGTGTTCCTCCT
CCCTCTATTACTGTTTCACCAGAGCTGTCTTAGCTCAAATCTGTTGTGTTTCTGAGTCTAGGGTCTGTACACTTGTTTATAATAAATGCA

>In-frame_SMARCC1_ENST00000254480_chr3_47747899_-_SHISA5_ENST00000426002_chr3_48511242_-_2800nt
GGCTGGGCGGGGCCGGGAAGCGGCAGTGGCGGCTACGCGCGCGGGGGTGCGCGCGGGAACGACCGGGAAACACCGCGAGGGCCGGGGTGG
GCCAGGCTGTGGGGACGACGGGCTGCGACGATGGCCGCAGCGGCGGGCGGCGGCGGGCCGGGGACAGCGGTAGGCGCCACGGGCTCGGGG
ATTGCGGCGGCAGCCGCAGGCCTAGCTGTTTATCGACGGAAGGATGGGGGCCCGGCCACCAAGTTTTGGGAGAGCCCGGAGACGGTGTCC
CAGCTGGATTCGGTGCGGGTCTGGCTGGGCAAGCACTACAAGAAGTATGTTCATGCGGATGCTCCTACCAATAAAACACTGGCTGGGCTG
GTGGTGCAGCTTCTTCAGTTCCAGGAAGATGCCTTTGGGAAGCATGTCACCAACCCGGCCTTCACCAAACTCCCTGCAAAGTGTTTCATG
GATTTCAAAGCTGGAGGCGCCTTATGTCACATTCTTGGGGCTGCTTACAAGTATAAAAATGAACAGGGATGGCGGAGGTTTGACCTACAG
AACCCATCTCGAATGGATCGTAATGTGGAAATGTTTATGAACATTGAAAAAACATTGGTGCAGAACAATTGTTTGACCAGACCCAACATC
TACCTCATTCCAGACATTGATCTGAAGTTGGCTAACAAATTGAAAGATATCATCAAACGACATCAGGGAACATTTACGGATGAGAAGTCA
AAAGCTTCCCACCACATTTACCCATATTCTTCCTCACAAGACGATGAAGAATGGTTGAGACCGGTGATGAGAAAAGAGAAGCAAGTGTTA
GTGCATTGGGGCTTTTACCCAGACAGCTATGATACTTGGGTCCATAGTAATGATGTTGATGCTGAAATTGAAGATCCACCAATTCCAGAA
AAACCATGGAAGGTTCATGTGAAATGGATTTTGGACACTGATATTTTCAATGAATGGATGAATGAGGAGGATTATGAGGTGGATGAAAAT
AGGAAGCCTGTGAGTTTTCGTCAGCGGATTTCAACCAAGAATGAAGAGCCAGTCAGAAGTCCAGAAAGAAGAGATAGAAAAGCATCAGCT
AATGCTCGAAAGAGGAAACATTCGCCTTCGCCTCCCCCTCCGACACCAACAGAATCACGGAAGAAGAGTGGGAAGAAAGGGTTCGGAGCG
ACCTTGGCCGTTGGCCTGACCATCTTTGTGCTGTCTGTCGTCACTATCATCATCTGCTTCACCTGCTCCTGCTGCTGCCTTTACAAGACG
TGCCGCCGACCACGTCCGGTTGTCACCACCACCACATCCACCACTGTGGTGCATGCCCCTTATCCTCAGCCTCCAAGTGTGCCGCCCAGC
TACCCTGGACCAAGCTACCAGGGCTACCACACCATGCCGCCTCAGCCAGGGATGCCAGCAGCACCCTACCCAATGCAGTACCCACCACCT
TACCCAGCCCAGCCCATGGGCCCACCGGCCTACCACGAGACCCTGGCTGGAGGAGCAGCCGCGCCCTACCCCGCCAGCCAGCCTCCTTAC
AACCCGGCCTACATGGATGCCCCGAAGGCGGCCCTCTGAGCATTCCCTGGCCTCTCTGGCTGCCACTTGGTTATGTTGTGTGTGTGCGTG
AGTGGTGTGCAGGCGCGGTTCCTTACGCCCCATGTGTGCTGTGTGTGTCCAGGCACGGTTCCTTACGCCCCATGTGTGCTGTGTGTGTCC
TGCCTGTATATGTGGCTTCCTCTGATGCTGACAAGGTGGGGAACAATCCTTGCCAGAGTGGGCTGGGACCAGACTTTGTTCTCTTCCTCA
CCTGAAATTATGCTTCCTAAAATCTCAAGCCAAACTCAAAGAATGGGGTGGTGGGGGGCACCCTGTGAGGTGGCCCCTGAGAGGTGGGGG
CCTCTCCAGGGCACATCTGGAGTTCTTCTCCAGCTTACCCTAGGGTGACCAAGTAGGGCCTGTCACACCAGGGTGGCGCAGCTTTCTGTG
TGATGCAGATGTGTCCTGGTTTCGGCAGCGTAGCCAGCTGCTGCTTGAGGCCATGGCTCGTCCCCGGAGTTGGGGGTACCCGTTGCAGAG
CCAGGGACATGATGCAGGCGAAGCTTGGGATCTGGCCAAGTTGGACTTTGATCCTTTGGGCAGATGTCCCATTGCTCCCTGGAGCCTGTC
ATGCCTGTTGGGGATCAGGCAGCCTCCTGATGCCAGAACACCTCAGGCAGAGCCCTACTCAGCTGTACCTGTCTGCCTGGACTGTCCCCT
GTCCCCGCATCTCCCCTGGGACCAGCTGGAGGGCCACATGCACACACAGCCTAGCTGCCCCCAGGGAGCTCTGCTGCCCTTGCTGGCCCT
GCCCTTCCCACAGGTGAGCAGGGCTCCTGTCCACCAGCACACTCAGTTCTCTTCCCTGCAGTGTTTTCATTTTATTTTAGCCAAACATTT
TGCCTGTTTTCTGTTTCAAACATGATAGTTGATATGAGACTGAAACCCCTGGGTTGTGGAGGGAAATTGGCTCAGAGATGGACAACCTGG
CAACTGTGAGTCCCTGCTTCCCGACACCAGCCTCATGGAATATGCAACAACTCCTGTACCCCAGTCCACGGTGTTCTGGCAGCAGGGACA
CCTGGGCCAATGGGCCATCTGGACCAAAGGTGGGGTGTGGGGCCCTGGATGGCAGCTCTGGCCCAGACATGAATACCTCGTGTTCCTCCT
CCCTCTATTACTGTTTCACCAGAGCTGTCTTAGCTCAAATCTGTTGTGTTTCTGAGTCTAGGGTCTGTACACTTGTTTATAATAAATGCA


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FusionGenePPI for SMARCC1_SHISA5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SMARCC1RELB, NR3C1, SMARCD1, SMARCB1, SMARCA4, SMARCA2, SIN3A, KLF1, GATA1, SP1, TP53, BRCA1, STAT2, CCNE1, HSP90B1, NCOR1, SMARCE1, CEBPB, CDK8, ING1, AR, ING2, TAF10, NR4A1, ARID1A, SMARCC2, PBRM1, ADD1, MCPH1, BCL7C, BRD7, ARID1B, AKT1, PRMT5, MYC, SMARCC1, HNRNPC, CHD4, SRRM2, TAF6, NR0B2, NONO, SMAD2, SMAD3, CARM1, EMD, DPF2, TRIM28, RUNX1, CHD7, ARID2, STK11, WHSC1L1, SMARCAD1, SOX2, ELAVL1, SIRT7, DPF3, PHF10, DPF1, ACTL6A, CUL3, CAND1, BAZ1B, SMARCD2, TOP2B, HDAC1, SMARCA5, RBBP5, KDM1A, SMARCA1, NOTCH1, EPAS1, VCP, HDAC6, ITCH, NEDD4, WWOX, AURKB, OTX1, PLSCR1, ADAMTSL4, MOV10, NXF1, MSL1, EED, RNF2, BMI1, SS18, NTRK1, MESDC2, MRE11A, SAMD9, BCL7A, CPSF6, DCTN2, FUBP1, FUBP3, KHSRP, MDC1, METTL13, NCAPH2, SF3A1, TMOD3, YLPM1, SMARCD3, SS18L1, TBL1XR1, NCOA1, KMT2A, EWSR1, HIST1H3E, RAB5C, NR2C2, FOS, JUN, NFATC1, NFATC2, C1orf131, SFPQ, CHEK1, TRIM25SHISA5COPS5, ALG2, HNRNPD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SMARCC1_SHISA5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SMARCC1_SHISA5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSMARCC1C0001418Adenocarcinoma1CTD_human
HgeneSMARCC1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneSMARCC1C0024121Lung Neoplasms1CTD_human