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Fusion gene ID: 34824 |
FusionGeneSummary for SMARCC1_MSN |
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Fusion gene information | Fusion gene name: SMARCC1_MSN | Fusion gene ID: 34824 | Hgene | Tgene | Gene symbol | SMARCC1 | MSN | Gene ID | 6599 | 4478 |
Gene name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 | moesin | |
Synonyms | BAF155|CRACC1|Rsc8|SRG3|SWI3 | HEL70|IMD50 | |
Cytomap | 3p21.31 | Xq12 | |
Type of gene | protein-coding | protein-coding | |
Description | SWI/SNF complex subunit SMARCC1BRG1-associated factor 155SWI/SNF complex 155 kDa subunitSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1chromatin remodeling complex BAF155 subunitmammalian chromatin remode | moesinepididymis luminal protein 70membrane-organizing extension spike protein | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | Q92922 | P26038 | |
Ensembl transtripts involved in fusion gene | ENST00000254480, ENST00000425518, | ENST00000609205, ENST00000360270, | |
Fusion gene scores | * DoF score | 13 X 10 X 9=1170 | 6 X 6 X 2=72 |
# samples | 17 | 7 | |
** MAII score | log2(17/1170*10)=-2.78290187833307 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SMARCC1 [Title/Abstract] AND MSN [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SMARCC1 | GO:0006337 | nucleosome disassembly | 8895581 |
Hgene | SMARCC1 | GO:0006338 | chromatin remodeling | 10078207|11018012|11726552 |
Hgene | SMARCC1 | GO:0045893 | positive regulation of transcription, DNA-templated | 11018012 |
Tgene | MSN | GO:0001771 | immunological synapse formation | 27405666 |
Tgene | MSN | GO:0042098 | T cell proliferation | 27405666 |
Tgene | MSN | GO:0070489 | T cell aggregation | 27405666 |
Tgene | MSN | GO:0071394 | cellular response to testosterone stimulus | 24065547 |
Tgene | MSN | GO:0072678 | T cell migration | 27405666 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE179599 | SMARCC1 | chr3 | 47704672 | + | MSN | chrX | 64960136 | - | ||
ChiTaRS3.1 | BE179463 | SMARCC1 | chr3 | 47704672 | + | MSN | chrX | 64960136 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000254480 | ENST00000609205 | SMARCC1 | chr3 | 47704672 | + | MSN | chrX | 64960136 | - |
intron-3UTR | ENST00000254480 | ENST00000360270 | SMARCC1 | chr3 | 47704672 | + | MSN | chrX | 64960136 | - |
intron-intron | ENST00000425518 | ENST00000609205 | SMARCC1 | chr3 | 47704672 | + | MSN | chrX | 64960136 | - |
intron-3UTR | ENST00000425518 | ENST00000360270 | SMARCC1 | chr3 | 47704672 | + | MSN | chrX | 64960136 | - |
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FusionProtFeatures for SMARCC1_MSN |
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Hgene | Tgene |
SMARCC1 | MSN |
Involved in transcriptional activation and repression ofselect genes by chromatin remodeling (alteration of DNA-nucleosometopology). Component of SWI/SNF chromatin remodeling complexesthat carry out key enzymatic activities, changing chromatinstructure by altering DNA-histone contacts within a nucleosome inan ATP-dependent manner. May stimulate the ATPase activity of thecatalytic subunit of the complex (PubMed:10078207). Belongs to theneural progenitors-specific chromatin remodeling complex (npBAFcomplex) and the neuron-specific chromatin remodeling complex(nBAF complex). During neural development a switch from astem/progenitor to a postmitotic chromatin remodeling mechanismoccurs as neurons exit the cell cycle and become committed totheir adult state. The transition from proliferating neuralstem/progenitor cells to postmitotic neurons requires a switch insubunit composition of the npBAF and nBAF complexes. As neuralprogenitors exit mitosis and differentiate into neurons, npBAFcomplexes which contain ACTL6A/BAF53A and PHF10/BAF45A, areexchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45Bor DPF3/BAF45C subunits in neuron-specific complexes (nBAF). ThenpBAF complex is essential for the self-renewal/proliferativecapacity of the multipotent neural stem cells. The nBAF complexalong with CREST plays a role regulating the activity of genesessential for dendrite growth (By similarity).{ECO:0000250|UniProtKB:P97496, ECO:0000269|PubMed:10078207,ECO:0000269|PubMed:11018012, ECO:0000303|PubMed:22952240,ECO:0000303|PubMed:26601204}. | Probably involved in connections of major cytoskeletalstructures to the plasma membrane. May inhibit herpes simplexvirus 1 infection at an early stage. Plays a role in regulatingthe proliferation, migration, and adhesion of human lymphoid cellsand participates in immunologic synapse formation(PubMed:27405666). {ECO:0000269|PubMed:21549406,ECO:0000269|PubMed:27405666}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SMARCC1_MSN |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SMARCC1_MSN |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SMARCC1_MSN |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SMARCC1_MSN |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SMARCC1 | C0001418 | Adenocarcinoma | 1 | CTD_human |
Hgene | SMARCC1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | SMARCC1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Tgene | MSN | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | MSN | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | MSN | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | MSN | C3495559 | Juvenile arthritis | 1 | CTD_human |