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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 34808

FusionGeneSummary for SMARCAD1_GRID2

check button Fusion gene summary
Fusion gene informationFusion gene name: SMARCAD1_GRID2
Fusion gene ID: 34808
HgeneTgene
Gene symbol

SMARCAD1

GRID2

Gene ID

56916

2895

Gene nameSWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1glutamate ionotropic receptor delta type subunit 2
SynonymsADERM|BASNS|ETL1|HEL1GluD2|SCAR18
Cytomap

4q22.3

4q22.1-q22.2

Type of geneprotein-codingprotein-coding
DescriptionSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1ATP-dependent helicase 1glutamate receptor ionotropic, delta-2gluR delta-2 subunitglutamate receptor delta-2 subunitglutamate receptor, ionotropic, delta 2
Modification date2018051920180523
UniProtAcc

Q9H4L7

O43424

Ensembl transtripts involved in fusion geneENST00000457823, ENST00000354268, 
ENST00000509418, 		ENST00000282020, 
ENST00000505687, ENST00000510992, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 5 X 5=125
# samples 25
** MAII scorelog2(2/8*10)=1.32192809488736log2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SMARCAD1 [Title/Abstract] AND GRID2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-DU-A7TD-01ASMARCAD1chr4

95174158

+GRID2chr4

94547420

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000457823ENST00000282020SMARCAD1chr4

95174158

+GRID2chr4

94547420

+
5CDS-intronENST00000457823ENST00000505687SMARCAD1chr4

95174158

+GRID2chr4

94547420

+
5CDS-intronENST00000457823ENST00000510992SMARCAD1chr4

95174158

+GRID2chr4

94547420

+
In-frameENST00000354268ENST00000282020SMARCAD1chr4

95174158

+GRID2chr4

94547420

+
5CDS-intronENST00000354268ENST00000505687SMARCAD1chr4

95174158

+GRID2chr4

94547420

+
5CDS-intronENST00000354268ENST00000510992SMARCAD1chr4

95174158

+GRID2chr4

94547420

+
intron-3CDSENST00000509418ENST00000282020SMARCAD1chr4

95174158

+GRID2chr4

94547420

+
intron-intronENST00000509418ENST00000505687SMARCAD1chr4

95174158

+GRID2chr4

94547420

+
intron-intronENST00000509418ENST00000510992SMARCAD1chr4

95174158

+GRID2chr4

94547420

+

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FusionProtFeatures for SMARCAD1_GRID2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SMARCAD1

Q9H4L7

GRID2

O43424

DNA helicase that possesses intrinsic ATP-dependentnucleosome-remodeling activity and is both required for DNA repairand heterochromatin organization. Promotes DNA end resection ofdouble-strand breaks (DSBs) following DNA damage: probably acts byweakening histone DNA interactions in nucleosomes flanking DSBs.Required for the restoration of heterochromatin organization afterreplication. Acts at replication sites to facilitate themaintenance of heterochromatin by directing H3 and H4 histonesdeacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restorationof silencing. {ECO:0000269|PubMed:21549307,ECO:0000269|PubMed:22960744}. Receptor for glutamate. L-glutamate acts as anexcitatory neurotransmitter at many synapses in the centralnervous system. The postsynaptic actions of Glu are mediated by avariety of receptors that are named according to their selectiveagonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptorendocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC)synapses through the beta-NRX1-CBLN1-GRID2 triad complex(PubMed:27418511). {ECO:0000269|PubMed:27418511}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000354268+924157_1994271027DomainCUE 1
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000354268+924251_2944271027DomainCUE 2
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000457823+924157_1994271029DomainCUE 1
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000457823+924251_2944271029DomainCUE 2
TgeneGRID2chr4:95174158chr4:94547420ENST00000282020+12161005_10077311008MotifPDZ-binding
TgeneGRID2chr4:95174158chr4:94547420ENST00000282020+1216852_10077311008Topological domainCytoplasmic
TgeneGRID2chr4:95174158chr4:94547420ENST00000282020+1216831_8517311008TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000354268+924509_6774271027DomainHelicase ATP-binding
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000354268+924858_10104271027DomainHelicase C-terminal
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000457823+924509_6774271029DomainHelicase ATP-binding
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000457823+924858_10104271029DomainHelicase C-terminal
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000509418+116157_199-129597DomainCUE 1
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000509418+116251_294-129597DomainCUE 2
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000509418+116509_677-129597DomainHelicase ATP-binding
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000509418+116858_1010-129597DomainHelicase C-terminal
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000354268+9241005_10084271027MotifNote=DEGD box
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000354268+924628_6314271027MotifNote=DEGH box
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000354268+924721_7384271027MotifNuclear localization signal
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000457823+9241005_10084271029MotifNote=DEGD box
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000457823+924628_6314271029MotifNote=DEGH box
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000457823+924721_7384271029MotifNuclear localization signal
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000509418+1161005_1008-129597MotifNote=DEGD box
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000509418+116628_631-129597MotifNote=DEGH box
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000509418+116721_738-129597MotifNuclear localization signal
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000354268+924521_5294271027Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000354268+924897_9044271027Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000457823+924521_5294271029Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000457823+924897_9044271029Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000509418+116521_529-129597Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000509418+116897_904-129597Nucleotide bindingATP
TgeneGRID2chr4:95174158chr4:94547420ENST00000282020+121624_5667311008Topological domainExtracellular
TgeneGRID2chr4:95174158chr4:94547420ENST00000282020+1216588_6357311008Topological domainCytoplasmic
TgeneGRID2chr4:95174158chr4:94547420ENST00000282020+1216657_8307311008Topological domainExtracellular
TgeneGRID2chr4:95174158chr4:94547420ENST00000282020+1216567_5877311008TransmembraneHelical
TgeneGRID2chr4:95174158chr4:94547420ENST00000282020+1216636_6567311008TransmembraneHelical


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FusionGeneSequence for SMARCAD1_GRID2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SMARCAD1_ENST00000457823_chr4_95174158_+_GRID2_ENST00000282020_chr4_94547420_+_704aa
MNLFNLDRFRFEKRNKIEEAPEATPQPSQPGPSSPISLSAEEENAEGEVSRANTPDSDITEKTEDSSVPETPDNERKASISYFKNQRGIQ
YIDLSSDSEDVVSPNCSNTVQEKTFNKDTVIIVSEPSEDEESQGLPTMARRNDDISELEDLSELEDLKDAKLQTLKELFPQRSDNDLLKL
IESTSTMDGAIAAALLMFGDAGGGPRKRKLSSSSEPYEEDEFNDDQSIKKTRLDHGEESNESAESSSNWEKQESIVLKLQKEFPNFDKQE
LREVLKEHEWMYTEALESLKVFAEDQDMQYVSQSEVPNGKEVSSRSQNYPKNATKTKLKQKFSMKAQNGFNKKRKKNVFNPKRVVEDSEY
DSGSDVGSSLDEDYSSGEEVMEDGYKGKILHFLQDASIGELTLIPQCSQKKAQKITELRPFNSWEALVKYGNYAFVWDAAVLEYVAINDP
DCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVL
SCFIAMLETWWNKRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSIDLTPLDIDTLPTRQALEQISDFRNTHITTTTFIP

>In-frame_SMARCAD1_ENST00000354268_chr4_95174158_+_GRID2_ENST00000282020_chr4_94547420_+_704aa
MNLFNLDRFRFEKRNKIEEAPEATPQPSQPGPSSPISLSAEEENAEGEVSRANTPDSDITEKTEDSSVPETPDNERKASISYFKNQRGIQ
YIDLSSDSEDVVSPNCSNTVQEKTFNKDTVIIVSEPSEDEESQGLPTMARRNDDISELEDLSELEDLKDAKLQTLKELFPQRSDNDLLKL
IESTSTMDGAIAAALLMFGDAGGGPRKRKLSSSSEPYEEDEFNDDQSIKKTRLDHGEESNESAESSSNWEKQESIVLKLQKEFPNFDKQE
LREVLKEHEWMYTEALESLKVFAEDQDMQYVSQSEVPNGKEVSSRSQNYPKNATKTKLKQKFSMKAQNGFNKKRKKNVFNPKRVVEDSEY
DSGSDVGSSLDEDYSSGEEVMEDGYKGKILHFLQDASIGELTLIPQCSQKKAQKITELRPFNSWEALVKYGNYAFVWDAAVLEYVAINDP
DCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVL
SCFIAMLETWWNKRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSIDLTPLDIDTLPTRQALEQISDFRNTHITTTTFIP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SMARCAD1_ENST00000457823_chr4_95174158_+_GRID2_ENST00000282020_chr4_94547420_+_2112nt
ATGAATCTTTTCAACCTGGACCGTTTTCGCTTTGAGAAAAGGAATAAGATTGAGGAAGCGCCCGAAGCAACCCCTCAACCTTCCCAGCCT
GGCCCTTCTTCACCAATTTCTCTTAGTGCTGAAGAGGAGAATGCTGAAGGGGAAGTTAGCAGGGCAAACACTCCTGATTCAGATATAACT
GAAAAAACAGAAGATTCTAGTGTTCCAGAAACTCCAGATAATGAAAGAAAAGCAAGTATATCATATTTCAAAAATCAAAGAGGAATACAG
TATATTGATTTGTCTTCTGATAGTGAAGATGTCGTTTCCCCAAATTGCTCCAATACAGTTCAAGAGAAAACATTCAACAAAGATACAGTG
ATTATAGTTTCTGAGCCATCTGAAGATGAAGAGTCCCAAGGCCTTCCTACCATGGCACGTAGAAATGATGATATTTCAGAACTGGAAGAC
CTTTCGGAATTGGAAGACCTTAAAGATGCTAAACTTCAGACTTTGAAGGAACTTTTTCCACAAAGAAGTGACAATGATTTACTTAAGTTG
ATTGAATCAACAAGCACTATGGATGGAGCAATTGCTGCTGCCTTGCTGATGTTTGGTGATGCAGGTGGTGGGCCCAGGAAAAGAAAATTA
TCTTCTTCTTCAGAGCCATATGAGGAAGATGAATTTAATGATGATCAATCTATAAAAAAGACAAGACTGGATCATGGAGAGGAATCAAAT
GAGTCTGCAGAATCTAGCAGTAATTGGGAAAAGCAGGAAAGTATTGTACTGAAATTGCAAAAGGAATTTCCCAATTTTGATAAACAGGAA
CTTAGAGAAGTACTCAAGGAACATGAATGGATGTACACAGAAGCTTTAGAATCTCTAAAAGTGTTTGCAGAAGACCAAGATATGCAATAT
GTATCACAAAGTGAGGTTCCAAATGGAAAAGAAGTTTCTTCAAGAAGTCAAAATTACCCTAAAAATGCAACTAAAACAAAACTAAAACAG
AAATTTTCAATGAAAGCACAAAATGGCTTTAACAAGAAACGTAAAAAAAATGTTTTTAATCCAAAGAGAGTTGTTGAAGACTCTGAATAT
GATTCAGGTTCTGATGTCGGTAGTTCACTAGATGAGGACTATAGTAGTGGTGAAGAAGTGATGGAGGATGGCTATAAAGGTAAAATTCTT
CACTTCCTTCAAGATGCTTCAATTGGTGAACTTACTTTGATTCCTCAGTGTTCTCAGAAAAAGGCTCAGAAGATAACAGAACTCCGGCCC
TTTAATAGTTGGGAGGCTCTGGTAAAATATGGAAATTATGCTTTCGTATGGGATGCAGCTGTATTGGAATATGTGGCTATCAATGACCCA
GATTGTTCCTTTTACACCATTGGAAATACTGTTGCTGATCGGGGATATGGAATTGCATTACAACATGGCAGTCCTTACCGAGATGTTTTT
TCACAAAGGATCCTGGAGCTTCAGCAGAATGGTGACATGGACATCCTGAAGCACAAATGGTGGCCTAAGAATGGCCAGTGTGACCTGTAC
TCGTCAGTGGACACAAAGCAGAAAGGAGGCGCCCTGGACATAAAGAGCTTTGCAGGGGTCTTTTGTATCCTGGCTGCTGGAATTGTCCTC
TCCTGCTTCATAGCCATGCTGGAGACGTGGTGGAACAAGAGGAAAGGCTCCCGGGTTCCATCAAAAGAGGATGACAAGGAAATTGACCTG
GAGCACCTCCATAGACGTGTAAATAGCTTGTGCACAGATGACGACAGCCCCCATAAACAGTTTTCCACCTCGTCAATTGATTTGACCCCT
CTGGACATTGACACTTTGCCAACACGACAAGCACTGGAGCAAATCAGTGATTTCAGGAACACTCATATTACCACAACAACCTTTATCCCA
GAGCAGATCCAGACTCTTAGCCGCACACTGTCAGCTAAAGCTGCTTCTGGTTTCACTTTTGGCAACGTGCCTGAGCACCGAACTGGCCCT
TTTAGGCACAGGGCACCTAATGGGGGCTTTTTCAGGAGTCCTATAAAAACAATGTCATCTATTCCTTATCAACCAACTCCTACCCTGGGG

>In-frame_SMARCAD1_ENST00000354268_chr4_95174158_+_GRID2_ENST00000282020_chr4_94547420_+_2112nt
ATGAATCTTTTCAACCTGGACCGTTTTCGCTTTGAGAAAAGGAATAAGATTGAGGAAGCGCCCGAAGCAACCCCTCAACCTTCCCAGCCT
GGCCCTTCTTCACCAATTTCTCTTAGTGCTGAAGAGGAGAATGCTGAAGGGGAAGTTAGCAGGGCAAACACTCCTGATTCAGATATAACT
GAAAAAACAGAAGATTCTAGTGTTCCAGAAACTCCAGATAATGAAAGAAAAGCAAGTATATCATATTTCAAAAATCAAAGAGGAATACAG
TATATTGATTTGTCTTCTGATAGTGAAGATGTCGTTTCCCCAAATTGCTCCAATACAGTTCAAGAGAAAACATTCAACAAAGATACAGTG
ATTATAGTTTCTGAGCCATCTGAAGATGAAGAGTCCCAAGGCCTTCCTACCATGGCACGTAGAAATGATGATATTTCAGAACTGGAAGAC
CTTTCGGAATTGGAAGACCTTAAAGATGCTAAACTTCAGACTTTGAAGGAACTTTTTCCACAAAGAAGTGACAATGATTTACTTAAGTTG
ATTGAATCAACAAGCACTATGGATGGAGCAATTGCTGCTGCCTTGCTGATGTTTGGTGATGCAGGTGGTGGGCCCAGGAAAAGAAAATTA
TCTTCTTCTTCAGAGCCATATGAGGAAGATGAATTTAATGATGATCAATCTATAAAAAAGACAAGACTGGATCATGGAGAGGAATCAAAT
GAGTCTGCAGAATCTAGCAGTAATTGGGAAAAGCAGGAAAGTATTGTACTGAAATTGCAAAAGGAATTTCCCAATTTTGATAAACAGGAA
CTTAGAGAAGTACTCAAGGAACATGAATGGATGTACACAGAAGCTTTAGAATCTCTAAAAGTGTTTGCAGAAGACCAAGATATGCAATAT
GTATCACAAAGTGAGGTTCCAAATGGAAAAGAAGTTTCTTCAAGAAGTCAAAATTACCCTAAAAATGCAACTAAAACAAAACTAAAACAG
AAATTTTCAATGAAAGCACAAAATGGCTTTAACAAGAAACGTAAAAAAAATGTTTTTAATCCAAAGAGAGTTGTTGAAGACTCTGAATAT
GATTCAGGTTCTGATGTCGGTAGTTCACTAGATGAGGACTATAGTAGTGGTGAAGAAGTGATGGAGGATGGCTATAAAGGTAAAATTCTT
CACTTCCTTCAAGATGCTTCAATTGGTGAACTTACTTTGATTCCTCAGTGTTCTCAGAAAAAGGCTCAGAAGATAACAGAACTCCGGCCC
TTTAATAGTTGGGAGGCTCTGGTAAAATATGGAAATTATGCTTTCGTATGGGATGCAGCTGTATTGGAATATGTGGCTATCAATGACCCA
GATTGTTCCTTTTACACCATTGGAAATACTGTTGCTGATCGGGGATATGGAATTGCATTACAACATGGCAGTCCTTACCGAGATGTTTTT
TCACAAAGGATCCTGGAGCTTCAGCAGAATGGTGACATGGACATCCTGAAGCACAAATGGTGGCCTAAGAATGGCCAGTGTGACCTGTAC
TCGTCAGTGGACACAAAGCAGAAAGGAGGCGCCCTGGACATAAAGAGCTTTGCAGGGGTCTTTTGTATCCTGGCTGCTGGAATTGTCCTC
TCCTGCTTCATAGCCATGCTGGAGACGTGGTGGAACAAGAGGAAAGGCTCCCGGGTTCCATCAAAAGAGGATGACAAGGAAATTGACCTG
GAGCACCTCCATAGACGTGTAAATAGCTTGTGCACAGATGACGACAGCCCCCATAAACAGTTTTCCACCTCGTCAATTGATTTGACCCCT
CTGGACATTGACACTTTGCCAACACGACAAGCACTGGAGCAAATCAGTGATTTCAGGAACACTCATATTACCACAACAACCTTTATCCCA
GAGCAGATCCAGACTCTTAGCCGCACACTGTCAGCTAAAGCTGCTTCTGGTTTCACTTTTGGCAACGTGCCTGAGCACCGAACTGGCCCT
TTTAGGCACAGGGCACCTAATGGGGGCTTTTTCAGGAGTCCTATAAAAACAATGTCATCTATTCCTTATCAACCAACTCCTACCCTGGGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_SMARCAD1_ENST00000457823_chr4_95174158_+_GRID2_ENST00000282020_chr4_94547420_+_4445nt
CTCTCAGCTGGGATCGCGCCGCGTCAACTTCCGGGCGGATGCCCGCCAGCACGGCCTCCGCCGCTCCCCTTCTTTGGCCCCTTTGTGTCC
CCGCAGTGTCGAGGCGCGGGCCCTGGCAGGTCCTTTCTCGAGGCAGGGGGCACGGTAGCACAGGGAGCTTCTCTTTGTGGGCGGGCGCGA
GGCCCGCTAGGGGGTTATACTGGGGAACGTGCCTGCGCGTGCTTGGATAGTTCATTTAAAGCCCCCATCCCTGCAAGGTGGTGCTTTCTA
CCAATATGAATCTTTTCAACCTGGACCGTTTTCGCTTTGAGAAAAGGAATAAGATTGAGGAAGCGCCCGAAGCAACCCCTCAACCTTCCC
AGCCTGGCCCTTCTTCACCAATTTCTCTTAGTGCTGAAGAGGAGAATGCTGAAGGGGAAGTTAGCAGGGCAAACACTCCTGATTCAGATA
TAACTGAAAAAACAGAAGATTCTAGTGTTCCAGAAACTCCAGATAATGAAAGAAAAGCAAGTATATCATATTTCAAAAATCAAAGAGGAA
TACAGTATATTGATTTGTCTTCTGATAGTGAAGATGTCGTTTCCCCAAATTGCTCCAATACAGTTCAAGAGAAAACATTCAACAAAGATA
CAGTGATTATAGTTTCTGAGCCATCTGAAGATGAAGAGTCCCAAGGCCTTCCTACCATGGCACGTAGAAATGATGATATTTCAGAACTGG
AAGACCTTTCGGAATTGGAAGACCTTAAAGATGCTAAACTTCAGACTTTGAAGGAACTTTTTCCACAAAGAAGTGACAATGATTTACTTA
AGTTGATTGAATCAACAAGCACTATGGATGGAGCAATTGCTGCTGCCTTGCTGATGTTTGGTGATGCAGGTGGTGGGCCCAGGAAAAGAA
AATTATCTTCTTCTTCAGAGCCATATGAGGAAGATGAATTTAATGATGATCAATCTATAAAAAAGACAAGACTGGATCATGGAGAGGAAT
CAAATGAGTCTGCAGAATCTAGCAGTAATTGGGAAAAGCAGGAAAGTATTGTACTGAAATTGCAAAAGGAATTTCCCAATTTTGATAAAC
AGGAACTTAGAGAAGTACTCAAGGAACATGAATGGATGTACACAGAAGCTTTAGAATCTCTAAAAGTGTTTGCAGAAGACCAAGATATGC
AATATGTATCACAAAGTGAGGTTCCAAATGGAAAAGAAGTTTCTTCAAGAAGTCAAAATTACCCTAAAAATGCAACTAAAACAAAACTAA
AACAGAAATTTTCAATGAAAGCACAAAATGGCTTTAACAAGAAACGTAAAAAAAATGTTTTTAATCCAAAGAGAGTTGTTGAAGACTCTG
AATATGATTCAGGTTCTGATGTCGGTAGTTCACTAGATGAGGACTATAGTAGTGGTGAAGAAGTGATGGAGGATGGCTATAAAGGTAAAA
TTCTTCACTTCCTTCAAGATGCTTCAATTGGTGAACTTACTTTGATTCCTCAGTGTTCTCAGAAAAAGGCTCAGAAGATAACAGAACTCC
GGCCCTTTAATAGTTGGGAGGCTCTGGTAAAATATGGAAATTATGCTTTCGTATGGGATGCAGCTGTATTGGAATATGTGGCTATCAATG
ACCCAGATTGTTCCTTTTACACCATTGGAAATACTGTTGCTGATCGGGGATATGGAATTGCATTACAACATGGCAGTCCTTACCGAGATG
TTTTTTCACAAAGGATCCTGGAGCTTCAGCAGAATGGTGACATGGACATCCTGAAGCACAAATGGTGGCCTAAGAATGGCCAGTGTGACC
TGTACTCGTCAGTGGACACAAAGCAGAAAGGAGGCGCCCTGGACATAAAGAGCTTTGCAGGGGTCTTTTGTATCCTGGCTGCTGGAATTG
TCCTCTCCTGCTTCATAGCCATGCTGGAGACGTGGTGGAACAAGAGGAAAGGCTCCCGGGTTCCATCAAAAGAGGATGACAAGGAAATTG
ACCTGGAGCACCTCCATAGACGTGTAAATAGCTTGTGCACAGATGACGACAGCCCCCATAAACAGTTTTCCACCTCGTCAATTGATTTGA
CCCCTCTGGACATTGACACTTTGCCAACACGACAAGCACTGGAGCAAATCAGTGATTTCAGGAACACTCATATTACCACAACAACCTTTA
TCCCAGAGCAGATCCAGACTCTTAGCCGCACACTGTCAGCTAAAGCTGCTTCTGGTTTCACTTTTGGCAACGTGCCTGAGCACCGAACTG
GCCCTTTTAGGCACAGGGCACCTAATGGGGGCTTTTTCAGGAGTCCTATAAAAACAATGTCATCTATTCCTTATCAACCAACTCCTACCC
TGGGGCTCAATCTGGGTAATGATCCAGACCGAGGCACCTCCATATGAGCATCAAACAAATCTCTTCACTGTTTCTTTTTTAGGACTCCCT
TTGCAAGGAGCAACTGTAATATTGTGGGACTAACATGGATGTAACGTTTAAAAAAAAGATCAGGATTATTAGTAACAATTCTAGTTTTTT
CCTCCCACCTTCTCCCTCTCCTCTCTCCTCTATGATTTTCTCTCTTTCCCCCTCCCTTCCTGTACATTTTCCTCCACTTTTTTTCATTAC
TCAACTTGTTCCCCAAGAAGGTAGTGTACTAGGATCCTATTAGTCTGCTTTTCATATACTGTACATCAAGTATAGGAAATGTGCACTGAG
TATACTAAAAGTATATGCAGGATTAATTTTACATAAAGGCCTCTTCTGTAACATTTCTCTATTTTTTGAAATACAATTGCAATAACTTCA
GTCTTTTTACATTCTTCTGCTGCATCCATACAATGCTCCACTGCTGTTGAGTGTCCTTTAACTGTGGACCAAAGGCAACCCCTGCAGTGT
TTATAAAACAATTTTAAGACCATTCAGGCCACATAAGATGAGAATGCAATTTTGTAGGATTACAAAAAAGCCATTAATATGCCAGTCAAG
ACTACAGTTAAAACTACTCTTGCACTGCAACAGTGCATATGACCTTTATGTGATTGTACAGTATTAAAAGTTTTTTCTTATGTACAGTAA
ACTTTATCATATGGCAGAAGCCTCTATTGTGTTAAATAAATTAGTATTTCATATATATACATATATATGCACCTATATAATGTGTATATA
TATAAAAAGGCAGCCATTGCTATTGCAATTCATTTAATAAAGCTTTAGTTTAAACAAAAGTATTGTATACAGGAACTATGTATAGTGCAG
GGGTTCTTTTCAGTTAGAAAAGGCAGGTTGCTTTAATGTTATTCTGACTCGCATTGTTTGCCAACAGAAAATATTTTATACTTTTGTTAT
TAAAGCATCCAGGGCAATTTAATATTTGTTCCTAGATGTAACTCATTTGAATAGGTTTTGCATTTGTTATTCAGCAGTGTATAAAGCTAA
CCTTGATAATTTTACTTTTAATTAATTATCTAAATGAAAAATGCTATTAGCTGAACCACATCCACAACAGCACATAGAGCTCTAGAAGAG
TTGAAACATAGATCATTGAAGGTTAAAAATCCTCTTCCAAAGCAGCAAGTCAATCAATACAATAATGATATTTGGGGAGGGGTGGGAGCC
CTTAAGAACTATTGATGTGGCCTTAAATTACTGTCATTTATTATCCTAAAGAAGAAAACATAATAACCATAATGGGCTCTCAACTCAACT
CCCTTTTTTATTTAGTTCTATTTGGAGGAGTTATGTATTTTTTACATTAGTGCCAAGTATATAGAAGGATGACAGCAAAAACAGTGCCTC
TTTGTGCACAATCCTTTTAAAGTAGCATTCTTACTTGTTAGAAATGTAGAATGAACTTTGTTTGTAATCCTTAAATTAAAATGTGGTAAG
TAGGAAGCAAGAACTTATTCTGTGTTTTTACGCAGCCATACACTTACTTTAATCTAACTCATTCTGTGGCTAGGATTGATATAGGAATCA
ACCTATGTGATTTGCTTTAGGAGAAATTAAAAGGTATATTCTTAAGATATATTATATTTTGATGCTAATTCTGTTCTGGGGAGCATCTTG
TATTGTCACTGTTTTGTACTAAATCTTCAAATATTGTCTACTGTGTAAGGCAGAAAAATTTCTTATCATGCAAAAACCATTTTGTTTCCA
GGGTAACAAGTAACTAAGTGCATGCACAACTTGTTTTCCCTTGTAACATTCATGATCTCATTTACAACTCTGATTTTAAAACAAAAAAAT
CTTTACAACAAGCTATATAGGGACATACCAGATGTTGCAGTGATTTTAGCTATCAACAAACTGTTAACCATGTACAATATTTAAAATAGG
CTTATTTTGATGTATCGCCTATTATACAAACACACAAAACATTTTTGGAGGCCTCAGTTATGAGTGACAGAGCTTTCTGTGTATAATTTG

>In-frame_SMARCAD1_ENST00000354268_chr4_95174158_+_GRID2_ENST00000282020_chr4_94547420_+_4243nt
GGGAACGTGCCTGCGCGTGCTTGGATAGTTCATTTAAAGCCCCCATCCCTGCAAGGTGGTGCTTTCTACCAATATGAATCTTTTCAACCT
GGACCGTTTTCGCTTTGAGAAAAGGAATAAGATTGAGGAAGCGCCCGAAGCAACCCCTCAACCTTCCCAGCCTGGCCCTTCTTCACCAAT
TTCTCTTAGTGCTGAAGAGGAGAATGCTGAAGGGGAAGTTAGCAGGGCAAACACTCCTGATTCAGATATAACTGAAAAAACAGAAGATTC
TAGTGTTCCAGAAACTCCAGATAATGAAAGAAAAGCAAGTATATCATATTTCAAAAATCAAAGAGGAATACAGTATATTGATTTGTCTTC
TGATAGTGAAGATGTCGTTTCCCCAAATTGCTCCAATACAGTTCAAGAGAAAACATTCAACAAAGATACAGTGATTATAGTTTCTGAGCC
ATCTGAAGATGAAGAGTCCCAAGGCCTTCCTACCATGGCACGTAGAAATGATGATATTTCAGAACTGGAAGACCTTTCGGAATTGGAAGA
CCTTAAAGATGCTAAACTTCAGACTTTGAAGGAACTTTTTCCACAAAGAAGTGACAATGATTTACTTAAGTTGATTGAATCAACAAGCAC
TATGGATGGAGCAATTGCTGCTGCCTTGCTGATGTTTGGTGATGCAGGTGGTGGGCCCAGGAAAAGAAAATTATCTTCTTCTTCAGAGCC
ATATGAGGAAGATGAATTTAATGATGATCAATCTATAAAAAAGACAAGACTGGATCATGGAGAGGAATCAAATGAGTCTGCAGAATCTAG
CAGTAATTGGGAAAAGCAGGAAAGTATTGTACTGAAATTGCAAAAGGAATTTCCCAATTTTGATAAACAGGAACTTAGAGAAGTACTCAA
GGAACATGAATGGATGTACACAGAAGCTTTAGAATCTCTAAAAGTGTTTGCAGAAGACCAAGATATGCAATATGTATCACAAAGTGAGGT
TCCAAATGGAAAAGAAGTTTCTTCAAGAAGTCAAAATTACCCTAAAAATGCAACTAAAACAAAACTAAAACAGAAATTTTCAATGAAAGC
ACAAAATGGCTTTAACAAGAAACGTAAAAAAAATGTTTTTAATCCAAAGAGAGTTGTTGAAGACTCTGAATATGATTCAGGTTCTGATGT
CGGTAGTTCACTAGATGAGGACTATAGTAGTGGTGAAGAAGTGATGGAGGATGGCTATAAAGGTAAAATTCTTCACTTCCTTCAAGATGC
TTCAATTGGTGAACTTACTTTGATTCCTCAGTGTTCTCAGAAAAAGGCTCAGAAGATAACAGAACTCCGGCCCTTTAATAGTTGGGAGGC
TCTGGTAAAATATGGAAATTATGCTTTCGTATGGGATGCAGCTGTATTGGAATATGTGGCTATCAATGACCCAGATTGTTCCTTTTACAC
CATTGGAAATACTGTTGCTGATCGGGGATATGGAATTGCATTACAACATGGCAGTCCTTACCGAGATGTTTTTTCACAAAGGATCCTGGA
GCTTCAGCAGAATGGTGACATGGACATCCTGAAGCACAAATGGTGGCCTAAGAATGGCCAGTGTGACCTGTACTCGTCAGTGGACACAAA
GCAGAAAGGAGGCGCCCTGGACATAAAGAGCTTTGCAGGGGTCTTTTGTATCCTGGCTGCTGGAATTGTCCTCTCCTGCTTCATAGCCAT
GCTGGAGACGTGGTGGAACAAGAGGAAAGGCTCCCGGGTTCCATCAAAAGAGGATGACAAGGAAATTGACCTGGAGCACCTCCATAGACG
TGTAAATAGCTTGTGCACAGATGACGACAGCCCCCATAAACAGTTTTCCACCTCGTCAATTGATTTGACCCCTCTGGACATTGACACTTT
GCCAACACGACAAGCACTGGAGCAAATCAGTGATTTCAGGAACACTCATATTACCACAACAACCTTTATCCCAGAGCAGATCCAGACTCT
TAGCCGCACACTGTCAGCTAAAGCTGCTTCTGGTTTCACTTTTGGCAACGTGCCTGAGCACCGAACTGGCCCTTTTAGGCACAGGGCACC
TAATGGGGGCTTTTTCAGGAGTCCTATAAAAACAATGTCATCTATTCCTTATCAACCAACTCCTACCCTGGGGCTCAATCTGGGTAATGA
TCCAGACCGAGGCACCTCCATATGAGCATCAAACAAATCTCTTCACTGTTTCTTTTTTAGGACTCCCTTTGCAAGGAGCAACTGTAATAT
TGTGGGACTAACATGGATGTAACGTTTAAAAAAAAGATCAGGATTATTAGTAACAATTCTAGTTTTTTCCTCCCACCTTCTCCCTCTCCT
CTCTCCTCTATGATTTTCTCTCTTTCCCCCTCCCTTCCTGTACATTTTCCTCCACTTTTTTTCATTACTCAACTTGTTCCCCAAGAAGGT
AGTGTACTAGGATCCTATTAGTCTGCTTTTCATATACTGTACATCAAGTATAGGAAATGTGCACTGAGTATACTAAAAGTATATGCAGGA
TTAATTTTACATAAAGGCCTCTTCTGTAACATTTCTCTATTTTTTGAAATACAATTGCAATAACTTCAGTCTTTTTACATTCTTCTGCTG
CATCCATACAATGCTCCACTGCTGTTGAGTGTCCTTTAACTGTGGACCAAAGGCAACCCCTGCAGTGTTTATAAAACAATTTTAAGACCA
TTCAGGCCACATAAGATGAGAATGCAATTTTGTAGGATTACAAAAAAGCCATTAATATGCCAGTCAAGACTACAGTTAAAACTACTCTTG
CACTGCAACAGTGCATATGACCTTTATGTGATTGTACAGTATTAAAAGTTTTTTCTTATGTACAGTAAACTTTATCATATGGCAGAAGCC
TCTATTGTGTTAAATAAATTAGTATTTCATATATATACATATATATGCACCTATATAATGTGTATATATATAAAAAGGCAGCCATTGCTA
TTGCAATTCATTTAATAAAGCTTTAGTTTAAACAAAAGTATTGTATACAGGAACTATGTATAGTGCAGGGGTTCTTTTCAGTTAGAAAAG
GCAGGTTGCTTTAATGTTATTCTGACTCGCATTGTTTGCCAACAGAAAATATTTTATACTTTTGTTATTAAAGCATCCAGGGCAATTTAA
TATTTGTTCCTAGATGTAACTCATTTGAATAGGTTTTGCATTTGTTATTCAGCAGTGTATAAAGCTAACCTTGATAATTTTACTTTTAAT
TAATTATCTAAATGAAAAATGCTATTAGCTGAACCACATCCACAACAGCACATAGAGCTCTAGAAGAGTTGAAACATAGATCATTGAAGG
TTAAAAATCCTCTTCCAAAGCAGCAAGTCAATCAATACAATAATGATATTTGGGGAGGGGTGGGAGCCCTTAAGAACTATTGATGTGGCC
TTAAATTACTGTCATTTATTATCCTAAAGAAGAAAACATAATAACCATAATGGGCTCTCAACTCAACTCCCTTTTTTATTTAGTTCTATT
TGGAGGAGTTATGTATTTTTTACATTAGTGCCAAGTATATAGAAGGATGACAGCAAAAACAGTGCCTCTTTGTGCACAATCCTTTTAAAG
TAGCATTCTTACTTGTTAGAAATGTAGAATGAACTTTGTTTGTAATCCTTAAATTAAAATGTGGTAAGTAGGAAGCAAGAACTTATTCTG
TGTTTTTACGCAGCCATACACTTACTTTAATCTAACTCATTCTGTGGCTAGGATTGATATAGGAATCAACCTATGTGATTTGCTTTAGGA
GAAATTAAAAGGTATATTCTTAAGATATATTATATTTTGATGCTAATTCTGTTCTGGGGAGCATCTTGTATTGTCACTGTTTTGTACTAA
ATCTTCAAATATTGTCTACTGTGTAAGGCAGAAAAATTTCTTATCATGCAAAAACCATTTTGTTTCCAGGGTAACAAGTAACTAAGTGCA
TGCACAACTTGTTTTCCCTTGTAACATTCATGATCTCATTTACAACTCTGATTTTAAAACAAAAAAATCTTTACAACAAGCTATATAGGG
ACATACCAGATGTTGCAGTGATTTTAGCTATCAACAAACTGTTAACCATGTACAATATTTAAAATAGGCTTATTTTGATGTATCGCCTAT
TATACAAACACACAAAACATTTTTGGAGGCCTCAGTTATGAGTGACAGAGCTTTCTGTGTATAATTTGTCTAAATAATTTGTCTAATAAA


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FusionGenePPI for SMARCAD1_GRID2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SMARCAD1TRIM28, CBX3, HDAC1, HDAC2, MTA3, RING1, MTA2, E2F6, EHMT2, YY1, L3MBTL2, DMAP1, EHMT1, PELP1, WIZ, KDM1A, CHD4, SIN3A, XRCC6, PARP1, MSH2, XRCC5, RFC4, SMC1A, RFC5, RFC3, RFC2, TOP2A, SMC3, MSH3, PRKDC, MSH6, RAD50, RUVBL2, RUVBL1, ACTL6A, SMARCC2, SMARCA5, SMARCB1, SMARCE1, HELLS, SMARCC1, SMARCA4, PBRM1, SMARCD2, SSRP1, BAZ1A, SUPT16H, ARID2, GTF3C4, GTF3C5, GTF3C3, GTF3C2, GTF3C1, DDX17, DDX5, ZNF8, ZNF649, ZNF566, ZNF460, RBAK, ZNF829, ZNF689, ZNF324, ZNF302, ZC3H18, ZNF24, ZNF235, ANAPC7, CDC23, CDC16, ANAPC5, ANAPC1, ANAPC2, CDC27, DDX3X, DDX19A, DHX9, HNRNPK, HNRNPH1, HNRNPM, MATR3, NUMA1, PTBP1, FUBP3, CPSF3, KHDRBS1, HNRNPR, DNAJA2, NR2F2, LAS1L, TMPO, PCBP1, HNRNPD, NONO, CPSF1, SRSF1, HNRNPU, WDR18, HNRNPL, POLR1E, PRPF19, ILF3, SF3B3, LMNB1, CSNK2A1, U2AF2, CPSF2, USP7, SF3B2, WDR33, BEND3, SYMPK, MDN1, PCNA, RAB3GAP2, GNE, KIF13A, DOK4, ZNF562, ANP32A, SNRPD3, NTRK1, CEP19, EPHA2, FOXL1, SNW1, CDC5L, TOPBP1, ZNF785, TRMT2A, ZNF764, ZNF211, ZNF816, ZNF669, ZNF550, ZNF214, ZNF324BGRID2GRID2IP, GRIA1, GRIK2, GRIK5, GRIA2, GOPC, PTPN4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneGRID2chr4:95174158chr4:94547420ENST00000282020+1216921_9917311008AP4M1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneGRID2chr4:95174158chr4:94547420ENST00000282020+121624_3457311008CBLN1 homotrimer


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SMARCAD1_GRID2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGRID2O43424DB00142Glutamic AcidGlutamate receptor ionotropic, delta-2small moleculeapproved|nutraceutical

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RelatedDiseases for SMARCAD1_GRID2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGRID2C4015505SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 181ORPHANET;UNIPROT