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Fusion gene ID: 34762 |
FusionGeneSummary for SMAD9_CCNA1 |
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Fusion gene information | Fusion gene name: SMAD9_CCNA1 | Fusion gene ID: 34762 | Hgene | Tgene | Gene symbol | SMAD9 | CCNA1 | Gene ID | 4093 | 8900 |
Gene name | SMAD family member 9 | cyclin A1 | |
Synonyms | MADH6|MADH9|PPH2|SMAD8|SMAD8/9|SMAD8A|SMAD8B | CT146 | |
Cytomap | 13q13.3 | 13q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | mothers against decapentaplegic homolog 9MAD homolog 9Mothers against decapentaplegic, drosophila, homolog of, 9SMAD, mothers against DPP homolog 9 | cyclin-A1testicular tissue protein Li 34 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | O15198 | P78396 | |
Ensembl transtripts involved in fusion gene | ENST00000350148, ENST00000379826, ENST00000483941, ENST00000399275, | ENST00000449823, ENST00000440264, ENST00000463403, ENST00000418263, ENST00000255465, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: SMAD9 [Title/Abstract] AND CCNA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-J4-AATZ-01A | SMAD9 | chr13 | 37427556 | - | CCNA1 | chr13 | 37007170 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000350148 | ENST00000449823 | SMAD9 | chr13 | 37427556 | - | CCNA1 | chr13 | 37007170 | + |
5CDS-5UTR | ENST00000350148 | ENST00000440264 | SMAD9 | chr13 | 37427556 | - | CCNA1 | chr13 | 37007170 | + |
5CDS-3UTR | ENST00000350148 | ENST00000463403 | SMAD9 | chr13 | 37427556 | - | CCNA1 | chr13 | 37007170 | + |
5CDS-3UTR | ENST00000350148 | ENST00000418263 | SMAD9 | chr13 | 37427556 | - | CCNA1 | chr13 | 37007170 | + |
5CDS-3UTR | ENST00000350148 | ENST00000255465 | SMAD9 | chr13 | 37427556 | - | CCNA1 | chr13 | 37007170 | + |
5CDS-5UTR | ENST00000379826 | ENST00000449823 | SMAD9 | chr13 | 37427556 | - | CCNA1 | chr13 | 37007170 | + |
5CDS-5UTR | ENST00000379826 | ENST00000440264 | SMAD9 | chr13 | 37427556 | - | CCNA1 | chr13 | 37007170 | + |
5CDS-3UTR | ENST00000379826 | ENST00000463403 | SMAD9 | chr13 | 37427556 | - | CCNA1 | chr13 | 37007170 | + |
5CDS-3UTR | ENST00000379826 | ENST00000418263 | SMAD9 | chr13 | 37427556 | - | CCNA1 | chr13 | 37007170 | + |
5CDS-3UTR | ENST00000379826 | ENST00000255465 | SMAD9 | chr13 | 37427556 | - | CCNA1 | chr13 | 37007170 | + |
intron-5UTR | ENST00000483941 | ENST00000449823 | SMAD9 | chr13 | 37427556 | - | CCNA1 | chr13 | 37007170 | + |
intron-5UTR | ENST00000483941 | ENST00000440264 | SMAD9 | chr13 | 37427556 | - | CCNA1 | chr13 | 37007170 | + |
intron-3UTR | ENST00000483941 | ENST00000463403 | SMAD9 | chr13 | 37427556 | - | CCNA1 | chr13 | 37007170 | + |
intron-3UTR | ENST00000483941 | ENST00000418263 | SMAD9 | chr13 | 37427556 | - | CCNA1 | chr13 | 37007170 | + |
intron-3UTR | ENST00000483941 | ENST00000255465 | SMAD9 | chr13 | 37427556 | - | CCNA1 | chr13 | 37007170 | + |
5CDS-5UTR | ENST00000399275 | ENST00000449823 | SMAD9 | chr13 | 37427556 | - | CCNA1 | chr13 | 37007170 | + |
5CDS-5UTR | ENST00000399275 | ENST00000440264 | SMAD9 | chr13 | 37427556 | - | CCNA1 | chr13 | 37007170 | + |
5CDS-3UTR | ENST00000399275 | ENST00000463403 | SMAD9 | chr13 | 37427556 | - | CCNA1 | chr13 | 37007170 | + |
5CDS-3UTR | ENST00000399275 | ENST00000418263 | SMAD9 | chr13 | 37427556 | - | CCNA1 | chr13 | 37007170 | + |
5CDS-3UTR | ENST00000399275 | ENST00000255465 | SMAD9 | chr13 | 37427556 | - | CCNA1 | chr13 | 37007170 | + |
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FusionProtFeatures for SMAD9_CCNA1 |
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Hgene | Tgene |
SMAD9 | CCNA1 |
Transcriptional modulator activated by BMP (bonemorphogenetic proteins) type 1 receptor kinase. SMAD9 is areceptor-regulated SMAD (R-SMAD). | May be involved in the control of the cell cycle at theG1/S (start) and G2/M (mitosis) transitions. May primarilyfunction in the control of the germline meiotic cell cycle andadditionally in the control of mitotic cell cycle in some somaticcells. {ECO:0000269|PubMed:10022926}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SMAD9_CCNA1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SMAD9_CCNA1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SMAD9 | SMAD4, SMAD9, TOB1, HMGA2, KAT2A, KAT2B, NOTCH1, UBA6, MTMR11, EIF3F, PIR, KMT2D, KDM6A, ZEB2, MCM3AP, MAN1A2, SF3B1, DKK1, AP2A1, CSH1, CSH2, FTL, CYP11A1, PSAP, SNRNP70, RFX1, MGAT1, YWHAQ, ARNT, GRN, PHKA2, QARS, PSMD8, ZNF83, AFF1, METAP1, TERF1, EIF3E, ACTB, DSTN, LMO4, SPTBN1, FLI1, DST, PPARD, PAPPA, PABPC4, TRIM29, TRIP12, PLEC, SMAD2, PPP2R5E, CAMSAP1, RNF123, CEP135, E4F1, CTR9, TTC37, CXXC5, EVC2, CHPF, PELP1, VPS8, TMEM57, ZNF557, ZSCAN4, EXPH5, ARID1B, ZNF592, ZNF587B, ABTB1, PNPLA2, DNAJA3, OTUB1, VCPIP1, SVEP1, ERVV-1, ASB2, RANBP9, SECISBP2, EIF3C, DNAJC7, PKP2, ARHGAP9, TBCD, TINAGL1, CLPB, SIL1, UNC45A, C10orf2, RMND5A, HEYL, MAN1C1, BAZ1A, UBQLN4, DIAPH3, MTMR10, RRBP1, ASH2L, LRP5, NAGK, UBQLN1, LEMD3, HEY1, KDM1A, PRMT6, SMAD3, PSG9, DSG4, VSIG8, SMAD7, ZNF143, SMAP2, RBMS1 | CCNA1 | CCAR2, TGFB1I1, VPS18, MCC, GPS2, XRCC6, GNB2L1, RBM4, INCA1, KLHDC9, PROCA1, PARK2, HIST1H1A, HIST1H2BA, CDK2, CDK1, CUX1, MYBL2, E2F1, RB1, RBL1, RBL2, CDC25A, CDC20, SKP2, CDKN1B, CDT1, SP1, USP2, MCM4, HIST1H1B, PGR, SRC, FZR1, NPAT, RPA1, PPP1CA, CUL1, COPS5, COPS6, CDKN1A, MCM6, CTNNB1, HECW2, CKS2, CKS1B, CCNA2, PTK2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SMAD9_CCNA1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SMAD9_CCNA1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SMAD9 | C3888002 | PULMONARY HYPERTENSION, PRIMARY, 2 | 1 | UNIPROT |
Tgene | CCNA1 | C0950124 | Papillomavirus Infections | 1 | CTD_human |
Tgene | CCNA1 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |
Tgene | CCNA1 | C2239176 | Liver carcinoma | 1 | CTD_human |