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Fusion gene ID: 34725 |
FusionGeneSummary for SLX4_ADAM32 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLX4_ADAM32 | Fusion gene ID: 34725 | Hgene | Tgene | Gene symbol | SLX4 | ADAM32 | Gene ID | 84464 | 203102 |
| Gene name | SLX4 structure-specific endonuclease subunit | ADAM metallopeptidase domain 32 | |
| Synonyms | BTBD12|FANCP|MUS312 | - | |
| Cytomap | 16p13.3 | 8p11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | structure-specific endonuclease subunit SLX4BTB/POZ domain-containing protein 12 | disintegrin and metalloproteinase domain-containing protein 32a disintegrin and metalloprotease domain 32a disintegrin and metalloproteinase domain 32metalloproteinase 12-like proteintesticular tissue protein Li 13 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8IY92 | Q8TC27 | |
| Ensembl transtripts involved in fusion gene | ENST00000294008, | ENST00000437682, ENST00000519315, ENST00000379907, ENST00000524303, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 6 X 6 X 5=180 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SLX4 [Title/Abstract] AND ADAM32 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-C8-A8HP-01A | SLX4 | chr16 | 3650980 | - | ADAM32 | chr8 | 39114706 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000294008 | ENST00000437682 | SLX4 | chr16 | 3650980 | - | ADAM32 | chr8 | 39114706 | + |
| In-frame | ENST00000294008 | ENST00000519315 | SLX4 | chr16 | 3650980 | - | ADAM32 | chr8 | 39114706 | + |
| In-frame | ENST00000294008 | ENST00000379907 | SLX4 | chr16 | 3650980 | - | ADAM32 | chr8 | 39114706 | + |
| 5CDS-intron | ENST00000294008 | ENST00000524303 | SLX4 | chr16 | 3650980 | - | ADAM32 | chr8 | 39114706 | + |
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FusionProtFeatures for SLX4_ADAM32 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLX4 | ADAM32 |
| Regulatory subunit that interacts with and increases theactivity of different structure-specific endonucleases. Hasseveral distinct roles in protecting genome stability by resolvingdiverse forms of deleterious DNA structures originating fromreplication and recombination intermediates and from DNA damage.Component of the SLX1-SLX4 structure-specific endonuclease thatresolves DNA secondary structures generated during DNA repair andrecombination. Has endonuclease activity towards branched DNAsubstrates, introducing single-strand cuts in duplex DNA close tojunctions with ss-DNA. Has a preference for 5'-flap structures,and promotes symmetrical cleavage of static and migrating Hollidayjunctions (HJs). Resolves HJs by generating two pairs ofligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage ofbubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap andreplication fork-like structures. SLX4 is required for recoveryfrom alkylation-induced DNA damage and is involved in theresolution of DNA double-strand breaks.{ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19595722,ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}. | May play a role in sperm development and fertilizationThis is a non-catalytic metalloprotease-like protein.{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ADAM32 | chr16:3650980 | chr8:39114706 | ENST00000379907 | + | 17 | 25 | 704_787 | 668 | 788 | Topological domain | Cytoplasmic |
| Tgene | >ADAM32 | chr16:3650980 | chr8:39114706 | ENST00000379907 | + | 17 | 25 | 683_703 | 668 | 788 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SLX4 | chr16:3650980 | chr8:39114706 | ENST00000294008 | - | 5 | 15 | 801_870 | 387 | 1835 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SLX4 | chr16:3650980 | chr8:39114706 | ENST00000294008 | - | 5 | 15 | 1710_1721 | 387 | 1835 | Compositional bias | Note=Poly-Ser |
| Hgene | >SLX4 | chr16:3650980 | chr8:39114706 | ENST00000294008 | - | 5 | 15 | 520_523 | 387 | 1835 | Compositional bias | Note=Poly-Pro |
| Hgene | >SLX4 | chr16:3650980 | chr8:39114706 | ENST00000294008 | - | 5 | 15 | 796_856 | 387 | 1835 | Compositional bias | Note=Glu-rich |
| Hgene | >SLX4 | chr16:3650980 | chr8:39114706 | ENST00000294008 | - | 5 | 15 | 691_764 | 387 | 1835 | Domain | BTB |
| Tgene | ADAM32 | chr16:3650980 | chr8:39114706 | ENST00000379907 | + | 17 | 25 | 480_502 | 668 | 788 | Compositional bias | Note=Cys-rich |
| Tgene | ADAM32 | chr16:3650980 | chr8:39114706 | ENST00000379907 | + | 17 | 25 | 186_383 | 668 | 788 | Domain | Peptidase M12B |
| Tgene | ADAM32 | chr16:3650980 | chr8:39114706 | ENST00000379907 | + | 17 | 25 | 391_479 | 668 | 788 | Domain | Disintegrin |
| Tgene | ADAM32 | chr16:3650980 | chr8:39114706 | ENST00000379907 | + | 17 | 25 | 622_654 | 668 | 788 | Domain | EGF-like |
| Tgene | ADAM32 | chr16:3650980 | chr8:39114706 | ENST00000379907 | + | 17 | 25 | 175_682 | 668 | 788 | Topological domain | Extracellular |
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FusionGeneSequence for SLX4_ADAM32 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SLX4_ENST00000294008_chr16_3650980_-_ADAM32_ENST00000437682_chr8_39114706_+_507aa MKLSVNEAQLGFYLGSLSHLSACPGIDPRSSEDQPESLKTGQMMDESDEDFKELCASFFQRVKKHGIKEVSGERKTQKAASNGTQIRSKL KRTKQTATKTKTLQGPAEKKPPSGSQAPRTKKQRVTKWQASEPAHSVNGEGGVLASAPDPPVLRETAQNTQTGNQQEPSPNLSREKTREN VPNSDSQPPPSCLTTAVPSPSKPRTAQLVLQRMQQFKRADPERLRHASEECSLEAAREENVPKDPQEEMMAGNVYGLGPPAPESDAAVAL TLQQEFARVGASAHDDSLEEKGLFFCQICQKNLSAMNVTRREQHVNRCLDEAEKTLRPSVPQIPECPICGKPFLTLKSRTSHLKQCAVKM EVGPQLLLQAVRLQTAQPEGSSSPPMFRFNHGKSIWEDXKHLASRFPHCSSYSHCNNRNSFGKETVEKVVRQGRGIPKXRIXIGRXHTDI >In-frame_SLX4_ENST00000294008_chr16_3650980_-_ADAM32_ENST00000519315_chr8_39114706_+_455aa MKLSVNEAQLGFYLGSLSHLSACPGIDPRSSEDQPESLKTGQMMDESDEDFKELCASFFQRVKKHGIKEVSGERKTQKAASNGTQIRSKL KRTKQTATKTKTLQGPAEKKPPSGSQAPRTKKQRVTKWQASEPAHSVNGEGGVLASAPDPPVLRETAQNTQTGNQQEPSPNLSREKTREN VPNSDSQPPPSCLTTAVPSPSKPRTAQLVLQRMQQFKRADPERLRHASEECSLEAAREENVPKDPQEEMMAGNVYGLGPPAPESDAAVAL TLQQEFARVGASAHDDSLEEKGLFFCQICQKNLSAMNVTRREQHVNRCLDEAEKTLRPSVPQIPECPICGKPFLTLKSRTSHLKQCAVKM EVGPQLLLQAVRLQTAQPEGSSSPPMFRFNHGKSIWEDXKHLASRFPHCSSYSHCNNRNSFGKETVEKVVRQGRGIPKXRIQITGQYPNT >In-frame_SLX4_ENST00000294008_chr16_3650980_-_ADAM32_ENST00000379907_chr8_39114706_+_507aa MKLSVNEAQLGFYLGSLSHLSACPGIDPRSSEDQPESLKTGQMMDESDEDFKELCASFFQRVKKHGIKEVSGERKTQKAASNGTQIRSKL KRTKQTATKTKTLQGPAEKKPPSGSQAPRTKKQRVTKWQASEPAHSVNGEGGVLASAPDPPVLRETAQNTQTGNQQEPSPNLSREKTREN VPNSDSQPPPSCLTTAVPSPSKPRTAQLVLQRMQQFKRADPERLRHASEECSLEAAREENVPKDPQEEMMAGNVYGLGPPAPESDAAVAL TLQQEFARVGASAHDDSLEEKGLFFCQICQKNLSAMNVTRREQHVNRCLDEAEKTLRPSVPQIPECPICGKPFLTLKSRTSHLKQCAVKM EVGPQLLLQAVRLQTAQPEGSSSPPMFRFNHGKSIWEDXKHLASRFPHCSSYSHCNNRNSFGKETVEKVVRQGRGIPKXRIXIGRXHTDI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SLX4_ENST00000294008_chr16_3650980_-_ADAM32_ENST00000437682_chr8_39114706_+_1522nt ATGAAACTGAGTGTGAATGAGGCTCAGCTAGGCTTCTACTTGGGTTCACTTTCTCATCTGTCTGCCTGTCCTGGGATTGACCCTCGCTCC TCTGAAGACCAGCCTGAAAGCCTTAAAACTGGTCAGATGATGGATGAGTCTGATGAGGACTTTAAAGAACTCTGCGCTAGCTTTTTCCAA AGGGTGAAAAAACATGGAATCAAGGAAGTGTCAGGAGAAAGGAAGACACAAAAGGCTGCCTCAAACGGCACTCAGATAAGAAGCAAATTG AAAAGGACCAAACAAACTGCTACCAAGACCAAAACCCTTCAAGGCCCTGCAGAGAAGAAACCTCCGTCTGGCAGCCAGGCCCCTAGGACT AAAAAGCAAAGGGTAACCAAATGGCAAGCAAGTGAACCGGCCCACTCTGTGAATGGGGAGGGGGGTGTGCTTGCCTCTGCTCCAGATCCA CCTGTGCTCCGGGAAACAGCACAAAACACCCAGACGGGTAACCAGCAAGAACCATCGCCAAACCTTTCCAGAGAGAAAACCAGAGAGAAT GTGCCCAACAGCGACTCCCAGCCTCCTCCTTCCTGTTTGACAACAGCAGTGCCAAGTCCCTCCAAACCCCGCACAGCACAATTGGTCCTA CAGCGAATGCAGCAGTTCAAGAGAGCAGACCCCGAGCGTTTGAGACACGCTTCAGAAGAGTGCTCCCTCGAGGCTGCGCGGGAAGAAAAT GTCCCAAAGGATCCTCAAGAGGAGATGATGGCGGGGAATGTGTATGGGCTTGGGCCCCCTGCCCCAGAGAGCGACGCTGCGGTGGCCTTG ACCCTGCAGCAGGAGTTTGCACGGGTAGGAGCATCGGCACATGATGATAGCCTGGAGGAAAAGGGTTTGTTCTTCTGCCAGATTTGTCAA AAGAACCTCTCAGCCATGAACGTGACCCGAAGGGAACAGCATGTGAACAGGTGCTTGGATGAAGCTGAAAAGACACTAAGACCTTCTGTG CCTCAGATCCCTGAGTGCCCGATTTGTGGGAAACCGTTTCTTACCTTAAAGAGCAGAACCAGTCACTTGAAGCAGTGTGCTGTGAAGATG GAGGTTGGCCCCCAGCTCCTGCTTCAGGCTGTGCGGCTGCAGACAGCACAGCCTGAGGGTAGCAGCAGCCCACCCATGTTCAGGTTCAAT CATGGAAAGAGCATCTGGGAAGACTGAAAACACCTGGCTTCTAGGTTTCCTCATTGCTCTTCCTATTCTCATTGTAACAACCGCAATAGT TTTGGCAAGGAAACAGTTGAAAAAGTGGTTCGCCAAGGAAGAGGAATTCCCAAGTAGCGAATCTAAATCGGAAGGTAGCACACAGACATA TGCCAGCCAATCCAGCTCAGAAGGCAGCACTCAGACATATGCCAGCCAAACCAGATCAGAAAGCAGCAGTCAAGCTGATACTAGCAAATC >In-frame_SLX4_ENST00000294008_chr16_3650980_-_ADAM32_ENST00000519315_chr8_39114706_+_1366nt ATGAAACTGAGTGTGAATGAGGCTCAGCTAGGCTTCTACTTGGGTTCACTTTCTCATCTGTCTGCCTGTCCTGGGATTGACCCTCGCTCC TCTGAAGACCAGCCTGAAAGCCTTAAAACTGGTCAGATGATGGATGAGTCTGATGAGGACTTTAAAGAACTCTGCGCTAGCTTTTTCCAA AGGGTGAAAAAACATGGAATCAAGGAAGTGTCAGGAGAAAGGAAGACACAAAAGGCTGCCTCAAACGGCACTCAGATAAGAAGCAAATTG AAAAGGACCAAACAAACTGCTACCAAGACCAAAACCCTTCAAGGCCCTGCAGAGAAGAAACCTCCGTCTGGCAGCCAGGCCCCTAGGACT AAAAAGCAAAGGGTAACCAAATGGCAAGCAAGTGAACCGGCCCACTCTGTGAATGGGGAGGGGGGTGTGCTTGCCTCTGCTCCAGATCCA CCTGTGCTCCGGGAAACAGCACAAAACACCCAGACGGGTAACCAGCAAGAACCATCGCCAAACCTTTCCAGAGAGAAAACCAGAGAGAAT GTGCCCAACAGCGACTCCCAGCCTCCTCCTTCCTGTTTGACAACAGCAGTGCCAAGTCCCTCCAAACCCCGCACAGCACAATTGGTCCTA CAGCGAATGCAGCAGTTCAAGAGAGCAGACCCCGAGCGTTTGAGACACGCTTCAGAAGAGTGCTCCCTCGAGGCTGCGCGGGAAGAAAAT GTCCCAAAGGATCCTCAAGAGGAGATGATGGCGGGGAATGTGTATGGGCTTGGGCCCCCTGCCCCAGAGAGCGACGCTGCGGTGGCCTTG ACCCTGCAGCAGGAGTTTGCACGGGTAGGAGCATCGGCACATGATGATAGCCTGGAGGAAAAGGGTTTGTTCTTCTGCCAGATTTGTCAA AAGAACCTCTCAGCCATGAACGTGACCCGAAGGGAACAGCATGTGAACAGGTGCTTGGATGAAGCTGAAAAGACACTAAGACCTTCTGTG CCTCAGATCCCTGAGTGCCCGATTTGTGGGAAACCGTTTCTTACCTTAAAGAGCAGAACCAGTCACTTGAAGCAGTGTGCTGTGAAGATG GAGGTTGGCCCCCAGCTCCTGCTTCAGGCTGTGCGGCTGCAGACAGCACAGCCTGAGGGTAGCAGCAGCCCACCCATGTTCAGGTTCAAT CATGGAAAGAGCATCTGGGAAGACTGAAAACACCTGGCTTCTAGGTTTCCTCATTGCTCTTCCTATTCTCATTGTAACAACCGCAATAGT TTTGGCAAGGAAACAGTTGAAAAAGTGGTTCGCCAAGGAAGAGGAATTCCCAAGTAGCGAATCCAAATCACAGGACAGTACCCAAACACA >In-frame_SLX4_ENST00000294008_chr16_3650980_-_ADAM32_ENST00000379907_chr8_39114706_+_1522nt ATGAAACTGAGTGTGAATGAGGCTCAGCTAGGCTTCTACTTGGGTTCACTTTCTCATCTGTCTGCCTGTCCTGGGATTGACCCTCGCTCC TCTGAAGACCAGCCTGAAAGCCTTAAAACTGGTCAGATGATGGATGAGTCTGATGAGGACTTTAAAGAACTCTGCGCTAGCTTTTTCCAA AGGGTGAAAAAACATGGAATCAAGGAAGTGTCAGGAGAAAGGAAGACACAAAAGGCTGCCTCAAACGGCACTCAGATAAGAAGCAAATTG AAAAGGACCAAACAAACTGCTACCAAGACCAAAACCCTTCAAGGCCCTGCAGAGAAGAAACCTCCGTCTGGCAGCCAGGCCCCTAGGACT AAAAAGCAAAGGGTAACCAAATGGCAAGCAAGTGAACCGGCCCACTCTGTGAATGGGGAGGGGGGTGTGCTTGCCTCTGCTCCAGATCCA CCTGTGCTCCGGGAAACAGCACAAAACACCCAGACGGGTAACCAGCAAGAACCATCGCCAAACCTTTCCAGAGAGAAAACCAGAGAGAAT GTGCCCAACAGCGACTCCCAGCCTCCTCCTTCCTGTTTGACAACAGCAGTGCCAAGTCCCTCCAAACCCCGCACAGCACAATTGGTCCTA CAGCGAATGCAGCAGTTCAAGAGAGCAGACCCCGAGCGTTTGAGACACGCTTCAGAAGAGTGCTCCCTCGAGGCTGCGCGGGAAGAAAAT GTCCCAAAGGATCCTCAAGAGGAGATGATGGCGGGGAATGTGTATGGGCTTGGGCCCCCTGCCCCAGAGAGCGACGCTGCGGTGGCCTTG ACCCTGCAGCAGGAGTTTGCACGGGTAGGAGCATCGGCACATGATGATAGCCTGGAGGAAAAGGGTTTGTTCTTCTGCCAGATTTGTCAA AAGAACCTCTCAGCCATGAACGTGACCCGAAGGGAACAGCATGTGAACAGGTGCTTGGATGAAGCTGAAAAGACACTAAGACCTTCTGTG CCTCAGATCCCTGAGTGCCCGATTTGTGGGAAACCGTTTCTTACCTTAAAGAGCAGAACCAGTCACTTGAAGCAGTGTGCTGTGAAGATG GAGGTTGGCCCCCAGCTCCTGCTTCAGGCTGTGCGGCTGCAGACAGCACAGCCTGAGGGTAGCAGCAGCCCACCCATGTTCAGGTTCAAT CATGGAAAGAGCATCTGGGAAGACTGAAAACACCTGGCTTCTAGGTTTCCTCATTGCTCTTCCTATTCTCATTGTAACAACCGCAATAGT TTTGGCAAGGAAACAGTTGAAAAAGTGGTTCGCCAAGGAAGAGGAATTCCCAAGTAGCGAATCTAAATCGGAAGGTAGCACACAGACATA TGCCAGCCAATCCAGCTCAGAAGGCAGCACTCAGACATATGCCAGCCAAACCAGATCAGAAAGCAGCAGTCAAGCTGATACTAGCAAATC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SLX4_ENST00000294008_chr16_3650980_-_ADAM32_ENST00000437682_chr8_39114706_+_2273nt GCGAGTCTCCGTTAAGAAGGTGCCGCGGCGGCGCCGGAGATGTGTAATTAAGTGAACCATATATGTTTCATCATCATGGAGATCTTGGAG AATTATCTGAGCACCAGGTTCATATGTATTCGATCTCAGAGGCATCTATTGGACAACAAAACACTCTTTCAGTTGTGAACTTTATTTATT TATTATTATTATTTTTTGAGACAGAGTTTTGCTCTTGTTGCCCAGGTTAGAGTGCAGTGGCACGATCTCGGCTCACTGCAATCTCCGCCT CCCAGGTTCAAGCGATTCTCTTGCCTCTGCCTCCCGAGTAGCTGGGATTACAGGCATCTGCTACCACGCCTGGCCAATTTTTTGTATTTT CAGTTGAAACGAGGTTTCACCATATTGGCCAGGCTGGTCTCGAACTTCTGACCTCAGGTGATCCACCCCCCGCCTCGTCCTCCAAAAGAG CTGGGATTACAAGTGTGAGCCACCGCGCCCGGCCCAGTTGTGGACTTTAACAGAGGGAAGCTTTAAACATGTTTAACCACAGGCCCAATT TGAACAAAGATACTTCAATCATTATAGAGAGGAAAACAGTACTTTTTGTTCAATTGTGCAAACTCTCCAAGTATCTAATGGAGAAGTAGA GAAGAACCCTAATGAAACTGAGTGTGAATGAGGCTCAGCTAGGCTTCTACTTGGGTTCACTTTCTCATCTGTCTGCCTGTCCTGGGATTG ACCCTCGCTCCTCTGAAGACCAGCCTGAAAGCCTTAAAACTGGTCAGATGATGGATGAGTCTGATGAGGACTTTAAAGAACTCTGCGCTA GCTTTTTCCAAAGGGTGAAAAAACATGGAATCAAGGAAGTGTCAGGAGAAAGGAAGACACAAAAGGCTGCCTCAAACGGCACTCAGATAA GAAGCAAATTGAAAAGGACCAAACAAACTGCTACCAAGACCAAAACCCTTCAAGGCCCTGCAGAGAAGAAACCTCCGTCTGGCAGCCAGG CCCCTAGGACTAAAAAGCAAAGGGTAACCAAATGGCAAGCAAGTGAACCGGCCCACTCTGTGAATGGGGAGGGGGGTGTGCTTGCCTCTG CTCCAGATCCACCTGTGCTCCGGGAAACAGCACAAAACACCCAGACGGGTAACCAGCAAGAACCATCGCCAAACCTTTCCAGAGAGAAAA CCAGAGAGAATGTGCCCAACAGCGACTCCCAGCCTCCTCCTTCCTGTTTGACAACAGCAGTGCCAAGTCCCTCCAAACCCCGCACAGCAC AATTGGTCCTACAGCGAATGCAGCAGTTCAAGAGAGCAGACCCCGAGCGTTTGAGACACGCTTCAGAAGAGTGCTCCCTCGAGGCTGCGC GGGAAGAAAATGTCCCAAAGGATCCTCAAGAGGAGATGATGGCGGGGAATGTGTATGGGCTTGGGCCCCCTGCCCCAGAGAGCGACGCTG CGGTGGCCTTGACCCTGCAGCAGGAGTTTGCACGGGTAGGAGCATCGGCACATGATGATAGCCTGGAGGAAAAGGGTTTGTTCTTCTGCC AGATTTGTCAAAAGAACCTCTCAGCCATGAACGTGACCCGAAGGGAACAGCATGTGAACAGGTGCTTGGATGAAGCTGAAAAGACACTAA GACCTTCTGTGCCTCAGATCCCTGAGTGCCCGATTTGTGGGAAACCGTTTCTTACCTTAAAGAGCAGAACCAGTCACTTGAAGCAGTGTG CTGTGAAGATGGAGGTTGGCCCCCAGCTCCTGCTTCAGGCTGTGCGGCTGCAGACAGCACAGCCTGAGGGTAGCAGCAGCCCACCCATGT TCAGGTTCAATCATGGAAAGAGCATCTGGGAAGACTGAAAACACCTGGCTTCTAGGTTTCCTCATTGCTCTTCCTATTCTCATTGTAACA ACCGCAATAGTTTTGGCAAGGAAACAGTTGAAAAAGTGGTTCGCCAAGGAAGAGGAATTCCCAAGTAGCGAATCTAAATCGGAAGGTAGC ACACAGACATATGCCAGCCAATCCAGCTCAGAAGGCAGCACTCAGACATATGCCAGCCAAACCAGATCAGAAAGCAGCAGTCAAGCTGAT ACTAGCAAATCCAAATCAGAAGATAGTGCTGAAGCATATACTAGCAGATCCAAATCACAGGACAGTACCCAAACACAAAGCAGTAGTAAC TAGTGATTCCTTCAGAAGGCAACGGATAACATCGAGAGTCTCGCTAAGAAATGAAAATTCTGTCTTTCCTTCCGTGGTCACAGCTGAAAG >In-frame_SLX4_ENST00000294008_chr16_3650980_-_ADAM32_ENST00000519315_chr8_39114706_+_2117nt GCGAGTCTCCGTTAAGAAGGTGCCGCGGCGGCGCCGGAGATGTGTAATTAAGTGAACCATATATGTTTCATCATCATGGAGATCTTGGAG AATTATCTGAGCACCAGGTTCATATGTATTCGATCTCAGAGGCATCTATTGGACAACAAAACACTCTTTCAGTTGTGAACTTTATTTATT TATTATTATTATTTTTTGAGACAGAGTTTTGCTCTTGTTGCCCAGGTTAGAGTGCAGTGGCACGATCTCGGCTCACTGCAATCTCCGCCT CCCAGGTTCAAGCGATTCTCTTGCCTCTGCCTCCCGAGTAGCTGGGATTACAGGCATCTGCTACCACGCCTGGCCAATTTTTTGTATTTT CAGTTGAAACGAGGTTTCACCATATTGGCCAGGCTGGTCTCGAACTTCTGACCTCAGGTGATCCACCCCCCGCCTCGTCCTCCAAAAGAG CTGGGATTACAAGTGTGAGCCACCGCGCCCGGCCCAGTTGTGGACTTTAACAGAGGGAAGCTTTAAACATGTTTAACCACAGGCCCAATT TGAACAAAGATACTTCAATCATTATAGAGAGGAAAACAGTACTTTTTGTTCAATTGTGCAAACTCTCCAAGTATCTAATGGAGAAGTAGA GAAGAACCCTAATGAAACTGAGTGTGAATGAGGCTCAGCTAGGCTTCTACTTGGGTTCACTTTCTCATCTGTCTGCCTGTCCTGGGATTG ACCCTCGCTCCTCTGAAGACCAGCCTGAAAGCCTTAAAACTGGTCAGATGATGGATGAGTCTGATGAGGACTTTAAAGAACTCTGCGCTA GCTTTTTCCAAAGGGTGAAAAAACATGGAATCAAGGAAGTGTCAGGAGAAAGGAAGACACAAAAGGCTGCCTCAAACGGCACTCAGATAA GAAGCAAATTGAAAAGGACCAAACAAACTGCTACCAAGACCAAAACCCTTCAAGGCCCTGCAGAGAAGAAACCTCCGTCTGGCAGCCAGG CCCCTAGGACTAAAAAGCAAAGGGTAACCAAATGGCAAGCAAGTGAACCGGCCCACTCTGTGAATGGGGAGGGGGGTGTGCTTGCCTCTG CTCCAGATCCACCTGTGCTCCGGGAAACAGCACAAAACACCCAGACGGGTAACCAGCAAGAACCATCGCCAAACCTTTCCAGAGAGAAAA CCAGAGAGAATGTGCCCAACAGCGACTCCCAGCCTCCTCCTTCCTGTTTGACAACAGCAGTGCCAAGTCCCTCCAAACCCCGCACAGCAC AATTGGTCCTACAGCGAATGCAGCAGTTCAAGAGAGCAGACCCCGAGCGTTTGAGACACGCTTCAGAAGAGTGCTCCCTCGAGGCTGCGC GGGAAGAAAATGTCCCAAAGGATCCTCAAGAGGAGATGATGGCGGGGAATGTGTATGGGCTTGGGCCCCCTGCCCCAGAGAGCGACGCTG CGGTGGCCTTGACCCTGCAGCAGGAGTTTGCACGGGTAGGAGCATCGGCACATGATGATAGCCTGGAGGAAAAGGGTTTGTTCTTCTGCC AGATTTGTCAAAAGAACCTCTCAGCCATGAACGTGACCCGAAGGGAACAGCATGTGAACAGGTGCTTGGATGAAGCTGAAAAGACACTAA GACCTTCTGTGCCTCAGATCCCTGAGTGCCCGATTTGTGGGAAACCGTTTCTTACCTTAAAGAGCAGAACCAGTCACTTGAAGCAGTGTG CTGTGAAGATGGAGGTTGGCCCCCAGCTCCTGCTTCAGGCTGTGCGGCTGCAGACAGCACAGCCTGAGGGTAGCAGCAGCCCACCCATGT TCAGGTTCAATCATGGAAAGAGCATCTGGGAAGACTGAAAACACCTGGCTTCTAGGTTTCCTCATTGCTCTTCCTATTCTCATTGTAACA ACCGCAATAGTTTTGGCAAGGAAACAGTTGAAAAAGTGGTTCGCCAAGGAAGAGGAATTCCCAAGTAGCGAATCCAAATCACAGGACAGT ACCCAAACACAAAGCAGTAGTAACTAGTGATTCCTTCAGAAGGCAACGGATAACATCGAGAGTCTCGCTAAGAAATGAAAATTCTGTCTT >In-frame_SLX4_ENST00000294008_chr16_3650980_-_ADAM32_ENST00000379907_chr8_39114706_+_2273nt GCGAGTCTCCGTTAAGAAGGTGCCGCGGCGGCGCCGGAGATGTGTAATTAAGTGAACCATATATGTTTCATCATCATGGAGATCTTGGAG AATTATCTGAGCACCAGGTTCATATGTATTCGATCTCAGAGGCATCTATTGGACAACAAAACACTCTTTCAGTTGTGAACTTTATTTATT TATTATTATTATTTTTTGAGACAGAGTTTTGCTCTTGTTGCCCAGGTTAGAGTGCAGTGGCACGATCTCGGCTCACTGCAATCTCCGCCT CCCAGGTTCAAGCGATTCTCTTGCCTCTGCCTCCCGAGTAGCTGGGATTACAGGCATCTGCTACCACGCCTGGCCAATTTTTTGTATTTT CAGTTGAAACGAGGTTTCACCATATTGGCCAGGCTGGTCTCGAACTTCTGACCTCAGGTGATCCACCCCCCGCCTCGTCCTCCAAAAGAG CTGGGATTACAAGTGTGAGCCACCGCGCCCGGCCCAGTTGTGGACTTTAACAGAGGGAAGCTTTAAACATGTTTAACCACAGGCCCAATT TGAACAAAGATACTTCAATCATTATAGAGAGGAAAACAGTACTTTTTGTTCAATTGTGCAAACTCTCCAAGTATCTAATGGAGAAGTAGA GAAGAACCCTAATGAAACTGAGTGTGAATGAGGCTCAGCTAGGCTTCTACTTGGGTTCACTTTCTCATCTGTCTGCCTGTCCTGGGATTG ACCCTCGCTCCTCTGAAGACCAGCCTGAAAGCCTTAAAACTGGTCAGATGATGGATGAGTCTGATGAGGACTTTAAAGAACTCTGCGCTA GCTTTTTCCAAAGGGTGAAAAAACATGGAATCAAGGAAGTGTCAGGAGAAAGGAAGACACAAAAGGCTGCCTCAAACGGCACTCAGATAA GAAGCAAATTGAAAAGGACCAAACAAACTGCTACCAAGACCAAAACCCTTCAAGGCCCTGCAGAGAAGAAACCTCCGTCTGGCAGCCAGG CCCCTAGGACTAAAAAGCAAAGGGTAACCAAATGGCAAGCAAGTGAACCGGCCCACTCTGTGAATGGGGAGGGGGGTGTGCTTGCCTCTG CTCCAGATCCACCTGTGCTCCGGGAAACAGCACAAAACACCCAGACGGGTAACCAGCAAGAACCATCGCCAAACCTTTCCAGAGAGAAAA CCAGAGAGAATGTGCCCAACAGCGACTCCCAGCCTCCTCCTTCCTGTTTGACAACAGCAGTGCCAAGTCCCTCCAAACCCCGCACAGCAC AATTGGTCCTACAGCGAATGCAGCAGTTCAAGAGAGCAGACCCCGAGCGTTTGAGACACGCTTCAGAAGAGTGCTCCCTCGAGGCTGCGC GGGAAGAAAATGTCCCAAAGGATCCTCAAGAGGAGATGATGGCGGGGAATGTGTATGGGCTTGGGCCCCCTGCCCCAGAGAGCGACGCTG CGGTGGCCTTGACCCTGCAGCAGGAGTTTGCACGGGTAGGAGCATCGGCACATGATGATAGCCTGGAGGAAAAGGGTTTGTTCTTCTGCC AGATTTGTCAAAAGAACCTCTCAGCCATGAACGTGACCCGAAGGGAACAGCATGTGAACAGGTGCTTGGATGAAGCTGAAAAGACACTAA GACCTTCTGTGCCTCAGATCCCTGAGTGCCCGATTTGTGGGAAACCGTTTCTTACCTTAAAGAGCAGAACCAGTCACTTGAAGCAGTGTG CTGTGAAGATGGAGGTTGGCCCCCAGCTCCTGCTTCAGGCTGTGCGGCTGCAGACAGCACAGCCTGAGGGTAGCAGCAGCCCACCCATGT TCAGGTTCAATCATGGAAAGAGCATCTGGGAAGACTGAAAACACCTGGCTTCTAGGTTTCCTCATTGCTCTTCCTATTCTCATTGTAACA ACCGCAATAGTTTTGGCAAGGAAACAGTTGAAAAAGTGGTTCGCCAAGGAAGAGGAATTCCCAAGTAGCGAATCTAAATCGGAAGGTAGC ACACAGACATATGCCAGCCAATCCAGCTCAGAAGGCAGCACTCAGACATATGCCAGCCAAACCAGATCAGAAAGCAGCAGTCAAGCTGAT ACTAGCAAATCCAAATCAGAAGATAGTGCTGAAGCATATACTAGCAGATCCAAATCACAGGACAGTACCCAAACACAAAGCAGTAGTAAC TAGTGATTCCTTCAGAAGGCAACGGATAACATCGAGAGTCTCGCTAAGAAATGAAAATTCTGTCTTTCCTTCCGTGGTCACAGCTGAAAG |
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FusionGenePPI for SLX4_ADAM32 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SLX4 | DCAF10, ERCC4, ERCC1, PNMA2, TSPYL1, PLK1, MUS81, TERF2, SLX1B, NUP188, EME1, TEX10, NUP50, GLTSCR2, SLX4IP, TERF2IP, PSMB4, LRRC1, GID8, PGAM5, KPNA1, MSH2, MSH3, MSH6, DDB1, VCP, PCNA, SPRTN, SLX1A, APP, UBC, DCLRE1B, SUMO2, TOPBP1, MRE11A, NBN, RPA1, SUMO3, SUMO1, UBE2I, USP45, SLX4, FANCD2 | ADAM32 | ITGA5, STAT5B, ASPHD2, LCLAT1, NOTCH3, JAG2, PLXNA2, KIAA0391, ADAMTS1, ADAM9, INTS4, KTN1, GAS6, IQCB1, BCL2L11, MAN1A2, CYP27C1, MAP2K7, GPR89A, POMGNT1, METTL9 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | SLX4 | chr16:3650980 | chr8:39114706 | ENST00000294008 | - | 5 | 15 | 1328_1648 | 387 | 1835 | MUS81 |
| Hgene | SLX4 | chr16:3650980 | chr8:39114706 | ENST00000294008 | - | 5 | 15 | 684_1834 | 387 | 1835 | PLK1 and TERF2-TERF2IP |
| Hgene | SLX4 | chr16:3650980 | chr8:39114706 | ENST00000294008 | - | 5 | 15 | 1632_1834 | 387 | 1835 | SLX1 |
| Hgene | SLX4 | chr16:3650980 | chr8:39114706 | ENST00000294008 | - | 5 | 15 | 1_669 | 387 | 1835 | SLX4IP%2C ERCC4 and MSH2 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLX4_ADAM32 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLX4_ADAM32 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SLX4 | C0015625 | Fanconi Anemia | 3 | CTD_human;ORPHANET |
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