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Fusion gene ID: 34708 |
FusionGeneSummary for SLPI_LRP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLPI_LRP1 | Fusion gene ID: 34708 | Hgene | Tgene | Gene symbol | SLPI | LRP1 | Gene ID | 6590 | 10438 |
| Gene name | secretory leukocyte peptidase inhibitor | C1D nuclear receptor corepressor | |
| Synonyms | ALK1|ALP|BLPI|HUSI|HUSI-I|MPI|WAP4|WFDC4 | LRP1|Rrp47|SUN-CoR|SUNCOR|hC1D | |
| Cytomap | 20q13.12 | 2p14 | |
| Type of gene | protein-coding | protein-coding | |
| Description | antileukoproteinaseHUSI-1WAP four-disulfide core domain protein 4mucus proteinase inhibitorprotease inhibitor WAP4secretory leukocyte protease inhibitor (antileukoproteinase)seminal proteinase inhibitor | nuclear nucleic acid-binding protein C1DC1D DNA-binding proteinC1D nuclear receptor co-repressornuclear DNA-binding proteinsmall unique nuclear receptor co-repressorsmall unique nuclear receptor corepressor | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P03973 | Q07954 | |
| Ensembl transtripts involved in fusion gene | ENST00000338380, | ENST00000553277, ENST00000243077, ENST00000338962, ENST00000554174, ENST00000553446, | |
| Fusion gene scores | * DoF score | 6 X 6 X 3=108 | 5 X 6 X 2=60 |
| # samples | 6 | 7 | |
| ** MAII score | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/60*10)=0.222392421336448 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SLPI [Title/Abstract] AND LRP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SLPI | GO:0019731 | antibacterial humoral response | 18714013 |
| Hgene | SLPI | GO:0032091 | negative regulation of protein binding | 19333378 |
| Hgene | SLPI | GO:0035821 | modification of morphology or physiology of other organism | 2467900 |
| Hgene | SLPI | GO:0045071 | negative regulation of viral genome replication | 19333378 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE764728 | SLPI | chr20 | 43881666 | - | LRP1 | chr12 | 57586056 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000338380 | ENST00000553277 | SLPI | chr20 | 43881666 | - | LRP1 | chr12 | 57586056 | - |
| intron-intron | ENST00000338380 | ENST00000243077 | SLPI | chr20 | 43881666 | - | LRP1 | chr12 | 57586056 | - |
| intron-intron | ENST00000338380 | ENST00000338962 | SLPI | chr20 | 43881666 | - | LRP1 | chr12 | 57586056 | - |
| intron-intron | ENST00000338380 | ENST00000554174 | SLPI | chr20 | 43881666 | - | LRP1 | chr12 | 57586056 | - |
| intron-intron | ENST00000338380 | ENST00000553446 | SLPI | chr20 | 43881666 | - | LRP1 | chr12 | 57586056 | - |
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FusionProtFeatures for SLPI_LRP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLPI | LRP1 |
| Acid-stable proteinase inhibitor with strong affinitiesfor trypsin, chymotrypsin, elastase, and cathepsin G(PubMed:3533531, PubMed:3462719, PubMed:2039600, PubMed:2110563,PubMed:10702419, PubMed:24121345). Modulates the inflammatory andimmune responses after bacterial infection, and after infection bythe intracellular parasite L.major. Down-regulates responses tobacterial lipopolysaccharide (LPS) (By similarity). Plays a rolein regulating the activation of NF-kappa-B and inflammatoryresponses (PubMed:10702419, PubMed:24352879). Has antimicrobialactivity against mycobacteria, but not against salmonella.Contributes to normal resistance against infection byM.tuberculosis. Required for normal resistance to infection byL.major. Required for normal wound healing, probably by preventingtissue damage by limiting protease activity (By similarity).Together with ELANE, required for normal differentiation andproliferation of bone marrow myeloid cells (PubMed:24352879).{ECO:0000250|UniProtKB:P97430, ECO:0000269|PubMed:10702419,ECO:0000269|PubMed:2039600, ECO:0000269|PubMed:2110563,ECO:0000269|PubMed:24121345, ECO:0000269|PubMed:24352879,ECO:0000269|PubMed:3462719, ECO:0000269|PubMed:3533531,ECO:0000305}. | Endocytic receptor involved in endocytosis and inphagocytosis of apoptotic cells. Required for early embryonicdevelopment. Involved in cellular lipid homeostasis. Involved inthe plasma clearance of chylomicron remnants and activated LRPAP1(alpha 2-macroglobulin), as well as the local metabolism ofcomplexes between plasminogen activators and their endogenousinhibitors. May modulate cellular events, such as APP metabolism,kinase-dependent intracellular signaling, neuronal calciumsignaling as well as neurotransmission (PubMed:11907044,PubMed:12888553, PubMed:12713657). Acts as an alpha-2-macroglobulin receptor (PubMed:26142438).{ECO:0000269|PubMed:11907044, ECO:0000269|PubMed:12713657,ECO:0000269|PubMed:12888553, ECO:0000269|PubMed:26142438}. (Microbial infection) Functions as a receptor forPseudomonas aeruginosa exotoxin A. {ECO:0000269|PubMed:1618748}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLPI_LRP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLPI_LRP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLPI_LRP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | LRP1 | Q07954 | DB00031 | Tenecteplase | Prolow-density lipoprotein receptor-related protein 1 | biotech | approved |
| Tgene | LRP1 | Q07954 | DB00025 | Antihemophilic factor, human recombinant | Prolow-density lipoprotein receptor-related protein 1 | biotech | approved|investigational |
| Tgene | LRP1 | Q07954 | DB00100 | Coagulation Factor IX (Recombinant) | Prolow-density lipoprotein receptor-related protein 1 | biotech | approved|investigational |
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RelatedDiseases for SLPI_LRP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SLPI | C0035126 | Reperfusion Injury | 1 | CTD_human |
| Hgene | SLPI | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
| Tgene | LRP1 | C0036341 | Schizophrenia | 1 | CTD_human |
| Tgene | LRP1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | LRP1 | C0149931 | Migraine Disorders | 1 | CTD_human |
| Tgene | LRP1 | C0338480 | Common Migraine | 1 | CTD_human |
| Tgene | LRP1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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