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Fusion gene ID: 34708 |
FusionGeneSummary for SLPI_LRP1 |
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Fusion gene information | Fusion gene name: SLPI_LRP1 | Fusion gene ID: 34708 | Hgene | Tgene | Gene symbol | SLPI | LRP1 | Gene ID | 6590 | 10438 |
Gene name | secretory leukocyte peptidase inhibitor | C1D nuclear receptor corepressor | |
Synonyms | ALK1|ALP|BLPI|HUSI|HUSI-I|MPI|WAP4|WFDC4 | LRP1|Rrp47|SUN-CoR|SUNCOR|hC1D | |
Cytomap | 20q13.12 | 2p14 | |
Type of gene | protein-coding | protein-coding | |
Description | antileukoproteinaseHUSI-1WAP four-disulfide core domain protein 4mucus proteinase inhibitorprotease inhibitor WAP4secretory leukocyte protease inhibitor (antileukoproteinase)seminal proteinase inhibitor | nuclear nucleic acid-binding protein C1DC1D DNA-binding proteinC1D nuclear receptor co-repressornuclear DNA-binding proteinsmall unique nuclear receptor co-repressorsmall unique nuclear receptor corepressor | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | P03973 | Q07954 | |
Ensembl transtripts involved in fusion gene | ENST00000338380, | ENST00000553277, ENST00000243077, ENST00000338962, ENST00000554174, ENST00000553446, | |
Fusion gene scores | * DoF score | 6 X 6 X 3=108 | 5 X 6 X 2=60 |
# samples | 6 | 7 | |
** MAII score | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/60*10)=0.222392421336448 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SLPI [Title/Abstract] AND LRP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SLPI | GO:0019731 | antibacterial humoral response | 18714013 |
Hgene | SLPI | GO:0032091 | negative regulation of protein binding | 19333378 |
Hgene | SLPI | GO:0035821 | modification of morphology or physiology of other organism | 2467900 |
Hgene | SLPI | GO:0045071 | negative regulation of viral genome replication | 19333378 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE764728 | SLPI | chr20 | 43881666 | - | LRP1 | chr12 | 57586056 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000338380 | ENST00000553277 | SLPI | chr20 | 43881666 | - | LRP1 | chr12 | 57586056 | - |
intron-intron | ENST00000338380 | ENST00000243077 | SLPI | chr20 | 43881666 | - | LRP1 | chr12 | 57586056 | - |
intron-intron | ENST00000338380 | ENST00000338962 | SLPI | chr20 | 43881666 | - | LRP1 | chr12 | 57586056 | - |
intron-intron | ENST00000338380 | ENST00000554174 | SLPI | chr20 | 43881666 | - | LRP1 | chr12 | 57586056 | - |
intron-intron | ENST00000338380 | ENST00000553446 | SLPI | chr20 | 43881666 | - | LRP1 | chr12 | 57586056 | - |
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FusionProtFeatures for SLPI_LRP1 |
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Hgene | Tgene |
SLPI | LRP1 |
Acid-stable proteinase inhibitor with strong affinitiesfor trypsin, chymotrypsin, elastase, and cathepsin G(PubMed:3533531, PubMed:3462719, PubMed:2039600, PubMed:2110563,PubMed:10702419, PubMed:24121345). Modulates the inflammatory andimmune responses after bacterial infection, and after infection bythe intracellular parasite L.major. Down-regulates responses tobacterial lipopolysaccharide (LPS) (By similarity). Plays a rolein regulating the activation of NF-kappa-B and inflammatoryresponses (PubMed:10702419, PubMed:24352879). Has antimicrobialactivity against mycobacteria, but not against salmonella.Contributes to normal resistance against infection byM.tuberculosis. Required for normal resistance to infection byL.major. Required for normal wound healing, probably by preventingtissue damage by limiting protease activity (By similarity).Together with ELANE, required for normal differentiation andproliferation of bone marrow myeloid cells (PubMed:24352879).{ECO:0000250|UniProtKB:P97430, ECO:0000269|PubMed:10702419,ECO:0000269|PubMed:2039600, ECO:0000269|PubMed:2110563,ECO:0000269|PubMed:24121345, ECO:0000269|PubMed:24352879,ECO:0000269|PubMed:3462719, ECO:0000269|PubMed:3533531,ECO:0000305}. | Endocytic receptor involved in endocytosis and inphagocytosis of apoptotic cells. Required for early embryonicdevelopment. Involved in cellular lipid homeostasis. Involved inthe plasma clearance of chylomicron remnants and activated LRPAP1(alpha 2-macroglobulin), as well as the local metabolism ofcomplexes between plasminogen activators and their endogenousinhibitors. May modulate cellular events, such as APP metabolism,kinase-dependent intracellular signaling, neuronal calciumsignaling as well as neurotransmission (PubMed:11907044,PubMed:12888553, PubMed:12713657). Acts as an alpha-2-macroglobulin receptor (PubMed:26142438).{ECO:0000269|PubMed:11907044, ECO:0000269|PubMed:12713657,ECO:0000269|PubMed:12888553, ECO:0000269|PubMed:26142438}. (Microbial infection) Functions as a receptor forPseudomonas aeruginosa exotoxin A. {ECO:0000269|PubMed:1618748}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLPI_LRP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLPI_LRP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLPI_LRP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | LRP1 | Q07954 | DB00031 | Tenecteplase | Prolow-density lipoprotein receptor-related protein 1 | biotech | approved |
Tgene | LRP1 | Q07954 | DB00025 | Antihemophilic factor, human recombinant | Prolow-density lipoprotein receptor-related protein 1 | biotech | approved|investigational |
Tgene | LRP1 | Q07954 | DB00100 | Coagulation Factor IX (Recombinant) | Prolow-density lipoprotein receptor-related protein 1 | biotech | approved|investigational |
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RelatedDiseases for SLPI_LRP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SLPI | C0035126 | Reperfusion Injury | 1 | CTD_human |
Hgene | SLPI | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Tgene | LRP1 | C0036341 | Schizophrenia | 1 | CTD_human |
Tgene | LRP1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | LRP1 | C0149931 | Migraine Disorders | 1 | CTD_human |
Tgene | LRP1 | C0338480 | Common Migraine | 1 | CTD_human |
Tgene | LRP1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |