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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34708

FusionGeneSummary for SLPI_LRP1

check button Fusion gene summary
Fusion gene informationFusion gene name: SLPI_LRP1
Fusion gene ID: 34708
HgeneTgene
Gene symbol

SLPI

LRP1

Gene ID

6590

10438

Gene namesecretory leukocyte peptidase inhibitorC1D nuclear receptor corepressor
SynonymsALK1|ALP|BLPI|HUSI|HUSI-I|MPI|WAP4|WFDC4LRP1|Rrp47|SUN-CoR|SUNCOR|hC1D
Cytomap

20q13.12

2p14

Type of geneprotein-codingprotein-coding
DescriptionantileukoproteinaseHUSI-1WAP four-disulfide core domain protein 4mucus proteinase inhibitorprotease inhibitor WAP4secretory leukocyte protease inhibitor (antileukoproteinase)seminal proteinase inhibitornuclear nucleic acid-binding protein C1DC1D DNA-binding proteinC1D nuclear receptor co-repressornuclear DNA-binding proteinsmall unique nuclear receptor co-repressorsmall unique nuclear receptor corepressor
Modification date2018051920180519
UniProtAcc

P03973

Q07954

Ensembl transtripts involved in fusion geneENST00000338380, ENST00000553277, 
ENST00000243077, ENST00000338962, 
ENST00000554174, ENST00000553446, 
Fusion gene scores* DoF score6 X 6 X 3=1085 X 6 X 2=60
# samples 67
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLPI [Title/Abstract] AND LRP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLPI

GO:0019731

antibacterial humoral response

18714013

HgeneSLPI

GO:0032091

negative regulation of protein binding

19333378

HgeneSLPI

GO:0035821

modification of morphology or physiology of other organism

2467900

HgeneSLPI

GO:0045071

negative regulation of viral genome replication

19333378


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE764728SLPIchr20

43881666

-LRP1chr12

57586056

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000338380ENST00000553277SLPIchr20

43881666

-LRP1chr12

57586056

-
intron-intronENST00000338380ENST00000243077SLPIchr20

43881666

-LRP1chr12

57586056

-
intron-intronENST00000338380ENST00000338962SLPIchr20

43881666

-LRP1chr12

57586056

-
intron-intronENST00000338380ENST00000554174SLPIchr20

43881666

-LRP1chr12

57586056

-
intron-intronENST00000338380ENST00000553446SLPIchr20

43881666

-LRP1chr12

57586056

-

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FusionProtFeatures for SLPI_LRP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLPI

P03973

LRP1

Q07954

Acid-stable proteinase inhibitor with strong affinitiesfor trypsin, chymotrypsin, elastase, and cathepsin G(PubMed:3533531, PubMed:3462719, PubMed:2039600, PubMed:2110563,PubMed:10702419, PubMed:24121345). Modulates the inflammatory andimmune responses after bacterial infection, and after infection bythe intracellular parasite L.major. Down-regulates responses tobacterial lipopolysaccharide (LPS) (By similarity). Plays a rolein regulating the activation of NF-kappa-B and inflammatoryresponses (PubMed:10702419, PubMed:24352879). Has antimicrobialactivity against mycobacteria, but not against salmonella.Contributes to normal resistance against infection byM.tuberculosis. Required for normal resistance to infection byL.major. Required for normal wound healing, probably by preventingtissue damage by limiting protease activity (By similarity).Together with ELANE, required for normal differentiation andproliferation of bone marrow myeloid cells (PubMed:24352879).{ECO:0000250|UniProtKB:P97430, ECO:0000269|PubMed:10702419,ECO:0000269|PubMed:2039600, ECO:0000269|PubMed:2110563,ECO:0000269|PubMed:24121345, ECO:0000269|PubMed:24352879,ECO:0000269|PubMed:3462719, ECO:0000269|PubMed:3533531,ECO:0000305}. Endocytic receptor involved in endocytosis and inphagocytosis of apoptotic cells. Required for early embryonicdevelopment. Involved in cellular lipid homeostasis. Involved inthe plasma clearance of chylomicron remnants and activated LRPAP1(alpha 2-macroglobulin), as well as the local metabolism ofcomplexes between plasminogen activators and their endogenousinhibitors. May modulate cellular events, such as APP metabolism,kinase-dependent intracellular signaling, neuronal calciumsignaling as well as neurotransmission (PubMed:11907044,PubMed:12888553, PubMed:12713657). Acts as an alpha-2-macroglobulin receptor (PubMed:26142438).{ECO:0000269|PubMed:11907044, ECO:0000269|PubMed:12713657,ECO:0000269|PubMed:12888553, ECO:0000269|PubMed:26142438}. (Microbial infection) Functions as a receptor forPseudomonas aeruginosa exotoxin A. {ECO:0000269|PubMed:1618748}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLPI_LRP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLPI_LRP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLPI_LRP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneLRP1Q07954DB00031TenecteplaseProlow-density lipoprotein receptor-related protein 1biotechapproved
TgeneLRP1Q07954DB00025Antihemophilic factor, human recombinantProlow-density lipoprotein receptor-related protein 1biotechapproved|investigational
TgeneLRP1Q07954DB00100Coagulation Factor IX (Recombinant)Prolow-density lipoprotein receptor-related protein 1biotechapproved|investigational

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RelatedDiseases for SLPI_LRP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLPIC0035126Reperfusion Injury1CTD_human
HgeneSLPIC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneLRP1C0036341Schizophrenia1CTD_human
TgeneLRP1C0041696Unipolar Depression1PSYGENET
TgeneLRP1C0149931Migraine Disorders1CTD_human
TgeneLRP1C0338480Common Migraine1CTD_human
TgeneLRP1C1269683Major Depressive Disorder1PSYGENET