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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34703

FusionGeneSummary for SLMAP_FAF1

check button Fusion gene summary
Fusion gene informationFusion gene name: SLMAP_FAF1
Fusion gene ID: 34703
HgeneTgene
Gene symbol

SLMAP

FAF1

Gene ID

7871

11124

Gene namesarcolemma associated proteinFas associated factor 1
SynonymsSLAPCGI-03|HFAF1s|UBXD12|UBXN3A|hFAF1
Cytomap

3p14.3

1p32.3

Type of geneprotein-codingprotein-coding
Descriptionsarcolemmal membrane-associated proteinFAS-associated factor 1Fas (TNFRSF6) associated factor 1TNFRSF6-associated factor 1UBX domain protein 3AUBX domain-containing protein 12UBX domain-containing protein 3A
Modification date2018052220180522
UniProtAcc

Q14BN4

Q9UNN5

Ensembl transtripts involved in fusion geneENST00000295951, ENST00000416870, 
ENST00000295952, ENST00000383718, 
ENST00000428312, ENST00000449503, 
ENST00000472546, ENST00000442599, 
ENST00000495364, ENST00000494088, 
ENST00000396153, ENST00000371778, 
ENST00000545823, ENST00000472808, 
Fusion gene scores* DoF score5 X 4 X 5=10017 X 15 X 9=2295
# samples 522
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/2295*10)=-3.38291872477651
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLMAP [Title/Abstract] AND FAF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFAF1

GO:0010942

positive regulation of cell death

15596450


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVESCATCGA-L5-A4OF-01ASLMAPchr3

57894877

+FAF1chr1

51267349

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000295951ENST00000396153SLMAPchr3

57894877

+FAF1chr1

51267349

-
Frame-shiftENST00000295951ENST00000371778SLMAPchr3

57894877

+FAF1chr1

51267349

-
5CDS-intronENST00000295951ENST00000545823SLMAPchr3

57894877

+FAF1chr1

51267349

-
5CDS-intronENST00000295951ENST00000472808SLMAPchr3

57894877

+FAF1chr1

51267349

-
Frame-shiftENST00000416870ENST00000396153SLMAPchr3

57894877

+FAF1chr1

51267349

-
Frame-shiftENST00000416870ENST00000371778SLMAPchr3

57894877

+FAF1chr1

51267349

-
5CDS-intronENST00000416870ENST00000545823SLMAPchr3

57894877

+FAF1chr1

51267349

-
5CDS-intronENST00000416870ENST00000472808SLMAPchr3

57894877

+FAF1chr1

51267349

-
Frame-shiftENST00000295952ENST00000396153SLMAPchr3

57894877

+FAF1chr1

51267349

-
Frame-shiftENST00000295952ENST00000371778SLMAPchr3

57894877

+FAF1chr1

51267349

-
5CDS-intronENST00000295952ENST00000545823SLMAPchr3

57894877

+FAF1chr1

51267349

-
5CDS-intronENST00000295952ENST00000472808SLMAPchr3

57894877

+FAF1chr1

51267349

-
intron-3CDSENST00000383718ENST00000396153SLMAPchr3

57894877

+FAF1chr1

51267349

-
intron-3CDSENST00000383718ENST00000371778SLMAPchr3

57894877

+FAF1chr1

51267349

-
intron-intronENST00000383718ENST00000545823SLMAPchr3

57894877

+FAF1chr1

51267349

-
intron-intronENST00000383718ENST00000472808SLMAPchr3

57894877

+FAF1chr1

51267349

-
Frame-shiftENST00000428312ENST00000396153SLMAPchr3

57894877

+FAF1chr1

51267349

-
Frame-shiftENST00000428312ENST00000371778SLMAPchr3

57894877

+FAF1chr1

51267349

-
5CDS-intronENST00000428312ENST00000545823SLMAPchr3

57894877

+FAF1chr1

51267349

-
5CDS-intronENST00000428312ENST00000472808SLMAPchr3

57894877

+FAF1chr1

51267349

-
Frame-shiftENST00000449503ENST00000396153SLMAPchr3

57894877

+FAF1chr1

51267349

-
Frame-shiftENST00000449503ENST00000371778SLMAPchr3

57894877

+FAF1chr1

51267349

-
5CDS-intronENST00000449503ENST00000545823SLMAPchr3

57894877

+FAF1chr1

51267349

-
5CDS-intronENST00000449503ENST00000472808SLMAPchr3

57894877

+FAF1chr1

51267349

-
intron-3CDSENST00000472546ENST00000396153SLMAPchr3

57894877

+FAF1chr1

51267349

-
intron-3CDSENST00000472546ENST00000371778SLMAPchr3

57894877

+FAF1chr1

51267349

-
intron-intronENST00000472546ENST00000545823SLMAPchr3

57894877

+FAF1chr1

51267349

-
intron-intronENST00000472546ENST00000472808SLMAPchr3

57894877

+FAF1chr1

51267349

-
intron-3CDSENST00000442599ENST00000396153SLMAPchr3

57894877

+FAF1chr1

51267349

-
intron-3CDSENST00000442599ENST00000371778SLMAPchr3

57894877

+FAF1chr1

51267349

-
intron-intronENST00000442599ENST00000545823SLMAPchr3

57894877

+FAF1chr1

51267349

-
intron-intronENST00000442599ENST00000472808SLMAPchr3

57894877

+FAF1chr1

51267349

-
Frame-shiftENST00000495364ENST00000396153SLMAPchr3

57894877

+FAF1chr1

51267349

-
Frame-shiftENST00000495364ENST00000371778SLMAPchr3

57894877

+FAF1chr1

51267349

-
5CDS-intronENST00000495364ENST00000545823SLMAPchr3

57894877

+FAF1chr1

51267349

-
5CDS-intronENST00000495364ENST00000472808SLMAPchr3

57894877

+FAF1chr1

51267349

-
Frame-shiftENST00000494088ENST00000396153SLMAPchr3

57894877

+FAF1chr1

51267349

-
Frame-shiftENST00000494088ENST00000371778SLMAPchr3

57894877

+FAF1chr1

51267349

-
5CDS-intronENST00000494088ENST00000545823SLMAPchr3

57894877

+FAF1chr1

51267349

-
5CDS-intronENST00000494088ENST00000472808SLMAPchr3

57894877

+FAF1chr1

51267349

-

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FusionProtFeatures for SLMAP_FAF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLMAP

Q14BN4

FAF1

Q9UNN5

Ubiquitin-binding protein (PubMed:19722279). Requiredfor the progression of DNA replication forks by targeting DNAreplication licensing factor CDT1 for degradation(PubMed:26842564). Potentiates but cannot initiate FAS-inducedapoptosis (By similarity). {ECO:0000250|UniProtKB:P54731,ECO:0000269|PubMed:19722279, ECO:0000269|PubMed:26842564}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLMAP_FAF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLMAP_FAF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLMAPSTK24, STRIP1, MOB4, PDCD10, STK26, SIKE1, STK25, STRN, STRN3, ZRANB1, PPP2CA, PPP2CB, PPP2R1A, STK4, STK3, CEP131, CENPJ, CEP192, CNTROB, EIF4EBP1, CCSER2, FAM83B, FGFR1OP2, FRYL, GFOD1, HDAC6, CEP170B, KIAA1522, OFD1, RABEP1, RABGEF1, RALGAPA1, RALGAPB, STRN4, TAB1, STX3, LYPD3, F2RL1, PSMC3, CATSPER4, RASSF3, PPP2R1B, STRIP2, PFDN6, PFDN2, PFDN4, IRF3, PTAR1, TNFRSF1A, PLP1, SYNC, PRPF19, NHSL2, PRDM14, TACR1, TCTN2, LIN9, CCDC89, KCNA10, ZNF550, CRNN, ACOX2, VAC14FAF1ASCC2, FAS, CSNK2B, G3BP1, RAE1, CASP8, CTNNB1, VCP, NPLOC4, UFD1L, CUL1, CUL2, CUL3, UBR1, HIF1A, ALPP, VCPIP1, SKP1, FBXW11, KLHL22, KBTBD7, WDR26, AMFR, UBR2, UBR4, PJA2, CDC73, TAF1D, RAP1B, UROD, TK1, ANXA1, DNAJB11, CDKN1A, TNNT1, SIRT6, HSD17B10, RCC1, NR1H2, ANXA7, TSC22D1, NR4A1, ITGB1BP1, IGF2, RAD23A, BTRC, NGLY1, UBC, HSPA4, RELA, HSPA8, FADD, IKBKB, NLRP3, NLRP2, NLRP7, NLRP12, NUDT21, SKIL, CARM1, CARS, FAM114A1, FARSB, GART, HIRIP3, HIST1H4A, HSPH1, ILK, PLOD2, PPM1G, PPP2R5C, PRMT3, PUF60, RANBP3, RPL24, SAMHD1, SEC23A, SET, SF1, SWAP70, TLN1, TROVE2, UGP2, XPO7, VAPA, VAPB, UBL4A, ASNA1, GET4, BAG6, RPN2, DDOST, FAF1, CD40, MAGIX, TCEAL1, CBX3, DNAJA1, ZC3H15, NTRK1, RAP1A, CDT1, IPO5, WDR24, YTHDF1, CDC5L, KCTD10, YTHDF3, WDR59, MMAB, NUP98, MYCBP2, USP11, NSFL1C, UBXN7, UBXN1, ASPSCR1, HSPA2, MIOS, UBXN6, BTBD9, KCTD13, TNFAIP1, UBXN2B, BHLHA15, CHCHD10, CLEC3A, PRCC, TRIM25, XIAP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLMAP_FAF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLMAP_FAF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource