	FusionGeneSummary
	FusionProtFeature
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Fusion gene ID: 34700

FusionGeneSummary for SLMAP_CUL4B

Fusion gene summary

Fusion gene information	Fusion gene name: SLMAP_CUL4B
	Fusion gene ID: 34700
		Hgene	Tgene
	Gene symbol	SLMAP	CUL4B
	Gene ID	7871	8450
	Gene name	sarcolemma associated protein	cullin 4B
	Synonyms	SLAP	CUL-4B\|MRXHF2\|MRXS15\|MRXSC\|SFM2
	Cytomap	3p14.3	Xq24
	Type of gene	protein-coding	protein-coding
	Description	sarcolemmal membrane-associated protein	cullin-4B
	Modification date	20180522	20180523
	UniProtAcc	Q14BN4	Q13620
	Ensembl transtripts involved in fusion gene	ENST00000295951, ENST00000416870, ENST00000295952, ENST00000383718, ENST00000428312, ENST00000449503, ENST00000472546, ENST00000442599, ENST00000495364, ENST00000494088,	ENST00000371322, ENST00000336592, ENST00000404115, ENST00000486604,
Fusion gene scores	* DoF score	5 X 4 X 5=100	3 X 2 X 3=18
	# samples	5	3
	** MAII score	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: SLMAP [Title/Abstract] AND CUL4B [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CUL4B	GO:0010498	proteasomal protein catabolic process	25970626
Tgene	CUL4B	GO:0035518	histone H2A monoubiquitination	22334663
Tgene	CUL4B	GO:0070914	UV-damage excision repair	22334663

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LIHC	TCGA-DD-A11C-01A	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000295951	ENST00000371322	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5CDS-intron	ENST00000295951	ENST00000336592	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5CDS-5UTR	ENST00000295951	ENST00000404115	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5CDS-5UTR	ENST00000295951	ENST00000486604	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5UTR-intron	ENST00000416870	ENST00000371322	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5UTR-intron	ENST00000416870	ENST00000336592	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5UTR-5UTR	ENST00000416870	ENST00000404115	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5UTR-5UTR	ENST00000416870	ENST00000486604	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5CDS-intron	ENST00000295952	ENST00000371322	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5CDS-intron	ENST00000295952	ENST00000336592	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5CDS-5UTR	ENST00000295952	ENST00000404115	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5CDS-5UTR	ENST00000295952	ENST00000486604	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5CDS-intron	ENST00000383718	ENST00000371322	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5CDS-intron	ENST00000383718	ENST00000336592	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5CDS-5UTR	ENST00000383718	ENST00000404115	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5CDS-5UTR	ENST00000383718	ENST00000486604	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5CDS-intron	ENST00000428312	ENST00000371322	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5CDS-intron	ENST00000428312	ENST00000336592	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5CDS-5UTR	ENST00000428312	ENST00000404115	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5CDS-5UTR	ENST00000428312	ENST00000486604	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5CDS-intron	ENST00000449503	ENST00000371322	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5CDS-intron	ENST00000449503	ENST00000336592	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5CDS-5UTR	ENST00000449503	ENST00000404115	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
5CDS-5UTR	ENST00000449503	ENST00000486604	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
intron-intron	ENST00000472546	ENST00000371322	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
intron-intron	ENST00000472546	ENST00000336592	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
intron-5UTR	ENST00000472546	ENST00000404115	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
intron-5UTR	ENST00000472546	ENST00000486604	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
intron-intron	ENST00000442599	ENST00000371322	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
intron-intron	ENST00000442599	ENST00000336592	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
intron-5UTR	ENST00000442599	ENST00000404115	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
intron-5UTR	ENST00000442599	ENST00000486604	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
intron-intron	ENST00000495364	ENST00000371322	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
intron-intron	ENST00000495364	ENST00000336592	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
intron-5UTR	ENST00000495364	ENST00000404115	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
intron-5UTR	ENST00000495364	ENST00000486604	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
intron-intron	ENST00000494088	ENST00000371322	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
intron-intron	ENST00000494088	ENST00000336592	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
intron-5UTR	ENST00000494088	ENST00000404115	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-
intron-5UTR	ENST00000494088	ENST00000486604	SLMAP	chr3	57743576	+	CUL4B	chrX	119708485	-

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FusionProtFeatures for SLMAP_CUL4B

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SLMAP Q14BN4	CUL4B Q13620

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for SLMAP_CUL4B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLMAP_CUL4B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
SLMAP	STK24, STRIP1, MOB4, PDCD10, STK26, SIKE1, STK25, STRN, STRN3, ZRANB1, PPP2CA, PPP2CB, PPP2R1A, STK4, STK3, CEP131, CENPJ, CEP192, CNTROB, EIF4EBP1, CCSER2, FAM83B, FGFR1OP2, FRYL, GFOD1, HDAC6, CEP170B, KIAA1522, OFD1, RABEP1, RABGEF1, RALGAPA1, RALGAPB, STRN4, TAB1, STX3, LYPD3, F2RL1, PSMC3, CATSPER4, RASSF3, PPP2R1B, STRIP2, PFDN6, PFDN2, PFDN4, IRF3, PTAR1, TNFRSF1A, PLP1, SYNC, PRPF19, NHSL2, PRDM14, TACR1, TCTN2, LIN9, CCDC89, KCNA10, ZNF550, CRNN, ACOX2, VAC14	CUL4B	CAND1, RBX1, DDB1, DDB2, CUL4A, COPS5, COPS6, WDR48, DTL, COPS3, TLE1, TLE2, TLE3, WDR26, SMU1, GRWD1, WDR82, RBBP5, RFWD2, WDR5B, POC1B, SNRNP40, WDR61, WDR76, WDR5, COMMD1, UBXN7, KPNA2, KPNA4, KPNA1, KPNB1, SALL2, SIRT7, NEDD8, CDT1, CCNE1, PCNA, CUL3, ACTA2, ACTBL2, AGL, AHCY, FBF1, ALDH9A1, ALDOA, ANKRD39, ANXA7, APBB1, ASB6, B3GNT4, BLMH, C14orf166, C1QBP, RTCB, DCAF16, C9orf117, CALM1, CALM2, CALM3, CCBL2, CCDC80, CD6, CDK4, CLPX, COG4, COPS2, COPS4, COPS7A, COPS7B, COPS8, YBX3, CSN2, CSTA, CTPS1, CUL5, DAZAP1, DCD, DCUN1D1, DDX1, DDX56, DDX3X, DDX5, DHX15, DHX30, DHX9, DLGAP3, DNAJA1, DNAJC10, DOCK9, DPY19L4, EEF1A2, EEF2, EIF5A2, ELAVL1, ENO1, ENO2, ERCC8, EWSR1, FAM103A1, FAM184A, FN3KRP, FUS, GAPDH, GPS1, H2AFV, HIST1H1C, HIST2H2BE, HNRNPA1, HNRNPA2B1, HNRNPA3, HNRNPAB, HNRNPCL1, HNRNPD, HNRNPF, HNRNPH1, HNRNPH3, HNRNPK, HNRNPR, HNRNPUL1, HNRNPDL, HSD17B10, HSP90AA1, HSP90AA2P, HSP90AB1, HSPA1A, HSPA1B, HSPA1L, HSPA5, HSPA7, HSPA8, HSPA9, TOR1AIP2, IGF2BP1, ILF2, IRS4, JUP, KDM4D, KHSRP, KRT1, KRT10, KRT13, KRT14, KRT16, KRT2, KRT24, KRT5, KRT71, KRT75, KRT76, KRT85, KRT9, LARP1, LDHB, LGALS3BP, IGHV3OR15-7, LRP1B, LYZ, MCCC1, MPPED1, MYCBP2, MYEOV2, MYO18A, NAP1L1, NCL, NFKB1, NUDT1, NUDT16L1, PABPC1, PABPC4, PCBD1, PGAM5, PHIP, PLOD1, PPIA, PRDX1, PRDX3, QPCT, RBM14, RBM4, RBM3, RBMXL2, RPL11, RPL12, RPL13, RPL14, RPL15, RPL18, RPL21P19, RPL21, RPL21P16, RPL23A, RPL24, RPL26L1, RPL27, RPL27A, RPL29P30, RPL3, RPL30, RPL31, RPL35, RPL35A, RPL36AP37, HNRNPH2, RPL4, RPL6, RPL7, RPL7P32, RPL7AP9, RPL7AP27, RPL8, RPL9, RPLP0, RPLP1, RPLP2, RPS14, RPS16, RPS18, RPS2, RPS20, RPS24, RPS25, RPS26P54, RPS3, RPS4X, RPS6, RPS7, RPS8, RPSAP12, RWDD4, S100A7, SART3, SRSF1, SRSF3, SRSF4, SRSF7, SLC25A5, SNRNP70, SNRPA, SNRPB, SNRPC, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPG, SSB, SYNCRIP, TAF15, TCEAL2, TFG, TIAL1, TRIM27, TTLL7, TTN, TUBA1C, TUBA4A, TUBB, TUBB1, TUBB4B, TUFM, TXN, USP11, USP15, USP4, USP7, VPRBP, XRN2, YBX1, ZCCHC11, HIST1H2AB, HIST1H2AE, HIST1H2AG, HIST1H2AL, HIST1H2AJ, HIST1H2AK, HIST1H2AI, HIST1H2AM, UBC, CUL2, CDK2, MDM2, ERCC6, GRK5, DDA1, APP, RPTOR, DCUN1D2, DCUN1D3, DCUN1D4, DCUN1D5, BAG3, POP7, PSMA1, EIF4B, STUB1, TTC1, VASP, OIP5, TP53, NR2C2, SHFM1, HDAC1, HDAC2, SIN3A, ARID4B, SAP130, SUDS3, SAP30, RBP1, AMBRA1, DCAF6, DCAF4, DCAF17, DET1, DCAF11, DCAF8, RNF7, EGFR, CLCN1, TMEM43, DCAF4L2, CCNG1, TUBG1, NHP2L1, NXF1, NTRK1, FBXO44, DYNLT1, CCS, CDCA8, KIF15, DCAF10, BRWD3, WDR62, RBBP7, MCM2, CRBN, HUWE1, UBE2D3, HSP90B1, FKBP8, TRPC4AP, GLMN, WDTC1, CRYBA4, DCAF4L1, TMCO3, GCNT3, LINC01587, MRPS11, DCAF12L2, UHRF2, TES

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for SLMAP_CUL4B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SLMAP_CUL4B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	CUL4B	C1845861	MENTAL RETARDATION, X-LINKED, WITH SHORT STATURE, HYPOGONADISM, AND ABNORMAL GAIT	1	CTD_human;ORPHANET;UNIPROT

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Fusion gene ID: 34700

FusionGeneSummary for SLMAP_CUL4B

FusionProtFeatures for SLMAP_CUL4B

FusionGeneSequence for SLMAP_CUL4B

FusionGenePPI for SLMAP_CUL4B

RelatedDrugs for SLMAP_CUL4B

RelatedDiseases for SLMAP_CUL4B