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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34689

FusionGeneSummary for SLIT3_HSD17B4

check button Fusion gene summary
Fusion gene informationFusion gene name: SLIT3_HSD17B4
Fusion gene ID: 34689
HgeneTgene
Gene symbol

SLIT3

HSD17B4

Gene ID

6586

3295

Gene nameslit guidance ligand 3hydroxysteroid 17-beta dehydrogenase 4
SynonymsMEGF5|SLIL2|SLIT1|Slit-3|slit2DBP|MFE-2|MPF-2|PRLTS1|SDR8C1
Cytomap

5q34-q35.1

5q23.1

Type of geneprotein-codingprotein-coding
Descriptionslit homolog 3 proteinmultiple EGF-like domains protein 5multiple epidermal growth factor-like domains protein 5slit homolog 3peroxisomal multifunctional enzyme type 217-beta-HSD 417-beta-HSD IV17-beta-hydroxysteroid dehydrogenase 417beta-estradiol dehydrogenase type IV3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydrataseD-3-hydroxyacyl-CoA dehydratase
Modification date2018052220180522
UniProtAcc

O75094

P51659

Ensembl transtripts involved in fusion geneENST00000519560, ENST00000332966, 
ENST00000404867, ENST00000521130, 
ENST00000256216, ENST00000515320, 
ENST00000510025, ENST00000504811, 
ENST00000414835, ENST00000513628, 
ENST00000509514, ENST00000522415, 
Fusion gene scores* DoF score7 X 5 X 4=1404 X 2 X 3=24
# samples 74
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLIT3 [Title/Abstract] AND HSD17B4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLIT3

GO:0007411

axon guidance

11748139

HgeneSLIT3

GO:0021834

chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration

11748139

HgeneSLIT3

GO:0048846

axon extension involved in axon guidance

16840550

HgeneSLIT3

GO:0050919

negative chemotaxis

11748139

TgeneHSD17B4

GO:0006635

fatty acid beta-oxidation

10400999

TgeneHSD17B4

GO:0008209

androgen metabolic process

7487879

TgeneHSD17B4

GO:0008210

estrogen metabolic process

7487879

TgeneHSD17B4

GO:0036111

very long-chain fatty-acyl-CoA metabolic process

9482850

TgeneHSD17B4

GO:0036112

medium-chain fatty-acyl-CoA metabolic process

9089413


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-EW-A1P0-01ASLIT3chr5

168310270

-HSD17B4chr5

118792010

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000519560ENST00000256216SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
5CDS-intronENST00000519560ENST00000515320SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
5CDS-5UTRENST00000519560ENST00000510025SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
5CDS-5UTRENST00000519560ENST00000504811SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
5CDS-5UTRENST00000519560ENST00000414835SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
5CDS-intronENST00000519560ENST00000513628SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
5CDS-intronENST00000519560ENST00000509514SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
5CDS-intronENST00000519560ENST00000522415SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
Frame-shitENST00000332966ENST00000256216SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
5CDS-intronENST00000332966ENST00000515320SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
5CDS-5UTRENST00000332966ENST00000510025SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
5CDS-5UTRENST00000332966ENST00000504811SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
5CDS-5UTRENST00000332966ENST00000414835SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
5CDS-intronENST00000332966ENST00000513628SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
5CDS-intronENST00000332966ENST00000509514SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
5CDS-intronENST00000332966ENST00000522415SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
Frame-shitENST00000404867ENST00000256216SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
5CDS-intronENST00000404867ENST00000515320SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
5CDS-5UTRENST00000404867ENST00000510025SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
5CDS-5UTRENST00000404867ENST00000504811SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
5CDS-5UTRENST00000404867ENST00000414835SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
5CDS-intronENST00000404867ENST00000513628SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
5CDS-intronENST00000404867ENST00000509514SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
5CDS-intronENST00000404867ENST00000522415SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
intron-3CDSENST00000521130ENST00000256216SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
intron-intronENST00000521130ENST00000515320SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
intron-5UTRENST00000521130ENST00000510025SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
intron-5UTRENST00000521130ENST00000504811SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
intron-5UTRENST00000521130ENST00000414835SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
intron-intronENST00000521130ENST00000513628SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
intron-intronENST00000521130ENST00000509514SLIT3chr5

168310270

-HSD17B4chr5

118792010

+
intron-intronENST00000521130ENST00000522415SLIT3chr5

168310270

-HSD17B4chr5

118792010

+

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FusionProtFeatures for SLIT3_HSD17B4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLIT3

O75094

HSD17B4

P51659

May act as molecular guidance cue in cellular migration,and function may be mediated by interaction with roundabouthomolog receptors. Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. {ECO:0000269|PubMed:8902629,ECO:0000269|PubMed:9089413}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLIT3_HSD17B4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLIT3_HSD17B4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLIT3CAPN1, OTUB1HSD17B4UBA5, UBC, NDRG1, MYC, GRB2, SNCA, ACAA1, SCP2, CAT, GRHPR, SSBP1, FIS1, GNB2L1, VAMP2, PEX5, PEX14, ADRB2, CASP9, BAK1, CDK7, MAPK8, HECW2, STAU1, CUL7, CCDC8, DECR1, EEF2, IDH1, NTRK1, SCARNA22, RPGRIP1, FOS, HNRNPD, HNRNPU, SORT1, RACGAP1, NF2, CDC73, PPM1A, DUSP22, DUSP4, IKZF1, DLD, DLST, PDHA1, SDHA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLIT3_HSD17B4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLIT3_HSD17B4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLIT3C0019284Diaphragmatic Hernia1CTD_human
HgeneSLIT3C0036341Schizophrenia1PSYGENET
HgeneSLIT3C0041696Unipolar Depression1PSYGENET
HgeneSLIT3C1269683Major Depressive Disorder1PSYGENET
TgeneHSD17B4C0342870Bifunctional peroxisomal enzyme deficiency4CTD_human;ORPHANET;UNIPROT
TgeneHSD17B4C0282528Peroxisomal Disorders2CTD_human
TgeneHSD17B4C0685838Gonadal dysgenesis XX type deafness2CTD_human;ORPHANET;UNIPROT
TgeneHSD17B4C0037769West Syndrome1CTD_human
TgeneHSD17B4C0043459Zellweger Syndrome1CTD_human