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Fusion gene ID: 34688 |
FusionGeneSummary for SLIT2_SLIT2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLIT2_SLIT2 | Fusion gene ID: 34688 | Hgene | Tgene | Gene symbol | SLIT2 | SLIT2 | Gene ID | 9353 | 9353 |
| Gene name | slit guidance ligand 2 | slit guidance ligand 2 | |
| Synonyms | SLIL3|Slit-2 | SLIL3|Slit-2 | |
| Cytomap | 4p15.31 | 4p15.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | slit homolog 2 protein | slit homolog 2 protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O94813 | O94813 | |
| Ensembl transtripts involved in fusion gene | ENST00000503823, ENST00000504154, ENST00000273739, ENST00000503837, ENST00000509394, | ENST00000503823, ENST00000504154, ENST00000273739, ENST00000503837, ENST00000509394, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: SLIT2 [Title/Abstract] AND SLIT2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SLIT2 | GO:0001933 | negative regulation of protein phosphorylation | 18345009 |
| Hgene | SLIT2 | GO:0002689 | negative regulation of leukocyte chemotaxis | 11309622 |
| Hgene | SLIT2 | GO:0007411 | axon guidance | 11748139 |
| Hgene | SLIT2 | GO:0008045 | motor neuron axon guidance | 10102268 |
| Hgene | SLIT2 | GO:0010593 | negative regulation of lamellipodium assembly | 16439689 |
| Hgene | SLIT2 | GO:0010596 | negative regulation of endothelial cell migration | 18345009 |
| Hgene | SLIT2 | GO:0014912 | negative regulation of smooth muscle cell migration | 16439689 |
| Hgene | SLIT2 | GO:0021834 | chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration | 11748139 |
| Hgene | SLIT2 | GO:0021836 | chemorepulsion involved in postnatal olfactory bulb interneuron migration | 15207848 |
| Hgene | SLIT2 | GO:0030336 | negative regulation of cell migration | 19005219 |
| Hgene | SLIT2 | GO:0030837 | negative regulation of actin filament polymerization | 19759280 |
| Hgene | SLIT2 | GO:0031290 | retinal ganglion cell axon guidance | 10864954|19498462 |
| Hgene | SLIT2 | GO:0043116 | negative regulation of vascular permeability | 18345009 |
| Hgene | SLIT2 | GO:0048754 | branching morphogenesis of an epithelial tube | 18345009 |
| Hgene | SLIT2 | GO:0048846 | axon extension involved in axon guidance | 16840550 |
| Hgene | SLIT2 | GO:0050919 | negative chemotaxis | 11748139 |
| Hgene | SLIT2 | GO:0050929 | induction of negative chemotaxis | 10197527 |
| Hgene | SLIT2 | GO:0051058 | negative regulation of small GTPase mediated signal transduction | 16439689 |
| Hgene | SLIT2 | GO:0071504 | cellular response to heparin | 17062560 |
| Hgene | SLIT2 | GO:0071672 | negative regulation of smooth muscle cell chemotaxis | 16439689 |
| Hgene | SLIT2 | GO:0071676 | negative regulation of mononuclear cell migration | 16439689 |
| Hgene | SLIT2 | GO:0090024 | negative regulation of neutrophil chemotaxis | 19759280 |
| Hgene | SLIT2 | GO:0090260 | negative regulation of retinal ganglion cell axon guidance | 17062560 |
| Hgene | SLIT2 | GO:0090288 | negative regulation of cellular response to growth factor stimulus | 16439689 |
| Tgene | SLIT2 | GO:0001933 | negative regulation of protein phosphorylation | 18345009 |
| Tgene | SLIT2 | GO:0002689 | negative regulation of leukocyte chemotaxis | 11309622 |
| Tgene | SLIT2 | GO:0007411 | axon guidance | 11748139 |
| Tgene | SLIT2 | GO:0008045 | motor neuron axon guidance | 10102268 |
| Tgene | SLIT2 | GO:0010593 | negative regulation of lamellipodium assembly | 16439689 |
| Tgene | SLIT2 | GO:0010596 | negative regulation of endothelial cell migration | 18345009 |
| Tgene | SLIT2 | GO:0014912 | negative regulation of smooth muscle cell migration | 16439689 |
| Tgene | SLIT2 | GO:0021834 | chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration | 11748139 |
| Tgene | SLIT2 | GO:0021836 | chemorepulsion involved in postnatal olfactory bulb interneuron migration | 15207848 |
| Tgene | SLIT2 | GO:0030336 | negative regulation of cell migration | 19005219 |
| Tgene | SLIT2 | GO:0030837 | negative regulation of actin filament polymerization | 19759280 |
| Tgene | SLIT2 | GO:0031290 | retinal ganglion cell axon guidance | 10864954|19498462 |
| Tgene | SLIT2 | GO:0043116 | negative regulation of vascular permeability | 18345009 |
| Tgene | SLIT2 | GO:0048754 | branching morphogenesis of an epithelial tube | 18345009 |
| Tgene | SLIT2 | GO:0048846 | axon extension involved in axon guidance | 16840550 |
| Tgene | SLIT2 | GO:0050919 | negative chemotaxis | 11748139 |
| Tgene | SLIT2 | GO:0050929 | induction of negative chemotaxis | 10197527 |
| Tgene | SLIT2 | GO:0051058 | negative regulation of small GTPase mediated signal transduction | 16439689 |
| Tgene | SLIT2 | GO:0071504 | cellular response to heparin | 17062560 |
| Tgene | SLIT2 | GO:0071672 | negative regulation of smooth muscle cell chemotaxis | 16439689 |
| Tgene | SLIT2 | GO:0071676 | negative regulation of mononuclear cell migration | 16439689 |
| Tgene | SLIT2 | GO:0090024 | negative regulation of neutrophil chemotaxis | 19759280 |
| Tgene | SLIT2 | GO:0090260 | negative regulation of retinal ganglion cell axon guidance | 17062560 |
| Tgene | SLIT2 | GO:0090288 | negative regulation of cellular response to growth factor stimulus | 16439689 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF996463 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000503823 | ENST00000503823 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| 5CDS-intron | ENST00000503823 | ENST00000504154 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| 5CDS-intron | ENST00000503823 | ENST00000273739 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| 5CDS-intron | ENST00000503823 | ENST00000503837 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| 5CDS-intron | ENST00000503823 | ENST00000509394 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| 5CDS-intron | ENST00000504154 | ENST00000503823 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| 5CDS-intron | ENST00000504154 | ENST00000504154 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| 5CDS-intron | ENST00000504154 | ENST00000273739 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| 5CDS-intron | ENST00000504154 | ENST00000503837 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| 5CDS-intron | ENST00000504154 | ENST00000509394 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| 5CDS-intron | ENST00000273739 | ENST00000503823 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| 5CDS-intron | ENST00000273739 | ENST00000504154 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| 5CDS-intron | ENST00000273739 | ENST00000273739 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| 5CDS-intron | ENST00000273739 | ENST00000503837 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| 5CDS-intron | ENST00000273739 | ENST00000509394 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| 5CDS-intron | ENST00000503837 | ENST00000503823 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| 5CDS-intron | ENST00000503837 | ENST00000504154 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| 5CDS-intron | ENST00000503837 | ENST00000273739 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| 5CDS-intron | ENST00000503837 | ENST00000503837 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| 5CDS-intron | ENST00000503837 | ENST00000509394 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| intron-intron | ENST00000509394 | ENST00000503823 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| intron-intron | ENST00000509394 | ENST00000504154 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| intron-intron | ENST00000509394 | ENST00000273739 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| intron-intron | ENST00000509394 | ENST00000503837 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
| intron-intron | ENST00000509394 | ENST00000509394 | SLIT2 | chr4 | 20535269 | + | SLIT2 | chr4 | 20526791 | - |
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FusionProtFeatures for SLIT2_SLIT2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLIT2 | SLIT2 |
| Thought to act as molecular guidance cue in cellularmigration, and function appears to be mediated by interaction withroundabout homolog receptors. During neural development involvedin axonal navigation at the ventral midline of the neural tube andprojection of axons to different regions. SLIT1 and SLIT2 seem tobe essential for midline guidance in the forebrain by acting asrepulsive signal preventing inappropriate midline crossing byaxons projecting from the olfactory bulb. In spinal chorddevelopment may play a role in guiding commissural axons once theyreached the floor plate by modulating the response to netrin. Invitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of aROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons thatcrossed the midline responded to SLIT2. In the developing visualsystem appears to function as repellent for retinal ganglion axonsby providing a repulsion that directs these axons along theirappropriate paths prior to, and after passage through, the opticchiasm. In vitro, collapses and repels retinal ganglion cellgrowth cones. Seems to play a role in branching and arborizationof CNS sensory axons, and in neuronal cell migration. In vitro,Slit homolog 2 protein N-product, but not Slit homolog 2 proteinC-product, repels olfactory bulb (OB) but not dorsal root ganglia(DRG) axons, induces OB growth cones collapse and inducesbranching of DRG axons. Seems to be involved in regulatingleukocyte migration. {ECO:0000269|PubMed:10102268,ECO:0000269|PubMed:10864954, ECO:0000269|PubMed:10975526,ECO:0000269|PubMed:11239147, ECO:0000269|PubMed:11309622,ECO:0000269|PubMed:11404413}. | Thought to act as molecular guidance cue in cellularmigration, and function appears to be mediated by interaction withroundabout homolog receptors. During neural development involvedin axonal navigation at the ventral midline of the neural tube andprojection of axons to different regions. SLIT1 and SLIT2 seem tobe essential for midline guidance in the forebrain by acting asrepulsive signal preventing inappropriate midline crossing byaxons projecting from the olfactory bulb. In spinal chorddevelopment may play a role in guiding commissural axons once theyreached the floor plate by modulating the response to netrin. Invitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of aROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons thatcrossed the midline responded to SLIT2. In the developing visualsystem appears to function as repellent for retinal ganglion axonsby providing a repulsion that directs these axons along theirappropriate paths prior to, and after passage through, the opticchiasm. In vitro, collapses and repels retinal ganglion cellgrowth cones. Seems to play a role in branching and arborizationof CNS sensory axons, and in neuronal cell migration. In vitro,Slit homolog 2 protein N-product, but not Slit homolog 2 proteinC-product, repels olfactory bulb (OB) but not dorsal root ganglia(DRG) axons, induces OB growth cones collapse and inducesbranching of DRG axons. Seems to be involved in regulatingleukocyte migration. {ECO:0000269|PubMed:10102268,ECO:0000269|PubMed:10864954, ECO:0000269|PubMed:10975526,ECO:0000269|PubMed:11239147, ECO:0000269|PubMed:11309622,ECO:0000269|PubMed:11404413}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLIT2_SLIT2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLIT2_SLIT2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLIT2_SLIT2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLIT2_SLIT2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SLIT2 | C0014556 | Epilepsy, Temporal Lobe | 1 | CTD_human |
| Hgene | SLIT2 | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
| Hgene | SLIT2 | C2239176 | Liver carcinoma | 1 | CTD_human |
| Tgene | SLIT2 | C0014556 | Epilepsy, Temporal Lobe | 1 | CTD_human |
| Tgene | SLIT2 | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
| Tgene | SLIT2 | C2239176 | Liver carcinoma | 1 | CTD_human |
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