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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 34687

FusionGeneSummary for SLIT2_PACRGL

check button Fusion gene summary
Fusion gene informationFusion gene name: SLIT2_PACRGL
Fusion gene ID: 34687
HgeneTgene
Gene symbol

SLIT2

PACRGL

Gene ID

9353

133015

Gene nameslit guidance ligand 2parkin coregulated like
SynonymsSLIL3|Slit-2C4orf28
Cytomap

4p15.31

4p15.31

Type of geneprotein-codingprotein-coding
Descriptionslit homolog 2 proteinPACRG-like proteinPARK2 co-regulated likePARK2 coregulated like
Modification date2018052320180519
UniProtAcc

O94813

Q8N7B6

Ensembl transtripts involved in fusion geneENST00000503823, ENST00000504154, 
ENST00000273739, ENST00000503837, 
ENST00000509394, 		ENST00000503585, 
ENST00000360916, ENST00000295290, 
ENST00000444671, ENST00000502374, 
ENST00000538990, ENST00000502938, 
ENST00000507634, ENST00000513459, 
ENST00000508753, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: SLIT2 [Title/Abstract] AND PACRGL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLIT2

GO:0001933

negative regulation of protein phosphorylation

18345009

HgeneSLIT2

GO:0002689

negative regulation of leukocyte chemotaxis

11309622

HgeneSLIT2

GO:0007411

axon guidance

11748139

HgeneSLIT2

GO:0008045

motor neuron axon guidance

10102268

HgeneSLIT2

GO:0010593

negative regulation of lamellipodium assembly

16439689

HgeneSLIT2

GO:0010596

negative regulation of endothelial cell migration

18345009

HgeneSLIT2

GO:0014912

negative regulation of smooth muscle cell migration

16439689

HgeneSLIT2

GO:0021834

chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration

11748139

HgeneSLIT2

GO:0021836

chemorepulsion involved in postnatal olfactory bulb interneuron migration

15207848

HgeneSLIT2

GO:0030336

negative regulation of cell migration

19005219

HgeneSLIT2

GO:0030837

negative regulation of actin filament polymerization

19759280

HgeneSLIT2

GO:0031290

retinal ganglion cell axon guidance

10864954|19498462

HgeneSLIT2

GO:0043116

negative regulation of vascular permeability

18345009

HgeneSLIT2

GO:0048754

branching morphogenesis of an epithelial tube

18345009

HgeneSLIT2

GO:0048846

axon extension involved in axon guidance

16840550

HgeneSLIT2

GO:0050919

negative chemotaxis

11748139

HgeneSLIT2

GO:0050929

induction of negative chemotaxis

10197527

HgeneSLIT2

GO:0051058

negative regulation of small GTPase mediated signal transduction

16439689

HgeneSLIT2

GO:0071504

cellular response to heparin

17062560

HgeneSLIT2

GO:0071672

negative regulation of smooth muscle cell chemotaxis

16439689

HgeneSLIT2

GO:0071676

negative regulation of mononuclear cell migration

16439689

HgeneSLIT2

GO:0090024

negative regulation of neutrophil chemotaxis

19759280

HgeneSLIT2

GO:0090260

negative regulation of retinal ganglion cell axon guidance

17062560

HgeneSLIT2

GO:0090288

negative regulation of cellular response to growth factor stimulus

16439689


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCECTCGA-KP-A3VZ-01ASLIT2chr4

20270504

+PACRGLchr4

20728908

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000503823ENST00000503585SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503823ENST00000360916SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503823ENST00000295290SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503823ENST00000444671SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503823ENST00000502374SLIT2chr4

20270504

+PACRGLchr4

20728908

+
In-frameENST00000503823ENST00000538990SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503823ENST00000502938SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503823ENST00000507634SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503823ENST00000513459SLIT2chr4

20270504

+PACRGLchr4

20728908

+
5CDS-intronENST00000503823ENST00000508753SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000504154ENST00000503585SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000504154ENST00000360916SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000504154ENST00000295290SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000504154ENST00000444671SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000504154ENST00000502374SLIT2chr4

20270504

+PACRGLchr4

20728908

+
In-frameENST00000504154ENST00000538990SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000504154ENST00000502938SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000504154ENST00000507634SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000504154ENST00000513459SLIT2chr4

20270504

+PACRGLchr4

20728908

+
5CDS-intronENST00000504154ENST00000508753SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000273739ENST00000503585SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000273739ENST00000360916SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000273739ENST00000295290SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000273739ENST00000444671SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000273739ENST00000502374SLIT2chr4

20270504

+PACRGLchr4

20728908

+
In-frameENST00000273739ENST00000538990SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000273739ENST00000502938SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000273739ENST00000507634SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000273739ENST00000513459SLIT2chr4

20270504

+PACRGLchr4

20728908

+
5CDS-intronENST00000273739ENST00000508753SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503837ENST00000503585SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503837ENST00000360916SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503837ENST00000295290SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503837ENST00000444671SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503837ENST00000502374SLIT2chr4

20270504

+PACRGLchr4

20728908

+
In-frameENST00000503837ENST00000538990SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503837ENST00000502938SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503837ENST00000507634SLIT2chr4

20270504

+PACRGLchr4

20728908

+
Frame-shiftENST00000503837ENST00000513459SLIT2chr4

20270504

+PACRGLchr4

20728908

+
5CDS-intronENST00000503837ENST00000508753SLIT2chr4

20270504

+PACRGLchr4

20728908

+
intron-3CDSENST00000509394ENST00000503585SLIT2chr4

20270504

+PACRGLchr4

20728908

+
intron-3CDSENST00000509394ENST00000360916SLIT2chr4

20270504

+PACRGLchr4

20728908

+
intron-3CDSENST00000509394ENST00000295290SLIT2chr4

20270504

+PACRGLchr4

20728908

+
intron-3CDSENST00000509394ENST00000444671SLIT2chr4

20270504

+PACRGLchr4

20728908

+
intron-3CDSENST00000509394ENST00000502374SLIT2chr4

20270504

+PACRGLchr4

20728908

+
intron-3CDSENST00000509394ENST00000538990SLIT2chr4

20270504

+PACRGLchr4

20728908

+
intron-3CDSENST00000509394ENST00000502938SLIT2chr4

20270504

+PACRGLchr4

20728908

+
intron-3CDSENST00000509394ENST00000507634SLIT2chr4

20270504

+PACRGLchr4

20728908

+
intron-3CDSENST00000509394ENST00000513459SLIT2chr4

20270504

+PACRGLchr4

20728908

+
intron-intronENST00000509394ENST00000508753SLIT2chr4

20270504

+PACRGLchr4

20728908

+

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FusionProtFeatures for SLIT2_PACRGL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLIT2

O94813

PACRGL

Q8N7B6

Thought to act as molecular guidance cue in cellularmigration, and function appears to be mediated by interaction withroundabout homolog receptors. During neural development involvedin axonal navigation at the ventral midline of the neural tube andprojection of axons to different regions. SLIT1 and SLIT2 seem tobe essential for midline guidance in the forebrain by acting asrepulsive signal preventing inappropriate midline crossing byaxons projecting from the olfactory bulb. In spinal chorddevelopment may play a role in guiding commissural axons once theyreached the floor plate by modulating the response to netrin. Invitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of aROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons thatcrossed the midline responded to SLIT2. In the developing visualsystem appears to function as repellent for retinal ganglion axonsby providing a repulsion that directs these axons along theirappropriate paths prior to, and after passage through, the opticchiasm. In vitro, collapses and repels retinal ganglion cellgrowth cones. Seems to play a role in branching and arborizationof CNS sensory axons, and in neuronal cell migration. In vitro,Slit homolog 2 protein N-product, but not Slit homolog 2 proteinC-product, repels olfactory bulb (OB) but not dorsal root ganglia(DRG) axons, induces OB growth cones collapse and inducesbranching of DRG axons. Seems to be involved in regulatingleukocyte migration. {ECO:0000269|PubMed:10102268,ECO:0000269|PubMed:10864954, ECO:0000269|PubMed:10975526,ECO:0000269|PubMed:11239147, ECO:0000269|PubMed:11309622,ECO:0000269|PubMed:11404413}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLIT2_PACRGL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SLIT2_ENST00000503823_chr4_20270504_+_PACRGL_ENST00000538990_chr4_20728908_+_150aa
MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENK

>In-frame_SLIT2_ENST00000504154_chr4_20270504_+_PACRGL_ENST00000538990_chr4_20728908_+_150aa
MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENK

>In-frame_SLIT2_ENST00000273739_chr4_20270504_+_PACRGL_ENST00000538990_chr4_20728908_+_150aa
MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENK

>In-frame_SLIT2_ENST00000503837_chr4_20270504_+_PACRGL_ENST00000538990_chr4_20728908_+_150aa
MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SLIT2_ENST00000503823_chr4_20270504_+_PACRGL_ENST00000538990_chr4_20728908_+_452nt
ATGCGCGGCGTTGGCTGGCAGATGCTGTCCCTGTCGCTGGGGTTAGTGCTGGCGATCCTGAACAAGGTGGCACCGCAGGCGTGCCCGGCG
CAGTGCTCTTGCTCGGGCAGCACAGTGGACTGTCACGGGCTGGCGCTGCGCAGCGTGCCCAGGAATATCCCCCGCAACACCGAGAGACTG
GATTTAAATGGAAATAACATCACAAGAATTACGAAGACAGATTTTGCTGGTCTTAGACATCTAAGAGTTCTTCAGCTTATGGAGAATAAG
ATTAGCACCATTGAAAGAGGAGCATTCCAGGATCTTAAAGAACTAGAGAGACTGCGTTTAAACAGAAATCACCTTCAGCTGTTTCCTGAG
TTGCTGTTTCTTGGGACTGCGAAGCTATACAGGCTGGGAGCCTTAGCATCATCAAATCTAAAATTCCAACATACTGCTCCATATGCTGTT

>In-frame_SLIT2_ENST00000504154_chr4_20270504_+_PACRGL_ENST00000538990_chr4_20728908_+_452nt
ATGCGCGGCGTTGGCTGGCAGATGCTGTCCCTGTCGCTGGGGTTAGTGCTGGCGATCCTGAACAAGGTGGCACCGCAGGCGTGCCCGGCG
CAGTGCTCTTGCTCGGGCAGCACAGTGGACTGTCACGGGCTGGCGCTGCGCAGCGTGCCCAGGAATATCCCCCGCAACACCGAGAGACTG
GATTTAAATGGAAATAACATCACAAGAATTACGAAGACAGATTTTGCTGGTCTTAGACATCTAAGAGTTCTTCAGCTTATGGAGAATAAG
ATTAGCACCATTGAAAGAGGAGCATTCCAGGATCTTAAAGAACTAGAGAGACTGCGTTTAAACAGAAATCACCTTCAGCTGTTTCCTGAG
TTGCTGTTTCTTGGGACTGCGAAGCTATACAGGCTGGGAGCCTTAGCATCATCAAATCTAAAATTCCAACATACTGCTCCATATGCTGTT

>In-frame_SLIT2_ENST00000273739_chr4_20270504_+_PACRGL_ENST00000538990_chr4_20728908_+_452nt
ATGCGCGGCGTTGGCTGGCAGATGCTGTCCCTGTCGCTGGGGTTAGTGCTGGCGATCCTGAACAAGGTGGCACCGCAGGCGTGCCCGGCG
CAGTGCTCTTGCTCGGGCAGCACAGTGGACTGTCACGGGCTGGCGCTGCGCAGCGTGCCCAGGAATATCCCCCGCAACACCGAGAGACTG
GATTTAAATGGAAATAACATCACAAGAATTACGAAGACAGATTTTGCTGGTCTTAGACATCTAAGAGTTCTTCAGCTTATGGAGAATAAG
ATTAGCACCATTGAAAGAGGAGCATTCCAGGATCTTAAAGAACTAGAGAGACTGCGTTTAAACAGAAATCACCTTCAGCTGTTTCCTGAG
TTGCTGTTTCTTGGGACTGCGAAGCTATACAGGCTGGGAGCCTTAGCATCATCAAATCTAAAATTCCAACATACTGCTCCATATGCTGTT

>In-frame_SLIT2_ENST00000503837_chr4_20270504_+_PACRGL_ENST00000538990_chr4_20728908_+_452nt
ATGCGCGGCGTTGGCTGGCAGATGCTGTCCCTGTCGCTGGGGTTAGTGCTGGCGATCCTGAACAAGGTGGCACCGCAGGCGTGCCCGGCG
CAGTGCTCTTGCTCGGGCAGCACAGTGGACTGTCACGGGCTGGCGCTGCGCAGCGTGCCCAGGAATATCCCCCGCAACACCGAGAGACTG
GATTTAAATGGAAATAACATCACAAGAATTACGAAGACAGATTTTGCTGGTCTTAGACATCTAAGAGTTCTTCAGCTTATGGAGAATAAG
ATTAGCACCATTGAAAGAGGAGCATTCCAGGATCTTAAAGAACTAGAGAGACTGCGTTTAAACAGAAATCACCTTCAGCTGTTTCCTGAG
TTGCTGTTTCTTGGGACTGCGAAGCTATACAGGCTGGGAGCCTTAGCATCATCAAATCTAAAATTCCAACATACTGCTCCATATGCTGTT


* Fusion transcript sequences (Full-length transcript).
>In-frame_SLIT2_ENST00000503823_chr4_20270504_+_PACRGL_ENST00000538990_chr4_20728908_+_1456nt
TGCCCCGCGCGCTCTGCTACGGGCCCGCTGGGCTTCCGCGCCTTCTAGCTTCCGGAGCCCACTTTGATCGGGGCCATAATACCTATTGAG
ATCCCCTCTTCTGTCTTGTACCTTCGCCACTGGCATCGGATTTGCAGAAGCGTGCGTGGGATCAGAGGACCGCCCTCCCCACAACAACCG
GCCCCTGCATCTTAGCAGCCGTTGGAAGCCCCAGCTCTTTTACCGCCAAGTTCATCCTTGGGAGACAGAAGACGCGTGATCTCCTCTCCG
CTGCTCTTGGGGTCTCCTTGCAGCCCTGGCCAGGCGGATTCATCCTCAGGACCTAAAGTTGCCCAAGGAGCTCCTGCTCTGCCAGAGGAG
GGTGGAGAGGGCGGTGGGAGGCGTGTGCCTGAGTGGGCTCTACTGCCTTGTTCCATATTATTTGGTGCACATTTTCCCTGGCACTCTGGG
TTGCTAGCCCCGCCGGGCACTGGGCCTCAGACACTGCGCGGTTCCCTCGGAGCAGCAAGCTAAAGAAAGCCCCCAGTGCCGGCGAGGAAG
GAGGCGGCGGGGAAAGATGCGCGGCGTTGGCTGGCAGATGCTGTCCCTGTCGCTGGGGTTAGTGCTGGCGATCCTGAACAAGGTGGCACC
GCAGGCGTGCCCGGCGCAGTGCTCTTGCTCGGGCAGCACAGTGGACTGTCACGGGCTGGCGCTGCGCAGCGTGCCCAGGAATATCCCCCG
CAACACCGAGAGACTGGATTTAAATGGAAATAACATCACAAGAATTACGAAGACAGATTTTGCTGGTCTTAGACATCTAAGAGTTCTTCA
GCTTATGGAGAATAAGATTAGCACCATTGAAAGAGGAGCATTCCAGGATCTTAAAGAACTAGAGAGACTGCGTTTAAACAGAAATCACCT
TCAGCTGTTTCCTGAGTTGCTGTTTCTTGGGACTGCGAAGCTATACAGGCTGGGAGCCTTAGCATCATCAAATCTAAAATTCCAACATAC
TGCTCCATATGCTGTTGAAGAAGGGAGCCAACAAAAATTGTTTTTTCTACCTGTTGACGTGTCAAGCACTAACTGTGGGTACTCATTTAT
TTTATTCTTTTGTAAATCACAGCCACCATTCATTATTTACTAGGTTAAGATGAATAGACACTGAATCAAAGTTATTCATCAACAAAAAAG
AACAGTTACTAATGGAAAGTTATTAAAATAAGTTCTATAAGAGTACAATTTTGAGGTTTATTTTTTGTATTTTTATTATTTGTGCGAAGA
ACCATTATTGAGTTTGCAAGATAAGATGTATTTGTATTTTCTAGTGTCTTTTTATTTATAACAACACTTTTTTGGCAATCAGTTTGTAGC
TGTGCCCTTATTTTTATAGATAGTTTGCCATTTCTTGGGTTTAATGTTTAACAAGGCTATAGAAGTTTAAAATAGTGGACAAATGTTTGT

>In-frame_SLIT2_ENST00000504154_chr4_20270504_+_PACRGL_ENST00000538990_chr4_20728908_+_1152nt
CGGATTCATCCTCAGGACCTAAAGTTGCCCAAGGAGCTCCTGCTCTGCCAGAGGAGGGTGGAGAGGGCGGTGGGAGGCGTGTGCCTGAGT
GGGCTCTACTGCCTTGTTCCATATTATTTGGTGCACATTTTCCCTGGCACTCTGGGTTGCTAGCCCCGCCGGGCACTGGGCCTCAGACAC
TGCGCGGTTCCCTCGGAGCAGCAAGCTAAAGAAAGCCCCCAGTGCCGGCGAGGAAGGAGGCGGCGGGGAAAGATGCGCGGCGTTGGCTGG
CAGATGCTGTCCCTGTCGCTGGGGTTAGTGCTGGCGATCCTGAACAAGGTGGCACCGCAGGCGTGCCCGGCGCAGTGCTCTTGCTCGGGC
AGCACAGTGGACTGTCACGGGCTGGCGCTGCGCAGCGTGCCCAGGAATATCCCCCGCAACACCGAGAGACTGGATTTAAATGGAAATAAC
ATCACAAGAATTACGAAGACAGATTTTGCTGGTCTTAGACATCTAAGAGTTCTTCAGCTTATGGAGAATAAGATTAGCACCATTGAAAGA
GGAGCATTCCAGGATCTTAAAGAACTAGAGAGACTGCGTTTAAACAGAAATCACCTTCAGCTGTTTCCTGAGTTGCTGTTTCTTGGGACT
GCGAAGCTATACAGGCTGGGAGCCTTAGCATCATCAAATCTAAAATTCCAACATACTGCTCCATATGCTGTTGAAGAAGGGAGCCAACAA
AAATTGTTTTTTCTACCTGTTGACGTGTCAAGCACTAACTGTGGGTACTCATTTATTTTATTCTTTTGTAAATCACAGCCACCATTCATT
ATTTACTAGGTTAAGATGAATAGACACTGAATCAAAGTTATTCATCAACAAAAAAGAACAGTTACTAATGGAAAGTTATTAAAATAAGTT
CTATAAGAGTACAATTTTGAGGTTTATTTTTTGTATTTTTATTATTTGTGCGAAGAACCATTATTGAGTTTGCAAGATAAGATGTATTTG
TATTTTCTAGTGTCTTTTTATTTATAACAACACTTTTTTGGCAATCAGTTTGTAGCTGTGCCCTTATTTTTATAGATAGTTTGCCATTTC

>In-frame_SLIT2_ENST00000273739_chr4_20270504_+_PACRGL_ENST00000538990_chr4_20728908_+_1126nt
GCCCAAGGAGCTCCTGCTCTGCCAGAGGAGGGTGGAGAGGGCGGTGGGAGGCGTGTGCCTGAGTGGGCTCTACTGCCTTGTTCCATATTA
TTTGGTGCACATTTTCCCTGGCACTCTGGGTTGCTAGCCCCGCCGGGCACTGGGCCTCAGACACTGCGCGGTTCCCTCGGAGCAGCAAGC
TAAAGAAAGCCCCCAGTGCCGGCGAGGAAGGAGGCGGCGGGGAAAGATGCGCGGCGTTGGCTGGCAGATGCTGTCCCTGTCGCTGGGGTT
AGTGCTGGCGATCCTGAACAAGGTGGCACCGCAGGCGTGCCCGGCGCAGTGCTCTTGCTCGGGCAGCACAGTGGACTGTCACGGGCTGGC
GCTGCGCAGCGTGCCCAGGAATATCCCCCGCAACACCGAGAGACTGGATTTAAATGGAAATAACATCACAAGAATTACGAAGACAGATTT
TGCTGGTCTTAGACATCTAAGAGTTCTTCAGCTTATGGAGAATAAGATTAGCACCATTGAAAGAGGAGCATTCCAGGATCTTAAAGAACT
AGAGAGACTGCGTTTAAACAGAAATCACCTTCAGCTGTTTCCTGAGTTGCTGTTTCTTGGGACTGCGAAGCTATACAGGCTGGGAGCCTT
AGCATCATCAAATCTAAAATTCCAACATACTGCTCCATATGCTGTTGAAGAAGGGAGCCAACAAAAATTGTTTTTTCTACCTGTTGACGT
GTCAAGCACTAACTGTGGGTACTCATTTATTTTATTCTTTTGTAAATCACAGCCACCATTCATTATTTACTAGGTTAAGATGAATAGACA
CTGAATCAAAGTTATTCATCAACAAAAAAGAACAGTTACTAATGGAAAGTTATTAAAATAAGTTCTATAAGAGTACAATTTTGAGGTTTA
TTTTTTGTATTTTTATTATTTGTGCGAAGAACCATTATTGAGTTTGCAAGATAAGATGTATTTGTATTTTCTAGTGTCTTTTTATTTATA
ACAACACTTTTTTGGCAATCAGTTTGTAGCTGTGCCCTTATTTTTATAGATAGTTTGCCATTTCTTGGGTTTAATGTTTAACAAGGCTAT

>In-frame_SLIT2_ENST00000503837_chr4_20270504_+_PACRGL_ENST00000538990_chr4_20728908_+_900nt
ATGCGCGGCGTTGGCTGGCAGATGCTGTCCCTGTCGCTGGGGTTAGTGCTGGCGATCCTGAACAAGGTGGCACCGCAGGCGTGCCCGGCG
CAGTGCTCTTGCTCGGGCAGCACAGTGGACTGTCACGGGCTGGCGCTGCGCAGCGTGCCCAGGAATATCCCCCGCAACACCGAGAGACTG
GATTTAAATGGAAATAACATCACAAGAATTACGAAGACAGATTTTGCTGGTCTTAGACATCTAAGAGTTCTTCAGCTTATGGAGAATAAG
ATTAGCACCATTGAAAGAGGAGCATTCCAGGATCTTAAAGAACTAGAGAGACTGCGTTTAAACAGAAATCACCTTCAGCTGTTTCCTGAG
TTGCTGTTTCTTGGGACTGCGAAGCTATACAGGCTGGGAGCCTTAGCATCATCAAATCTAAAATTCCAACATACTGCTCCATATGCTGTT
GAAGAAGGGAGCCAACAAAAATTGTTTTTTCTACCTGTTGACGTGTCAAGCACTAACTGTGGGTACTCATTTATTTTATTCTTTTGTAAA
TCACAGCCACCATTCATTATTTACTAGGTTAAGATGAATAGACACTGAATCAAAGTTATTCATCAACAAAAAAGAACAGTTACTAATGGA
AAGTTATTAAAATAAGTTCTATAAGAGTACAATTTTGAGGTTTATTTTTTGTATTTTTATTATTTGTGCGAAGAACCATTATTGAGTTTG
CAAGATAAGATGTATTTGTATTTTCTAGTGTCTTTTTATTTATAACAACACTTTTTTGGCAATCAGTTTGTAGCTGTGCCCTTATTTTTA
TAGATAGTTTGCCATTTCTTGGGTTTAATGTTTAACAAGGCTATAGAAGTTTAAAATAGTGGACAAATGTTTGTGAATACACTTTTAAAA


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FusionGenePPI for SLIT2_PACRGL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLIT2ROBO4, GPC1, MYC, UBC, CCDC8, ANKRD12, PTCH1, DEFA1, PRICKLE3, PRG3, LUM, RSRC1, EXOSC9, EXOSC7, EXOSC2, EXOSC4, LRRC47PACRGLFAM3A, MYOG, RCN3, GRB2, PIK3R3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLIT2_PACRGL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLIT2_PACRGL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLIT2C0014556Epilepsy, Temporal Lobe1CTD_human
HgeneSLIT2C0149925Small cell carcinoma of lung1CTD_human
HgeneSLIT2C2239176Liver carcinoma1CTD_human