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Fusion gene ID: 34682 |
FusionGeneSummary for SLIRP_RAP2C |
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Fusion gene information | Fusion gene name: SLIRP_RAP2C | Fusion gene ID: 34682 | Hgene | Tgene | Gene symbol | SLIRP | RAP2C | Gene ID | 81892 | 57826 |
Gene name | SRA stem-loop interacting RNA binding protein | RAP2C, member of RAS oncogene family | |
Synonyms | C14orf156|DC50|PD04872 | - | |
Cytomap | 14q24.3 | Xq26.2 | |
Type of gene | protein-coding | protein-coding | |
Description | SRA stem-loop-interacting RNA-binding protein, mitochondrial | ras-related protein Rap-2csmall GTPase RAP2C | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q9GZT3 | Q9Y3L5 | |
Ensembl transtripts involved in fusion gene | ENST00000557342, ENST00000238688, ENST00000557623, ENST00000557431, | ENST00000342983, ENST00000370874, ENST00000460462, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 2 X 3 X 1=6 |
# samples | 2 | 4 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(4/6*10)=2.73696559416621 | |
Context | PubMed: SLIRP [Title/Abstract] AND RAP2C [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DB310659 | SLIRP | chr14 | 78174450 | - | RAP2C | chrX | 131343035 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-intron | ENST00000557342 | ENST00000342983 | SLIRP | chr14 | 78174450 | - | RAP2C | chrX | 131343035 | + |
5UTR-intron | ENST00000557342 | ENST00000370874 | SLIRP | chr14 | 78174450 | - | RAP2C | chrX | 131343035 | + |
5UTR-intron | ENST00000557342 | ENST00000460462 | SLIRP | chr14 | 78174450 | - | RAP2C | chrX | 131343035 | + |
5UTR-intron | ENST00000238688 | ENST00000342983 | SLIRP | chr14 | 78174450 | - | RAP2C | chrX | 131343035 | + |
5UTR-intron | ENST00000238688 | ENST00000370874 | SLIRP | chr14 | 78174450 | - | RAP2C | chrX | 131343035 | + |
5UTR-intron | ENST00000238688 | ENST00000460462 | SLIRP | chr14 | 78174450 | - | RAP2C | chrX | 131343035 | + |
intron-intron | ENST00000557623 | ENST00000342983 | SLIRP | chr14 | 78174450 | - | RAP2C | chrX | 131343035 | + |
intron-intron | ENST00000557623 | ENST00000370874 | SLIRP | chr14 | 78174450 | - | RAP2C | chrX | 131343035 | + |
intron-intron | ENST00000557623 | ENST00000460462 | SLIRP | chr14 | 78174450 | - | RAP2C | chrX | 131343035 | + |
intron-intron | ENST00000557431 | ENST00000342983 | SLIRP | chr14 | 78174450 | - | RAP2C | chrX | 131343035 | + |
intron-intron | ENST00000557431 | ENST00000370874 | SLIRP | chr14 | 78174450 | - | RAP2C | chrX | 131343035 | + |
intron-intron | ENST00000557431 | ENST00000460462 | SLIRP | chr14 | 78174450 | - | RAP2C | chrX | 131343035 | + |
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FusionProtFeatures for SLIRP_RAP2C |
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Hgene | Tgene |
SLIRP | RAP2C |
RNA-binding protein that acts as a nuclear receptorcorepressor. Probably acts by binding the SRA RNA, and repressingthe SRA-mediated nuclear receptor coactivation. Binds the STR7loop of SRA RNA. Also able to repress glucocorticoid (GR),androgen (AR), thyroid (TR) and VDR-mediated transactivation.{ECO:0000269|PubMed:16762838}. | Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role incytoskeletal rearrangements and regulate cell spreading throughactivation of the effector TNIK. May play a role in SRE-mediatedgene transcription. {ECO:0000269|PubMed:17447155}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLIRP_RAP2C |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLIRP_RAP2C |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLIRP_RAP2C |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLIRP_RAP2C |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |