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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34682

FusionGeneSummary for SLIRP_RAP2C

check button Fusion gene summary
Fusion gene informationFusion gene name: SLIRP_RAP2C
Fusion gene ID: 34682
HgeneTgene
Gene symbol

SLIRP

RAP2C

Gene ID

81892

57826

Gene nameSRA stem-loop interacting RNA binding proteinRAP2C, member of RAS oncogene family
SynonymsC14orf156|DC50|PD04872-
Cytomap

14q24.3

Xq26.2

Type of geneprotein-codingprotein-coding
DescriptionSRA stem-loop-interacting RNA-binding protein, mitochondrialras-related protein Rap-2csmall GTPase RAP2C
Modification date2018052320180522
UniProtAcc

Q9GZT3

Q9Y3L5

Ensembl transtripts involved in fusion geneENST00000557342, ENST00000238688, 
ENST00000557623, ENST00000557431, 
ENST00000342983, ENST00000370874, 
ENST00000460462, 
Fusion gene scores* DoF score2 X 2 X 1=42 X 3 X 1=6
# samples 24
** MAII scorelog2(2/4*10)=2.32192809488736log2(4/6*10)=2.73696559416621
Context

PubMed: SLIRP [Title/Abstract] AND RAP2C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB310659SLIRPchr14

78174450

-RAP2CchrX

131343035

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000557342ENST00000342983SLIRPchr14

78174450

-RAP2CchrX

131343035

+
5UTR-intronENST00000557342ENST00000370874SLIRPchr14

78174450

-RAP2CchrX

131343035

+
5UTR-intronENST00000557342ENST00000460462SLIRPchr14

78174450

-RAP2CchrX

131343035

+
5UTR-intronENST00000238688ENST00000342983SLIRPchr14

78174450

-RAP2CchrX

131343035

+
5UTR-intronENST00000238688ENST00000370874SLIRPchr14

78174450

-RAP2CchrX

131343035

+
5UTR-intronENST00000238688ENST00000460462SLIRPchr14

78174450

-RAP2CchrX

131343035

+
intron-intronENST00000557623ENST00000342983SLIRPchr14

78174450

-RAP2CchrX

131343035

+
intron-intronENST00000557623ENST00000370874SLIRPchr14

78174450

-RAP2CchrX

131343035

+
intron-intronENST00000557623ENST00000460462SLIRPchr14

78174450

-RAP2CchrX

131343035

+
intron-intronENST00000557431ENST00000342983SLIRPchr14

78174450

-RAP2CchrX

131343035

+
intron-intronENST00000557431ENST00000370874SLIRPchr14

78174450

-RAP2CchrX

131343035

+
intron-intronENST00000557431ENST00000460462SLIRPchr14

78174450

-RAP2CchrX

131343035

+

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FusionProtFeatures for SLIRP_RAP2C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLIRP

Q9GZT3

RAP2C

Q9Y3L5

RNA-binding protein that acts as a nuclear receptorcorepressor. Probably acts by binding the SRA RNA, and repressingthe SRA-mediated nuclear receptor coactivation. Binds the STR7loop of SRA RNA. Also able to repress glucocorticoid (GR),androgen (AR), thyroid (TR) and VDR-mediated transactivation.{ECO:0000269|PubMed:16762838}. Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role incytoskeletal rearrangements and regulate cell spreading throughactivation of the effector TNIK. May play a role in SRE-mediatedgene transcription. {ECO:0000269|PubMed:17447155}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLIRP_RAP2C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLIRP_RAP2C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLIRP_RAP2C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLIRP_RAP2C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource