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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34675

FusionGeneSummary for SLFN11_CPE

check button Fusion gene summary
Fusion gene informationFusion gene name: SLFN11_CPE
Fusion gene ID: 34675
HgeneTgene
Gene symbol

SLFN11

CPE

Gene ID

91607

1363

Gene nameschlafen family member 11carboxypeptidase E
SynonymsSLFN8/9CPH
Cytomap

17q12

4q32.3

Type of geneprotein-codingprotein-coding
Descriptionschlafen family member 11carboxypeptidase Ecarboxypeptidase Hcobalt-stimulated chromaffin granule carboxypeptidaseenkephalin convertaseinsulin granule-associated carboxypeptidaseprohormone-processing carboxypeptidase
Modification date2018052320180527
UniProtAcc

Q7Z7L1

P16870

Ensembl transtripts involved in fusion geneENST00000308377, ENST00000394566, 
ENST00000402744, 
Fusion gene scores* DoF score3 X 3 X 3=276 X 5 X 5=150
# samples 46
** MAII scorelog2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLFN11 [Title/Abstract] AND CPE [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLFN11

GO:0006974

cellular response to DNA damage stimulus

29395061

HgeneSLFN11

GO:0008156

negative regulation of DNA replication

29395061

HgeneSLFN11

GO:0010942

positive regulation of cell death

29395061

HgeneSLFN11

GO:0043111

replication fork arrest

29395061

TgeneCPE

GO:0016055

Wnt signaling pathway

22824791

TgeneCPE

GO:0072657

protein localization to membrane

19166515


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF935865SLFN11chr17

33680029

-CPEchr4

166385720

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000308377ENST00000402744SLFN11chr17

33680029

-CPEchr4

166385720

+
intron-3CDSENST00000394566ENST00000402744SLFN11chr17

33680029

-CPEchr4

166385720

+

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FusionProtFeatures for SLFN11_CPE


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLFN11

Q7Z7L1

CPE

P16870

Inhibitor of DNA replication that promotes cell death inresponse to DNA damage (PubMed:22927417, PubMed:26658330,PubMed:29395061). Acts as a guardian of the genome by killingcells with defective replication (PubMed:29395061). Persistentlyblocks stressed replication forks by opening chromatin acrossreplication initiation sites at stressed replication forks,possibly leading to unwind DNA ahead of the MCM helicase and blockfork progression, ultimately leading to cell death(PubMed:29395061). Acts independently of ATR (PubMed:29395061).Also acts as an interferon (IFN)-induced antiviral protein whichacts as an inhibitor of retrovirus protein synthesis(PubMed:23000900). Specifically abrogates the production ofretroviruses such as human immunodeficiency virus 1 (HIV-1) byacting as a specific inhibitor of the synthesis of retrovirusesencoded proteins in a codon-usage-dependent manner(PubMed:23000900). Binds to tRNAs and exploits the unique viralcodon bias towards A/T nucleotides (PubMed:23000900). The exactinhibition mechanism is unclear: may either sequester tRNAs,prevent their maturation via post-transcriptional processing ormay accelerate their deacylation (PubMed:23000900). Does notinhibit reverse transcription, integration or production andnuclear export of viral RNA (PubMed:23000900).{ECO:0000269|PubMed:22927417, ECO:0000269|PubMed:23000900,ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061}. Removes residual C-terminal Arg or Lys remaining afterinitial endoprotease cleavage during prohormone processing.Processes proinsulin.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLFN11_CPE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLFN11_CPE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLFN11_CPE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCPEP16870DB00071Insulin PorkCarboxypeptidase Ebiotechapproved
TgeneCPEP16870DB00030Insulin HumanCarboxypeptidase Ebiotechapproved|investigational

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RelatedDiseases for SLFN11_CPE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCPEC0028754Obesity2CTD_human
TgeneCPEC0014130Endocrine System Diseases1CTD_human
TgeneCPEC0021655Insulin Resistance1CTD_human