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Fusion gene ID: 34675 |
FusionGeneSummary for SLFN11_CPE |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLFN11_CPE | Fusion gene ID: 34675 | Hgene | Tgene | Gene symbol | SLFN11 | CPE | Gene ID | 91607 | 1363 |
| Gene name | schlafen family member 11 | carboxypeptidase E | |
| Synonyms | SLFN8/9 | CPH | |
| Cytomap | 17q12 | 4q32.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | schlafen family member 11 | carboxypeptidase Ecarboxypeptidase Hcobalt-stimulated chromaffin granule carboxypeptidaseenkephalin convertaseinsulin granule-associated carboxypeptidaseprohormone-processing carboxypeptidase | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q7Z7L1 | P16870 | |
| Ensembl transtripts involved in fusion gene | ENST00000308377, ENST00000394566, | ENST00000402744, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 6 X 5 X 5=150 |
| # samples | 4 | 6 | |
| ** MAII score | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SLFN11 [Title/Abstract] AND CPE [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SLFN11 | GO:0006974 | cellular response to DNA damage stimulus | 29395061 |
| Hgene | SLFN11 | GO:0008156 | negative regulation of DNA replication | 29395061 |
| Hgene | SLFN11 | GO:0010942 | positive regulation of cell death | 29395061 |
| Hgene | SLFN11 | GO:0043111 | replication fork arrest | 29395061 |
| Tgene | CPE | GO:0016055 | Wnt signaling pathway | 22824791 |
| Tgene | CPE | GO:0072657 | protein localization to membrane | 19166515 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF935865 | SLFN11 | chr17 | 33680029 | - | CPE | chr4 | 166385720 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000308377 | ENST00000402744 | SLFN11 | chr17 | 33680029 | - | CPE | chr4 | 166385720 | + |
| intron-3CDS | ENST00000394566 | ENST00000402744 | SLFN11 | chr17 | 33680029 | - | CPE | chr4 | 166385720 | + |
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FusionProtFeatures for SLFN11_CPE |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLFN11 | CPE |
| Inhibitor of DNA replication that promotes cell death inresponse to DNA damage (PubMed:22927417, PubMed:26658330,PubMed:29395061). Acts as a guardian of the genome by killingcells with defective replication (PubMed:29395061). Persistentlyblocks stressed replication forks by opening chromatin acrossreplication initiation sites at stressed replication forks,possibly leading to unwind DNA ahead of the MCM helicase and blockfork progression, ultimately leading to cell death(PubMed:29395061). Acts independently of ATR (PubMed:29395061).Also acts as an interferon (IFN)-induced antiviral protein whichacts as an inhibitor of retrovirus protein synthesis(PubMed:23000900). Specifically abrogates the production ofretroviruses such as human immunodeficiency virus 1 (HIV-1) byacting as a specific inhibitor of the synthesis of retrovirusesencoded proteins in a codon-usage-dependent manner(PubMed:23000900). Binds to tRNAs and exploits the unique viralcodon bias towards A/T nucleotides (PubMed:23000900). The exactinhibition mechanism is unclear: may either sequester tRNAs,prevent their maturation via post-transcriptional processing ormay accelerate their deacylation (PubMed:23000900). Does notinhibit reverse transcription, integration or production andnuclear export of viral RNA (PubMed:23000900).{ECO:0000269|PubMed:22927417, ECO:0000269|PubMed:23000900,ECO:0000269|PubMed:26658330, ECO:0000269|PubMed:29395061}. | Removes residual C-terminal Arg or Lys remaining afterinitial endoprotease cleavage during prohormone processing.Processes proinsulin. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLFN11_CPE |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLFN11_CPE |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLFN11_CPE |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | CPE | P16870 | DB00071 | Insulin Pork | Carboxypeptidase E | biotech | approved |
| Tgene | CPE | P16870 | DB00030 | Insulin Human | Carboxypeptidase E | biotech | approved|investigational |
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RelatedDiseases for SLFN11_CPE |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CPE | C0028754 | Obesity | 2 | CTD_human |
| Tgene | CPE | C0014130 | Endocrine System Diseases | 1 | CTD_human |
| Tgene | CPE | C0021655 | Insulin Resistance | 1 | CTD_human |
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