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Fusion gene ID: 34672 |
FusionGeneSummary for SLCO4C1_ARHGEF38 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLCO4C1_ARHGEF38 | Fusion gene ID: 34672 | Hgene | Tgene | Gene symbol | SLCO4C1 | ARHGEF38 | Gene ID | 353189 | 54848 |
| Gene name | solute carrier organic anion transporter family member 4C1 | Rho guanine nucleotide exchange factor 38 | |
| Synonyms | OATP-H|OATP-M1|OATP4C1|OATPX|PRO2176|SLC21A20 | - | |
| Cytomap | 5q21.1 | 4q24 | |
| Type of gene | protein-coding | protein-coding | |
| Description | solute carrier organic anion transporter family member 4C1organic anion transporter M1solute carrier family 21 member 20 | rho guanine nucleotide exchange factor 38Rho guanine nucleotide exchange factor (GEF) 38 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q6ZQN7 | Q9NXL2 | |
| Ensembl transtripts involved in fusion gene | ENST00000310954, | ENST00000420470, ENST00000508036, ENST00000265154, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 4 X 4=48 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SLCO4C1 [Title/Abstract] AND ARHGEF38 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | KIRC | TCGA-B8-A54H-01A | SLCO4C1 | chr5 | 101576422 | - | ARHGEF38 | chr4 | 106621345 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000310954 | ENST00000420470 | SLCO4C1 | chr5 | 101576422 | - | ARHGEF38 | chr4 | 106621345 | + |
| 5CDS-intron | ENST00000310954 | ENST00000508036 | SLCO4C1 | chr5 | 101576422 | - | ARHGEF38 | chr4 | 106621345 | + |
| 5CDS-intron | ENST00000310954 | ENST00000265154 | SLCO4C1 | chr5 | 101576422 | - | ARHGEF38 | chr4 | 106621345 | + |
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FusionProtFeatures for SLCO4C1_ARHGEF38 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLCO4C1 | ARHGEF38 |
| Organic anion transporter, capable of transportingpharmacological substances such as digoxin, ouabain, thyroxine,methotrexate and cAMP. May participate in the regulation ofmembrane transport of ouabain. Involved in the uptake of thedipeptidyl peptidase-4 inhibitor sitagliptin and hence may play arole in its transport into and out of renal proximal tubule cells.May be involved in the first step of the transport pathway ofdigoxin and various compounds into the urine in the kidney. May beinvolved in sperm maturation by enabling directed movement oforganic anions and compounds within or between cells. This ion-transporting process is important to maintain the strictepididymal homeostasis necessary for sperm maturation. May have arole in secretory functions since seminal vesicle epithelial cellsare assumed to secrete proteins involved in decapacitation bymodifying surface proteins to facilitate the acquisition of theability to fertilize the egg. {ECO:0000250|UniProtKB:Q8BGD4,ECO:0000269|PubMed:14993604, ECO:0000269|PubMed:17314201}. | May act as a guanine-nucleotide releasing factor.{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLCO4C1_ARHGEF38 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLCO4C1_ARHGEF38 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SLCO4C1 | HECW2, TMEM17 | ARHGEF38 | CLASP1, TMEM261 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLCO4C1_ARHGEF38 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLCO4C1_ARHGEF38 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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