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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34655

FusionGeneSummary for SLCO2A1_RREB1

check button Fusion gene summary
Fusion gene informationFusion gene name: SLCO2A1_RREB1
Fusion gene ID: 34655
HgeneTgene
Gene symbol

SLCO2A1

RREB1

Gene ID

6578

6239

Gene namesolute carrier organic anion transporter family member 2A1ras responsive element binding protein 1
SynonymsMATR1|OATP2A1|PGT|PHOAR2|SLC21A2FINB|HNT|LZ321|RREB-1|Zep-1
Cytomap

3q22.1-q22.2

6p24.3

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier organic anion transporter family member 2A1matrin F/G 1solute carrier family 21 (prostaglandin transporter), member 2ras-responsive element-binding protein 1DNA-binding proteinfinger protein in nuclear bodieshindsight homolograf-responsive zinc finger protein LZ321zinc finger motif enhancer-binding protein 1
Modification date2018052320180523
UniProtAcc

Q92959

Q92766

Ensembl transtripts involved in fusion geneENST00000310926, ENST00000493729, 
ENST00000478651, 
ENST00000379933, 
ENST00000379938, ENST00000334984, 
ENST00000349384, 
Fusion gene scores* DoF score4 X 4 X 2=329 X 7 X 4=252
# samples 49
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLCO2A1 [Title/Abstract] AND RREB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRREB1

GO:0045944

positive regulation of transcription by RNA polymerase II

8816445


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW845389SLCO2A1chr3

133724042

+RREB1chr6

7251441

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000310926ENST00000379933SLCO2A1chr3

133724042

+RREB1chr6

7251441

+
intron-3UTRENST00000310926ENST00000379938SLCO2A1chr3

133724042

+RREB1chr6

7251441

+
intron-intronENST00000310926ENST00000334984SLCO2A1chr3

133724042

+RREB1chr6

7251441

+
intron-intronENST00000310926ENST00000349384SLCO2A1chr3

133724042

+RREB1chr6

7251441

+
intron-intronENST00000493729ENST00000379933SLCO2A1chr3

133724042

+RREB1chr6

7251441

+
intron-3UTRENST00000493729ENST00000379938SLCO2A1chr3

133724042

+RREB1chr6

7251441

+
intron-intronENST00000493729ENST00000334984SLCO2A1chr3

133724042

+RREB1chr6

7251441

+
intron-intronENST00000493729ENST00000349384SLCO2A1chr3

133724042

+RREB1chr6

7251441

+
intron-intronENST00000478651ENST00000379933SLCO2A1chr3

133724042

+RREB1chr6

7251441

+
intron-3UTRENST00000478651ENST00000379938SLCO2A1chr3

133724042

+RREB1chr6

7251441

+
intron-intronENST00000478651ENST00000334984SLCO2A1chr3

133724042

+RREB1chr6

7251441

+
intron-intronENST00000478651ENST00000349384SLCO2A1chr3

133724042

+RREB1chr6

7251441

+

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FusionProtFeatures for SLCO2A1_RREB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLCO2A1

Q92959

RREB1

Q92766

May mediate the release of newly synthesizedprostaglandins from cells, the transepithelial transport ofprostaglandins, and the clearance of prostaglandins from thecirculation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLCO2A1_RREB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLCO2A1_RREB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLCO2A1_RREB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLCO2A1_RREB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLCO2A1C3280800HYPERTROPHIC OSTEOARTHROPATHY, PRIMARY, AUTOSOMAL RECESSIVE, 24UNIPROT
HgeneSLCO2A1C0041755Adverse reaction to drug1CTD_human