![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 34649 |
FusionGeneSummary for SLC9A9_TNRC6A |
![]() |
Fusion gene information | Fusion gene name: SLC9A9_TNRC6A | Fusion gene ID: 34649 | Hgene | Tgene | Gene symbol | SLC9A9 | TNRC6A | Gene ID | 285195 | 27327 |
Gene name | solute carrier family 9 member A9 | trinucleotide repeat containing 6A | |
Synonyms | AUTS16|NHE9 | CAGH26|GW1|GW182|TNRC6 | |
Cytomap | 3q24 | 16p12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | sodium/hydrogen exchanger 9Na(+)/H(+) exchanger 9putative protein product of Nbla00118sodium/proton exchanger NHE9solute carrier family 9 (sodium/hydrogen exchanger)solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 | trinucleotide repeat-containing gene 6A proteinCAG repeat protein 26CTD-2540M10.1EDIEEMSY interactor proteinGW182 autoantigenglycine-tryptophan protein of 182 kDa | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q8IVB4 | Q8NDV7 | |
Ensembl transtripts involved in fusion gene | ENST00000316549, ENST00000498717, | ENST00000315183, ENST00000562829, ENST00000395799, ENST00000432286, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 11 X 11 X 3=363 |
# samples | 3 | 11 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/363*10)=-1.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SLC9A9 [Title/Abstract] AND TNRC6A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TNRC6A | GO:0035278 | miRNA mediated inhibition of translation | 17671087 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CV353496 | SLC9A9 | chr3 | 143030963 | + | TNRC6A | chr16 | 24769851 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000316549 | ENST00000315183 | SLC9A9 | chr3 | 143030963 | + | TNRC6A | chr16 | 24769851 | - |
intron-intron | ENST00000316549 | ENST00000562829 | SLC9A9 | chr3 | 143030963 | + | TNRC6A | chr16 | 24769851 | - |
intron-intron | ENST00000316549 | ENST00000395799 | SLC9A9 | chr3 | 143030963 | + | TNRC6A | chr16 | 24769851 | - |
intron-intron | ENST00000316549 | ENST00000432286 | SLC9A9 | chr3 | 143030963 | + | TNRC6A | chr16 | 24769851 | - |
intron-intron | ENST00000498717 | ENST00000315183 | SLC9A9 | chr3 | 143030963 | + | TNRC6A | chr16 | 24769851 | - |
intron-intron | ENST00000498717 | ENST00000562829 | SLC9A9 | chr3 | 143030963 | + | TNRC6A | chr16 | 24769851 | - |
intron-intron | ENST00000498717 | ENST00000395799 | SLC9A9 | chr3 | 143030963 | + | TNRC6A | chr16 | 24769851 | - |
intron-intron | ENST00000498717 | ENST00000432286 | SLC9A9 | chr3 | 143030963 | + | TNRC6A | chr16 | 24769851 | - |
Top |
FusionProtFeatures for SLC9A9_TNRC6A |
![]() |
Hgene | Tgene |
SLC9A9 | TNRC6A |
May act in electroneutral exchange of protons for Na(+)across membranes. Involved in the effusion of Golgi luminal H(+)in exchange for cytosolic cations. Involved in organelle ionhomeostasis by contributing to the maintenance of the uniqueacidic pH values of the Golgi and post-Golgi compartments in thecell. {ECO:0000269|PubMed:15522866}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for SLC9A9_TNRC6A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for SLC9A9_TNRC6A |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SLC9A9_TNRC6A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SLC9A9_TNRC6A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SLC9A9 | C0004352 | Autistic Disorder | 1 | CTD_human |