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Fusion gene ID: 34648 |
FusionGeneSummary for SLC9A9_PDLIM3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLC9A9_PDLIM3 | Fusion gene ID: 34648 | Hgene | Tgene | Gene symbol | SLC9A9 | PDLIM3 | Gene ID | 285195 | 27295 |
| Gene name | solute carrier family 9 member A9 | PDZ and LIM domain 3 | |
| Synonyms | AUTS16|NHE9 | ALP | |
| Cytomap | 3q24 | 4q35.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sodium/hydrogen exchanger 9Na(+)/H(+) exchanger 9putative protein product of Nbla00118sodium/proton exchanger NHE9solute carrier family 9 (sodium/hydrogen exchanger)solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 | PDZ and LIM domain protein 3alpha-actinin-2-associated LIM proteinenigma homolog | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q8IVB4 | Q53GG5 | |
| Ensembl transtripts involved in fusion gene | ENST00000316549, ENST00000498717, | ENST00000284770, ENST00000284771, ENST00000284767, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 4 X 3 X 4=48 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SLC9A9 [Title/Abstract] AND PDLIM3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-4L-AA1F-01A | SLC9A9 | chr3 | 143513843 | - | PDLIM3 | chr4 | 186427806 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000316549 | ENST00000284770 | SLC9A9 | chr3 | 143513843 | - | PDLIM3 | chr4 | 186427806 | - |
| In-frame | ENST00000316549 | ENST00000284771 | SLC9A9 | chr3 | 143513843 | - | PDLIM3 | chr4 | 186427806 | - |
| 5CDS-3UTR | ENST00000316549 | ENST00000284767 | SLC9A9 | chr3 | 143513843 | - | PDLIM3 | chr4 | 186427806 | - |
| intron-3CDS | ENST00000498717 | ENST00000284770 | SLC9A9 | chr3 | 143513843 | - | PDLIM3 | chr4 | 186427806 | - |
| intron-3CDS | ENST00000498717 | ENST00000284771 | SLC9A9 | chr3 | 143513843 | - | PDLIM3 | chr4 | 186427806 | - |
| intron-3UTR | ENST00000498717 | ENST00000284767 | SLC9A9 | chr3 | 143513843 | - | PDLIM3 | chr4 | 186427806 | - |
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FusionProtFeatures for SLC9A9_PDLIM3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLC9A9 | PDLIM3 |
| May act in electroneutral exchange of protons for Na(+)across membranes. Involved in the effusion of Golgi luminal H(+)in exchange for cytosolic cations. Involved in organelle ionhomeostasis by contributing to the maintenance of the uniqueacidic pH values of the Golgi and post-Golgi compartments in thecell. {ECO:0000269|PubMed:15522866}. | May play a role in the organization of actin filamentarrays within muscle cells. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SLC9A9 | chr3:143513843 | chr4:186427806 | ENST00000316549 | - | 4 | 16 | 127_147 | 177 | 646 | Transmembrane | Helical |
| Hgene | SLC9A9 | chr3:143513843 | chr4:186427806 | ENST00000316549 | - | 4 | 16 | 21_41 | 177 | 646 | Transmembrane | Helical |
| Hgene | SLC9A9 | chr3:143513843 | chr4:186427806 | ENST00000316549 | - | 4 | 16 | 46_66 | 177 | 646 | Transmembrane | Helical |
| Tgene | >PDLIM3 | chr3:143513843 | chr4:186427806 | ENST00000284767 | - | 5 | 9 | 292_351 | 283 | 406 | Domain | LIM zinc-binding |
| Tgene | >PDLIM3 | chr3:143513843 | chr4:186427806 | ENST00000284770 | - | 4 | 8 | 292_351 | 220 | 365 | Domain | LIM zinc-binding |
| Tgene | >PDLIM3 | chr3:143513843 | chr4:186427806 | ENST00000284771 | - | 3 | 7 | 292_351 | 172 | 317 | Domain | LIM zinc-binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SLC9A9 | chr3:143513843 | chr4:186427806 | ENST00000316549 | - | 4 | 16 | 165_185 | 177 | 646 | Transmembrane | Helical |
| Hgene | >SLC9A9 | chr3:143513843 | chr4:186427806 | ENST00000316549 | - | 4 | 16 | 204_224 | 177 | 646 | Transmembrane | Helical |
| Hgene | >SLC9A9 | chr3:143513843 | chr4:186427806 | ENST00000316549 | - | 4 | 16 | 236_256 | 177 | 646 | Transmembrane | Helical |
| Hgene | >SLC9A9 | chr3:143513843 | chr4:186427806 | ENST00000316549 | - | 4 | 16 | 278_298 | 177 | 646 | Transmembrane | Helical |
| Hgene | >SLC9A9 | chr3:143513843 | chr4:186427806 | ENST00000316549 | - | 4 | 16 | 302_322 | 177 | 646 | Transmembrane | Helical |
| Hgene | >SLC9A9 | chr3:143513843 | chr4:186427806 | ENST00000316549 | - | 4 | 16 | 323_343 | 177 | 646 | Transmembrane | Helical |
| Hgene | >SLC9A9 | chr3:143513843 | chr4:186427806 | ENST00000316549 | - | 4 | 16 | 365_385 | 177 | 646 | Transmembrane | Helical |
| Hgene | >SLC9A9 | chr3:143513843 | chr4:186427806 | ENST00000316549 | - | 4 | 16 | 387_407 | 177 | 646 | Transmembrane | Helical |
| Hgene | >SLC9A9 | chr3:143513843 | chr4:186427806 | ENST00000316549 | - | 4 | 16 | 430_450 | 177 | 646 | Transmembrane | Helical |
| Hgene | >SLC9A9 | chr3:143513843 | chr4:186427806 | ENST00000316549 | - | 4 | 16 | 466_486 | 177 | 646 | Transmembrane | Helical |
| Tgene | PDLIM3 | chr3:143513843 | chr4:186427806 | ENST00000284767 | - | 5 | 9 | 1_84 | 283 | 406 | Domain | PDZ |
| Tgene | PDLIM3 | chr3:143513843 | chr4:186427806 | ENST00000284770 | - | 4 | 8 | 1_84 | 220 | 365 | Domain | PDZ |
| Tgene | PDLIM3 | chr3:143513843 | chr4:186427806 | ENST00000284771 | - | 3 | 7 | 1_84 | 172 | 317 | Domain | PDZ |
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FusionGeneSequence for SLC9A9_PDLIM3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SLC9A9_ENST00000316549_chr3_143513843_-_PDLIM3_ENST00000284770_chr4_186427806_-_322aa MERQSRVMSEKDEYQFQHQGAVELLVFNFLLILTILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYATAPTDIESGTVYDCVKLTFSP STLLVNITDQVYEYKYKREISQHNINPHQGNAILEKMTFDPEIFFNVLLPPIIFHAGYSLKKRHFFQNLGSILTYAFLGTAISCIVIGEP TASVPPESDVYRMLHDNRNEPTQPRQSGSFRVLQGMVDDGSDDRPAGTRSVRAPVTKVHGGSGGAQRMPLCDKCGSGIVGAVVKARDKYR >In-frame_SLC9A9_ENST00000316549_chr3_143513843_-_PDLIM3_ENST00000284771_chr4_186427806_-_322aa MERQSRVMSEKDEYQFQHQGAVELLVFNFLLILTILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYATAPTDIESGTVYDCVKLTFSP STLLVNITDQVYEYKYKREISQHNINPHQGNAILEKMTFDPEIFFNVLLPPIIFHAGYSLKKRHFFQNLGSILTYAFLGTAISCIVIGEP TASVPPESDVYRMLHDNRNEPTQPRQSGSFRVLQGMVDDGSDDRPAGTRSVRAPVTKVHGGSGGAQRMPLCDKCGSGIVGAVVKARDKYR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SLC9A9_ENST00000316549_chr3_143513843_-_PDLIM3_ENST00000284770_chr4_186427806_-_966nt ATGGAGAGACAGTCAAGGGTTATGTCAGAAAAGGATGAGTATCAGTTTCAACATCAGGGAGCGGTGGAGCTGCTTGTCTTCAATTTTTTG CTCATCCTTACCATTTTGACAATCTGGTTATTTAAAAATCATCGATTCCGCTTCTTGCATGAAACTGGAGGAGCAATGGTGTATGGCCTT ATAATGGGACTAATTTTACGATATGCTACAGCACCAACTGATATTGAAAGTGGAACTGTCTATGACTGTGTAAAACTAACTTTCAGTCCA TCAACTCTGCTGGTTAATATCACTGACCAAGTTTATGAATATAAATACAAAAGAGAAATAAGTCAGCACAACATCAATCCTCATCAAGGA AATGCTATACTTGAAAAGATGACATTTGATCCAGAAATCTTCTTCAATGTTTTACTGCCACCAATTATATTTCATGCAGGATATAGTCTA AAGAAGAGACACTTTTTTCAAAACTTAGGATCTATTTTAACGTATGCCTTCTTGGGAACTGCCATCTCCTGCATCGTCATAGGCGAGCCC ACAGCCTCGGTGCCCCCCGAGTCGGACGTGTACCGGATGCTCCACGACAATCGGAATGAGCCCACACAGCCTCGCCAGTCGGGCTCCTTC AGAGTGCTCCAGGGAATGGTGGACGATGGCTCTGATGACCGTCCGGCTGGAACGCGGAGTGTGAGAGCTCCGGTGACGAAAGTCCATGGC GGTTCAGGCGGGGCACAGAGGATGCCGCTCTGTGACAAATGTGGGAGTGGCATAGTCGGTGCTGTGGTGAAGGCGCGGGATAAGTACCGG CACCCTGAGTGCTTCGTGTGTGCCGACTGCAACCTCAACCTCAAGCAAAAGGGCTACTTCTTCATAGAAGGGGAGCTGTACTGCGAAACC >In-frame_SLC9A9_ENST00000316549_chr3_143513843_-_PDLIM3_ENST00000284771_chr4_186427806_-_966nt ATGGAGAGACAGTCAAGGGTTATGTCAGAAAAGGATGAGTATCAGTTTCAACATCAGGGAGCGGTGGAGCTGCTTGTCTTCAATTTTTTG CTCATCCTTACCATTTTGACAATCTGGTTATTTAAAAATCATCGATTCCGCTTCTTGCATGAAACTGGAGGAGCAATGGTGTATGGCCTT ATAATGGGACTAATTTTACGATATGCTACAGCACCAACTGATATTGAAAGTGGAACTGTCTATGACTGTGTAAAACTAACTTTCAGTCCA TCAACTCTGCTGGTTAATATCACTGACCAAGTTTATGAATATAAATACAAAAGAGAAATAAGTCAGCACAACATCAATCCTCATCAAGGA AATGCTATACTTGAAAAGATGACATTTGATCCAGAAATCTTCTTCAATGTTTTACTGCCACCAATTATATTTCATGCAGGATATAGTCTA AAGAAGAGACACTTTTTTCAAAACTTAGGATCTATTTTAACGTATGCCTTCTTGGGAACTGCCATCTCCTGCATCGTCATAGGCGAGCCC ACAGCCTCGGTGCCCCCCGAGTCGGACGTGTACCGGATGCTCCACGACAATCGGAATGAGCCCACACAGCCTCGCCAGTCGGGCTCCTTC AGAGTGCTCCAGGGAATGGTGGACGATGGCTCTGATGACCGTCCGGCTGGAACGCGGAGTGTGAGAGCTCCGGTGACGAAAGTCCATGGC GGTTCAGGCGGGGCACAGAGGATGCCGCTCTGTGACAAATGTGGGAGTGGCATAGTCGGTGCTGTGGTGAAGGCGCGGGATAAGTACCGG CACCCTGAGTGCTTCGTGTGTGCCGACTGCAACCTCAACCTCAAGCAAAAGGGCTACTTCTTCATAGAAGGGGAGCTGTACTGCGAAACC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SLC9A9_ENST00000316549_chr3_143513843_-_PDLIM3_ENST00000284770_chr4_186427806_-_1772nt AAAAGAGACAGGGCTGCTTTAAGAGAGAAACAGGAAGTTGTAACTAGAAGCCATCTGAATACTAAGCCAGGGCAGAATGCTTGTGAAGTA GCAACTAAAGTGGCAGTGTTTCTTCTGAAATTCTCAGGCAGTCAGACTGTCTTAGGCAAATCTTGATAAAATAGCCTTTATCCAGGTTTT TATCTAAGGAATCCCAAGAAGACTGGGGAATGGAGAGACAGTCAAGGGTTATGTCAGAAAAGGATGAGTATCAGTTTCAACATCAGGGAG CGGTGGAGCTGCTTGTCTTCAATTTTTTGCTCATCCTTACCATTTTGACAATCTGGTTATTTAAAAATCATCGATTCCGCTTCTTGCATG AAACTGGAGGAGCAATGGTGTATGGCCTTATAATGGGACTAATTTTACGATATGCTACAGCACCAACTGATATTGAAAGTGGAACTGTCT ATGACTGTGTAAAACTAACTTTCAGTCCATCAACTCTGCTGGTTAATATCACTGACCAAGTTTATGAATATAAATACAAAAGAGAAATAA GTCAGCACAACATCAATCCTCATCAAGGAAATGCTATACTTGAAAAGATGACATTTGATCCAGAAATCTTCTTCAATGTTTTACTGCCAC CAATTATATTTCATGCAGGATATAGTCTAAAGAAGAGACACTTTTTTCAAAACTTAGGATCTATTTTAACGTATGCCTTCTTGGGAACTG CCATCTCCTGCATCGTCATAGGCGAGCCCACAGCCTCGGTGCCCCCCGAGTCGGACGTGTACCGGATGCTCCACGACAATCGGAATGAGC CCACACAGCCTCGCCAGTCGGGCTCCTTCAGAGTGCTCCAGGGAATGGTGGACGATGGCTCTGATGACCGTCCGGCTGGAACGCGGAGTG TGAGAGCTCCGGTGACGAAAGTCCATGGCGGTTCAGGCGGGGCACAGAGGATGCCGCTCTGTGACAAATGTGGGAGTGGCATAGTCGGTG CTGTGGTGAAGGCGCGGGATAAGTACCGGCACCCTGAGTGCTTCGTGTGTGCCGACTGCAACCTCAACCTCAAGCAAAAGGGCTACTTCT TCATAGAAGGGGAGCTGTACTGCGAAACCCACGCAAGAGCCCGCACAAAGCCCCCAGAGGGCTATGACACGGTCACTCTGTATCCCAAAG CTTAAGTCTCTGCAGGCGTGGCACGCACGCACGCACCCACCCACGCGCACTTACACGAGAAGACATTCATGGCTTTGGGCAGAAGGATTG TGCAGATTGTCAACTCCAAATCTAAAGTCAAGGCTTTAGACCTTTATCCTATTGTTTATTGAGGAAAAGGAATGGGAGGCAAATGCCTGC TATGTGAAAAAAACATACACTTAGCTATGTTTTGCAACTCTTTTTGGGGCTAGCAATAATGATATTTAAAGCAATAATTTTTTGTATGTC ATACTCCACAATTTACATGTATATTACAGCCATCAAACACATAAACATCAAGATATTTGAAGGACTCTAATTGTCTTTCCTTGACAAGTT GATTTTGCAATTGTGGTAAATAGCAAATAACAATCTTGTATTCTAACATAATCTGCAGTTGTCTGTATGTGTTTTAACTATTACAGTGCA TGTTAGGGAGAAATTCCCTGAATTTCTTTAGTTTTGTATTCAAACAATTATGCCACTCGATGCAACAAACATAATAAATACATAAAAGAT >In-frame_SLC9A9_ENST00000316549_chr3_143513843_-_PDLIM3_ENST00000284771_chr4_186427806_-_1718nt AAAAGAGACAGGGCTGCTTTAAGAGAGAAACAGGAAGTTGTAACTAGAAGCCATCTGAATACTAAGCCAGGGCAGAATGCTTGTGAAGTA GCAACTAAAGTGGCAGTGTTTCTTCTGAAATTCTCAGGCAGTCAGACTGTCTTAGGCAAATCTTGATAAAATAGCCTTTATCCAGGTTTT TATCTAAGGAATCCCAAGAAGACTGGGGAATGGAGAGACAGTCAAGGGTTATGTCAGAAAAGGATGAGTATCAGTTTCAACATCAGGGAG CGGTGGAGCTGCTTGTCTTCAATTTTTTGCTCATCCTTACCATTTTGACAATCTGGTTATTTAAAAATCATCGATTCCGCTTCTTGCATG AAACTGGAGGAGCAATGGTGTATGGCCTTATAATGGGACTAATTTTACGATATGCTACAGCACCAACTGATATTGAAAGTGGAACTGTCT ATGACTGTGTAAAACTAACTTTCAGTCCATCAACTCTGCTGGTTAATATCACTGACCAAGTTTATGAATATAAATACAAAAGAGAAATAA GTCAGCACAACATCAATCCTCATCAAGGAAATGCTATACTTGAAAAGATGACATTTGATCCAGAAATCTTCTTCAATGTTTTACTGCCAC CAATTATATTTCATGCAGGATATAGTCTAAAGAAGAGACACTTTTTTCAAAACTTAGGATCTATTTTAACGTATGCCTTCTTGGGAACTG CCATCTCCTGCATCGTCATAGGCGAGCCCACAGCCTCGGTGCCCCCCGAGTCGGACGTGTACCGGATGCTCCACGACAATCGGAATGAGC CCACACAGCCTCGCCAGTCGGGCTCCTTCAGAGTGCTCCAGGGAATGGTGGACGATGGCTCTGATGACCGTCCGGCTGGAACGCGGAGTG TGAGAGCTCCGGTGACGAAAGTCCATGGCGGTTCAGGCGGGGCACAGAGGATGCCGCTCTGTGACAAATGTGGGAGTGGCATAGTCGGTG CTGTGGTGAAGGCGCGGGATAAGTACCGGCACCCTGAGTGCTTCGTGTGTGCCGACTGCAACCTCAACCTCAAGCAAAAGGGCTACTTCT TCATAGAAGGGGAGCTGTACTGCGAAACCCACGCAAGAGCCCGCACAAAGCCCCCAGAGGGCTATGACACGGTCACTCTGTATCCCAAAG CTTAAGTCTCTGCAGGCGTGGCACGCACGCACGCACCCACCCACGCGCACTTACACGAGAAGACATTCATGGCTTTGGGCAGAAGGATTG TGCAGATTGTCAACTCCAAATCTAAAGTCAAGGCTTTAGACCTTTATCCTATTGTTTATTGAGGAAAAGGAATGGGAGGCAAATGCCTGC TATGTGAAAAAAACATACACTTAGCTATGTTTTGCAACTCTTTTTGGGGCTAGCAATAATGATATTTAAAGCAATAATTTTTTGTATGTC ATACTCCACAATTTACATGTATATTACAGCCATCAAACACATAAACATCAAGATATTTGAAGGACTCTAATTGTCTTTCCTTGACAAGTT GATTTTGCAATTGTGGTAAATAGCAAATAACAATCTTGTATTCTAACATAATCTGCAGTTGTCTGTATGTGTTTTAACTATTACAGTGCA TGTTAGGGAGAAATTCCCTGAATTTCTTTAGTTTTGTATTCAAACAATTATGCCACTCGATGCAACAAACATAATAAATACATAAAAGAT |
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FusionGenePPI for SLC9A9_PDLIM3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SLC9A9 | ZDHHC17, TP53 | PDLIM3 | LMNA, BAG3, ACTN2, ALK, RHOU |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC9A9_PDLIM3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC9A9_PDLIM3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SLC9A9 | C0004352 | Autistic Disorder | 1 | CTD_human |
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