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Fusion gene ID: 34633 |
FusionGeneSummary for SLC9A1_COL4A1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLC9A1_COL4A1 | Fusion gene ID: 34633 | Hgene | Tgene | Gene symbol | SLC9A1 | COL4A1 | Gene ID | 6548 | 1282 |
| Gene name | solute carrier family 9 member A1 | collagen type IV alpha 1 chain | |
| Synonyms | APNH|LIKNS|NHE-1|NHE1|PPP1R143 | BSVD|RATOR | |
| Cytomap | 1p36.11 | 13q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sodium/hydrogen exchanger 1Na(+)/H(+) exchanger 1Na-Li countertransporterprotein phosphatase 1, regulatory subunit 143solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive)solute carrier family 9 (sod | collagen alpha-1(IV) chainCOL4A1 NC1 domainarrestencollagen IV, alpha-1 polypeptidecollagen of basement membrane, alpha-1 chain | |
| Modification date | 20180527 | 20180527 | |
| UniProtAcc | P19634 | P02462 | |
| Ensembl transtripts involved in fusion gene | ENST00000263980, ENST00000490329, ENST00000545949, ENST00000374086, | ENST00000375820, ENST00000543140, ENST00000467182, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 8 X 8 X 5=320 |
| # samples | 3 | 10 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/320*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SLC9A1 [Title/Abstract] AND COL4A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SLC9A1 | GO:0006883 | cellular sodium ion homeostasis | 24840010 |
| Hgene | SLC9A1 | GO:0006885 | regulation of pH | 8901634 |
| Hgene | SLC9A1 | GO:0010447 | response to acidic pH | 8901634 |
| Hgene | SLC9A1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 22688515 |
| Hgene | SLC9A1 | GO:0051453 | regulation of intracellular pH | 15035633|24840010 |
| Hgene | SLC9A1 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade | 22688515 |
| Hgene | SLC9A1 | GO:0071468 | cellular response to acidic pH | 24840010 |
| Hgene | SLC9A1 | GO:0098719 | sodium ion import across plasma membrane | 24840010 |
| Hgene | SLC9A1 | GO:1902600 | proton transmembrane transport | 24840010 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI992338 | SLC9A1 | chr1 | 27425417 | + | COL4A1 | chr13 | 110861195 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000263980 | ENST00000375820 | SLC9A1 | chr1 | 27425417 | + | COL4A1 | chr13 | 110861195 | + |
| intron-intron | ENST00000263980 | ENST00000543140 | SLC9A1 | chr1 | 27425417 | + | COL4A1 | chr13 | 110861195 | + |
| intron-intron | ENST00000263980 | ENST00000467182 | SLC9A1 | chr1 | 27425417 | + | COL4A1 | chr13 | 110861195 | + |
| intron-intron | ENST00000490329 | ENST00000375820 | SLC9A1 | chr1 | 27425417 | + | COL4A1 | chr13 | 110861195 | + |
| intron-intron | ENST00000490329 | ENST00000543140 | SLC9A1 | chr1 | 27425417 | + | COL4A1 | chr13 | 110861195 | + |
| intron-intron | ENST00000490329 | ENST00000467182 | SLC9A1 | chr1 | 27425417 | + | COL4A1 | chr13 | 110861195 | + |
| intron-intron | ENST00000545949 | ENST00000375820 | SLC9A1 | chr1 | 27425417 | + | COL4A1 | chr13 | 110861195 | + |
| intron-intron | ENST00000545949 | ENST00000543140 | SLC9A1 | chr1 | 27425417 | + | COL4A1 | chr13 | 110861195 | + |
| intron-intron | ENST00000545949 | ENST00000467182 | SLC9A1 | chr1 | 27425417 | + | COL4A1 | chr13 | 110861195 | + |
| intron-intron | ENST00000374086 | ENST00000375820 | SLC9A1 | chr1 | 27425417 | + | COL4A1 | chr13 | 110861195 | + |
| intron-intron | ENST00000374086 | ENST00000543140 | SLC9A1 | chr1 | 27425417 | + | COL4A1 | chr13 | 110861195 | + |
| intron-intron | ENST00000374086 | ENST00000467182 | SLC9A1 | chr1 | 27425417 | + | COL4A1 | chr13 | 110861195 | + |
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FusionProtFeatures for SLC9A1_COL4A1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLC9A1 | COL4A1 |
| Involved in pH regulation to eliminate acids generatedby active metabolism or to counter adverse environmentalconditions. Major proton extruding system driven by the inwardsodium ion chemical gradient. Plays an important role in signaltransduction. {ECO:0000269|PubMed:11350981,ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:8901634}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLC9A1_COL4A1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLC9A1_COL4A1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC9A1_COL4A1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | SLC9A1 | P19634 | DB00594 | Amiloride | Sodium/hydrogen exchanger 1 | small molecule | approved |
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RelatedDiseases for SLC9A1_COL4A1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SLC9A1 | C0004763 | Barrett Esophagus | 1 | CTD_human |
| Hgene | SLC9A1 | C0007194 | Hypertrophic Cardiomyopathy | 1 | CTD_human |
| Hgene | SLC9A1 | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
| Hgene | SLC9A1 | C0013604 | Edema | 1 | CTD_human |
| Hgene | SLC9A1 | C0018801 | Heart failure | 1 | CTD_human |
| Hgene | SLC9A1 | C0030193 | Pain | 1 | CTD_human |
| Hgene | SLC9A1 | C0035126 | Reperfusion Injury | 1 | CTD_human |
| Hgene | SLC9A1 | C0036982 | Shock, Hemorrhagic | 1 | CTD_human |
| Hgene | SLC9A1 | C4225383 | LICHTENSTEIN-KNORR SYNDROME | 1 | ORPHANET;UNIPROT |
| Tgene | COL4A1 | C4013035 | BRAIN SMALL VESSEL DISEASE WITH OR WITHOUT OCULAR ANOMALIES | 8 | ORPHANET;UNIPROT |
| Tgene | COL4A1 | C1867983 | PORENCEPHALY, FAMILIAL | 3 | ORPHANET;UNIPROT |
| Tgene | COL4A1 | C2673195 | Angiopathy, Hereditary, With Nephropathy, Aneurysms, And Muscle Cramps | 3 | CTD_human;ORPHANET;UNIPROT |
| Tgene | COL4A1 | C0017668 | Focal glomerulosclerosis | 2 | CTD_human |
| Tgene | COL4A1 | C0011881 | Diabetic Nephropathy | 1 | CTD_human |
| Tgene | COL4A1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | COL4A1 | C0027726 | Nephrotic Syndrome | 1 | CTD_human |
| Tgene | COL4A1 | C0266484 | Schizencephaly | 1 | HPO;ORPHANET;UNIPROT |
| Tgene | COL4A1 | C3281105 | HEMORRHAGE, INTRACEREBRAL, SUSCEPTIBILITY TO | 1 | UNIPROT |
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