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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34609

FusionGeneSummary for SLC7A2_BAZ2B

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC7A2_BAZ2B
Fusion gene ID: 34609
HgeneTgene
Gene symbol

SLC7A2

BAZ2B

Gene ID

6542

29994

Gene namesolute carrier family 7 member 2bromodomain adjacent to zinc finger domain 2B
SynonymsATRC2|CAT2|HCAT2WALp4
Cytomap

8p22

2q24.2

Type of geneprotein-codingprotein-coding
Descriptioncationic amino acid transporter 2low affinity cationic amino acid transporter 2solute carrier family 7 (cationic amino acid transporter, y+ system), member 2bromodomain adjacent to zinc finger domain protein 2B
Modification date2018052320180519
UniProtAcc

P52569

Q9UIF8

Ensembl transtripts involved in fusion geneENST00000494857, ENST00000522656, 
ENST00000470360, ENST00000004531, 
ENST00000398090, 
ENST00000355831, 
ENST00000343439, ENST00000392782, 
ENST00000392783, ENST00000483316, 
Fusion gene scores* DoF score5 X 4 X 3=606 X 6 X 4=144
# samples 56
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC7A2 [Title/Abstract] AND BAZ2B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-13-0923-01ASLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000494857ENST00000355831SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000494857ENST00000343439SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000494857ENST00000392782SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000494857ENST00000392783SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000494857ENST00000483316SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000522656ENST00000355831SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000522656ENST00000343439SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000522656ENST00000392782SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000522656ENST00000392783SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000522656ENST00000483316SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000470360ENST00000355831SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000470360ENST00000343439SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000470360ENST00000392782SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000470360ENST00000392783SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000470360ENST00000483316SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000004531ENST00000355831SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000004531ENST00000343439SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000004531ENST00000392782SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000004531ENST00000392783SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000004531ENST00000483316SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000398090ENST00000355831SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000398090ENST00000343439SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000398090ENST00000392782SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000398090ENST00000392783SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-
5CDS-5UTRENST00000398090ENST00000483316SLC7A2chr8

17402115

+BAZ2Bchr2

160412376

-

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FusionProtFeatures for SLC7A2_BAZ2B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC7A2

P52569

BAZ2B

Q9UIF8

Functions as permease involved in the transport of thecationic amino acids (arginine, lysine and ornithine); theaffinity for its substrates differs between isoforms created byalternative splicing. Isoform 1 functions as permease thatmediates the transport of the cationic amino acids (arginine,lysine and ornithine), and it has much higher affinity forarginine than isoform 2. Isoform 2 functions as low-affinity, highcapacity permease involved in the transport of the cationic aminoacids (arginine, lysine and ornithine) (PubMed:9174363). May playa role in classical or alternative activation of macrophages viaits role in arginine transport. {ECO:0000250|UniProtKB:P18581,ECO:0000269|PubMed:9174363}. May play a role in transcriptional regulationinteracting with ISWI.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC7A2_BAZ2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC7A2_BAZ2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC7A2LGALS3, TSPAN5, TMEM171, GABRE, NT5E, VSIG4, CYP2C18, VAPB, TP53, TMEM17, CD83, ATP6V0E1, FPR2, DLK2, TMPRSS11B, UPK1A, YIPF3, PTGIR, ZFYVE27, VIPR1, C5AR2, C3AR1, MFSD4BAZ2BCTBP2, ELAVL1, PRNP, SOX2, ZBTB14, FXR2, STAC3, ZBTB8A, TRIM23, HDGFRP3, INA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC7A2_BAZ2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneSLC7A2P52569DB00123L-LysineCationic amino acid transporter 2small moleculeapproved|nutraceutical

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RelatedDiseases for SLC7A2_BAZ2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource