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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34578

FusionGeneSummary for SLC5A10_FGG

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC5A10_FGG
Fusion gene ID: 34578
HgeneTgene
Gene symbol

SLC5A10

FGG

Gene ID

125206

2266

Gene namesolute carrier family 5 member 10fibrinogen gamma chain
SynonymsSGLT-5|SGLT5-
Cytomap

17p11.2

4q32.1

Type of geneprotein-codingprotein-coding
Descriptionsodium/glucose cotransporter 5Na(+)/glucose cotransporter 5solute carrier family 5 (sodium/glucose cotransporter), member 10solute carrier family 5 (sodium/sugar cotransporter), member 10fibrinogen gamma chainfibrinogen, gamma polypeptidetesticular tissue protein Li 70
Modification date2018040320180519
UniProtAcc

A0PJK1

P02679

Ensembl transtripts involved in fusion geneENST00000317977, ENST00000395642, 
ENST00000395647, ENST00000417251, 
ENST00000395643, ENST00000395645, 
ENST00000404648, ENST00000405164, 
ENST00000336098, ENST00000407946, 
Fusion gene scores* DoF score1 X 1 X 1=18 X 9 X 3=216
# samples 614
** MAII scorelog2(6/1*10)=5.90689059560852log2(14/216*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC5A10 [Title/Abstract] AND FGG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFGG

GO:0007160

cell-matrix adhesion

10903502

TgeneFGG

GO:0031639

plasminogen activation

16846481

TgeneFGG

GO:0034116

positive regulation of heterotypic cell-cell adhesion

8100742

TgeneFGG

GO:0034622

cellular protein-containing complex assembly

8910396

TgeneFGG

GO:0042730

fibrinolysis

16846481

TgeneFGG

GO:0045907

positive regulation of vasoconstriction

15739255

TgeneFGG

GO:0045921

positive regulation of exocytosis

19193866

TgeneFGG

GO:0050714

positive regulation of protein secretion

19193866

TgeneFGG

GO:0051592

response to calcium ion

6777381

TgeneFGG

GO:0070374

positive regulation of ERK1 and ERK2 cascade

10903502|19193866

TgeneFGG

GO:0070527

platelet aggregation

6281794

TgeneFGG

GO:0072378

blood coagulation, fibrin clot formation

16846481

TgeneFGG

GO:0090277

positive regulation of peptide hormone secretion

19193866

TgeneFGG

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

10903502

TgeneFGG

GO:2000352

negative regulation of endothelial cell apoptotic process

10903502


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AV657449SLC5A10chr17

18872216

+FGGchr4

155533792

-
ChiTaRS3.1AV657451SLC5A10chr17

18872216

+FGGchr4

155533792

-
ChiTaRS3.1AV657521SLC5A10chr17

18872216

+FGGchr4

155533792

-
ChiTaRS3.1AV657691SLC5A10chr17

18872216

+FGGchr4

155533792

-
ChiTaRS3.1AV657724SLC5A10chr17

18872216

+FGGchr4

155533792

-
ChiTaRS3.1AV657679SLC5A10chr17

18872216

+FGGchr4

155533792

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000317977ENST00000404648SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000317977ENST00000405164SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000317977ENST00000336098SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000317977ENST00000407946SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000395642ENST00000404648SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000395642ENST00000405164SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000395642ENST00000336098SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000395642ENST00000407946SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000395647ENST00000404648SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000395647ENST00000405164SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000395647ENST00000336098SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000395647ENST00000407946SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000417251ENST00000404648SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000417251ENST00000405164SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000417251ENST00000336098SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000417251ENST00000407946SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000395643ENST00000404648SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000395643ENST00000405164SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000395643ENST00000336098SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000395643ENST00000407946SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000395645ENST00000404648SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000395645ENST00000405164SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000395645ENST00000336098SLC5A10chr17

18872216

+FGGchr4

155533792

-
intron-5UTRENST00000395645ENST00000407946SLC5A10chr17

18872216

+FGGchr4

155533792

-

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FusionProtFeatures for SLC5A10_FGG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC5A10

A0PJK1

FGG

P02679

High capacity transporter for mannose and fructose and,to a lesser extent, glucose, AMG, and galactose.{ECO:0000269|PubMed:22212718}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC5A10_FGG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC5A10_FGG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC5A10_FGG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFGGP02679DB00364SucralfateFibrinogen gamma chainsmall moleculeapproved

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RelatedDiseases for SLC5A10_FGG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFGGC0272350Dysfibrinogenemia, Congenital7ORPHANET;UNIPROT
TgeneFGGC0022548Keloid1CTD_human
TgeneFGGC0038356Stomach Neoplasms1CTD_human
TgeneFGGC2584774Congenital hypofibrinogenemia1ORPHANET;UNIPROT