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Fusion gene ID: 34575 |
FusionGeneSummary for SLC50A1_SLC1A2 |
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Fusion gene information | Fusion gene name: SLC50A1_SLC1A2 | Fusion gene ID: 34575 | Hgene | Tgene | Gene symbol | SLC50A1 | SLC1A2 | Gene ID | 55974 | 6506 |
Gene name | solute carrier family 50 member 1 | solute carrier family 1 member 2 | |
Synonyms | HsSWEET1|RAG1AP1|SCP|SWEET1|slv | EAAT2|EIEE41|GLT-1|HBGT | |
Cytomap | 1q22 | 11p13 | |
Type of gene | protein-coding | protein-coding | |
Description | sugar transporter SWEET1RAG1-activating protein 1RP11-540D14.5RZPDo834D038Dprobable sugar transporter RAG1AP1recombination activating gene 1 activating protein 1solute carrier family 50 (sugar efflux transporter), member 1solute carrier family 50 ( | excitatory amino acid transporter 2excitotoxic amino acid transporter 2glutamate/aspartate transporter IIsodium-dependent glutamate/aspartate transporter 2solute carrier family 1 (glial high affinity glutamate transporter), member 2 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9BRV3 | P43004 | |
Ensembl transtripts involved in fusion gene | ENST00000484157, ENST00000303343, ENST00000368404, ENST00000368401, ENST00000368405, | ENST00000278379, ENST00000395750, ENST00000395753, ENST00000606205, ENST00000479543, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 9 X 8 X 5=360 |
# samples | 2 | 11 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SLC50A1 [Title/Abstract] AND SLC1A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SLC1A2 | GO:0015813 | L-glutamate transmembrane transport | 26690923 |
Tgene | SLC1A2 | GO:0070207 | protein homotrimerization | 15265858|15483603 |
Tgene | SLC1A2 | GO:0070779 | D-aspartate import across plasma membrane | 7521911 |
Tgene | SLC1A2 | GO:0098712 | L-glutamate import across plasma membrane | 7521911|15265858|26690923 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA269573 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000484157 | ENST00000278379 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
intron-3UTR | ENST00000484157 | ENST00000395750 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
intron-3UTR | ENST00000484157 | ENST00000395753 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
intron-intron | ENST00000484157 | ENST00000606205 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
intron-intron | ENST00000484157 | ENST00000479543 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
5CDS-3UTR | ENST00000303343 | ENST00000278379 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
5CDS-3UTR | ENST00000303343 | ENST00000395750 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
5CDS-3UTR | ENST00000303343 | ENST00000395753 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
5CDS-intron | ENST00000303343 | ENST00000606205 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
5CDS-intron | ENST00000303343 | ENST00000479543 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
5CDS-3UTR | ENST00000368404 | ENST00000278379 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
5CDS-3UTR | ENST00000368404 | ENST00000395750 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
5CDS-3UTR | ENST00000368404 | ENST00000395753 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
5CDS-intron | ENST00000368404 | ENST00000606205 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
5CDS-intron | ENST00000368404 | ENST00000479543 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
5UTR-3UTR | ENST00000368401 | ENST00000278379 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
5UTR-3UTR | ENST00000368401 | ENST00000395750 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
5UTR-3UTR | ENST00000368401 | ENST00000395753 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
5UTR-intron | ENST00000368401 | ENST00000606205 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
5UTR-intron | ENST00000368401 | ENST00000479543 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
3UTR-3UTR | ENST00000368405 | ENST00000278379 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
3UTR-3UTR | ENST00000368405 | ENST00000395750 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
3UTR-3UTR | ENST00000368405 | ENST00000395753 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
3UTR-intron | ENST00000368405 | ENST00000606205 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
3UTR-intron | ENST00000368405 | ENST00000479543 | SLC50A1 | chr1 | 155108396 | + | SLC1A2 | chr11 | 35280230 | - |
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FusionProtFeatures for SLC50A1_SLC1A2 |
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Hgene | Tgene |
SLC50A1 | SLC1A2 |
Mediates sugar transport across membranes. May stimulateV(D)J recombination by the activation of RAG1.{ECO:0000269|PubMed:21107422}. | Sodium-dependent, high-affinity amino acid transporterthat mediates the uptake of L-glutamate and also L-aspartate andD-aspartate (PubMed:7521911, PubMed:14506254, PubMed:15265858,PubMed:26690923). Functions as a symporter that transports oneamino acid molecule together with two or three Na(+) ions and oneproton, in parallel with the counter-transport of one K(+) ion(PubMed:14506254). Mediates Cl(-) flux that is not coupled toamino acid transport; this avoids the accumulation of negativecharges due to aspartate and Na(+) symport (PubMed:14506254).Essential for the rapid removal of released glutamate from thesynaptic cleft, and for terminating the postsynaptic action ofglutamate (By similarity). {ECO:0000250|UniProtKB:P43006,ECO:0000269|PubMed:15265858, ECO:0000269|PubMed:26690923,ECO:0000269|PubMed:7521911}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLC50A1_SLC1A2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLC50A1_SLC1A2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC50A1_SLC1A2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | SLC1A2 | P43004 | DB00142 | Glutamic Acid | Excitatory amino acid transporter 2 | small molecule | approved|nutraceutical |
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RelatedDiseases for SLC50A1_SLC1A2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SLC1A2 | C0005586 | Bipolar Disorder | 4 | PSYGENET |
Tgene | SLC1A2 | C0036341 | Schizophrenia | 4 | PSYGENET |
Tgene | SLC1A2 | C0001973 | Alcoholic Intoxication, Chronic | 3 | PSYGENET |
Tgene | SLC1A2 | C0011570 | Mental Depression | 3 | PSYGENET |
Tgene | SLC1A2 | C0011581 | Depressive disorder | 3 | PSYGENET |
Tgene | SLC1A2 | C0002736 | Amyotrophic Lateral Sclerosis | 1 | CTD_human |
Tgene | SLC1A2 | C0014544 | Epilepsy | 1 | CTD_human |
Tgene | SLC1A2 | C0027746 | Nerve Degeneration | 1 | CTD_human |
Tgene | SLC1A2 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Tgene | SLC1A2 | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
Tgene | SLC1A2 | C0525045 | Mood Disorders | 1 | PSYGENET |