	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 34515

FusionGeneSummary for SLC44A4_ANKRD17

Fusion gene summary

Fusion gene information	Fusion gene name: SLC44A4_ANKRD17
	Fusion gene ID: 34515
		Hgene	Tgene
	Gene symbol	SLC44A4	ANKRD17
	Gene ID	80736	26057
	Gene name	solute carrier family 44 member 4	ankyrin repeat domain 17
	Synonyms	C6orf29\|CTL4\|DFNA72\|NG22\|TPPT\|hTPPT1	GTAR\|MASK2\|NY-BR-16
	Cytomap	6p21.33	4q13.3
	Type of gene	protein-coding	protein-coding
	Description	choline transporter-like protein 4testicular tissue protein Li 48thiamine pyrophosphate transporterthiamine pyrophosphate transporter 1	ankyrin repeat domain-containing protein 17gene trap ankyrin repeat proteinserologically defined breast cancer antigen NY-BR-16
	Modification date	20180409	20180523
	UniProtAcc	Q53GD3	O75179
	Ensembl transtripts involved in fusion gene	ENST00000229729, ENST00000544672, ENST00000375562, ENST00000465707, ENST00000417894, ENST00000550821, ENST00000550401, ENST00000492911, ENST00000453831, ENST00000546461, ENST00000551168, ENST00000495620, ENST00000425238, ENST00000548188, ENST00000549663, ENST00000469478, ENST00000415517, ENST00000547288, ENST00000547493, ENST00000463111, ENST00000383379, ENST00000547684, ENST00000549677, ENST00000497745, ENST00000366281, ENST00000442152, ENST00000553147, ENST00000553121, ENST00000495181,	ENST00000358602, ENST00000509867, ENST00000330838, ENST00000514252,
Fusion gene scores	* DoF score	4 X 4 X 3=48	8 X 14 X 3=336
	# samples	4	18
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(18/336*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SLC44A4 [Title/Abstract] AND ANKRD17 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SLC44A4	GO:0030974	thiamine pyrophosphate transmembrane transport	24379411
Tgene	ANKRD17	GO:0042742	defense response to bacterium	23711367
Tgene	ANKRD17	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	22328336
Tgene	ANKRD17	GO:0045087	innate immune response	23711367
Tgene	ANKRD17	GO:1900245	positive regulation of MDA-5 signaling pathway	22328336
Tgene	ANKRD17	GO:1900246	positive regulation of RIG-I signaling pathway	22328336

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BC014659	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000229729	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000229729	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000229729	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000229729	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000544672	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000544672	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000544672	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000544672	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000375562	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000375562	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000375562	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000375562	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000465707	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000465707	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000465707	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000465707	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000417894	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000417894	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000417894	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000417894	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000550821	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000550821	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000550821	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000550821	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000550401	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000550401	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000550401	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000550401	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000492911	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000492911	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000492911	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000492911	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000453831	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000453831	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000453831	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000453831	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000546461	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000546461	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000546461	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000546461	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000551168	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000551168	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000551168	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000551168	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000495620	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000495620	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000495620	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000495620	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000425238	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000425238	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000425238	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000425238	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000548188	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000548188	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000548188	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000548188	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000549663	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000549663	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000549663	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000549663	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000469478	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000469478	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000469478	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000469478	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000415517	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000415517	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000415517	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000415517	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000547288	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000547288	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000547288	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000547288	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000547493	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000547493	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000547493	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000547493	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000463111	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000463111	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000463111	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000463111	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000383379	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000383379	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000383379	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000383379	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000547684	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000547684	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000547684	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000547684	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000549677	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000549677	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000549677	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000549677	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000497745	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000497745	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000497745	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000497745	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000366281	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000366281	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000366281	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000366281	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
5CDS-intron	ENST00000442152	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
5CDS-intron	ENST00000442152	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
5CDS-intron	ENST00000442152	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
5CDS-intron	ENST00000442152	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
5CDS-intron	ENST00000553147	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
5CDS-intron	ENST00000553147	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
5CDS-intron	ENST00000553147	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
5CDS-intron	ENST00000553147	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
5CDS-intron	ENST00000553121	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
5CDS-intron	ENST00000553121	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
5CDS-intron	ENST00000553121	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
5CDS-intron	ENST00000553121	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000495181	ENST00000358602	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000495181	ENST00000509867	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000495181	ENST00000330838	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+
intron-intron	ENST00000495181	ENST00000514252	SLC44A4	chr6	3163722	-	ANKRD17	chr4	74084357	+

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FusionProtFeatures for SLC44A4_ANKRD17

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SLC44A4 Q53GD3	ANKRD17 O75179

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for SLC44A4_ANKRD17

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC44A4_ANKRD17

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for SLC44A4_ANKRD17

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SLC44A4_ANKRD17

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 34515

FusionGeneSummary for SLC44A4_ANKRD17

FusionProtFeatures for SLC44A4_ANKRD17

FusionGeneSequence for SLC44A4_ANKRD17

FusionGenePPI for SLC44A4_ANKRD17

RelatedDrugs for SLC44A4_ANKRD17

RelatedDiseases for SLC44A4_ANKRD17