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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 34512

FusionGeneSummary for SLC44A2_PTPRQ

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC44A2_PTPRQ
Fusion gene ID: 34512
HgeneTgene
Gene symbol

SLC44A2

PTPRQ

Gene ID

57153

374462

Gene namesolute carrier family 44 member 2protein tyrosine phosphatase, receptor type Q
SynonymsCTL2|PP1292DFNA73|DFNB84|DFNB84A|PTPGMC1|R-PTP-Q
Cytomap

19p13.2

12q21.31

Type of geneprotein-codingprotein-coding
Descriptioncholine transporter-like protein 2solute carrier family 44 (choline transporter), member 2testicular tissue protein Li 47phosphatidylinositol phosphatase PTPRQphosphotidylinositol phosphatase PTPRQprotein-tyrosine phosphatase, receptor-type, expressed by glomerular mesangial cells
Modification date2018052520180519
UniProtAcc

Q8IWA5

Q9UMZ3

Ensembl transtripts involved in fusion geneENST00000407327, ENST00000335757, 
ENST00000586078, ENST00000588214, 
ENST00000266688, ENST00000547485, 
Fusion gene scores* DoF score5 X 4 X 3=608 X 6 X 4=192
# samples 46
** MAII scorelog2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/192*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC44A2 [Title/Abstract] AND PTPRQ [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePTPRQ

GO:0045598

regulation of fat cell differentiation

19351528


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-FX-A3NK-01ASLC44A2chr19

10713237

+PTPRQchr12

80981908

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000407327ENST00000266688SLC44A2chr19

10713237

+PTPRQchr12

80981908

+
5CDS-intronENST00000407327ENST00000547485SLC44A2chr19

10713237

+PTPRQchr12

80981908

+
intron-3CDSENST00000335757ENST00000266688SLC44A2chr19

10713237

+PTPRQchr12

80981908

+
intron-intronENST00000335757ENST00000547485SLC44A2chr19

10713237

+PTPRQchr12

80981908

+
intron-3CDSENST00000586078ENST00000266688SLC44A2chr19

10713237

+PTPRQchr12

80981908

+
intron-intronENST00000586078ENST00000547485SLC44A2chr19

10713237

+PTPRQchr12

80981908

+
intron-3CDSENST00000588214ENST00000266688SLC44A2chr19

10713237

+PTPRQchr12

80981908

+
intron-intronENST00000588214ENST00000547485SLC44A2chr19

10713237

+PTPRQchr12

80981908

+

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FusionProtFeatures for SLC44A2_PTPRQ


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC44A2

Q8IWA5

PTPRQ

Q9UMZ3

Phosphatidylinositol phosphatase required for auditoryfunction. May act by regulating the level of phosphatidylinositol4,5-bisphosphate (PIP2) level in the basal region of hair bundles.Can dephosphorylate a broad range of phosphatidylinositolphosphates, including phosphatidylinositol 3,4,5-trisphosphate andmost phosphatidylinositol monophosphates and diphosphates.Phosphate can be hydrolyzed from the D3 and D5 positions in theinositol ring. Has low tyrosine-protein phosphatase activity;however, the relevance of such activity in vivo is unclear. Playsan important role in adipogenesis of mesenchymal stem cells(MSCs). Regulates the phosphorylation state of AKT1 by suppressingthe phosphatidylinositol 3,4,5-trisphosphate (PIP3) level in MSCsand preadipocyte cells. {ECO:0000269|PubMed:19351528}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePTPRQchr19:10713237chr12:80981908ENST00000266688+29501474_157814242296DomainFibronectin type-III 16
TgenePTPRQchr19:10713237chr12:80981908ENST00000266688+29501583_168114242296DomainFibronectin type-III 17
TgenePTPRQchr19:10713237chr12:80981908ENST00000266688+29501686_178714242296DomainFibronectin type-III 18
TgenePTPRQchr19:10713237chr12:80981908ENST00000266688+29502036_229214242296DomainTyrosine-protein phosphatase
TgenePTPRQchr19:10713237chr12:80981908ENST00000266688+29501969_233214242296Topological domainCytoplasmic
TgenePTPRQchr19:10713237chr12:80981908ENST00000266688+29501948_196814242296TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000335757+1221_33-126707Topological domainCytoplasmic
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000335757+122254_256-126707Topological domainCytoplasmic
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000335757+122278_315-126707Topological domainExtracellular
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000335757+122337_364-126707Topological domainCytoplasmic
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000335757+122386_457-126707Topological domainExtracellular
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000335757+122481_504-126707Topological domainCytoplasmic
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000335757+122526_563-126707Topological domainExtracellular
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000335757+12255_232-126707Topological domainExtracellular
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000335757+122585_599-126707Topological domainCytoplasmic
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000335757+122621_638-126707Topological domainExtracellular
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000335757+122660_706-126707Topological domainCytoplasmic
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000407327+1221_3310705Topological domainCytoplasmic
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000407327+122254_25610705Topological domainCytoplasmic
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000407327+122278_31510705Topological domainExtracellular
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000407327+122337_36410705Topological domainCytoplasmic
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000407327+122386_45710705Topological domainExtracellular
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000407327+122481_50410705Topological domainCytoplasmic
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000407327+122526_56310705Topological domainExtracellular
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000407327+12255_23210705Topological domainExtracellular
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000407327+122585_59910705Topological domainCytoplasmic
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000407327+122621_63810705Topological domainExtracellular
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000407327+122660_70610705Topological domainCytoplasmic
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000586078+1221_33-37712Topological domainCytoplasmic
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000586078+122254_256-37712Topological domainCytoplasmic
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000586078+122278_315-37712Topological domainExtracellular
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000586078+122337_364-37712Topological domainCytoplasmic
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000586078+122386_457-37712Topological domainExtracellular
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000586078+122481_504-37712Topological domainCytoplasmic
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000586078+122526_563-37712Topological domainExtracellular
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000586078+12255_232-37712Topological domainExtracellular
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000586078+122585_599-37712Topological domainCytoplasmic
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000586078+122621_638-37712Topological domainExtracellular
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000586078+122660_706-37712Topological domainCytoplasmic
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000335757+122233_253-126707TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000335757+122257_277-126707TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000335757+122316_336-126707TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000335757+12234_54-126707TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000335757+122365_385-126707TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000335757+122458_480-126707TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000335757+122505_525-126707TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000335757+122564_584-126707TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000335757+122600_620-126707TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000335757+122639_659-126707TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000407327+122233_25310705TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000407327+122257_27710705TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000407327+122316_33610705TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000407327+12234_5410705TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000407327+122365_38510705TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000407327+122458_48010705TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000407327+122505_52510705TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000407327+122564_58410705TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000407327+122600_62010705TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000407327+122639_65910705TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000586078+122233_253-37712TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000586078+122257_277-37712TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000586078+122316_336-37712TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000586078+12234_54-37712TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000586078+122365_385-37712TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000586078+122458_480-37712TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000586078+122505_525-37712TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000586078+122564_584-37712TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000586078+122600_620-37712TransmembraneHelical
HgeneSLC44A2chr19:10713237chr12:80981908ENST00000586078+122639_659-37712TransmembraneHelical
TgenePTPRQchr19:10713237chr12:80981908ENST00000266688+2950100_19514242296DomainFibronectin type-III 2
TgenePTPRQchr19:10713237chr12:80981908ENST00000266688+29501098_119014242296DomainFibronectin type-III 12
TgenePTPRQchr19:10713237chr12:80981908ENST00000266688+29501192_128214242296DomainFibronectin type-III 13
TgenePTPRQchr19:10713237chr12:80981908ENST00000266688+29501287_138014242296DomainFibronectin type-III 14
TgenePTPRQchr19:10713237chr12:80981908ENST00000266688+29501384_147014242296DomainFibronectin type-III 15
TgenePTPRQchr19:10713237chr12:80981908ENST00000266688+2950199_29414242296DomainFibronectin type-III 3
TgenePTPRQchr19:10713237chr12:80981908ENST00000266688+2950350_43814242296DomainFibronectin type-III 4
TgenePTPRQchr19:10713237chr12:80981908ENST00000266688+295036_9914242296DomainFibronectin type-III 1
TgenePTPRQchr19:10713237chr12:80981908ENST00000266688+2950441_53914242296DomainFibronectin type-III 5
TgenePTPRQchr19:10713237chr12:80981908ENST00000266688+2950514_60614242296DomainFibronectin type-III 6
TgenePTPRQchr19:10713237chr12:80981908ENST00000266688+2950610_70514242296DomainFibronectin type-III 7
TgenePTPRQchr19:10713237chr12:80981908ENST00000266688+2950710_79914242296DomainFibronectin type-III 8
TgenePTPRQchr19:10713237chr12:80981908ENST00000266688+2950804_89414242296DomainFibronectin type-III 9
TgenePTPRQchr19:10713237chr12:80981908ENST00000266688+2950899_98814242296DomainFibronectin type-III 10
TgenePTPRQchr19:10713237chr12:80981908ENST00000266688+2950993_109314242296DomainFibronectin type-III 11
TgenePTPRQchr19:10713237chr12:80981908ENST00000266688+295036_194714242296Topological domainExtracellular


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FusionGeneSequence for SLC44A2_PTPRQ


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SLC44A2_ENST00000407327_chr19_10713237_+_PTPRQ_ENST00000266688_chr12_80981908_+_882aa
MEDERKNGAYVPSVPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFR
WYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEPAVITGPTCYLIDVKSVDNDEFNISFIKSNEENKTIE
IKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPT
AVQIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVPMRITMDIKAPARPKTKPTPIYDATGKLLVTSTTITIRMPICYY
SDDHGPIKNVQVLVTETGAQHDGNVTKWYDAYFNKARPYFTNEGFPNPPCTEGKTKFSGNEEIYIIGADNACMIPGNEDKICNGPLKPKK
QYLFKFRATNIMGQFTDSDYSDPVKTLGEGLSERTVEIILSVTLCILSIILLGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLI
TVADLELKDERLTRLLSYRKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFPNIKPYNNNRVKLIA
DASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDV
QIDWTIRDLKIERHGDCMTVRQCNFTAWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SLC44A2_ENST00000407327_chr19_10713237_+_PTPRQ_ENST00000266688_chr12_80981908_+_2646nt
ATGGAGGACGAGCGGAAAAACGGAGCCTACGTTCCCAGTGTTCCCACAAATATTGCTTTTTCTGATGTTCAGTCAACTAGTGCAACATTG
ACATGGATAAGACCTGACACTATCCTTGGCTACTTTCAAAATTACAAAATTACCACTCAACTTCGTGCTCAAAAATGCAAAGAATGGGAA
TCCGAAGAATGTGTTGAATATCAAAAAATTCAATACCTCTATGAAGCTCACTTAACTGAAGAGACAGTATATGGATTAAAGAAATTTAGA
TGGTATAGATTCCAAGTGGCTGCCAGCACCAATGCTGGCTATGGCAATGCTTCAAACTGGATTTCTACAAAAACTCTGCCTGGCCCTCCA
GATGGTCCTCCTGAAAATGTTCATGTAGTAGCAACATCACCTTTTAGCATCAGCATAAGCTGGAGTGAACCTGCTGTCATTACTGGACCA
ACATGTTATCTGATTGATGTCAAATCGGTAGATAATGATGAATTTAATATATCCTTCATCAAGTCAAATGAAGAAAATAAAACCATAGAA
ATTAAAGATTTAGAAATATTCACAAGGTATTCTGTAGTGATCACTGCATTTACTGGGAACATTAGTGCTGCATATGTAGAAGGGAAGTCA
AGTGCTGAAATGATTGTTACTACTTTAGAATCAGCCCCAAAGGACCCACCTAACAACATGACATTTCAGAAGATACCAGATGAAGTTACA
AAATTTCAATTAACGTTCCTTCCTCCTTCTCAACCTAATGGAAATATCCAAGTATATCAAGCTCTGGTTTACCGAGAAGATGATCCTACT
GCTGTCCAGATTCACAACCTCAGTATTATACAGAAAACCAACACATTCGTCATTGCAATGCTAGAAGGACTAAAAGGTGGACATACATAC
AATATCAGTGTTTACGCAGTCAATAGTGCTGGTGCAGGTCCAAAGGTTCCGATGAGAATAACCATGGATATCAAAGCTCCAGCACGACCA
AAAACCAAACCAACCCCTATTTATGATGCCACAGGAAAACTGCTTGTGACTTCAACAACAATTACAATCAGAATGCCAATATGTTACTAC
AGTGATGATCATGGACCAATAAAAAATGTACAAGTGCTTGTGACAGAAACAGGAGCTCAGCATGATGGAAATGTAACAAAGTGGTATGAT
GCATATTTTAATAAAGCAAGGCCATATTTTACAAATGAAGGCTTTCCTAACCCTCCATGTACAGAAGGAAAGACAAAGTTTAGTGGCAAT
GAAGAAATCTACATCATAGGTGCTGATAATGCATGCATGATTCCTGGCAATGAAGACAAAATTTGCAATGGACCACTGAAACCAAAAAAG
CAATACTTATTTAAATTTAGAGCTACAAATATTATGGGACAATTTACTGACTCTGATTATTCTGACCCTGTTAAGACTTTAGGGGAAGGA
CTTTCAGAAAGAACCGTAGAGATCATTCTTTCCGTCACTTTGTGTATCCTTTCAATAATTCTCCTTGGAACAGCTATTTTTGCATTTGCA
AGAATTCGACAGAAGCAGAAAGAAGGTGGCACATACTCTCCTCAGGATGCAGAAATTATTGACACTAAATTGAAGCTGGATCAGCTCATC
ACAGTGGCAGACCTGGAACTGAAGGACGAGAGATTAACGCGGTTACTTAGTTATAGAAAATCCATCAAGCCAATAAGCAAGAAATCCTTC
CTGCAACATGTTGAAGAGCTTTGCACAAACAACAACCTAAAGTTTCAAGAAGAATTTTCGGAATTACCAAAATTTCTTCAGGATCTTTCT
TCAACTGATGCTGATCTGCCTTGGAATAGAGCAAAAAACCGCTTCCCAAACATAAAACCATATAATAATAACAGAGTAAAGCTGATAGCT
GACGCTAGTGTTCCAGGTTCGGATTATATTAATGCCAGCTATATTTCTGGTTATTTATGTCCAAATGAATTTATTGCTACTCAAGGTCCA
CTACCAGGAACAGTTGGAGATTTTTGGAGAATGGTGTGGGAAACCAGAGCAAAAACATTAGTAATGCTAACACAGTGTTTTGAAAAAGGA
CGGATCAGATGCCATCAGTATTGGCCAGAGGACAACAAGCCAGTTACTGTCTTTGGAGATATAGTGATTACAAAGCTAATGGAGGATGTT
CAAATAGATTGGACTATCAGGGATCTGAAAATTGAAAGGCATGGGGATTGCATGACTGTTCGACAGTGTAACTTTACTGCCTGGCCAGAG
CATGGGGTTCCTGAGAACAGCGCCCCTCTAATTCACTTTGTGAAGTTGGTTCGAGCAAGCAGGGCACATGACACCACACCTATGATTGTT
CACTGCAGTGCTGGAGTTGGAAGAACTGGAGTTTTTATTGCTCTGGACCATTTAACACAACATATAAATGACCATGATTTTGTGGATATA
TATGGACTAGTAGCTGAACTGAGAAGTGAAAGAATGTGCATGGTGCAGAATCTGGCACAGTATATCTTTTTACACCAGTGCATTCTGGAT
CTCTTATCAAATAAGGGAAGTAATCAGCCCATCTGTTTTGTTAACTATTCAGCACTTCAGAAGATGGACTCTTTGGACGCCATGGAAGGT


* Fusion transcript sequences (Full-length transcript).
>In-frame_SLC44A2_ENST00000407327_chr19_10713237_+_PTPRQ_ENST00000266688_chr12_80981908_+_2667nt
GCTCCCCGCCCCGCCGCGGCCATGGAGGACGAGCGGAAAAACGGAGCCTACGTTCCCAGTGTTCCCACAAATATTGCTTTTTCTGATGTT
CAGTCAACTAGTGCAACATTGACATGGATAAGACCTGACACTATCCTTGGCTACTTTCAAAATTACAAAATTACCACTCAACTTCGTGCT
CAAAAATGCAAAGAATGGGAATCCGAAGAATGTGTTGAATATCAAAAAATTCAATACCTCTATGAAGCTCACTTAACTGAAGAGACAGTA
TATGGATTAAAGAAATTTAGATGGTATAGATTCCAAGTGGCTGCCAGCACCAATGCTGGCTATGGCAATGCTTCAAACTGGATTTCTACA
AAAACTCTGCCTGGCCCTCCAGATGGTCCTCCTGAAAATGTTCATGTAGTAGCAACATCACCTTTTAGCATCAGCATAAGCTGGAGTGAA
CCTGCTGTCATTACTGGACCAACATGTTATCTGATTGATGTCAAATCGGTAGATAATGATGAATTTAATATATCCTTCATCAAGTCAAAT
GAAGAAAATAAAACCATAGAAATTAAAGATTTAGAAATATTCACAAGGTATTCTGTAGTGATCACTGCATTTACTGGGAACATTAGTGCT
GCATATGTAGAAGGGAAGTCAAGTGCTGAAATGATTGTTACTACTTTAGAATCAGCCCCAAAGGACCCACCTAACAACATGACATTTCAG
AAGATACCAGATGAAGTTACAAAATTTCAATTAACGTTCCTTCCTCCTTCTCAACCTAATGGAAATATCCAAGTATATCAAGCTCTGGTT
TACCGAGAAGATGATCCTACTGCTGTCCAGATTCACAACCTCAGTATTATACAGAAAACCAACACATTCGTCATTGCAATGCTAGAAGGA
CTAAAAGGTGGACATACATACAATATCAGTGTTTACGCAGTCAATAGTGCTGGTGCAGGTCCAAAGGTTCCGATGAGAATAACCATGGAT
ATCAAAGCTCCAGCACGACCAAAAACCAAACCAACCCCTATTTATGATGCCACAGGAAAACTGCTTGTGACTTCAACAACAATTACAATC
AGAATGCCAATATGTTACTACAGTGATGATCATGGACCAATAAAAAATGTACAAGTGCTTGTGACAGAAACAGGAGCTCAGCATGATGGA
AATGTAACAAAGTGGTATGATGCATATTTTAATAAAGCAAGGCCATATTTTACAAATGAAGGCTTTCCTAACCCTCCATGTACAGAAGGA
AAGACAAAGTTTAGTGGCAATGAAGAAATCTACATCATAGGTGCTGATAATGCATGCATGATTCCTGGCAATGAAGACAAAATTTGCAAT
GGACCACTGAAACCAAAAAAGCAATACTTATTTAAATTTAGAGCTACAAATATTATGGGACAATTTACTGACTCTGATTATTCTGACCCT
GTTAAGACTTTAGGGGAAGGACTTTCAGAAAGAACCGTAGAGATCATTCTTTCCGTCACTTTGTGTATCCTTTCAATAATTCTCCTTGGA
ACAGCTATTTTTGCATTTGCAAGAATTCGACAGAAGCAGAAAGAAGGTGGCACATACTCTCCTCAGGATGCAGAAATTATTGACACTAAA
TTGAAGCTGGATCAGCTCATCACAGTGGCAGACCTGGAACTGAAGGACGAGAGATTAACGCGGTTACTTAGTTATAGAAAATCCATCAAG
CCAATAAGCAAGAAATCCTTCCTGCAACATGTTGAAGAGCTTTGCACAAACAACAACCTAAAGTTTCAAGAAGAATTTTCGGAATTACCA
AAATTTCTTCAGGATCTTTCTTCAACTGATGCTGATCTGCCTTGGAATAGAGCAAAAAACCGCTTCCCAAACATAAAACCATATAATAAT
AACAGAGTAAAGCTGATAGCTGACGCTAGTGTTCCAGGTTCGGATTATATTAATGCCAGCTATATTTCTGGTTATTTATGTCCAAATGAA
TTTATTGCTACTCAAGGTCCACTACCAGGAACAGTTGGAGATTTTTGGAGAATGGTGTGGGAAACCAGAGCAAAAACATTAGTAATGCTA
ACACAGTGTTTTGAAAAAGGACGGATCAGATGCCATCAGTATTGGCCAGAGGACAACAAGCCAGTTACTGTCTTTGGAGATATAGTGATT
ACAAAGCTAATGGAGGATGTTCAAATAGATTGGACTATCAGGGATCTGAAAATTGAAAGGCATGGGGATTGCATGACTGTTCGACAGTGT
AACTTTACTGCCTGGCCAGAGCATGGGGTTCCTGAGAACAGCGCCCCTCTAATTCACTTTGTGAAGTTGGTTCGAGCAAGCAGGGCACAT
GACACCACACCTATGATTGTTCACTGCAGTGCTGGAGTTGGAAGAACTGGAGTTTTTATTGCTCTGGACCATTTAACACAACATATAAAT
GACCATGATTTTGTGGATATATATGGACTAGTAGCTGAACTGAGAAGTGAAAGAATGTGCATGGTGCAGAATCTGGCACAGTATATCTTT
TTACACCAGTGCATTCTGGATCTCTTATCAAATAAGGGAAGTAATCAGCCCATCTGTTTTGTTAACTATTCAGCACTTCAGAAGATGGAC


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FusionGenePPI for SLC44A2_PTPRQ


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC44A2RP2PTPRQEEA1, PIBF1, SNX27, SLC9A3R1, AHI1, ATP2B2, SLC9A3R2, EZR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC44A2_PTPRQ


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC44A2_PTPRQ


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC44A2C0023893Liver Cirrhosis, Experimental1CTD_human
TgenePTPRQC3150654DEAFNESS, AUTOSOMAL RECESSIVE 84A1CTD_human;UNIPROT