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Fusion gene ID: 34468 |
FusionGeneSummary for SLC39A8_RHEB |
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Fusion gene information | Fusion gene name: SLC39A8_RHEB | Fusion gene ID: 34468 | Hgene | Tgene | Gene symbol | SLC39A8 | RHEB | Gene ID | 64116 | 6009 |
Gene name | solute carrier family 39 member 8 | Ras homolog, mTORC1 binding | |
Synonyms | BIGM103|CDG2N|LZT-Hs6|PP3105|ZIP8 | RHEB2 | |
Cytomap | 4q24 | 7q36.1 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc transporter ZIP8BCG induced integral membrane protein BIGM103BCG-induced integral membrane protein in monocyte clone 103 proteinLIV-1 subfamily of ZIP zinc transporter 6ZIP-8Zrt- and Irt-like protein 8solute carrier family 39 (metal ion transpo | GTP-binding protein RhebRas homolog enriched in brain 2 | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | Q9C0K1 | Q15382 | |
Ensembl transtripts involved in fusion gene | ENST00000424970, ENST00000394833, ENST00000356736, ENST00000510255, | ENST00000262187, ENST00000472642, ENST00000496004, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 5 X 5 X 4=100 |
# samples | 3 | 5 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SLC39A8 [Title/Abstract] AND RHEB [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-HC-7821-01A | SLC39A8 | chr4 | 103265601 | - | RHEB | chr7 | 151174501 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000424970 | ENST00000262187 | SLC39A8 | chr4 | 103265601 | - | RHEB | chr7 | 151174501 | - |
5CDS-5UTR | ENST00000424970 | ENST00000472642 | SLC39A8 | chr4 | 103265601 | - | RHEB | chr7 | 151174501 | - |
5CDS-5UTR | ENST00000424970 | ENST00000496004 | SLC39A8 | chr4 | 103265601 | - | RHEB | chr7 | 151174501 | - |
In-frame | ENST00000394833 | ENST00000262187 | SLC39A8 | chr4 | 103265601 | - | RHEB | chr7 | 151174501 | - |
5CDS-5UTR | ENST00000394833 | ENST00000472642 | SLC39A8 | chr4 | 103265601 | - | RHEB | chr7 | 151174501 | - |
5CDS-5UTR | ENST00000394833 | ENST00000496004 | SLC39A8 | chr4 | 103265601 | - | RHEB | chr7 | 151174501 | - |
In-frame | ENST00000356736 | ENST00000262187 | SLC39A8 | chr4 | 103265601 | - | RHEB | chr7 | 151174501 | - |
5CDS-5UTR | ENST00000356736 | ENST00000472642 | SLC39A8 | chr4 | 103265601 | - | RHEB | chr7 | 151174501 | - |
5CDS-5UTR | ENST00000356736 | ENST00000496004 | SLC39A8 | chr4 | 103265601 | - | RHEB | chr7 | 151174501 | - |
intron-3CDS | ENST00000510255 | ENST00000262187 | SLC39A8 | chr4 | 103265601 | - | RHEB | chr7 | 151174501 | - |
intron-5UTR | ENST00000510255 | ENST00000472642 | SLC39A8 | chr4 | 103265601 | - | RHEB | chr7 | 151174501 | - |
intron-5UTR | ENST00000510255 | ENST00000496004 | SLC39A8 | chr4 | 103265601 | - | RHEB | chr7 | 151174501 | - |
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FusionProtFeatures for SLC39A8_RHEB |
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Hgene | Tgene |
SLC39A8 | RHEB |
Acts as a manganese and zinc influx transporter(PubMed:12504855, PubMed:26637978). Plays a role in manganesereabsorption in the proximal tubule of the kidney and in manganeseuptake into the brain (PubMed:26637978).{ECO:0000269|PubMed:12504855, ECO:0000305|PubMed:26637978}. | Activates the protein kinase activity of mTORC1, andthereby plays a role in the regulation of apoptosis. Stimulatesthe phosphorylation of S6K1 and EIF4EBP1 through activation ofmTORC1 signaling. Has low intrinsic GTPase activity.{ECO:0000269|PubMed:12271141, ECO:0000269|PubMed:12869586,ECO:0000269|PubMed:15340059, ECO:0000269|PubMed:15854902,ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:20381137}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLC39A8_RHEB |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_SLC39A8_ENST00000394833_chr4_103265601_-_RHEB_ENST00000262187_chr7_151174501_-_194aa MAPGRAVAGLLLLAAAGLGGVAEGPGLAFSEDVLSVFGANLSLSAAQLQHLLEQMGAASRVGVPEPGQLHFNQDEYSIFPQTYSIDINGY ILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKMD >In-frame_SLC39A8_ENST00000356736_chr4_103265601_-_RHEB_ENST00000262187_chr7_151174501_-_194aa MAPGRAVAGLLLLAAAGLGGVAEGPGLAFSEDVLSVFGANLSLSAAQLQHLLEQMGAASRVGVPEPGQLHFNQDEYSIFPQTYSIDINGY ILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKMD |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_SLC39A8_ENST00000394833_chr4_103265601_-_RHEB_ENST00000262187_chr7_151174501_-_582nt ATGGCCCCGGGTCGCGCGGTGGCCGGGCTCCTGTTGCTGGCGGCCGCCGGCCTCGGAGGAGTGGCGGAGGGGCCAGGGCTAGCCTTCAGC GAGGATGTGCTGAGCGTGTTCGGCGCGAATCTGAGCCTGTCGGCGGCGCAGCTCCAGCACTTGCTGGAGCAGATGGGAGCCGCCTCCCGC GTGGGCGTCCCGGAGCCTGGCCAGCTGCACTTCAACCAGGATGAATATTCTATCTTTCCTCAGACATACTCCATAGATATTAATGGCTAT ATTCTTGTGTATTCTGTTACATCAATCAAAAGTTTTGAAGTGATTAAAGTTATCCATGGCAAATTGTTGGATATGGTGGGGAAAGTACAA ATACCTATTATGTTGGTTGGGAATAAGAAAGACCTGCATATGGAAAGGGTGATCAGTTATGAAGAAGGGAAAGCTTTGGCAGAATCTTGG AATGCAGCTTTTTTGGAATCTTCTGCTAAAGAAAATCAGACTGCTGTGGATGTTTTTCGAAGGATAATTTTGGAGGCAGAAAAAATGGAC >In-frame_SLC39A8_ENST00000356736_chr4_103265601_-_RHEB_ENST00000262187_chr7_151174501_-_582nt ATGGCCCCGGGTCGCGCGGTGGCCGGGCTCCTGTTGCTGGCGGCCGCCGGCCTCGGAGGAGTGGCGGAGGGGCCAGGGCTAGCCTTCAGC GAGGATGTGCTGAGCGTGTTCGGCGCGAATCTGAGCCTGTCGGCGGCGCAGCTCCAGCACTTGCTGGAGCAGATGGGAGCCGCCTCCCGC GTGGGCGTCCCGGAGCCTGGCCAGCTGCACTTCAACCAGGATGAATATTCTATCTTTCCTCAGACATACTCCATAGATATTAATGGCTAT ATTCTTGTGTATTCTGTTACATCAATCAAAAGTTTTGAAGTGATTAAAGTTATCCATGGCAAATTGTTGGATATGGTGGGGAAAGTACAA ATACCTATTATGTTGGTTGGGAATAAGAAAGACCTGCATATGGAAAGGGTGATCAGTTATGAAGAAGGGAAAGCTTTGGCAGAATCTTGG AATGCAGCTTTTTTGGAATCTTCTGCTAAAGAAAATCAGACTGCTGTGGATGTTTTTCGAAGGATAATTTTGGAGGCAGAAAAAATGGAC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_SLC39A8_ENST00000394833_chr4_103265601_-_RHEB_ENST00000262187_chr7_151174501_-_2166nt AGTGTGGTTTTAGTTTTTCCTAAGAAGTGGCGTGGTTTGGGGCTTTATATCCGGGAGGAGCATATGTACGCAAATCCTGGGGCGTTTGCA AACCCGGATCCGGGGCGTCTGGCCCCATGCCCGGCCGGGCGTTTGAGGGCTACTGCCACGCAGCGTTTCTGGAGCCTGCCGGCTGGTGCC CTGGTGGCCTTTATCTCTGTCCCCCTTTGTCCTCTTTATCTCAGGCTCTCCAGGAGGCCGGGGGGCCCACTCCGCCTATCGCTCCCCTCG GCTACGCTGCCACTTCAATGCCCCGCAGGTCGCGAGCTGCTGTTCTTTCGAAGGCGTCGGAGAACCAGGGGCGTCCCGCGCCACCTCTGA CTCGGAGCAGCGCCGAGCACTGACGCTCCCGCCCTTGGGCAAGGACGCCAGTGCGCCCGCGCGCGTCCCTCTGCGCGGCAGCCCGTCGCG GGCCCTCAAGGGGAAGCCCAGGCCAGGATGGCCCCGGGTCGCGCGGTGGCCGGGCTCCTGTTGCTGGCGGCCGCCGGCCTCGGAGGAGTG GCGGAGGGGCCAGGGCTAGCCTTCAGCGAGGATGTGCTGAGCGTGTTCGGCGCGAATCTGAGCCTGTCGGCGGCGCAGCTCCAGCACTTG CTGGAGCAGATGGGAGCCGCCTCCCGCGTGGGCGTCCCGGAGCCTGGCCAGCTGCACTTCAACCAGGATGAATATTCTATCTTTCCTCAG ACATACTCCATAGATATTAATGGCTATATTCTTGTGTATTCTGTTACATCAATCAAAAGTTTTGAAGTGATTAAAGTTATCCATGGCAAA TTGTTGGATATGGTGGGGAAAGTACAAATACCTATTATGTTGGTTGGGAATAAGAAAGACCTGCATATGGAAAGGGTGATCAGTTATGAA GAAGGGAAAGCTTTGGCAGAATCTTGGAATGCAGCTTTTTTGGAATCTTCTGCTAAAGAAAATCAGACTGCTGTGGATGTTTTTCGAAGG ATAATTTTGGAGGCAGAAAAAATGGACGGGGCAGCTTCACAAGGCAAGTCTTCATGCTCGGTGATGTGATTCTGCTGCAAAGCCTGAGGA CACTGGGAATATATTCTACCTGAAGAAGCAAACTGCCCGTTCTCCTTGAAGATAAACTATGCTTCTTTTTTCTTCTGTTAACCTGAAAGA TATCATTTGGGTCAGAGCTCCCCTCCCTTCAGATTATGTTAACTCTGAGTCTGTCCAAATGAGTTCACTTCCATTTTCAAATTTTAAGCA ATCATATTTTCAATTTATATATTGTATTTCTTAATATTATGACCAAGAATTTTATCGGCATTAATTTTTCAGTGTAGTTTGTTGTTTAAA ATAATGTAATCATCAAAATGATGCATATTGTTACACTACTATTAACTAGGCTTCAGTATATCAGTGTTTATTTCATTGTGTTAAATGTAT ACTTGTAAATAAAATAGCTGCAAACCTCAGTCCTTTGTGCTACTTGATGTGGCTTTCAAAGAAGAGAAGCCTTGTCCTGAGTTTCTCACT TGGCTTCAGGAAGGCCCCAGGTTGGATTCCAGAAACCAGTGAAGATGTGGCCACAGGAGGAGGTGTGCTGAGGTGGCTGCTGACCGTGGA CTCCCTGCGCAGTGGCCTGCAGATGTTGGGGCTGGGTTACAGCTGATTGAAGCTGAGTGGCCCTGGGGGGTCTGTGAGGGGAGTTCCTCC CCAGTGATGAAATTCTCTCCTTCCACCCTCAAATCCCTAGACCTTGACTGAAATGCTCCGTGGTCGGGAGCCTGGTCAAGGAGGAGGAGC TGCTGAGAGGCATTGTTCGCCCTTGCTCATAGCTTAGCTCGATGTCCGTGTCAGACAGGAGATGATTGAGAACAGCCTTGCCTGTCACTG TCCTAGAACACCCTGGAGTTTAGTGTTCTGTGTCAGAGTCTTGGGAGCCTCCTTCAGACCCAGATGACGGGCCTCCCTCTGTCCAAGGAG CAGCTGTAAAGGAGAAGAGGGATTTCATTTGTTTGGTGGCTGTTACCTTGTCTGTAAGTCAAACTTGGAGTTGAGCAGTGCTTTTTAAAC GATTCCCTTTTGCAGCTAAAATTTCACAGGGCTATTTCTAATACGTAAGCAAATGTTACCATTGACTTTATTAATAAAATATAGTTTTGC >In-frame_SLC39A8_ENST00000356736_chr4_103265601_-_RHEB_ENST00000262187_chr7_151174501_-_2072nt CCGCGGACCTGTCAGAGATACAGAGGTTGTGGGGGCGGGAGACAGAAAGAGAGAGAGATCCAGAGACCGAGTCTTACGTTGACACGCAGA GAGAAAGACGCAGAGACAGACAAACAAACAGATAGGAGAGGCTCTCCAGGAGGCCGGGGGGCCCACTCCGCCTATCGCTCCCCTCGGCTA CGCTGCCACTTCAATGCCCCGCAGGTCGCGAGCTGCTGTTCTTTCGAAGGCGTCGGAGAACCAGGGGCGTCCCGCGCCACCTCTGACTCG GAGCAGCGCCGAGCACTGACGCTCCCGCCCTTGGGCAAGGACGCCAGTGCGCCCGCGCGCGTCCCTCTGCGCGGCAGCCCGTCGCGGGCC CTCAAGGGGAAGCCCAGGCCAGGATGGCCCCGGGTCGCGCGGTGGCCGGGCTCCTGTTGCTGGCGGCCGCCGGCCTCGGAGGAGTGGCGG AGGGGCCAGGGCTAGCCTTCAGCGAGGATGTGCTGAGCGTGTTCGGCGCGAATCTGAGCCTGTCGGCGGCGCAGCTCCAGCACTTGCTGG AGCAGATGGGAGCCGCCTCCCGCGTGGGCGTCCCGGAGCCTGGCCAGCTGCACTTCAACCAGGATGAATATTCTATCTTTCCTCAGACAT ACTCCATAGATATTAATGGCTATATTCTTGTGTATTCTGTTACATCAATCAAAAGTTTTGAAGTGATTAAAGTTATCCATGGCAAATTGT TGGATATGGTGGGGAAAGTACAAATACCTATTATGTTGGTTGGGAATAAGAAAGACCTGCATATGGAAAGGGTGATCAGTTATGAAGAAG GGAAAGCTTTGGCAGAATCTTGGAATGCAGCTTTTTTGGAATCTTCTGCTAAAGAAAATCAGACTGCTGTGGATGTTTTTCGAAGGATAA TTTTGGAGGCAGAAAAAATGGACGGGGCAGCTTCACAAGGCAAGTCTTCATGCTCGGTGATGTGATTCTGCTGCAAAGCCTGAGGACACT GGGAATATATTCTACCTGAAGAAGCAAACTGCCCGTTCTCCTTGAAGATAAACTATGCTTCTTTTTTCTTCTGTTAACCTGAAAGATATC ATTTGGGTCAGAGCTCCCCTCCCTTCAGATTATGTTAACTCTGAGTCTGTCCAAATGAGTTCACTTCCATTTTCAAATTTTAAGCAATCA TATTTTCAATTTATATATTGTATTTCTTAATATTATGACCAAGAATTTTATCGGCATTAATTTTTCAGTGTAGTTTGTTGTTTAAAATAA TGTAATCATCAAAATGATGCATATTGTTACACTACTATTAACTAGGCTTCAGTATATCAGTGTTTATTTCATTGTGTTAAATGTATACTT GTAAATAAAATAGCTGCAAACCTCAGTCCTTTGTGCTACTTGATGTGGCTTTCAAAGAAGAGAAGCCTTGTCCTGAGTTTCTCACTTGGC TTCAGGAAGGCCCCAGGTTGGATTCCAGAAACCAGTGAAGATGTGGCCACAGGAGGAGGTGTGCTGAGGTGGCTGCTGACCGTGGACTCC CTGCGCAGTGGCCTGCAGATGTTGGGGCTGGGTTACAGCTGATTGAAGCTGAGTGGCCCTGGGGGGTCTGTGAGGGGAGTTCCTCCCCAG TGATGAAATTCTCTCCTTCCACCCTCAAATCCCTAGACCTTGACTGAAATGCTCCGTGGTCGGGAGCCTGGTCAAGGAGGAGGAGCTGCT GAGAGGCATTGTTCGCCCTTGCTCATAGCTTAGCTCGATGTCCGTGTCAGACAGGAGATGATTGAGAACAGCCTTGCCTGTCACTGTCCT AGAACACCCTGGAGTTTAGTGTTCTGTGTCAGAGTCTTGGGAGCCTCCTTCAGACCCAGATGACGGGCCTCCCTCTGTCCAAGGAGCAGC TGTAAAGGAGAAGAGGGATTTCATTTGTTTGGTGGCTGTTACCTTGTCTGTAAGTCAAACTTGGAGTTGAGCAGTGCTTTTTAAACGATT CCCTTTTGCAGCTAAAATTTCACAGGGCTATTTCTAATACGTAAGCAAATGTTACCATTGACTTTATTAATAAAATATAGTTTTGCTTTG |
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FusionGenePPI for SLC39A8_RHEB |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SLC39A8 | TAOK2, GPD2, RMDN2, SLC9A6, LEMD2, C1GALT1C1, C1orf43, ERGIC2, ZDHHC17, EXTL2, VAPB, EDA, ST7L, SGPP1, MGAT5, HMOX1, SPPL3, STX4, SLC22A18, ERGIC3, TMEM179B, TMPPE, VANGL2, TMX2, SLC4A2, GP1BB, TRIM25 | RHEB | TSC2, PDE6D, ATM, ATR, MTOR, HRAS, RAF1, RAP1A, TSC1, RAB7A, RAB9A, RPTOR, A2M, ECSIT, PSEN2, APOE, PSEN1, BNIP3, BNIP3L, RABAC1, TRAF2, ARIH2, NCAM1, FKBP8, PLD1, RPS6KB1, VPS4A, ITGB8, TNF, LDHB, CREB3, DUSP19, SPATA19, NEDD9, NFATC2IP, RAC1, UBB, IL20RA, LAMP2, SRPRB, SLC15A1, ENPP7, LGALS7, TMEM52B, RELL2, HTT, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC39A8_RHEB |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC39A8_RHEB |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SLC39A8 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | SLC39A8 | C4225234 | CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIn | 1 | ORPHANET;UNIPROT |
Tgene | RHEB | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |