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Fusion gene ID: 34466 |
FusionGeneSummary for SLC39A8_GLS |
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Fusion gene information | Fusion gene name: SLC39A8_GLS | Fusion gene ID: 34466 | Hgene | Tgene | Gene symbol | SLC39A8 | GLS | Gene ID | 64116 | 27165 |
Gene name | solute carrier family 39 member 8 | glutaminase 2 | |
Synonyms | BIGM103|CDG2N|LZT-Hs6|PP3105|ZIP8 | GA|GLS|LGA|hLGA | |
Cytomap | 4q24 | 12q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc transporter ZIP8BCG induced integral membrane protein BIGM103BCG-induced integral membrane protein in monocyte clone 103 proteinLIV-1 subfamily of ZIP zinc transporter 6ZIP-8Zrt- and Irt-like protein 8solute carrier family 39 (metal ion transpo | glutaminase liver isoform, mitochondrialL-glutamine amidohydrolasebreast cell glutaminaseglutaminase 2 (liver, mitochondrial)glutaminase Iphosphate-activated glutaminasephosphate-dependent glutaminase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9C0K1 | O94925 | |
Ensembl transtripts involved in fusion gene | ENST00000424970, ENST00000394833, ENST00000356736, ENST00000510255, | ENST00000320717, ENST00000338435, ENST00000409626, ENST00000409428, ENST00000409215, ENST00000471443, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 8 X 7 X 3=168 |
# samples | 3 | 8 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SLC39A8 [Title/Abstract] AND GLS [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW999094 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000424970 | ENST00000320717 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-3UTR | ENST00000424970 | ENST00000338435 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-intron | ENST00000424970 | ENST00000409626 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-intron | ENST00000424970 | ENST00000409428 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-intron | ENST00000424970 | ENST00000409215 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-intron | ENST00000424970 | ENST00000471443 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-intron | ENST00000394833 | ENST00000320717 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-3UTR | ENST00000394833 | ENST00000338435 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-intron | ENST00000394833 | ENST00000409626 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-intron | ENST00000394833 | ENST00000409428 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-intron | ENST00000394833 | ENST00000409215 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-intron | ENST00000394833 | ENST00000471443 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-intron | ENST00000356736 | ENST00000320717 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-3UTR | ENST00000356736 | ENST00000338435 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-intron | ENST00000356736 | ENST00000409626 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-intron | ENST00000356736 | ENST00000409428 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-intron | ENST00000356736 | ENST00000409215 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-intron | ENST00000356736 | ENST00000471443 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-intron | ENST00000510255 | ENST00000320717 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-3UTR | ENST00000510255 | ENST00000338435 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-intron | ENST00000510255 | ENST00000409626 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-intron | ENST00000510255 | ENST00000409428 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-intron | ENST00000510255 | ENST00000409215 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
intron-intron | ENST00000510255 | ENST00000471443 | SLC39A8 | chr4 | 103183326 | - | GLS | chr2 | 191798952 | - |
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FusionProtFeatures for SLC39A8_GLS |
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Hgene | Tgene |
SLC39A8 | GLS |
Acts as a manganese and zinc influx transporter(PubMed:12504855, PubMed:26637978). Plays a role in manganesereabsorption in the proximal tubule of the kidney and in manganeseuptake into the brain (PubMed:26637978).{ECO:0000269|PubMed:12504855, ECO:0000305|PubMed:26637978}. | Catalyzes the first reaction in the primary pathway forthe renal catabolism of glutamine. Plays a role in maintainingacid-base homeostasis. Regulates the levels of theneurotransmitter glutamate in the brain. Isoform 2 lacks catalyticactivity. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLC39A8_GLS |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLC39A8_GLS |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC39A8_GLS |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | GLS | O94925 | DB00142 | Glutamic Acid | Glutaminase kidney isoform, mitochondrial | small molecule | approved|nutraceutical |
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RelatedDiseases for SLC39A8_GLS |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SLC39A8 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | SLC39A8 | C4225234 | CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIn | 1 | ORPHANET;UNIPROT |
Tgene | GLS | C0000786 | Spontaneous abortion | 1 | CTD_human |
Tgene | GLS | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | GLS | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | GLS | C0036341 | Schizophrenia | 1 | PSYGENET |