FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 34466

FusionGeneSummary for SLC39A8_GLS

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC39A8_GLS
Fusion gene ID: 34466
HgeneTgene
Gene symbol

SLC39A8

GLS

Gene ID

64116

27165

Gene namesolute carrier family 39 member 8glutaminase 2
SynonymsBIGM103|CDG2N|LZT-Hs6|PP3105|ZIP8GA|GLS|LGA|hLGA
Cytomap

4q24

12q13.3

Type of geneprotein-codingprotein-coding
Descriptionzinc transporter ZIP8BCG induced integral membrane protein BIGM103BCG-induced integral membrane protein in monocyte clone 103 proteinLIV-1 subfamily of ZIP zinc transporter 6ZIP-8Zrt- and Irt-like protein 8solute carrier family 39 (metal ion transpoglutaminase liver isoform, mitochondrialL-glutamine amidohydrolasebreast cell glutaminaseglutaminase 2 (liver, mitochondrial)glutaminase Iphosphate-activated glutaminasephosphate-dependent glutaminase
Modification date2018052320180523
UniProtAcc

Q9C0K1

O94925

Ensembl transtripts involved in fusion geneENST00000424970, ENST00000394833, 
ENST00000356736, ENST00000510255, 
ENST00000320717, ENST00000338435, 
ENST00000409626, ENST00000409428, 
ENST00000409215, ENST00000471443, 
Fusion gene scores* DoF score3 X 3 X 3=278 X 7 X 3=168
# samples 38
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC39A8 [Title/Abstract] AND GLS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW999094SLC39A8chr4

103183326

-GLSchr2

191798952

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000424970ENST00000320717SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-3UTRENST00000424970ENST00000338435SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-intronENST00000424970ENST00000409626SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-intronENST00000424970ENST00000409428SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-intronENST00000424970ENST00000409215SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-intronENST00000424970ENST00000471443SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-intronENST00000394833ENST00000320717SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-3UTRENST00000394833ENST00000338435SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-intronENST00000394833ENST00000409626SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-intronENST00000394833ENST00000409428SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-intronENST00000394833ENST00000409215SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-intronENST00000394833ENST00000471443SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-intronENST00000356736ENST00000320717SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-3UTRENST00000356736ENST00000338435SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-intronENST00000356736ENST00000409626SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-intronENST00000356736ENST00000409428SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-intronENST00000356736ENST00000409215SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-intronENST00000356736ENST00000471443SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-intronENST00000510255ENST00000320717SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-3UTRENST00000510255ENST00000338435SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-intronENST00000510255ENST00000409626SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-intronENST00000510255ENST00000409428SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-intronENST00000510255ENST00000409215SLC39A8chr4

103183326

-GLSchr2

191798952

-
intron-intronENST00000510255ENST00000471443SLC39A8chr4

103183326

-GLSchr2

191798952

-

Top

FusionProtFeatures for SLC39A8_GLS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC39A8

Q9C0K1

GLS

O94925

Acts as a manganese and zinc influx transporter(PubMed:12504855, PubMed:26637978). Plays a role in manganesereabsorption in the proximal tubule of the kidney and in manganeseuptake into the brain (PubMed:26637978).{ECO:0000269|PubMed:12504855, ECO:0000305|PubMed:26637978}. Catalyzes the first reaction in the primary pathway forthe renal catabolism of glutamine. Plays a role in maintainingacid-base homeostasis. Regulates the levels of theneurotransmitter glutamate in the brain. Isoform 2 lacks catalyticactivity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SLC39A8_GLS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SLC39A8_GLS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SLC39A8_GLS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneGLSO94925DB00142Glutamic AcidGlutaminase kidney isoform, mitochondrialsmall moleculeapproved|nutraceutical

Top

RelatedDiseases for SLC39A8_GLS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC39A8C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneSLC39A8C4225234CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIn1ORPHANET;UNIPROT
TgeneGLSC0000786Spontaneous abortion1CTD_human
TgeneGLSC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneGLSC0029408Degenerative polyarthritis1CTD_human
TgeneGLSC0036341Schizophrenia1PSYGENET