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Fusion gene ID: 34453 |
FusionGeneSummary for SLC39A3_SGTA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLC39A3_SGTA | Fusion gene ID: 34453 | Hgene | Tgene | Gene symbol | SLC39A3 | SGTA | Gene ID | 29985 | 6449 |
| Gene name | solute carrier family 39 member 3 | small glutamine rich tetratricopeptide repeat containing alpha | |
| Synonyms | ZIP-3|ZIP3 | SGT|alphaSGT|hSGT | |
| Cytomap | 19p13.3 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc transporter ZIP3solute carrier family 39 (zinc transporter), member 3zrt- and Irt-like protein 3 | small glutamine-rich tetratricopeptide repeat-containing protein alphaUBPalpha-SGTprotein containing three tetratricopeptide repeatssmall glutamine-rich tetratricopeptide repeat (TPR)-containing, alphavpu-binding protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9BRY0 | O43765 | |
| Ensembl transtripts involved in fusion gene | ENST00000545664, ENST00000269740, ENST00000455372, ENST00000590875, | ENST00000221566, ENST00000586711, | |
| Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 5 X 4 X 4=80 |
| # samples | 5 | 6 | |
| ** MAII score | log2(5/32*10)=0.643856189774725 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SLC39A3 [Title/Abstract] AND SGTA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SGTA | GO:0030433 | ubiquitin-dependent ERAD pathway | 23129660 |
| Tgene | SGTA | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process | 23129660 |
| Tgene | SGTA | GO:2000059 | negative regulation of ubiquitin-dependent protein catabolic process | 23129660 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | GBM | TCGA-06-0125-02A | SLC39A3 | chr19 | 2737046 | - | SGTA | chr19 | 2765283 | - |
| TCGA | RV | GBM | TCGA-06-0125-01A | SLC39A3 | chr19 | 2737046 | - | SGTA | chr19 | 2765283 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000545664 | ENST00000221566 | SLC39A3 | chr19 | 2737046 | - | SGTA | chr19 | 2765283 | - |
| 5CDS-intron | ENST00000545664 | ENST00000586711 | SLC39A3 | chr19 | 2737046 | - | SGTA | chr19 | 2765283 | - |
| Frame-shift | ENST00000269740 | ENST00000221566 | SLC39A3 | chr19 | 2737046 | - | SGTA | chr19 | 2765283 | - |
| 5CDS-intron | ENST00000269740 | ENST00000586711 | SLC39A3 | chr19 | 2737046 | - | SGTA | chr19 | 2765283 | - |
| intron-3CDS | ENST00000455372 | ENST00000221566 | SLC39A3 | chr19 | 2737046 | - | SGTA | chr19 | 2765283 | - |
| intron-intron | ENST00000455372 | ENST00000586711 | SLC39A3 | chr19 | 2737046 | - | SGTA | chr19 | 2765283 | - |
| intron-3CDS | ENST00000590875 | ENST00000221566 | SLC39A3 | chr19 | 2737046 | - | SGTA | chr19 | 2765283 | - |
| intron-intron | ENST00000590875 | ENST00000586711 | SLC39A3 | chr19 | 2737046 | - | SGTA | chr19 | 2765283 | - |
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FusionProtFeatures for SLC39A3_SGTA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLC39A3 | SGTA |
| Acts as a zinc-influx transporter. {ECO:0000305}. | Co-chaperone that binds misfolded and hydrophobicpatches-containing client proteins in the cytosol. Mediates theirtargeting to the endoplasmic reticulum but also regulates theirsorting to the proteasome when targeting fails (PubMed:28104892).Functions in tail-anchored/type II transmembrane proteins membraneinsertion constituting with ASNA1 and the BAG6 complex a targetingmodule (PubMed:28104892). Functions upstream of the BAG6 complexand ASNA1, binding more rapidly the transmembrane domain of newlysynthesized proteins (PubMed:28104892, PubMed:25535373). It isalso involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interactionwith BAG6: collaborates with the BAG6 complex to maintainhydrophobic substrates in non-ubiquitinated states(PubMed:23129660, PubMed:25179605). Competes with RNF126 forinteraction with BAG6, preventing the ubiquitination of clientproteins associated with the BAG6 complex (PubMed:27193484). Bindsdirectly to HSC70 and HSP70 and regulates their ATPase activity(PubMed:18759457). {ECO:0000269|PubMed:18759457,ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:25179605,ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:27193484,ECO:0000269|PubMed:28104892}. (Microbial infection) In case of infection bypolyomavirus, involved in the virus endoplasmic reticulum membranepenetration and infection via interaction with DNAJB12, DNAJB14and HSPA8/Hsc70 (PubMed:24675744). {ECO:0000269|PubMed:24675744}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLC39A3_SGTA |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLC39A3_SGTA |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SLC39A3 | HLA-B, BSCL2, EVA1C, TMPRSS11B, TNFSF8, MANSC1, PMEL, SEC22B, TRIM25 | SGTA | SPP1, F11R, SRGN, EFEMP2, NME3, GPX7, C1QTNF1, SPPL2A, SYT4, EFEMP1, IGLC1, GHR, PFN2, PTN, HSPA4, HSP90AA1, UBL4A, RNF185, UBC, PPP1R3C, HSPA8, BAG6, CD2BP2, AHCYL1, LSM4, PHKA1, CPLX1, ADSS, SMC5, DSTN, PFAS, SEC23A, KYNU, SEC61B, IRF3, IRF5, HSP90AB1, C1QA, CXCL8, CD99, TNFRSF1A, PIAS1, NXF1, GABARAPL2, BCL2L12, AASDHPPT, ACAA2, CAPZA1, CAPZA2, CTBP2, DPP3, GGH, HK1, PABPC1, PCNA, PDCD10, GDI1, TRIP13, TRIP6, YWHAB, BAG2, GET4, ASNA1, DNAJB12, HSPA4L, SERP1, CD79B, CDH15, COL1A2, COL8A2, CSF1, CST1, CTSL, GIP, GRN, GYPA, IGL, KRT6A, KTN1, LAIR2, MSMB, SERPINE1, PPIB, PPIC, RARRES3, RPN1, SDC4, SGCA, SLPI, SOD3, HSPA13, TFF3, TFRC, TGFA, UPK3A, VIP, ADIPOQ, SYT11, TNFRSF13B, LAT, TXNDC12, GAL, FKBP7, FXYD7, WBP1L, EVA1B, CARKD, C19orf10, PCDHA4, TWSG1, SMAGP, PBXIP1, TMUB2, C3orf52, FIP1L1, C1QTNF6, PRAP1, ERP27, ZG16B, TMEM174, CCDC155, ITPRIPL1, AGR3, TMEM31, FERD3L, ZG16, NR3C1, PGR, CTH, LSM7, MCFD2, CUL1, PSMD12, PSMD14, ADRM1, TRIM25, CCND2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC39A3_SGTA |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC39A3_SGTA |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SLC39A3 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | SLC39A3 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Hgene | SLC39A3 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
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