![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 34386 |
FusionGeneSummary for SLC36A4_CSH1 |
![]() |
Fusion gene information | Fusion gene name: SLC36A4_CSH1 | Fusion gene ID: 34386 | Hgene | Tgene | Gene symbol | SLC36A4 | CSH1 | Gene ID | 120103 | 1442 |
Gene name | solute carrier family 36 member 4 | chorionic somatomammotropin hormone 1 | |
Synonyms | PAT4 | CS-1|CSA|CSMT|GHB3|PL|hCS-1|hCS-A | |
Cytomap | 11q21 | 17q23.3 | |
Type of gene | protein-coding | protein-coding | |
Description | proton-coupled amino acid transporter 4solute carrier family 36 (proton/amino acid symporter), member 4 | chorionic somatomammotropin hormone 1choriomammotropinchorionic somatomammotropin Achorionic somatomammotropin-1growth hormone B3placental lactogen | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q6YBV0 | ||
Ensembl transtripts involved in fusion gene | ENST00000326402, ENST00000529184, | ENST00000453363, ENST00000316193, ENST00000329882, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 7 X 7 X 1=49 |
# samples | 1 | 7 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/49*10)=0.514573172829758 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SLC36A4 [Title/Abstract] AND CSH1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SLC36A4 | GO:0015808 | L-alanine transport | 21097500 |
Hgene | SLC36A4 | GO:0015824 | proline transport | 21097500 |
Hgene | SLC36A4 | GO:0015827 | tryptophan transport | 21097500 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AK096714 | SLC36A4 | chr11 | 92899518 | - | CSH1 | chr17 | 61973143 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000326402 | ENST00000453363 | SLC36A4 | chr11 | 92899518 | - | CSH1 | chr17 | 61973143 | - |
intron-intron | ENST00000326402 | ENST00000316193 | SLC36A4 | chr11 | 92899518 | - | CSH1 | chr17 | 61973143 | - |
intron-intron | ENST00000326402 | ENST00000329882 | SLC36A4 | chr11 | 92899518 | - | CSH1 | chr17 | 61973143 | - |
intron-intron | ENST00000529184 | ENST00000453363 | SLC36A4 | chr11 | 92899518 | - | CSH1 | chr17 | 61973143 | - |
intron-intron | ENST00000529184 | ENST00000316193 | SLC36A4 | chr11 | 92899518 | - | CSH1 | chr17 | 61973143 | - |
intron-intron | ENST00000529184 | ENST00000329882 | SLC36A4 | chr11 | 92899518 | - | CSH1 | chr17 | 61973143 | - |
Top |
FusionProtFeatures for SLC36A4_CSH1 |
![]() |
Hgene | Tgene |
SLC36A4 | CSH1 |
Functions as a sodium-independent electroneutraltransporter for tryptophan, proline and alanine. Inhibited bysarcosine. {ECO:0000269|PubMed:21097500}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for SLC36A4_CSH1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for SLC36A4_CSH1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SLC36A4_CSH1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SLC36A4_CSH1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CSH1 | C0175693 | Russell-Silver syndrome | 1 | CTD_human |