FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 34342

FusionGeneSummary for SLC34A2_ZBTB43

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC34A2_ZBTB43
Fusion gene ID: 34342
HgeneTgene
Gene symbol

SLC34A2

ZBTB43

Gene ID

10568

23099

Gene namesolute carrier family 34 member 2zinc finger and BTB domain containing 43
SynonymsNAPI-3B|NAPI-IIb|NPTIIbZBTB22B|ZNF-X|ZNF297B
Cytomap

4p15.2

9q33.3

Type of geneprotein-codingprotein-coding
Descriptionsodium-dependent phosphate transport protein 2Bsodium/phosphate cotransporter 2Bsolute carrier family 34 (sodium phosphate), member 2solute carrier family 34 (type II sodium/phosphate cotransporter), member 2type II sodium-dependent phosphate transporzinc finger and BTB domain-containing protein 43zinc finger and BTB domain-containing protein 22Bzinc finger protein 297B
Modification date2018052320180519
UniProtAcc

O95436

O43298

Ensembl transtripts involved in fusion geneENST00000504570, ENST00000382051, 
ENST00000503434, ENST00000510033, 
ENST00000449886, ENST00000373464, 
ENST00000373457, ENST00000497064, 
Fusion gene scores* DoF score6 X 5 X 3=902 X 2 X 1=4
# samples 113
** MAII scorelog2(11/90*10)=0.289506617194985
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/4*10)=2.90689059560852
Context

PubMed: SLC34A2 [Title/Abstract] AND ZBTB43 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC34A2

GO:0006817

phosphate ion transport

10329428|10610722|12488042

HgeneSLC34A2

GO:0030643

cellular phosphate ion homeostasis

10610722


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC142704SLC34A2chr4

25679926

+ZBTB43chr9

129600373

+
ChiTaRS3.1BC146666SLC34A2chr4

25679926

+ZBTB43chr9

129600373

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000504570ENST00000449886SLC34A2chr4

25679926

+ZBTB43chr9

129600373

+
intron-3UTRENST00000504570ENST00000373464SLC34A2chr4

25679926

+ZBTB43chr9

129600373

+
intron-intronENST00000504570ENST00000373457SLC34A2chr4

25679926

+ZBTB43chr9

129600373

+
intron-intronENST00000504570ENST00000497064SLC34A2chr4

25679926

+ZBTB43chr9

129600373

+
3UTR-3UTRENST00000382051ENST00000449886SLC34A2chr4

25679926

+ZBTB43chr9

129600373

+
3UTR-3UTRENST00000382051ENST00000373464SLC34A2chr4

25679926

+ZBTB43chr9

129600373

+
3UTR-intronENST00000382051ENST00000373457SLC34A2chr4

25679926

+ZBTB43chr9

129600373

+
3UTR-intronENST00000382051ENST00000497064SLC34A2chr4

25679926

+ZBTB43chr9

129600373

+
intron-3UTRENST00000503434ENST00000449886SLC34A2chr4

25679926

+ZBTB43chr9

129600373

+
intron-3UTRENST00000503434ENST00000373464SLC34A2chr4

25679926

+ZBTB43chr9

129600373

+
intron-intronENST00000503434ENST00000373457SLC34A2chr4

25679926

+ZBTB43chr9

129600373

+
intron-intronENST00000503434ENST00000497064SLC34A2chr4

25679926

+ZBTB43chr9

129600373

+
intron-3UTRENST00000510033ENST00000449886SLC34A2chr4

25679926

+ZBTB43chr9

129600373

+
intron-3UTRENST00000510033ENST00000373464SLC34A2chr4

25679926

+ZBTB43chr9

129600373

+
intron-intronENST00000510033ENST00000373457SLC34A2chr4

25679926

+ZBTB43chr9

129600373

+
intron-intronENST00000510033ENST00000497064SLC34A2chr4

25679926

+ZBTB43chr9

129600373

+

Top

FusionProtFeatures for SLC34A2_ZBTB43


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC34A2

O95436

ZBTB43

O43298

May be involved in actively transporting phosphate intocells via Na(+) cotransport. It may be the main phosphatetransport protein in the intestinal brush border membrane. Mayhave a role in the synthesis of surfactant in lungs' alveoli. May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SLC34A2_ZBTB43


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SLC34A2_ZBTB43


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SLC34A2_ZBTB43


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SLC34A2_ZBTB43


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC34A2C0007131Non-Small Cell Lung Carcinoma2CTD_human
HgeneSLC34A2C0041755Adverse reaction to drug1CTD_human
HgeneSLC34A2C0155912Pulmonary Alveolar Microlithiasis1CTD_human;ORPHANET;UNIPROT