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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34341

FusionGeneSummary for SLC34A2_SLC34A2

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC34A2_SLC34A2
Fusion gene ID: 34341
HgeneTgene
Gene symbol

SLC34A2

SLC34A2

Gene ID

10568

10568

Gene namesolute carrier family 34 member 2solute carrier family 34 member 2
SynonymsNAPI-3B|NAPI-IIb|NPTIIbNAPI-3B|NAPI-IIb|NPTIIb
Cytomap

4p15.2

4p15.2

Type of geneprotein-codingprotein-coding
Descriptionsodium-dependent phosphate transport protein 2Bsodium/phosphate cotransporter 2Bsolute carrier family 34 (sodium phosphate), member 2solute carrier family 34 (type II sodium/phosphate cotransporter), member 2type II sodium-dependent phosphate transporsodium-dependent phosphate transport protein 2Bsodium/phosphate cotransporter 2Bsolute carrier family 34 (sodium phosphate), member 2solute carrier family 34 (type II sodium/phosphate cotransporter), member 2type II sodium-dependent phosphate transpor
Modification date2018052320180523
UniProtAcc

O95436

O95436

Ensembl transtripts involved in fusion geneENST00000504570, ENST00000382051, 
ENST00000503434, ENST00000510033, 
ENST00000504570, ENST00000382051, 
ENST00000503434, ENST00000510033, 
Fusion gene scores* DoF score6 X 5 X 3=901 X 1 X 1=1
# samples 111
** MAII scorelog2(11/90*10)=0.289506617194985
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: SLC34A2 [Title/Abstract] AND SLC34A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC34A2

GO:0006817

phosphate ion transport

10329428|10610722|12488042

HgeneSLC34A2

GO:0030643

cellular phosphate ion homeostasis

10610722

TgeneSLC34A2

GO:0006817

phosphate ion transport

10329428|10610722|12488042

TgeneSLC34A2

GO:0030643

cellular phosphate ion homeostasis

10610722


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG996029SLC34A2chr4

25679051

-SLC34A2chr4

25679893

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000504570ENST00000504570SLC34A2chr4

25679051

-SLC34A2chr4

25679893

+
intron-3UTRENST00000504570ENST00000382051SLC34A2chr4

25679051

-SLC34A2chr4

25679893

+
intron-intronENST00000504570ENST00000503434SLC34A2chr4

25679051

-SLC34A2chr4

25679893

+
intron-intronENST00000504570ENST00000510033SLC34A2chr4

25679051

-SLC34A2chr4

25679893

+
3UTR-intronENST00000382051ENST00000504570SLC34A2chr4

25679051

-SLC34A2chr4

25679893

+
3UTR-3UTRENST00000382051ENST00000382051SLC34A2chr4

25679051

-SLC34A2chr4

25679893

+
3UTR-intronENST00000382051ENST00000503434SLC34A2chr4

25679051

-SLC34A2chr4

25679893

+
3UTR-intronENST00000382051ENST00000510033SLC34A2chr4

25679051

-SLC34A2chr4

25679893

+
intron-intronENST00000503434ENST00000504570SLC34A2chr4

25679051

-SLC34A2chr4

25679893

+
intron-3UTRENST00000503434ENST00000382051SLC34A2chr4

25679051

-SLC34A2chr4

25679893

+
intron-intronENST00000503434ENST00000503434SLC34A2chr4

25679051

-SLC34A2chr4

25679893

+
intron-intronENST00000503434ENST00000510033SLC34A2chr4

25679051

-SLC34A2chr4

25679893

+
intron-intronENST00000510033ENST00000504570SLC34A2chr4

25679051

-SLC34A2chr4

25679893

+
intron-3UTRENST00000510033ENST00000382051SLC34A2chr4

25679051

-SLC34A2chr4

25679893

+
intron-intronENST00000510033ENST00000503434SLC34A2chr4

25679051

-SLC34A2chr4

25679893

+
intron-intronENST00000510033ENST00000510033SLC34A2chr4

25679051

-SLC34A2chr4

25679893

+

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FusionProtFeatures for SLC34A2_SLC34A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC34A2

O95436

SLC34A2

O95436

May be involved in actively transporting phosphate intocells via Na(+) cotransport. It may be the main phosphatetransport protein in the intestinal brush border membrane. Mayhave a role in the synthesis of surfactant in lungs' alveoli. May be involved in actively transporting phosphate intocells via Na(+) cotransport. It may be the main phosphatetransport protein in the intestinal brush border membrane. Mayhave a role in the synthesis of surfactant in lungs' alveoli.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC34A2_SLC34A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC34A2_SLC34A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC34A2_SLC34A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC34A2_SLC34A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC34A2C0007131Non-Small Cell Lung Carcinoma2CTD_human
HgeneSLC34A2C0041755Adverse reaction to drug1CTD_human
HgeneSLC34A2C0155912Pulmonary Alveolar Microlithiasis1CTD_human;ORPHANET;UNIPROT
TgeneSLC34A2C0007131Non-Small Cell Lung Carcinoma2CTD_human
TgeneSLC34A2C0041755Adverse reaction to drug1CTD_human
TgeneSLC34A2C0155912Pulmonary Alveolar Microlithiasis1CTD_human;ORPHANET;UNIPROT