![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 34338 |
FusionGeneSummary for SLC34A2_EEA1 |
![]() |
Fusion gene information | Fusion gene name: SLC34A2_EEA1 | Fusion gene ID: 34338 | Hgene | Tgene | Gene symbol | SLC34A2 | EEA1 | Gene ID | 10568 | 8411 |
Gene name | solute carrier family 34 member 2 | early endosome antigen 1 | |
Synonyms | NAPI-3B|NAPI-IIb|NPTIIb | MST105|MSTP105|ZFYVE2 | |
Cytomap | 4p15.2 | 12q22 | |
Type of gene | protein-coding | protein-coding | |
Description | sodium-dependent phosphate transport protein 2Bsodium/phosphate cotransporter 2Bsolute carrier family 34 (sodium phosphate), member 2solute carrier family 34 (type II sodium/phosphate cotransporter), member 2type II sodium-dependent phosphate transpor | early endosome antigen 1early endosome antigen 1, 162kDearly endosome-associated proteinendosome-associated protein p162zinc finger FYVE domain-containing protein 2 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | O95436 | Q15075 | |
Ensembl transtripts involved in fusion gene | ENST00000504570, ENST00000382051, ENST00000503434, ENST00000510033, | ENST00000322349, ENST00000547833, | |
Fusion gene scores | * DoF score | 6 X 5 X 3=90 | 22 X 3 X 11=726 |
# samples | 11 | 20 | |
** MAII score | log2(11/90*10)=0.289506617194985 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(20/726*10)=-1.85996954822103 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SLC34A2 [Title/Abstract] AND EEA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SLC34A2 | GO:0006817 | phosphate ion transport | 10329428|10610722|12488042 |
Hgene | SLC34A2 | GO:0030643 | cellular phosphate ion homeostasis | 10610722 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-55-7727-01A | SLC34A2 | chr4 | 25680370 | + | EEA1 | chr12 | 93229203 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000504570 | ENST00000322349 | SLC34A2 | chr4 | 25680370 | + | EEA1 | chr12 | 93229203 | - |
intron-intron | ENST00000504570 | ENST00000547833 | SLC34A2 | chr4 | 25680370 | + | EEA1 | chr12 | 93229203 | - |
5CDS-intron | ENST00000382051 | ENST00000322349 | SLC34A2 | chr4 | 25680370 | + | EEA1 | chr12 | 93229203 | - |
5CDS-intron | ENST00000382051 | ENST00000547833 | SLC34A2 | chr4 | 25680370 | + | EEA1 | chr12 | 93229203 | - |
intron-intron | ENST00000503434 | ENST00000322349 | SLC34A2 | chr4 | 25680370 | + | EEA1 | chr12 | 93229203 | - |
intron-intron | ENST00000503434 | ENST00000547833 | SLC34A2 | chr4 | 25680370 | + | EEA1 | chr12 | 93229203 | - |
intron-intron | ENST00000510033 | ENST00000322349 | SLC34A2 | chr4 | 25680370 | + | EEA1 | chr12 | 93229203 | - |
intron-intron | ENST00000510033 | ENST00000547833 | SLC34A2 | chr4 | 25680370 | + | EEA1 | chr12 | 93229203 | - |
Top |
FusionProtFeatures for SLC34A2_EEA1 |
![]() |
Hgene | Tgene |
SLC34A2 | EEA1 |
May be involved in actively transporting phosphate intocells via Na(+) cotransport. It may be the main phosphatetransport protein in the intestinal brush border membrane. Mayhave a role in the synthesis of surfactant in lungs' alveoli. | Binds phospholipid vesicles containingphosphatidylinositol 3-phosphate and participates in endosomaltrafficking. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for SLC34A2_EEA1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for SLC34A2_EEA1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SLC34A2 | NUDCD1, PCDH10, KRIT1, ENDOD1, ZDHHC18, LMTK2, LINGO2, ATP6V0A1, KIAA1715, ATP11C, ATP6V0A2, SYNGR2, CACNA2D1, SLC30A7 | EEA1 | RAB22A, RAB5A, EEA1, STX12, NSF, RABEP1, RAB5C, IGF1R, PXK, PDCD6IP, RABGEF1, TNK2, VCP, ERBB2, CFTR, CCDC8, RNF2, BMI1, FCGR2A, PPP1R3C, MARS, PCNA, TP53, RRAD, NUPL1, MLLT6, SERPINB2, FUOM, BMP1, SNRNP27, TMA16, USP47, RAB31, PTPRQ, PIBF1, SNX27 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SLC34A2_EEA1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SLC34A2_EEA1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SLC34A2 | C0007131 | Non-Small Cell Lung Carcinoma | 2 | CTD_human |
Hgene | SLC34A2 | C0041755 | Adverse reaction to drug | 1 | CTD_human |
Hgene | SLC34A2 | C0155912 | Pulmonary Alveolar Microlithiasis | 1 | CTD_human;ORPHANET;UNIPROT |