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Fusion gene ID: 34337 |
FusionGeneSummary for SLC34A2_CLDN7 |
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Fusion gene information | Fusion gene name: SLC34A2_CLDN7 | Fusion gene ID: 34337 | Hgene | Tgene | Gene symbol | SLC34A2 | CLDN7 | Gene ID | 10568 | 1366 |
Gene name | solute carrier family 34 member 2 | claudin 7 | |
Synonyms | NAPI-3B|NAPI-IIb|NPTIIb | CEPTRL2|CLDN-7|CPETRL2|Hs.84359|claudin-1 | |
Cytomap | 4p15.2 | 17p13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | sodium-dependent phosphate transport protein 2Bsodium/phosphate cotransporter 2Bsolute carrier family 34 (sodium phosphate), member 2solute carrier family 34 (type II sodium/phosphate cotransporter), member 2type II sodium-dependent phosphate transpor | claudin-7clostridium perfringens enterotoxin receptor-like 2 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | O95436 | O95471 | |
Ensembl transtripts involved in fusion gene | ENST00000504570, ENST00000382051, ENST00000503434, ENST00000510033, | ENST00000360325, ENST00000538261, ENST00000397317, ENST00000571881, ENST00000573745, | |
Fusion gene scores | * DoF score | 6 X 5 X 3=90 | 5 X 1 X 4=20 |
# samples | 11 | 6 | |
** MAII score | log2(11/90*10)=0.289506617194985 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/20*10)=1.58496250072116 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SLC34A2 [Title/Abstract] AND CLDN7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SLC34A2 | GO:0006817 | phosphate ion transport | 10329428|10610722|12488042 |
Hgene | SLC34A2 | GO:0030643 | cellular phosphate ion homeostasis | 10610722 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | THCA | TCGA-FE-A231-01A | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
TCGA | RV | THCA | TCGA-IM-A3U3-01A | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000504570 | ENST00000360325 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
intron-intron | ENST00000504570 | ENST00000538261 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
intron-intron | ENST00000504570 | ENST00000397317 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
intron-intron | ENST00000504570 | ENST00000571881 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
intron-5UTR | ENST00000504570 | ENST00000573745 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
5CDS-intron | ENST00000382051 | ENST00000360325 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
5CDS-intron | ENST00000382051 | ENST00000538261 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
5CDS-intron | ENST00000382051 | ENST00000397317 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
5CDS-intron | ENST00000382051 | ENST00000571881 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
5CDS-5UTR | ENST00000382051 | ENST00000573745 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
intron-intron | ENST00000503434 | ENST00000360325 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
intron-intron | ENST00000503434 | ENST00000538261 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
intron-intron | ENST00000503434 | ENST00000397317 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
intron-intron | ENST00000503434 | ENST00000571881 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
intron-5UTR | ENST00000503434 | ENST00000573745 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
intron-intron | ENST00000510033 | ENST00000360325 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
intron-intron | ENST00000510033 | ENST00000538261 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
intron-intron | ENST00000510033 | ENST00000397317 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
intron-intron | ENST00000510033 | ENST00000571881 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
intron-5UTR | ENST00000510033 | ENST00000573745 | SLC34A2 | chr4 | 25680370 | + | CLDN7 | chr17 | 7166264 | - |
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FusionProtFeatures for SLC34A2_CLDN7 |
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Hgene | Tgene |
SLC34A2 | CLDN7 |
May be involved in actively transporting phosphate intocells via Na(+) cotransport. It may be the main phosphatetransport protein in the intestinal brush border membrane. Mayhave a role in the synthesis of surfactant in lungs' alveoli. | Plays a major role in tight junction-specificobliteration of the intercellular space. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLC34A2_CLDN7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLC34A2_CLDN7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SLC34A2 | NUDCD1, PCDH10, KRIT1, ENDOD1, ZDHHC18, LMTK2, LINGO2, ATP6V0A1, KIAA1715, ATP11C, ATP6V0A2, SYNGR2, CACNA2D1, SLC30A7 | CLDN7 | RHOXF2, TJP1, HGD, SYNE4, GLP1R, SCARB1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC34A2_CLDN7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC34A2_CLDN7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SLC34A2 | C0007131 | Non-Small Cell Lung Carcinoma | 2 | CTD_human |
Hgene | SLC34A2 | C0041755 | Adverse reaction to drug | 1 | CTD_human |
Hgene | SLC34A2 | C0155912 | Pulmonary Alveolar Microlithiasis | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | CLDN7 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | CLDN7 | C0677886 | Epithelial ovarian cancer | 1 | CTD_human |