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Fusion gene ID: 34335 |
FusionGeneSummary for SLC30A9_XRCC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLC30A9_XRCC2 | Fusion gene ID: 34335 | Hgene | Tgene | Gene symbol | SLC30A9 | XRCC2 | Gene ID | 10463 | 7516 |
| Gene name | solute carrier family 30 member 9 | X-ray repair cross complementing 2 | |
| Synonyms | BILAPES|C4orf1|GAC63|HUEL|ZNT9 | FANCU | |
| Cytomap | 4p13 | 7q36.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc transporter 9GRIP1-dependent nuclear receptor coactivatorexpressed in human embryonic lunghuman embryonic lung proteinsolute carrier family 30 (zinc transporter), member 9znT-9 | DNA repair protein XRCC2X-ray repair complementing defective repair in Chinese hamster cells 2X-ray repair cross-complementing protein 2 | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q6PML9 | O43543 | |
| Ensembl transtripts involved in fusion gene | ENST00000264451, | ENST00000495707, ENST00000359321, | |
| Fusion gene scores | * DoF score | 5 X 6 X 2=60 | 2 X 2 X 2=8 |
| # samples | 6 | 2 | |
| ** MAII score | log2(6/60*10)=0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: SLC30A9 [Title/Abstract] AND XRCC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | XRCC2 | GO:0042148 | strand invasion | 11834724 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BI060642 | SLC30A9 | chr4 | 42088862 | - | XRCC2 | chr7 | 152372503 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000264451 | ENST00000495707 | SLC30A9 | chr4 | 42088862 | - | XRCC2 | chr7 | 152372503 | + |
| 3UTR-intron | ENST00000264451 | ENST00000359321 | SLC30A9 | chr4 | 42088862 | - | XRCC2 | chr7 | 152372503 | + |
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FusionProtFeatures for SLC30A9_XRCC2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLC30A9 | XRCC2 |
| Acts as a zinc transporter involved in intracellularzinc homeostasis (PubMed:28334855). Functions as a secondarycoactivator for nuclear receptors by cooperating with p160coactivators subtypes. Plays a role in transcriptional activationof Wnt-responsive genes (By similarity).{ECO:0000250|UniProtKB:Q5IRJ6, ECO:0000269|PubMed:28334855}. | Involved in the homologous recombination repair (HRR)pathway of double-stranded DNA, thought to repair chromosomalfragmentation, translocations and deletions. Part of the Rad21paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream ofBRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 bindspredominantly to the intersection of the four duplex arms of theHolliday junction and to junction of replication forks. The BCDX2complex was originally reported to bind single-stranded DNA,single-stranded gaps in duplex DNA and specifically to nicks induplex DNA. {ECO:0000269|PubMed:11751635,ECO:0000269|PubMed:11834724, ECO:0000269|PubMed:21276791,ECO:0000269|PubMed:23149936, ECO:0000269|PubMed:27233470}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLC30A9_XRCC2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLC30A9_XRCC2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC30A9_XRCC2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC30A9_XRCC2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | XRCC2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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