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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34334

FusionGeneSummary for SLC30A9_SLC30A9

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC30A9_SLC30A9
Fusion gene ID: 34334
HgeneTgene
Gene symbol

SLC30A9

SLC30A9

Gene ID

10463

10463

Gene namesolute carrier family 30 member 9solute carrier family 30 member 9
SynonymsBILAPES|C4orf1|GAC63|HUEL|ZNT9BILAPES|C4orf1|GAC63|HUEL|ZNT9
Cytomap

4p13

4p13

Type of geneprotein-codingprotein-coding
Descriptionzinc transporter 9GRIP1-dependent nuclear receptor coactivatorexpressed in human embryonic lunghuman embryonic lung proteinsolute carrier family 30 (zinc transporter), member 9znT-9zinc transporter 9GRIP1-dependent nuclear receptor coactivatorexpressed in human embryonic lunghuman embryonic lung proteinsolute carrier family 30 (zinc transporter), member 9znT-9
Modification date2018051920180519
UniProtAcc

Q6PML9

Q6PML9

Ensembl transtripts involved in fusion geneENST00000264451, ENST00000264451, 
Fusion gene scores* DoF score5 X 6 X 2=603 X 5 X 3=45
# samples 64
** MAII scorelog2(6/60*10)=0log2(4/45*10)=-0.169925001442312
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC30A9 [Title/Abstract] AND SLC30A9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA721604SLC30A9chr4

42068638

+SLC30A9chr4

42069208

-
ChiTaRS3.1BM906216SLC30A9chr4

42088924

-SLC30A9chr4

42088945

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264451ENST00000264451SLC30A9chr4

42068638

+SLC30A9chr4

42069208

-
3UTR-3UTRENST00000264451ENST00000264451SLC30A9chr4

42088924

-SLC30A9chr4

42088945

+

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FusionProtFeatures for SLC30A9_SLC30A9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC30A9

Q6PML9

SLC30A9

Q6PML9

Acts as a zinc transporter involved in intracellularzinc homeostasis (PubMed:28334855). Functions as a secondarycoactivator for nuclear receptors by cooperating with p160coactivators subtypes. Plays a role in transcriptional activationof Wnt-responsive genes (By similarity).{ECO:0000250|UniProtKB:Q5IRJ6, ECO:0000269|PubMed:28334855}. Acts as a zinc transporter involved in intracellularzinc homeostasis (PubMed:28334855). Functions as a secondarycoactivator for nuclear receptors by cooperating with p160coactivators subtypes. Plays a role in transcriptional activationof Wnt-responsive genes (By similarity).{ECO:0000250|UniProtKB:Q5IRJ6, ECO:0000269|PubMed:28334855}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC30A9_SLC30A9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC30A9_SLC30A9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC30A9_SLC30A9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC30A9_SLC30A9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource