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Fusion gene ID: 34331 |
FusionGeneSummary for SLC30A9_HOXC6 |
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Fusion gene information | Fusion gene name: SLC30A9_HOXC6 | Fusion gene ID: 34331 | Hgene | Tgene | Gene symbol | SLC30A9 | HOXC6 | Gene ID | 10463 | 3223 |
Gene name | solute carrier family 30 member 9 | homeobox C6 | |
Synonyms | BILAPES|C4orf1|GAC63|HUEL|ZNT9 | CP25|HHO.C8|HOX3|HOX3C | |
Cytomap | 4p13 | 12q13.13 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc transporter 9GRIP1-dependent nuclear receptor coactivatorexpressed in human embryonic lunghuman embryonic lung proteinsolute carrier family 30 (zinc transporter), member 9znT-9 | homeobox protein Hox-C6homeo box 3Chomeo box C8 proteinhomeobox protein CP25homeobox protein HHO.C8homeobox protein Hox-3C | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q6PML9 | P09630 | |
Ensembl transtripts involved in fusion gene | ENST00000264451, | ENST00000394331, ENST00000243108, | |
Fusion gene scores | * DoF score | 5 X 6 X 2=60 | 2 X 2 X 1=4 |
# samples | 6 | 2 | |
** MAII score | log2(6/60*10)=0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: SLC30A9 [Title/Abstract] AND HOXC6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF802799 | SLC30A9 | chr4 | 42072675 | + | HOXC6 | chr12 | 54414157 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000264451 | ENST00000394331 | SLC30A9 | chr4 | 42072675 | + | HOXC6 | chr12 | 54414157 | - |
5CDS-intron | ENST00000264451 | ENST00000243108 | SLC30A9 | chr4 | 42072675 | + | HOXC6 | chr12 | 54414157 | - |
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FusionProtFeatures for SLC30A9_HOXC6 |
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Hgene | Tgene |
SLC30A9 | HOXC6 |
Acts as a zinc transporter involved in intracellularzinc homeostasis (PubMed:28334855). Functions as a secondarycoactivator for nuclear receptors by cooperating with p160coactivators subtypes. Plays a role in transcriptional activationof Wnt-responsive genes (By similarity).{ECO:0000250|UniProtKB:Q5IRJ6, ECO:0000269|PubMed:28334855}. | Sequence-specific transcription factor which is part ofa developmental regulatory system that provides cells withspecific positional identities on the anterior-posterior axis. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLC30A9_HOXC6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLC30A9_HOXC6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC30A9_HOXC6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC30A9_HOXC6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |