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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34329

FusionGeneSummary for SLC30A7_CMTM8

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC30A7_CMTM8
Fusion gene ID: 34329
HgeneTgene
Gene symbol

SLC30A7

CMTM8

Gene ID

148867

152189

Gene namesolute carrier family 30 member 7CKLF like MARVEL transmembrane domain containing 8
SynonymsZNT7|ZnT-7|ZnTL2CKLFSF8|CKLFSF8-V2
Cytomap

1p21.2

3p22.3

Type of geneprotein-codingprotein-coding
Descriptionzinc transporter 7solute carrier family 30 (zinc transporter), member 7zinc transporter ZnT-7zinc transporter like 2znt-like transporter 2CKLF-like MARVEL transmembrane domain-containing protein 8chemokine-like factor superfamily member 8
Modification date2018052320180523
UniProtAcc

Q8NEW0

Q8IZV2

Ensembl transtripts involved in fusion geneENST00000370112, ENST00000357650, 
ENST00000458535, ENST00000307526, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 1 X 2=4
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: SLC30A7 [Title/Abstract] AND CMTM8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-HC-8259-01ASLC30A7chr1

101362227

+CMTM8chr3

32409364

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000370112ENST00000458535SLC30A7chr1

101362227

+CMTM8chr3

32409364

+
Frame-shiftENST00000370112ENST00000307526SLC30A7chr1

101362227

+CMTM8chr3

32409364

+
Frame-shiftENST00000357650ENST00000458535SLC30A7chr1

101362227

+CMTM8chr3

32409364

+
Frame-shiftENST00000357650ENST00000307526SLC30A7chr1

101362227

+CMTM8chr3

32409364

+

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FusionProtFeatures for SLC30A7_CMTM8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC30A7

Q8NEW0

CMTM8

Q8IZV2

Seems to facilitate zinc transport from the cytoplasminto the Golgi apparatus. Partly regulates cellular zinchomeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zincinto the lumens of the Golgi apparatus and the vesicularcompartments where ALPs locate, thus, converting apoALPs toholoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP(By similarity). {ECO:0000250, ECO:0000269|PubMed:15276077,ECO:0000269|PubMed:15994300}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC30A7_CMTM8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC30A7_CMTM8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC30A7CD40, ELAVL1, RIC3, SPINT2, B3GNT3, P2RY12, LYPD3, WBP1, LPAR1, CHRNA9, CLPSL1, LYPD6, TCTN3, KATNA1, MRPL1, ST3GAL1, C12orf49, SLC34A2CMTM8TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC30A7_CMTM8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC30A7_CMTM8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC30A7C0014859Esophageal Neoplasms1CTD_human