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Fusion gene ID: 34329 |
FusionGeneSummary for SLC30A7_CMTM8 |
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Fusion gene information | Fusion gene name: SLC30A7_CMTM8 | Fusion gene ID: 34329 | Hgene | Tgene | Gene symbol | SLC30A7 | CMTM8 | Gene ID | 148867 | 152189 |
Gene name | solute carrier family 30 member 7 | CKLF like MARVEL transmembrane domain containing 8 | |
Synonyms | ZNT7|ZnT-7|ZnTL2 | CKLFSF8|CKLFSF8-V2 | |
Cytomap | 1p21.2 | 3p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc transporter 7solute carrier family 30 (zinc transporter), member 7zinc transporter ZnT-7zinc transporter like 2znt-like transporter 2 | CKLF-like MARVEL transmembrane domain-containing protein 8chemokine-like factor superfamily member 8 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8NEW0 | Q8IZV2 | |
Ensembl transtripts involved in fusion gene | ENST00000370112, ENST00000357650, | ENST00000458535, ENST00000307526, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 1 X 2=4 |
# samples | 2 | 2 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: SLC30A7 [Title/Abstract] AND CMTM8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-HC-8259-01A | SLC30A7 | chr1 | 101362227 | + | CMTM8 | chr3 | 32409364 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000370112 | ENST00000458535 | SLC30A7 | chr1 | 101362227 | + | CMTM8 | chr3 | 32409364 | + |
Frame-shift | ENST00000370112 | ENST00000307526 | SLC30A7 | chr1 | 101362227 | + | CMTM8 | chr3 | 32409364 | + |
Frame-shift | ENST00000357650 | ENST00000458535 | SLC30A7 | chr1 | 101362227 | + | CMTM8 | chr3 | 32409364 | + |
Frame-shift | ENST00000357650 | ENST00000307526 | SLC30A7 | chr1 | 101362227 | + | CMTM8 | chr3 | 32409364 | + |
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FusionProtFeatures for SLC30A7_CMTM8 |
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Hgene | Tgene |
SLC30A7 | CMTM8 |
Seems to facilitate zinc transport from the cytoplasminto the Golgi apparatus. Partly regulates cellular zinchomeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zincinto the lumens of the Golgi apparatus and the vesicularcompartments where ALPs locate, thus, converting apoALPs toholoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP(By similarity). {ECO:0000250, ECO:0000269|PubMed:15276077,ECO:0000269|PubMed:15994300}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLC30A7_CMTM8 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLC30A7_CMTM8 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SLC30A7 | CD40, ELAVL1, RIC3, SPINT2, B3GNT3, P2RY12, LYPD3, WBP1, LPAR1, CHRNA9, CLPSL1, LYPD6, TCTN3, KATNA1, MRPL1, ST3GAL1, C12orf49, SLC34A2 | CMTM8 | TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC30A7_CMTM8 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC30A7_CMTM8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SLC30A7 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |