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Fusion gene ID: 34316 |
FusionGeneSummary for SLC30A4_CLRN2 |
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Fusion gene information | Fusion gene name: SLC30A4_CLRN2 | Fusion gene ID: 34316 | Hgene | Tgene | Gene symbol | SLC30A4 | CLRN2 | Gene ID | 7782 | 645104 |
Gene name | solute carrier family 30 member 4 | clarin 2 | |
Synonyms | ZNT4|znT-4 | - | |
Cytomap | 15q21.1|15q21.1 | 4p15.32 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc transporter 4solute carrier family 30 (zinc transporter), member 4 | clarin-2 | |
Modification date | 20180523 | 20180329 | |
UniProtAcc | O14863 | A0PK11 | |
Ensembl transtripts involved in fusion gene | ENST00000261867, ENST00000559667, | ENST00000511148, | |
Fusion gene scores | * DoF score | 5 X 3 X 2=30 | 1 X 1 X 1=1 |
# samples | 5 | 1 | |
** MAII score | log2(5/30*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: SLC30A4 [Title/Abstract] AND CLRN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SLC30A4 | GO:0009636 | response to toxic substance | 17575980 |
Hgene | SLC30A4 | GO:0061088 | regulation of sequestering of zinc ion | 17349999 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-G9-6342-01A | SLC30A4 | chr15 | 45814162 | - | CLRN2 | chr4 | 17528440 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000261867 | ENST00000511148 | SLC30A4 | chr15 | 45814162 | - | CLRN2 | chr4 | 17528440 | + |
5UTR-3CDS | ENST00000559667 | ENST00000511148 | SLC30A4 | chr15 | 45814162 | - | CLRN2 | chr4 | 17528440 | + |
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FusionProtFeatures for SLC30A4_CLRN2 |
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Hgene | Tgene |
SLC30A4 | CLRN2 |
Probably involved in zinc transport out of thecytoplasm, maybe by sequestration into an intracellularcompartment. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLC30A4_CLRN2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLC30A4_CLRN2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SLC30A4 | CIAO1, YES1, BLK, NCAM1, COLEC12, EIF5, GNAO1, RBM25, RAP2A, PDS5B, PDS5A, NAPA, NOP9, PRPF40A, KIAA1524, GNB4, HBD, C19orf25, CSTF2, SPAG9, MLST8 | CLRN2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC30A4_CLRN2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC30A4_CLRN2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SLC30A4 | C0002395 | Alzheimer's Disease | 1 | CTD_human |
Hgene | SLC30A4 | C0035228 | Respiratory Hypersensitivity | 1 | CTD_human |
Hgene | SLC30A4 | C0036344 | Schizophrenia, Catatonic | 1 | PSYGENET |