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Fusion gene ID: 34315 |
FusionGeneSummary for SLC30A10_MEX3A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLC30A10_MEX3A | Fusion gene ID: 34315 | Hgene | Tgene | Gene symbol | SLC30A10 | MEX3A | Gene ID | 55532 | 92312 |
| Gene name | solute carrier family 30 member 10 | mex-3 RNA binding family member A | |
| Synonyms | HMDPC|HMNDYT1|ZNT10|ZNT8|ZRC1|ZnT-10 | MEX-3A|RKHD4|RNF162 | |
| Cytomap | 1q41 | 1q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | zinc transporter 10manganese transporter SLC30A10zinc transporter 8 | RNA-binding protein MEX3ARING finger and KH domain-containing protein 4ring finger and KH domain containing 4ring finger and KH domain containing protein | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q6XR72 | A1L020 | |
| Ensembl transtripts involved in fusion gene | ENST00000484079, ENST00000366926, ENST00000536446, ENST00000536992, | ENST00000532414, ENST00000442784, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 2 X 3=18 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SLC30A10 [Title/Abstract] AND MEX3A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SLC30A10 | GO:0007173 | epidermal growth factor receptor signaling pathway | 26728129 |
| Hgene | SLC30A10 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 26728129 |
| Hgene | SLC30A10 | GO:0071421 | manganese ion transmembrane transport | 25319704 |
| Hgene | SLC30A10 | GO:0071579 | regulation of zinc ion transport | 22427991|26728129 |
| Hgene | SLC30A10 | GO:1903427 | negative regulation of reactive oxygen species biosynthetic process | 22427991 |
| Hgene | SLC30A10 | GO:1904385 | cellular response to angiotensin | 22427991 |
| Hgene | SLC30A10 | GO:1905802 | regulation of cellular response to manganese ion | 25319704 |
| Hgene | SLC30A10 | GO:2000773 | negative regulation of cellular senescence | 22427991 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-CC-A1HT-01A | SLC30A10 | chr1 | 220100370 | - | MEX3A | chr1 | 156047473 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000484079 | ENST00000532414 | SLC30A10 | chr1 | 220100370 | - | MEX3A | chr1 | 156047473 | - |
| intron-5UTR | ENST00000484079 | ENST00000442784 | SLC30A10 | chr1 | 220100370 | - | MEX3A | chr1 | 156047473 | - |
| Frame-shift | ENST00000366926 | ENST00000532414 | SLC30A10 | chr1 | 220100370 | - | MEX3A | chr1 | 156047473 | - |
| 5CDS-5UTR | ENST00000366926 | ENST00000442784 | SLC30A10 | chr1 | 220100370 | - | MEX3A | chr1 | 156047473 | - |
| 5UTR-3CDS | ENST00000536446 | ENST00000532414 | SLC30A10 | chr1 | 220100370 | - | MEX3A | chr1 | 156047473 | - |
| 5UTR-5UTR | ENST00000536446 | ENST00000442784 | SLC30A10 | chr1 | 220100370 | - | MEX3A | chr1 | 156047473 | - |
| intron-3CDS | ENST00000536992 | ENST00000532414 | SLC30A10 | chr1 | 220100370 | - | MEX3A | chr1 | 156047473 | - |
| intron-5UTR | ENST00000536992 | ENST00000442784 | SLC30A10 | chr1 | 220100370 | - | MEX3A | chr1 | 156047473 | - |
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FusionProtFeatures for SLC30A10_MEX3A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLC30A10 | MEX3A |
| Plays a pivotal role in manganese transport. Manganeseis an essential cation for the function of several enzymes,including some crucially important for the metabolism ofneurotransmitters and other neuronal metabolic pathways. However,elevated levels of manganese are cytotoxic and induce oxidativestress, mitochondrial dysfunction and apoptosis. Acts as manganeseefflux transporter and confers protection against manganese-induced cell death (PubMed:22341972, PubMed:22341971,PubMed:25319704, PubMed:27226609, PubMed:27307044). Also acts aszinc transporter involved in zinc homeostasis. Seems to mediatezinc transport into early endosomes and recycling endosomes toprevent zinc toxicity; the function may be regulated byheterodimerization with other zinc transporters of the SLC30Asubfamily. The SLC30A3:SLC30A10 heterodimer is involved in zinctransport-dependent regulation of the EGFR/ERK transductionpathway in endosomes. May be involved in regulation of zinc-dependent senescence of vascular smooth muscle cells(PubMed:22706290, PubMed:22427991, PubMed:26728129).{ECO:0000269|PubMed:22341971, ECO:0000269|PubMed:22341972,ECO:0000269|PubMed:22427991, ECO:0000269|PubMed:25319704,ECO:0000269|PubMed:27226609, ECO:0000305|PubMed:22706290}. | RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLC30A10_MEX3A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLC30A10_MEX3A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SLC30A10 | MEX3A | PABPC1, NTRK1, ERP44, G3BP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC30A10_MEX3A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC30A10_MEX3A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SLC30A10 | C2750442 | Hypermanganesemia with Dystonia Polycythemia and Cirrhosis | 3 | CTD_human;ORPHANET;UNIPROT |
| Hgene | SLC30A10 | C0013421 | Dystonia | 1 | CTD_human;HPO |
| Hgene | SLC30A10 | C0023890 | Liver Cirrhosis | 1 | CTD_human;HPO |
| Hgene | SLC30A10 | C0030567 | Parkinson Disease | 1 | CTD_human |
| Hgene | SLC30A10 | C0032461 | Polycythemia | 1 | CTD_human;HPO |
| Hgene | SLC30A10 | C0242422 | Parkinsonian Disorders | 1 | CTD_human;HPO |
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