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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34315

FusionGeneSummary for SLC30A10_MEX3A

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC30A10_MEX3A
Fusion gene ID: 34315
HgeneTgene
Gene symbol

SLC30A10

MEX3A

Gene ID

55532

92312

Gene namesolute carrier family 30 member 10mex-3 RNA binding family member A
SynonymsHMDPC|HMNDYT1|ZNT10|ZNT8|ZRC1|ZnT-10MEX-3A|RKHD4|RNF162
Cytomap

1q41

1q22

Type of geneprotein-codingprotein-coding
Descriptionzinc transporter 10manganese transporter SLC30A10zinc transporter 8RNA-binding protein MEX3ARING finger and KH domain-containing protein 4ring finger and KH domain containing 4ring finger and KH domain containing protein
Modification date2018052320180522
UniProtAcc

Q6XR72

A1L020

Ensembl transtripts involved in fusion geneENST00000484079, ENST00000366926, 
ENST00000536446, ENST00000536992, 
ENST00000532414, ENST00000442784, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 2 X 3=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC30A10 [Title/Abstract] AND MEX3A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC30A10

GO:0007173

epidermal growth factor receptor signaling pathway

26728129

HgeneSLC30A10

GO:0070374

positive regulation of ERK1 and ERK2 cascade

26728129

HgeneSLC30A10

GO:0071421

manganese ion transmembrane transport

25319704

HgeneSLC30A10

GO:0071579

regulation of zinc ion transport

22427991|26728129

HgeneSLC30A10

GO:1903427

negative regulation of reactive oxygen species biosynthetic process

22427991

HgeneSLC30A10

GO:1904385

cellular response to angiotensin

22427991

HgeneSLC30A10

GO:1905802

regulation of cellular response to manganese ion

25319704

HgeneSLC30A10

GO:2000773

negative regulation of cellular senescence

22427991


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-CC-A1HT-01ASLC30A10chr1

220100370

-MEX3Achr1

156047473

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000484079ENST00000532414SLC30A10chr1

220100370

-MEX3Achr1

156047473

-
intron-5UTRENST00000484079ENST00000442784SLC30A10chr1

220100370

-MEX3Achr1

156047473

-
Frame-shitENST00000366926ENST00000532414SLC30A10chr1

220100370

-MEX3Achr1

156047473

-
5CDS-5UTRENST00000366926ENST00000442784SLC30A10chr1

220100370

-MEX3Achr1

156047473

-
5UTR-3CDSENST00000536446ENST00000532414SLC30A10chr1

220100370

-MEX3Achr1

156047473

-
5UTR-5UTRENST00000536446ENST00000442784SLC30A10chr1

220100370

-MEX3Achr1

156047473

-
intron-3CDSENST00000536992ENST00000532414SLC30A10chr1

220100370

-MEX3Achr1

156047473

-
intron-5UTRENST00000536992ENST00000442784SLC30A10chr1

220100370

-MEX3Achr1

156047473

-

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FusionProtFeatures for SLC30A10_MEX3A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC30A10

Q6XR72

MEX3A

A1L020

Plays a pivotal role in manganese transport. Manganeseis an essential cation for the function of several enzymes,including some crucially important for the metabolism ofneurotransmitters and other neuronal metabolic pathways. However,elevated levels of manganese are cytotoxic and induce oxidativestress, mitochondrial dysfunction and apoptosis. Acts as manganeseefflux transporter and confers protection against manganese-induced cell death (PubMed:22341972, PubMed:22341971,PubMed:25319704, PubMed:27226609, PubMed:27307044). Also acts aszinc transporter involved in zinc homeostasis. Seems to mediatezinc transport into early endosomes and recycling endosomes toprevent zinc toxicity; the function may be regulated byheterodimerization with other zinc transporters of the SLC30Asubfamily. The SLC30A3:SLC30A10 heterodimer is involved in zinctransport-dependent regulation of the EGFR/ERK transductionpathway in endosomes. May be involved in regulation of zinc-dependent senescence of vascular smooth muscle cells(PubMed:22706290, PubMed:22427991, PubMed:26728129).{ECO:0000269|PubMed:22341971, ECO:0000269|PubMed:22341972,ECO:0000269|PubMed:22427991, ECO:0000269|PubMed:25319704,ECO:0000269|PubMed:27226609, ECO:0000305|PubMed:22706290}. RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC30A10_MEX3A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC30A10_MEX3A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC30A10MEX3APABPC1, NTRK1, ERP44, G3BP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC30A10_MEX3A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC30A10_MEX3A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC30A10C2750442Hypermanganesemia with Dystonia Polycythemia and Cirrhosis3CTD_human;ORPHANET;UNIPROT
HgeneSLC30A10C0013421Dystonia1CTD_human;HPO
HgeneSLC30A10C0023890Liver Cirrhosis1CTD_human;HPO
HgeneSLC30A10C0030567Parkinson Disease1CTD_human
HgeneSLC30A10C0032461Polycythemia1CTD_human;HPO
HgeneSLC30A10C0242422Parkinsonian Disorders1CTD_human;HPO