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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionGeneSequence

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Fusion gene ID: 34314

FusionGeneSummary for SLC2A9_RAD51

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC2A9_RAD51
Fusion gene ID: 34314
HgeneTgene
Gene symbol

SLC2A9

RAD51

Gene ID

56606

5888

Gene namesolute carrier family 2 member 9RAD51 recombinase
SynonymsGLUT9|GLUTX|UAQTL2|URATv1BRCC5|FANCR|HRAD51|HsRad51|HsT16930|MRMV2|RAD51A|RECA
Cytomap

4p16.1

15q15.1

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 2, facilitated glucose transporter member 9GLUT-9glucose transporter type 9human glucose transporter-like protein-9solute carrier family 2 (facilitated glucose transporter), member 9urate voltage-driven efflux transporter 1DNA repair protein RAD51 homolog 1BRCA1/BRCA2-containing complex, subunit 5RAD51 homolog ARecA, E. coli, homolog ofRecA-like proteinrecombination protein A
Modification date2018052720180527
UniProtAcc

Q9NRM0

Q06609

Ensembl transtripts involved in fusion geneENST00000264784, ENST00000506583, 
ENST00000309065, ENST00000481042, 
ENST00000423169, ENST00000267868, 
ENST00000557850, ENST00000532743, 
ENST00000382643, ENST00000530766, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 3=27
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC2A9 [Title/Abstract] AND RAD51 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRAD51

GO:0000724

double-strand break repair via homologous recombination

16428451

TgeneRAD51

GO:0006268

DNA unwinding involved in DNA replication

7988572

TgeneRAD51

GO:0006974

cellular response to DNA damage stimulus

23509288|25585578

TgeneRAD51

GO:0010569

regulation of double-strand break repair via homologous recombination

23754376

TgeneRAD51

GO:0031297

replication fork processing

25585578

TgeneRAD51

GO:0051106

positive regulation of DNA ligation

8929543

TgeneRAD51

GO:0071479

cellular response to ionizing radiation

23509288|23754376

TgeneRAD51

GO:0072757

cellular response to camptothecin

23509288


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-DK-A3X1-01ASLC2A9chr4

10020599

-RAD51chr15

40998375

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000264784ENST00000423169SLC2A9chr4

10020599

-RAD51chr15

40998375

+
In-frameENST00000264784ENST00000267868SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000264784ENST00000557850SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000264784ENST00000532743SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000264784ENST00000382643SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000264784ENST00000530766SLC2A9chr4

10020599

-RAD51chr15

40998375

+
Frame-shiftENST00000506583ENST00000423169SLC2A9chr4

10020599

-RAD51chr15

40998375

+
Frame-shiftENST00000506583ENST00000267868SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000506583ENST00000557850SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000506583ENST00000532743SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000506583ENST00000382643SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000506583ENST00000530766SLC2A9chr4

10020599

-RAD51chr15

40998375

+
Frame-shiftENST00000309065ENST00000423169SLC2A9chr4

10020599

-RAD51chr15

40998375

+
Frame-shiftENST00000309065ENST00000267868SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000309065ENST00000557850SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000309065ENST00000532743SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000309065ENST00000382643SLC2A9chr4

10020599

-RAD51chr15

40998375

+
5CDS-intronENST00000309065ENST00000530766SLC2A9chr4

10020599

-RAD51chr15

40998375

+
intron-3CDSENST00000481042ENST00000423169SLC2A9chr4

10020599

-RAD51chr15

40998375

+
intron-3CDSENST00000481042ENST00000267868SLC2A9chr4

10020599

-RAD51chr15

40998375

+
intron-intronENST00000481042ENST00000557850SLC2A9chr4

10020599

-RAD51chr15

40998375

+
intron-intronENST00000481042ENST00000532743SLC2A9chr4

10020599

-RAD51chr15

40998375

+
intron-intronENST00000481042ENST00000382643SLC2A9chr4

10020599

-RAD51chr15

40998375

+
intron-intronENST00000481042ENST00000530766SLC2A9chr4

10020599

-RAD51chr15

40998375

+

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FusionProtFeatures for SLC2A9_RAD51


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC2A9

Q9NRM0

RAD51

Q06609

Transport urate and fructose. May have a role in theurate reabsorption by proximal tubules. Also transports glucose atlow rate. {ECO:0000269|PubMed:14739288,ECO:0000269|PubMed:18327257}. Plays an important role in homologous strand exchange, akey step in DNA repair through homologous recombination (HR)(PubMed:28575658). Binds to single and double-stranded DNA andexhibits DNA-dependent ATPase activity. Catalyzes the recognitionof homology and strand exchange between homologous DNA partners toform a joint molecule between a processed DNA break and the repairtemplate. Binds to single-stranded DNA in an ATP-dependent mannerto form nucleoprotein filaments which are essential for thehomology search and strand exchange (PubMed:26681308). Part of aPALB2-scaffolded HR complex containing BRCA2 and RAD51C and whichis thought to play a role in DNA repair by HR. Plays a role inregulating mitochondrial DNA copy number under conditions ofoxidative stress in the presence of RAD51C and XRCC3. Alsoinvolved in interstrand cross-link repair (PubMed:26253028).{ECO:0000269|PubMed:12205100, ECO:0000269|PubMed:12442171,ECO:0000269|PubMed:18417535, ECO:0000269|PubMed:20231364,ECO:0000269|PubMed:20348101, ECO:0000269|PubMed:20413593,ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376,ECO:0000269|PubMed:26253028, ECO:0000269|PubMed:26681308,ECO:0000269|PubMed:28575658}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-2121_5183541Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-3131_5154512Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-4141_5154512Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-21252_7283541TransmembraneHelical%3B Name%3D1
TgeneRAD51chr4:10020599chr15:40998375ENST00000382643+01048_77-50341DomainNote=HhH
TgeneRAD51chr4:10020599chr15:40998375ENST00000532743+01048_77-85341DomainNote=HhH
TgeneRAD51chr4:10020599chr15:40998375ENST00000557850+0848_77-86243DomainNote=HhH
TgeneRAD51chr4:10020599chr15:40998375ENST00000267868+210127_13475340Nucleotide bindingATP
TgeneRAD51chr4:10020599chr15:40998375ENST00000382643+010127_134-50341Nucleotide bindingATP
TgeneRAD51chr4:10020599chr15:40998375ENST00000423169+29127_13475281Nucleotide bindingATP
TgeneRAD51chr4:10020599chr15:40998375ENST00000532743+010127_134-85341Nucleotide bindingATP
TgeneRAD51chr4:10020599chr15:40998375ENST00000557850+08127_134-86243Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212327_33383541RegionMonosaccharide binding
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313327_33354512RegionMonosaccharide binding
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414327_33354512RegionMonosaccharide binding
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212129_14083541Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212162_17183541Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212193_20083541Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212222_23183541Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212253_31683541Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212338_35483541Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212376_38183541Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212403_41583541Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212437_45183541Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212473_47883541Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212500_54083541Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-21273_10783541Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313129_14054512Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313162_17154512Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313193_20054512Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313222_23154512Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313253_31654512Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313338_35454512Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313376_38154512Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313403_41554512Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313437_45154512Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313473_47854512Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313500_54054512Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-31373_10754512Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414129_14054512Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414162_17154512Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414193_20054512Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414222_23154512Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414253_31654512Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414338_35454512Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414376_38154512Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414403_41554512Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414437_45154512Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414473_47854512Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414500_54054512Topological domainCytoplasmic
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-41473_10754512Topological domainExtracellular
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212108_12883541TransmembraneHelical%3B Name%3D2
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212141_16183541TransmembraneHelical%3B Name%3D3
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212172_19283541TransmembraneHelical%3B Name%3D4
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212201_22183541TransmembraneHelical%3B Name%3D5
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212232_25283541TransmembraneHelical%3B Name%3D6
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212317_33783541TransmembraneHelical%3B Name%3D7
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212355_37583541TransmembraneHelical%3B Name%3D8
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212382_40283541TransmembraneHelical%3B Name%3D9
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212416_43683541TransmembraneHelical%3B Name%3D10
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212452_47283541TransmembraneHelical%3B Name%3D11
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000264784-212479_49983541TransmembraneHelical%3B Name%3D12
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313108_12854512TransmembraneHelical%3B Name%3D2
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313141_16154512TransmembraneHelical%3B Name%3D3
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313172_19254512TransmembraneHelical%3B Name%3D4
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313201_22154512TransmembraneHelical%3B Name%3D5
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313232_25254512TransmembraneHelical%3B Name%3D6
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313317_33754512TransmembraneHelical%3B Name%3D7
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313355_37554512TransmembraneHelical%3B Name%3D8
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313382_40254512TransmembraneHelical%3B Name%3D9
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313416_43654512TransmembraneHelical%3B Name%3D10
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313452_47254512TransmembraneHelical%3B Name%3D11
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-313479_49954512TransmembraneHelical%3B Name%3D12
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000309065-31352_7254512TransmembraneHelical%3B Name%3D1
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414108_12854512TransmembraneHelical%3B Name%3D2
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414141_16154512TransmembraneHelical%3B Name%3D3
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414172_19254512TransmembraneHelical%3B Name%3D4
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414201_22154512TransmembraneHelical%3B Name%3D5
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414232_25254512TransmembraneHelical%3B Name%3D6
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414317_33754512TransmembraneHelical%3B Name%3D7
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414355_37554512TransmembraneHelical%3B Name%3D8
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414382_40254512TransmembraneHelical%3B Name%3D9
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414416_43654512TransmembraneHelical%3B Name%3D10
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414452_47254512TransmembraneHelical%3B Name%3D11
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-414479_49954512TransmembraneHelical%3B Name%3D12
HgeneSLC2A9chr4:10020599chr15:40998375ENST00000506583-41452_7254512TransmembraneHelical%3B Name%3D1
TgeneRAD51chr4:10020599chr15:40998375ENST00000267868+21048_7775340DomainNote=HhH
TgeneRAD51chr4:10020599chr15:40998375ENST00000423169+2948_7775281DomainNote=HhH


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FusionGeneSequence for SLC2A9_RAD51


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SLC2A9_ENST00000264784_chr4_10020599_-_RAD51_ENST00000423169_chr15_40998375_+_289aa
MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNAPTPAEAAKLV
PMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLL
AVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEIVSE

>In-frame_SLC2A9_ENST00000264784_chr4_10020599_-_RAD51_ENST00000267868_chr15_40998375_+_348aa
MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNAPTPAEAAKLV
PMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLL
AVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SLC2A9_ENST00000264784_chr4_10020599_-_RAD51_ENST00000423169_chr15_40998375_+_867nt
ATGGCAAGGAAACAAAATAGGAATTCCAAGGAACTGGGCCTAGTTCCCCTCACAGATGACACCAGCCACGCCGGGCCTCCAGGGCCAGGG
AGGGCACTGCTGGAGTGTGACCACCTGAGGAGTGGGGTGCCAGGTGGAAGGAGAAGAAAGGACTGGTCCTGCTCGCTCCTCGTGGCCTCC
CTCGCGGGCGCCTTCGGCTCCTCCTTCCTCTACGGCTACAACCTGTCGGTGGTGAATGCCCCCACCCCGGCTGAGGCAGCTAAATTAGTT
CCAATGGGTTTCACCACTGCAACTGAATTCCACCAAAGGCGGTCAGAGATCATACAGATTACTACTGGCTCCAAAGAGCTTGACAAACTA
CTTCAAGGTGGAATTGAGACTGGATCTATCACAGAAATGTTTGGAGAATTCCGAACTGGGAAGACCCAGATCTGTCATACGCTAGCTGTC
ACCTGCCAGCTTCCCATTGACCGGGGTGGAGGTGAAGGAAAGGCCATGTACATTGACACTGAGGGTACCTTTAGGCCAGAACGGCTGCTG
GCAGTGGCTGAGAGGTATGGTCTCTCTGGCAGTGATGTCCTGGATAATGTAGCATATGCTCGAGCGTTCAACACAGACCACCAGACCCAG
CTCCTTTATCAAGCATCAGCCATGATGGTAGAATCTAGGTATGCACTGCTTATTGTAGACAGTGCCACCGCCCTTTACAGAACAGACTAC
TCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCACTTGGCCAGGTTTCTGCGGATGCTTCTGCGACTCGCTGATGAGATTGTATCTGAG

>In-frame_SLC2A9_ENST00000264784_chr4_10020599_-_RAD51_ENST00000267868_chr15_40998375_+_1044nt
ATGGCAAGGAAACAAAATAGGAATTCCAAGGAACTGGGCCTAGTTCCCCTCACAGATGACACCAGCCACGCCGGGCCTCCAGGGCCAGGG
AGGGCACTGCTGGAGTGTGACCACCTGAGGAGTGGGGTGCCAGGTGGAAGGAGAAGAAAGGACTGGTCCTGCTCGCTCCTCGTGGCCTCC
CTCGCGGGCGCCTTCGGCTCCTCCTTCCTCTACGGCTACAACCTGTCGGTGGTGAATGCCCCCACCCCGGCTGAGGCAGCTAAATTAGTT
CCAATGGGTTTCACCACTGCAACTGAATTCCACCAAAGGCGGTCAGAGATCATACAGATTACTACTGGCTCCAAAGAGCTTGACAAACTA
CTTCAAGGTGGAATTGAGACTGGATCTATCACAGAAATGTTTGGAGAATTCCGAACTGGGAAGACCCAGATCTGTCATACGCTAGCTGTC
ACCTGCCAGCTTCCCATTGACCGGGGTGGAGGTGAAGGAAAGGCCATGTACATTGACACTGAGGGTACCTTTAGGCCAGAACGGCTGCTG
GCAGTGGCTGAGAGGTATGGTCTCTCTGGCAGTGATGTCCTGGATAATGTAGCATATGCTCGAGCGTTCAACACAGACCACCAGACCCAG
CTCCTTTATCAAGCATCAGCCATGATGGTAGAATCTAGGTATGCACTGCTTATTGTAGACAGTGCCACCGCCCTTTACAGAACAGACTAC
TCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCACTTGGCCAGGTTTCTGCGGATGCTTCTGCGACTCGCTGATGAGTTTGGTGTAGCA
GTGGTAATCACTAATCAGGTGGTAGCTCAAGTGGATGGAGCAGCGATGTTTGCTGCTGATCCCAAAAAACCTATTGGAGGAAATATCATC
GCCCATGCATCAACAACCAGATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_SLC2A9_ENST00000264784_chr4_10020599_-_RAD51_ENST00000423169_chr15_40998375_+_1390nt
CTTGGCAGAGTCTGGGGTCCCTGGACTGAGCCATCAGCTGGGTCACTGAGACCCATGGCAAGGAAACAAAATAGGAATTCCAAGGAACTG
GGCCTAGTTCCCCTCACAGATGACACCAGCCACGCCGGGCCTCCAGGGCCAGGGAGGGCACTGCTGGAGTGTGACCACCTGAGGAGTGGG
GTGCCAGGTGGAAGGAGAAGAAAGGACTGGTCCTGCTCGCTCCTCGTGGCCTCCCTCGCGGGCGCCTTCGGCTCCTCCTTCCTCTACGGC
TACAACCTGTCGGTGGTGAATGCCCCCACCCCGGCTGAGGCAGCTAAATTAGTTCCAATGGGTTTCACCACTGCAACTGAATTCCACCAA
AGGCGGTCAGAGATCATACAGATTACTACTGGCTCCAAAGAGCTTGACAAACTACTTCAAGGTGGAATTGAGACTGGATCTATCACAGAA
ATGTTTGGAGAATTCCGAACTGGGAAGACCCAGATCTGTCATACGCTAGCTGTCACCTGCCAGCTTCCCATTGACCGGGGTGGAGGTGAA
GGAAAGGCCATGTACATTGACACTGAGGGTACCTTTAGGCCAGAACGGCTGCTGGCAGTGGCTGAGAGGTATGGTCTCTCTGGCAGTGAT
GTCCTGGATAATGTAGCATATGCTCGAGCGTTCAACACAGACCACCAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCT
AGGTATGCACTGCTTATTGTAGACAGTGCCACCGCCCTTTACAGAACAGACTACTCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCAC
TTGGCCAGGTTTCTGCGGATGCTTCTGCGACTCGCTGATGAGATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTA
CGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGATGGAGTGGGAGATGCCAAAGACTGAATCATTGGGTTTTT
CCTCTGTTAAAAACCTTAAGTGCTGCAGCCTAATGAGAGTGCACTGCTCCCTGGGGTTCTCTACAGGCCTCTTCCTGTTGTGACTGCCAG
GATAAAGCTTCCGGGAAAACAGCTATTATATCAGCTTTTCTGATGGTATAAACAGGAGACAGGTCAGTAGTCACAAACTGATCTAAAATG
TTTATTCCTTCTGTAGTGTATTAATCTCTGTGTGTTTTCTTTGGTTTTGGAGGAGGGGTATGAAGTATCTTTGACATGGTGCCTTAGGAA
TGACTTGGGTTTAACAAGCTGTCTACTGGACAATCTTATGTTTCCAAGAGAACTAAAGCTGGAGAGACCTGACCCTTCTCTCACTTCTAA

>In-frame_SLC2A9_ENST00000264784_chr4_10020599_-_RAD51_ENST00000267868_chr15_40998375_+_2076nt
CTTGGCAGAGTCTGGGGTCCCTGGACTGAGCCATCAGCTGGGTCACTGAGACCCATGGCAAGGAAACAAAATAGGAATTCCAAGGAACTG
GGCCTAGTTCCCCTCACAGATGACACCAGCCACGCCGGGCCTCCAGGGCCAGGGAGGGCACTGCTGGAGTGTGACCACCTGAGGAGTGGG
GTGCCAGGTGGAAGGAGAAGAAAGGACTGGTCCTGCTCGCTCCTCGTGGCCTCCCTCGCGGGCGCCTTCGGCTCCTCCTTCCTCTACGGC
TACAACCTGTCGGTGGTGAATGCCCCCACCCCGGCTGAGGCAGCTAAATTAGTTCCAATGGGTTTCACCACTGCAACTGAATTCCACCAA
AGGCGGTCAGAGATCATACAGATTACTACTGGCTCCAAAGAGCTTGACAAACTACTTCAAGGTGGAATTGAGACTGGATCTATCACAGAA
ATGTTTGGAGAATTCCGAACTGGGAAGACCCAGATCTGTCATACGCTAGCTGTCACCTGCCAGCTTCCCATTGACCGGGGTGGAGGTGAA
GGAAAGGCCATGTACATTGACACTGAGGGTACCTTTAGGCCAGAACGGCTGCTGGCAGTGGCTGAGAGGTATGGTCTCTCTGGCAGTGAT
GTCCTGGATAATGTAGCATATGCTCGAGCGTTCAACACAGACCACCAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCT
AGGTATGCACTGCTTATTGTAGACAGTGCCACCGCCCTTTACAGAACAGACTACTCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCAC
TTGGCCAGGTTTCTGCGGATGCTTCTGCGACTCGCTGATGAGTTTGGTGTAGCAGTGGTAATCACTAATCAGGTGGTAGCTCAAGTGGAT
GGAGCAGCGATGTTTGCTGCTGATCCCAAAAAACCTATTGGAGGAAATATCATCGCCCATGCATCAACAACCAGATTGTATCTGAGGAAA
GGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGATGGAGTG
GGAGATGCCAAAGACTGAATCATTGGGTTTTTCCTCTGTTAAAAACCTTAAGTGCTGCAGCCTAATGAGAGTGCACTGCTCCCTGGGGTT
CTCTACAGGCCTCTTCCTGTTGTGACTGCCAGGATAAAGCTTCCGGGAAAACAGCTATTATATCAGCTTTTCTGATGGTATAAACAGGAG
ACAGGTCAGTAGTCACAAACTGATCTAAAATGTTTATTCCTTCTGTAGTGTATTAATCTCTGTGTGTTTTCTTTGGTTTTGGAGGAGGGG
TATGAAGTATCTTTGACATGGTGCCTTAGGAATGACTTGGGTTTAACAAGCTGTCTACTGGACAATCTTATGTTTCCAAGAGAACTAAAG
CTGGAGAGACCTGACCCTTCTCTCACTTCTAAATTAATGGTAAAATAAAATGCCTCAGCTATGTAGCAAAGGGAATGGGTCTGCACAGAT
TCTTTTTTTCTGTCAGTAAAACTCTCAAGCAGGTTTTTAAGTTGTCTGTCTGAATGATCTTGTGTAAGGTTTTGGTTATGGAGTCTTGTG
CCAAACCTACTAGGCCATTAGCCCTTCACCATCTACCTGCTTGGTCTTTCATTGCTAAGACTAACTCAAGATAATCCTAGAGTCTTAAAG
CATTTCAGGCCAGTGTGGTGTCTTGCGCCTGTACTCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCGCTTGAGCCCAGGAGTTTTAAG
TCCAGCTTGGCCAAGGTGGTGAAATCCCATCTCTACAAAAAATGCAGAACTTAATCTGGACACACTGTTACACGTGCCTGTAGTCCCAGC
TACTCGATAGCCTGAGGTGGGAGAATCACTTAAGCCTGGAAGGTGGAAGTTGCAGTGAGTCGAGATTGCACTGCTGCATTCCAGCCAGGG
TGACAGAGTGAGACCATGTTTCAAACAAGAAACATTTCAGAGGGTAAGTAAACAGATTTGATTGTGAGGCTTCTAATAAAGTAGTTATTA


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FusionGenePPI for SLC2A9_RAD51


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC2A9TKTRAD51BRCA2, RAD51AP1, DMC1, EIF2D, CAB39, TIMM13, H2AFX, BRCA1, BARD1, BRE, BRCC3, TP53, ABL1, RAD52, BLM, RAD51, RAD51B, RAD51C, RAD51D, XRCC2, XRCC3, ATM, VIM, CHD3, RAD54B, ATRX, DNAJA3, SUMO1, UBE2I, RPA1, MSH4, RAD18, MCPH1, SP1, MDC1, PALB2, MORF4L1, POLN, WRN, UHRF2, MSH2, MSH6, TERF2IP, PML, SWI5, SFR1, RECQL5, CHEK1, SWSAP1, AICDA, RPA3, PFN1, FBXO18, UGDH, NXF1, HNRNPA2B1, HNRNPC, ZDHHC17, TEAD1, PDS5B, CDH13, CST6, FAM84B, IL24, ITIH5, NAT2, ST14, TFF1, WHSC1L1, NELFB, CSNK2B, HSP90AA1, MAPK8IP3, PCSK1N, SIRT2, UMPS, USP10, CDC42, IGBP1, MYH11, PPP3CB, RAB5C, LRP8, CBX4, SLC33A1, HMG20A, RNASEH2A, TUBGCP2, POLK, RTEL1, KIF21A, UGGT1, CDC73, CXXC4, ELMSAN1, NAF1, SGOL1, HMGXB4, CASP3, TUBG1, ESR1, FANCD2, PCNA, ERCC5, SHFM1, UCHL3, DUSP21, FIGNL1, SNX32, DNA2, HSFY1, PARPBP, TUBA1A, LMNB1, FANCA, SPTA1, WDR48, KEAP1, BCR, RFWD3, USP21, RNF115


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneRAD51chr4:10020599chr15:40998375ENST00000267868+210184_25775340PALB2
TgeneRAD51chr4:10020599chr15:40998375ENST00000382643+010184_257-50341PALB2
TgeneRAD51chr4:10020599chr15:40998375ENST00000423169+29184_25775281PALB2
TgeneRAD51chr4:10020599chr15:40998375ENST00000532743+010184_257-85341PALB2
TgeneRAD51chr4:10020599chr15:40998375ENST00000557850+08184_257-86243PALB2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC2A9_RAD51


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC2A9_RAD51


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC2A9C2677549Hypouricemia, Renal, 23CTD_human;UNIPROT
HgeneSLC2A9C0018099Gout2CTD_human
HgeneSLC2A9C0473219Renal hypouricemia2CTD_human;ORPHANET
HgeneSLC2A9C0740394Hyperuricemia1CTD_human
TgeneRAD51C0006142Malignant neoplasm of breast1UNIPROT
TgeneRAD51C0018671Head and Neck Neoplasms1CTD_human
TgeneRAD51C1449861Micronuclei, Chromosome-Defective1CTD_human