|
Fusion gene ID: 34307 |
FusionGeneSummary for SLC2A1_ELOVL1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: SLC2A1_ELOVL1 | Fusion gene ID: 34307 | Hgene | Tgene | Gene symbol | SLC2A1 | ELOVL1 | Gene ID | 6513 | 64834 |
Gene name | solute carrier family 2 member 1 | ELOVL fatty acid elongase 1 | |
Synonyms | CSE|DYT17|DYT18|DYT9|EIG12|GLUT|GLUT-1|GLUT1|GLUT1DS|HTLVR|PED|SDCHCN | CGI-88|Ssc1 | |
Cytomap | 1p34.2 | 1p34.2 | |
Type of gene | protein-coding | protein-coding | |
Description | solute carrier family 2, facilitated glucose transporter member 1choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)glucose transporter type 1, erythrocyte/brainhepG2 glucose transporterhuman T-cell leukemia virus (I and II) r | elongation of very long chain fatty acids protein 13-keto acyl-CoA synthase ELOVL1ELOVL FA elongase 1elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1very long chain 3-ketoacyl-CoA synthase 1very long chain 3-oxoacyl-CoA | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P11166 | Q9BW60 | |
Ensembl transtripts involved in fusion gene | ENST00000426263, ENST00000475162, ENST00000415851, ENST00000372500, | ENST00000372458, ENST00000413844, ENST00000470769, | |
Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 3 X 3 X 3=27 |
# samples | 4 | 3 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SLC2A1 [Title/Abstract] AND ELOVL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SLC2A1 | GO:0065003 | protein-containing complex assembly | 18347014 |
Hgene | SLC2A1 | GO:1904659 | glucose transmembrane transport | 18245775 |
Tgene | ELOVL1 | GO:0019367 | fatty acid elongation, saturated fatty acid | 20166112|20937905 |
Tgene | ELOVL1 | GO:0034625 | fatty acid elongation, monounsaturated fatty acid | 20166112 |
Tgene | ELOVL1 | GO:0042761 | very long-chain fatty acid biosynthetic process | 20166112|20937905 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-64-1679-01A | SLC2A1 | chr1 | 43424305 | - | ELOVL1 | chr1 | 43830465 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000426263 | ENST00000372458 | SLC2A1 | chr1 | 43424305 | - | ELOVL1 | chr1 | 43830465 | - |
In-frame | ENST00000426263 | ENST00000413844 | SLC2A1 | chr1 | 43424305 | - | ELOVL1 | chr1 | 43830465 | - |
5CDS-5UTR | ENST00000426263 | ENST00000470769 | SLC2A1 | chr1 | 43424305 | - | ELOVL1 | chr1 | 43830465 | - |
intron-3CDS | ENST00000475162 | ENST00000372458 | SLC2A1 | chr1 | 43424305 | - | ELOVL1 | chr1 | 43830465 | - |
intron-3CDS | ENST00000475162 | ENST00000413844 | SLC2A1 | chr1 | 43424305 | - | ELOVL1 | chr1 | 43830465 | - |
intron-5UTR | ENST00000475162 | ENST00000470769 | SLC2A1 | chr1 | 43424305 | - | ELOVL1 | chr1 | 43830465 | - |
In-frame | ENST00000415851 | ENST00000372458 | SLC2A1 | chr1 | 43424305 | - | ELOVL1 | chr1 | 43830465 | - |
In-frame | ENST00000415851 | ENST00000413844 | SLC2A1 | chr1 | 43424305 | - | ELOVL1 | chr1 | 43830465 | - |
5CDS-5UTR | ENST00000415851 | ENST00000470769 | SLC2A1 | chr1 | 43424305 | - | ELOVL1 | chr1 | 43830465 | - |
In-frame | ENST00000372500 | ENST00000372458 | SLC2A1 | chr1 | 43424305 | - | ELOVL1 | chr1 | 43830465 | - |
In-frame | ENST00000372500 | ENST00000413844 | SLC2A1 | chr1 | 43424305 | - | ELOVL1 | chr1 | 43830465 | - |
5CDS-5UTR | ENST00000372500 | ENST00000470769 | SLC2A1 | chr1 | 43424305 | - | ELOVL1 | chr1 | 43830465 | - |
Top |
FusionProtFeatures for SLC2A1_ELOVL1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
SLC2A1 | ELOVL1 |
Facilitative glucose transporter. This isoform may beresponsible for constitutive or basal glucose uptake. Has a verybroad substrate specificity; can transport a wide range of aldosesincluding both pentoses and hexoses. {ECO:0000269|PubMed:18245775,ECO:0000269|PubMed:19449892}. | Catalyzes the first and rate-limiting reaction of thefour that constitute the long-chain fatty acids elongation cycle.This endoplasmic reticulum-bound enzymatic process, allows theaddition of 2 carbons to the chain of long- and very long-chainfatty acids/VLCFAs per cycle. Condensing enzyme that exhibitsactivity toward saturated C18 to C26 acyl-CoA substrates, with thehighest activity towards C22:0 acyl-CoA. May participate in theproduction of both saturated and monounsaturated VLCFAs ofdifferent chain lengths that are involved in multiple biologicalprocesses as precursors of membrane lipids and lipid mediators.Important for saturated C24:0 and monounsaturated C24:1sphingolipid synthesis. Indirectly inhibits RPE65 via productionof VLCFAs. {ECO:0000255|HAMAP-Rule:MF_03201,ECO:0000269|PubMed:20166112, ECO:0000269|PubMed:20937905}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >ELOVL1 | chr1:43424305 | chr1:43830465 | ENST00000372458 | - | 3 | 8 | 275_279 | 106 | 280 | Motif | Di-lysine motif |
Tgene | >ELOVL1 | chr1:43424305 | chr1:43830465 | ENST00000413844 | - | 2 | 7 | 275_279 | 79 | 253 | Motif | Di-lysine motif |
Tgene | >ELOVL1 | chr1:43424305 | chr1:43830465 | ENST00000372458 | - | 3 | 8 | 110_130 | 106 | 280 | Transmembrane | Helical |
Tgene | >ELOVL1 | chr1:43424305 | chr1:43830465 | ENST00000372458 | - | 3 | 8 | 137_154 | 106 | 280 | Transmembrane | Helical |
Tgene | >ELOVL1 | chr1:43424305 | chr1:43830465 | ENST00000372458 | - | 3 | 8 | 176_196 | 106 | 280 | Transmembrane | Helical |
Tgene | >ELOVL1 | chr1:43424305 | chr1:43830465 | ENST00000372458 | - | 3 | 8 | 201_221 | 106 | 280 | Transmembrane | Helical |
Tgene | >ELOVL1 | chr1:43424305 | chr1:43830465 | ENST00000372458 | - | 3 | 8 | 231_251 | 106 | 280 | Transmembrane | Helical |
Tgene | >ELOVL1 | chr1:43424305 | chr1:43830465 | ENST00000413844 | - | 2 | 7 | 110_130 | 79 | 253 | Transmembrane | Helical |
Tgene | >ELOVL1 | chr1:43424305 | chr1:43830465 | ENST00000413844 | - | 2 | 7 | 137_154 | 79 | 253 | Transmembrane | Helical |
Tgene | >ELOVL1 | chr1:43424305 | chr1:43830465 | ENST00000413844 | - | 2 | 7 | 176_196 | 79 | 253 | Transmembrane | Helical |
Tgene | >ELOVL1 | chr1:43424305 | chr1:43830465 | ENST00000413844 | - | 2 | 7 | 201_221 | 79 | 253 | Transmembrane | Helical |
Tgene | >ELOVL1 | chr1:43424305 | chr1:43830465 | ENST00000413844 | - | 2 | 7 | 231_251 | 79 | 253 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 282_288 | 6 | 493 | Region | Note=Monosaccharide binding |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 113_120 | 6 | 493 | Topological domain | Extracellular |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 145_155 | 6 | 493 | Topological domain | Cytoplasmic |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 177_185 | 6 | 493 | Topological domain | Extracellular |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 1_11 | 6 | 493 | Topological domain | Cytoplasmic |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 207_271 | 6 | 493 | Topological domain | Cytoplasmic |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 294_306 | 6 | 493 | Topological domain | Extracellular |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 329_334 | 6 | 493 | Topological domain | Cytoplasmic |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 34_66 | 6 | 493 | Topological domain | Extracellular |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 356_365 | 6 | 493 | Topological domain | Extracellular |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 389_401 | 6 | 493 | Topological domain | Cytoplasmic |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 423_429 | 6 | 493 | Topological domain | Extracellular |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 451_492 | 6 | 493 | Topological domain | Cytoplasmic |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 88_90 | 6 | 493 | Topological domain | Cytoplasmic |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 121_144 | 6 | 493 | Transmembrane | Note=Helical%3B Name%3D4 |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 12_33 | 6 | 493 | Transmembrane | Note=Helical%3B Name%3D1 |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 156_176 | 6 | 493 | Transmembrane | Note=Helical%3B Name%3D5 |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 186_206 | 6 | 493 | Transmembrane | Note=Helical%3B Name%3D6 |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 272_293 | 6 | 493 | Transmembrane | Note=Helical%3B Name%3D7 |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 307_328 | 6 | 493 | Transmembrane | Note=Helical%3B Name%3D8 |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 335_355 | 6 | 493 | Transmembrane | Note=Helical%3B Name%3D9 |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 366_388 | 6 | 493 | Transmembrane | Note=Helical%3B Name%3D10 |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 402_422 | 6 | 493 | Transmembrane | Note=Helical%3B Name%3D11 |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 430_450 | 6 | 493 | Transmembrane | Note=Helical%3B Name%3D12 |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 67_87 | 6 | 493 | Transmembrane | Note=Helical%3B Name%3D2 |
Hgene | >SLC2A1 | chr1:43424305 | chr1:43830465 | ENST00000426263 | - | 1 | 10 | 91_112 | 6 | 493 | Transmembrane | Note=Helical%3B Name%3D3 |
Tgene | ELOVL1 | chr1:43424305 | chr1:43830465 | ENST00000372458 | - | 3 | 8 | 23_43 | 106 | 280 | Transmembrane | Helical |
Tgene | ELOVL1 | chr1:43424305 | chr1:43830465 | ENST00000372458 | - | 3 | 8 | 61_81 | 106 | 280 | Transmembrane | Helical |
Tgene | ELOVL1 | chr1:43424305 | chr1:43830465 | ENST00000413844 | - | 2 | 7 | 23_43 | 79 | 253 | Transmembrane | Helical |
Tgene | ELOVL1 | chr1:43424305 | chr1:43830465 | ENST00000413844 | - | 2 | 7 | 61_81 | 79 | 253 | Transmembrane | Helical |
Top |
FusionGeneSequence for SLC2A1_ELOVL1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_SLC2A1_ENST00000426263_chr1_43424305_-_ELOVL1_ENST00000372458_chr1_43830465_-_180aa MEPSSKMVRVAWLFLFSKFIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYLYYGLSAFGPV AQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYGTIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKANX >In-frame_SLC2A1_ENST00000426263_chr1_43424305_-_ELOVL1_ENST00000413844_chr1_43830465_-_180aa MEPSSKMVRVAWLFLFSKFIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYLYYGLSAFGPV AQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYGTIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKANX >In-frame_SLC2A1_ENST00000415851_chr1_43424305_-_ELOVL1_ENST00000372458_chr1_43830465_-_180aa MEPSSKMVRVAWLFLFSKFIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYLYYGLSAFGPV AQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYGTIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKANX >In-frame_SLC2A1_ENST00000415851_chr1_43424305_-_ELOVL1_ENST00000413844_chr1_43830465_-_180aa MEPSSKMVRVAWLFLFSKFIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYLYYGLSAFGPV AQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYGTIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKANX >In-frame_SLC2A1_ENST00000372500_chr1_43424305_-_ELOVL1_ENST00000372458_chr1_43830465_-_180aa MEPSSKMVRVAWLFLFSKFIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYLYYGLSAFGPV AQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYGTIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKANX >In-frame_SLC2A1_ENST00000372500_chr1_43424305_-_ELOVL1_ENST00000413844_chr1_43830465_-_180aa MEPSSKMVRVAWLFLFSKFIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYLYYGLSAFGPV AQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYGTIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKANX |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_SLC2A1_ENST00000426263_chr1_43424305_-_ELOVL1_ENST00000372458_chr1_43830465_-_540nt ATGGAGCCCAGCAGCAAGATGGTTCGGGTGGCCTGGCTCTTCCTCTTCTCCAAGTTCATTGAGCTGATGGACACAGTGATCTTTATTCTC CGAAAGAAAGACGGGCAGGTGACCTTCCTACATGTCTTCCATCACTCTGTGCTTCCCTGGAGCTGGTGGTGGGGGGTAAAGATTGCCCCG GGAGGAATGGGCTCTTTCCATGCCATGATAAACTCTTCCGTGCATGTCATAATGTACCTGTACTACGGATTATCTGCCTTTGGCCCTGTG GCACAACCCTACCTTTGGTGGAAAAAGCACATGACAGCCATTCAGCTGATCCAGTTTGTCCTGGTCTCACTGCACATCTCCCAGTACTAC TTTATGTCCAGCTGTAACTACCAGTACCCAGTCATTATTCACCTCATCTGGATGTATGGCACCATCTTCTTCATGCTGTTCTCCAACTTC TGGTATCACTCTTATACCAAGGGCAAGCGGCTGCCCCGTGCACTTCAGCAAAATGGAGCTCCAGGTATTGCCAAGGTCAAGGCCAACTGA >In-frame_SLC2A1_ENST00000426263_chr1_43424305_-_ELOVL1_ENST00000413844_chr1_43830465_-_540nt ATGGAGCCCAGCAGCAAGATGGTTCGGGTGGCCTGGCTCTTCCTCTTCTCCAAGTTCATTGAGCTGATGGACACAGTGATCTTTATTCTC CGAAAGAAAGACGGGCAGGTGACCTTCCTACATGTCTTCCATCACTCTGTGCTTCCCTGGAGCTGGTGGTGGGGGGTAAAGATTGCCCCG GGAGGAATGGGCTCTTTCCATGCCATGATAAACTCTTCCGTGCATGTCATAATGTACCTGTACTACGGATTATCTGCCTTTGGCCCTGTG GCACAACCCTACCTTTGGTGGAAAAAGCACATGACAGCCATTCAGCTGATCCAGTTTGTCCTGGTCTCACTGCACATCTCCCAGTACTAC TTTATGTCCAGCTGTAACTACCAGTACCCAGTCATTATTCACCTCATCTGGATGTATGGCACCATCTTCTTCATGCTGTTCTCCAACTTC TGGTATCACTCTTATACCAAGGGCAAGCGGCTGCCCCGTGCACTTCAGCAAAATGGAGCTCCAGGTATTGCCAAGGTCAAGGCCAACTGA >In-frame_SLC2A1_ENST00000415851_chr1_43424305_-_ELOVL1_ENST00000372458_chr1_43830465_-_540nt ATGGAGCCCAGCAGCAAGATGGTTCGGGTGGCCTGGCTCTTCCTCTTCTCCAAGTTCATTGAGCTGATGGACACAGTGATCTTTATTCTC CGAAAGAAAGACGGGCAGGTGACCTTCCTACATGTCTTCCATCACTCTGTGCTTCCCTGGAGCTGGTGGTGGGGGGTAAAGATTGCCCCG GGAGGAATGGGCTCTTTCCATGCCATGATAAACTCTTCCGTGCATGTCATAATGTACCTGTACTACGGATTATCTGCCTTTGGCCCTGTG GCACAACCCTACCTTTGGTGGAAAAAGCACATGACAGCCATTCAGCTGATCCAGTTTGTCCTGGTCTCACTGCACATCTCCCAGTACTAC TTTATGTCCAGCTGTAACTACCAGTACCCAGTCATTATTCACCTCATCTGGATGTATGGCACCATCTTCTTCATGCTGTTCTCCAACTTC TGGTATCACTCTTATACCAAGGGCAAGCGGCTGCCCCGTGCACTTCAGCAAAATGGAGCTCCAGGTATTGCCAAGGTCAAGGCCAACTGA >In-frame_SLC2A1_ENST00000415851_chr1_43424305_-_ELOVL1_ENST00000413844_chr1_43830465_-_540nt ATGGAGCCCAGCAGCAAGATGGTTCGGGTGGCCTGGCTCTTCCTCTTCTCCAAGTTCATTGAGCTGATGGACACAGTGATCTTTATTCTC CGAAAGAAAGACGGGCAGGTGACCTTCCTACATGTCTTCCATCACTCTGTGCTTCCCTGGAGCTGGTGGTGGGGGGTAAAGATTGCCCCG GGAGGAATGGGCTCTTTCCATGCCATGATAAACTCTTCCGTGCATGTCATAATGTACCTGTACTACGGATTATCTGCCTTTGGCCCTGTG GCACAACCCTACCTTTGGTGGAAAAAGCACATGACAGCCATTCAGCTGATCCAGTTTGTCCTGGTCTCACTGCACATCTCCCAGTACTAC TTTATGTCCAGCTGTAACTACCAGTACCCAGTCATTATTCACCTCATCTGGATGTATGGCACCATCTTCTTCATGCTGTTCTCCAACTTC TGGTATCACTCTTATACCAAGGGCAAGCGGCTGCCCCGTGCACTTCAGCAAAATGGAGCTCCAGGTATTGCCAAGGTCAAGGCCAACTGA >In-frame_SLC2A1_ENST00000372500_chr1_43424305_-_ELOVL1_ENST00000372458_chr1_43830465_-_540nt ATGGAGCCCAGCAGCAAGATGGTTCGGGTGGCCTGGCTCTTCCTCTTCTCCAAGTTCATTGAGCTGATGGACACAGTGATCTTTATTCTC CGAAAGAAAGACGGGCAGGTGACCTTCCTACATGTCTTCCATCACTCTGTGCTTCCCTGGAGCTGGTGGTGGGGGGTAAAGATTGCCCCG GGAGGAATGGGCTCTTTCCATGCCATGATAAACTCTTCCGTGCATGTCATAATGTACCTGTACTACGGATTATCTGCCTTTGGCCCTGTG GCACAACCCTACCTTTGGTGGAAAAAGCACATGACAGCCATTCAGCTGATCCAGTTTGTCCTGGTCTCACTGCACATCTCCCAGTACTAC TTTATGTCCAGCTGTAACTACCAGTACCCAGTCATTATTCACCTCATCTGGATGTATGGCACCATCTTCTTCATGCTGTTCTCCAACTTC TGGTATCACTCTTATACCAAGGGCAAGCGGCTGCCCCGTGCACTTCAGCAAAATGGAGCTCCAGGTATTGCCAAGGTCAAGGCCAACTGA >In-frame_SLC2A1_ENST00000372500_chr1_43424305_-_ELOVL1_ENST00000413844_chr1_43830465_-_540nt ATGGAGCCCAGCAGCAAGATGGTTCGGGTGGCCTGGCTCTTCCTCTTCTCCAAGTTCATTGAGCTGATGGACACAGTGATCTTTATTCTC CGAAAGAAAGACGGGCAGGTGACCTTCCTACATGTCTTCCATCACTCTGTGCTTCCCTGGAGCTGGTGGTGGGGGGTAAAGATTGCCCCG GGAGGAATGGGCTCTTTCCATGCCATGATAAACTCTTCCGTGCATGTCATAATGTACCTGTACTACGGATTATCTGCCTTTGGCCCTGTG GCACAACCCTACCTTTGGTGGAAAAAGCACATGACAGCCATTCAGCTGATCCAGTTTGTCCTGGTCTCACTGCACATCTCCCAGTACTAC TTTATGTCCAGCTGTAACTACCAGTACCCAGTCATTATTCACCTCATCTGGATGTATGGCACCATCTTCTTCATGCTGTTCTCCAACTTC TGGTATCACTCTTATACCAAGGGCAAGCGGCTGCCCCGTGCACTTCAGCAAAATGGAGCTCCAGGTATTGCCAAGGTCAAGGCCAACTGA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_SLC2A1_ENST00000426263_chr1_43424305_-_ELOVL1_ENST00000372458_chr1_43830465_-_1238nt TAGTCGCGGGTCCCCGAGTGAGCACGCCAGGGAGCAGGAGACCAAACGACGGGGGTCGGAGTCAGAGTCGCAGTGGGAGTCCCCGGACCG GAGCACGAGCCTGAGCGGGAGAGCGCCGCTCGCACGCCCGTCGCCACCCGCGTACCCGGCGCAGCCAGAGCCACCAGCGCAGCGCTGCCA TGGAGCCCAGCAGCAAGATGGTTCGGGTGGCCTGGCTCTTCCTCTTCTCCAAGTTCATTGAGCTGATGGACACAGTGATCTTTATTCTCC GAAAGAAAGACGGGCAGGTGACCTTCCTACATGTCTTCCATCACTCTGTGCTTCCCTGGAGCTGGTGGTGGGGGGTAAAGATTGCCCCGG GAGGAATGGGCTCTTTCCATGCCATGATAAACTCTTCCGTGCATGTCATAATGTACCTGTACTACGGATTATCTGCCTTTGGCCCTGTGG CACAACCCTACCTTTGGTGGAAAAAGCACATGACAGCCATTCAGCTGATCCAGTTTGTCCTGGTCTCACTGCACATCTCCCAGTACTACT TTATGTCCAGCTGTAACTACCAGTACCCAGTCATTATTCACCTCATCTGGATGTATGGCACCATCTTCTTCATGCTGTTCTCCAACTTCT GGTATCACTCTTATACCAAGGGCAAGCGGCTGCCCCGTGCACTTCAGCAAAATGGAGCTCCAGGTATTGCCAAGGTCAAGGCCAACTGAG AAGCATGGCCTAGATAGGCGCCCACCTAAGTGCCTCAGGACTGCACCTTAGGGCAGTGTCCGTCAGTGCCCTCTCCACCTACACCTGTGA CCAAGGCTTATGTGGTCAGGACTGAGCAGGGGACTGGCCCTCCCCTCCCCACAGCTGCTCTACAGGGACCACGGCTTTGGTTCCTCACCC ACTTCCCCCGGGCAGCTCCAGGGATGTGGCCTCATTGCTGTCTGCCACTCCAGAGCTGGGGGCTAAAAGGGCTGTACAGTTATTTCCCCC TCCCTGCCTTAAAACTTGGGAGAGGAGCACTCAGGGCTGGCCCCACAAAGGGTCTCGTGGCCTTTTTCCTCACACAGAAGAGGTCAGCAA TAATGTCACTGTGGACCCAGTCTCACTCCTCCACCCCACACACTGAAGCAGTAGCTTCTGGGCCAAAGGTCAGGGTGGGCGGGGGCCTGG >In-frame_SLC2A1_ENST00000426263_chr1_43424305_-_ELOVL1_ENST00000413844_chr1_43830465_-_1233nt TAGTCGCGGGTCCCCGAGTGAGCACGCCAGGGAGCAGGAGACCAAACGACGGGGGTCGGAGTCAGAGTCGCAGTGGGAGTCCCCGGACCG GAGCACGAGCCTGAGCGGGAGAGCGCCGCTCGCACGCCCGTCGCCACCCGCGTACCCGGCGCAGCCAGAGCCACCAGCGCAGCGCTGCCA TGGAGCCCAGCAGCAAGATGGTTCGGGTGGCCTGGCTCTTCCTCTTCTCCAAGTTCATTGAGCTGATGGACACAGTGATCTTTATTCTCC GAAAGAAAGACGGGCAGGTGACCTTCCTACATGTCTTCCATCACTCTGTGCTTCCCTGGAGCTGGTGGTGGGGGGTAAAGATTGCCCCGG GAGGAATGGGCTCTTTCCATGCCATGATAAACTCTTCCGTGCATGTCATAATGTACCTGTACTACGGATTATCTGCCTTTGGCCCTGTGG CACAACCCTACCTTTGGTGGAAAAAGCACATGACAGCCATTCAGCTGATCCAGTTTGTCCTGGTCTCACTGCACATCTCCCAGTACTACT TTATGTCCAGCTGTAACTACCAGTACCCAGTCATTATTCACCTCATCTGGATGTATGGCACCATCTTCTTCATGCTGTTCTCCAACTTCT GGTATCACTCTTATACCAAGGGCAAGCGGCTGCCCCGTGCACTTCAGCAAAATGGAGCTCCAGGTATTGCCAAGGTCAAGGCCAACTGAG AAGCATGGCCTAGATAGGCGCCCACCTAAGTGCCTCAGGACTGCACCTTAGGGCAGTGTCCGTCAGTGCCCTCTCCACCTACACCTGTGA CCAAGGCTTATGTGGTCAGGACTGAGCAGGGGACTGGCCCTCCCCTCCCCACAGCTGCTCTACAGGGACCACGGCTTTGGTTCCTCACCC ACTTCCCCCGGGCAGCTCCAGGGATGTGGCCTCATTGCTGTCTGCCACTCCAGAGCTGGGGGCTAAAAGGGCTGTACAGTTATTTCCCCC TCCCTGCCTTAAAACTTGGGAGAGGAGCACTCAGGGCTGGCCCCACAAAGGGTCTCGTGGCCTTTTTCCTCACACAGAAGAGGTCAGCAA TAATGTCACTGTGGACCCAGTCTCACTCCTCCACCCCACACACTGAAGCAGTAGCTTCTGGGCCAAAGGTCAGGGTGGGCGGGGGCCTGG >In-frame_SLC2A1_ENST00000415851_chr1_43424305_-_ELOVL1_ENST00000372458_chr1_43830465_-_1237nt AGTCGCGGGTCCCCGAGTGAGCACGCCAGGGAGCAGGAGACCAAACGACGGGGGTCGGAGTCAGAGTCGCAGTGGGAGTCCCCGGACCGG AGCACGAGCCTGAGCGGGAGAGCGCCGCTCGCACGCCCGTCGCCACCCGCGTACCCGGCGCAGCCAGAGCCACCAGCGCAGCGCTGCCAT GGAGCCCAGCAGCAAGATGGTTCGGGTGGCCTGGCTCTTCCTCTTCTCCAAGTTCATTGAGCTGATGGACACAGTGATCTTTATTCTCCG AAAGAAAGACGGGCAGGTGACCTTCCTACATGTCTTCCATCACTCTGTGCTTCCCTGGAGCTGGTGGTGGGGGGTAAAGATTGCCCCGGG AGGAATGGGCTCTTTCCATGCCATGATAAACTCTTCCGTGCATGTCATAATGTACCTGTACTACGGATTATCTGCCTTTGGCCCTGTGGC ACAACCCTACCTTTGGTGGAAAAAGCACATGACAGCCATTCAGCTGATCCAGTTTGTCCTGGTCTCACTGCACATCTCCCAGTACTACTT TATGTCCAGCTGTAACTACCAGTACCCAGTCATTATTCACCTCATCTGGATGTATGGCACCATCTTCTTCATGCTGTTCTCCAACTTCTG GTATCACTCTTATACCAAGGGCAAGCGGCTGCCCCGTGCACTTCAGCAAAATGGAGCTCCAGGTATTGCCAAGGTCAAGGCCAACTGAGA AGCATGGCCTAGATAGGCGCCCACCTAAGTGCCTCAGGACTGCACCTTAGGGCAGTGTCCGTCAGTGCCCTCTCCACCTACACCTGTGAC CAAGGCTTATGTGGTCAGGACTGAGCAGGGGACTGGCCCTCCCCTCCCCACAGCTGCTCTACAGGGACCACGGCTTTGGTTCCTCACCCA CTTCCCCCGGGCAGCTCCAGGGATGTGGCCTCATTGCTGTCTGCCACTCCAGAGCTGGGGGCTAAAAGGGCTGTACAGTTATTTCCCCCT CCCTGCCTTAAAACTTGGGAGAGGAGCACTCAGGGCTGGCCCCACAAAGGGTCTCGTGGCCTTTTTCCTCACACAGAAGAGGTCAGCAAT AATGTCACTGTGGACCCAGTCTCACTCCTCCACCCCACACACTGAAGCAGTAGCTTCTGGGCCAAAGGTCAGGGTGGGCGGGGGCCTGGG >In-frame_SLC2A1_ENST00000415851_chr1_43424305_-_ELOVL1_ENST00000413844_chr1_43830465_-_1232nt AGTCGCGGGTCCCCGAGTGAGCACGCCAGGGAGCAGGAGACCAAACGACGGGGGTCGGAGTCAGAGTCGCAGTGGGAGTCCCCGGACCGG AGCACGAGCCTGAGCGGGAGAGCGCCGCTCGCACGCCCGTCGCCACCCGCGTACCCGGCGCAGCCAGAGCCACCAGCGCAGCGCTGCCAT GGAGCCCAGCAGCAAGATGGTTCGGGTGGCCTGGCTCTTCCTCTTCTCCAAGTTCATTGAGCTGATGGACACAGTGATCTTTATTCTCCG AAAGAAAGACGGGCAGGTGACCTTCCTACATGTCTTCCATCACTCTGTGCTTCCCTGGAGCTGGTGGTGGGGGGTAAAGATTGCCCCGGG AGGAATGGGCTCTTTCCATGCCATGATAAACTCTTCCGTGCATGTCATAATGTACCTGTACTACGGATTATCTGCCTTTGGCCCTGTGGC ACAACCCTACCTTTGGTGGAAAAAGCACATGACAGCCATTCAGCTGATCCAGTTTGTCCTGGTCTCACTGCACATCTCCCAGTACTACTT TATGTCCAGCTGTAACTACCAGTACCCAGTCATTATTCACCTCATCTGGATGTATGGCACCATCTTCTTCATGCTGTTCTCCAACTTCTG GTATCACTCTTATACCAAGGGCAAGCGGCTGCCCCGTGCACTTCAGCAAAATGGAGCTCCAGGTATTGCCAAGGTCAAGGCCAACTGAGA AGCATGGCCTAGATAGGCGCCCACCTAAGTGCCTCAGGACTGCACCTTAGGGCAGTGTCCGTCAGTGCCCTCTCCACCTACACCTGTGAC CAAGGCTTATGTGGTCAGGACTGAGCAGGGGACTGGCCCTCCCCTCCCCACAGCTGCTCTACAGGGACCACGGCTTTGGTTCCTCACCCA CTTCCCCCGGGCAGCTCCAGGGATGTGGCCTCATTGCTGTCTGCCACTCCAGAGCTGGGGGCTAAAAGGGCTGTACAGTTATTTCCCCCT CCCTGCCTTAAAACTTGGGAGAGGAGCACTCAGGGCTGGCCCCACAAAGGGTCTCGTGGCCTTTTTCCTCACACAGAAGAGGTCAGCAAT AATGTCACTGTGGACCCAGTCTCACTCCTCCACCCCACACACTGAAGCAGTAGCTTCTGGGCCAAAGGTCAGGGTGGGCGGGGGCCTGGG >In-frame_SLC2A1_ENST00000372500_chr1_43424305_-_ELOVL1_ENST00000372458_chr1_43830465_-_1267nt GAGGTAGCAACAGCGAGCGTGCCGGTCGCTAGTCGCGGGTCCCCGAGTGAGCACGCCAGGGAGCAGGAGACCAAACGACGGGGGTCGGAG TCAGAGTCGCAGTGGGAGTCCCCGGACCGGAGCACGAGCCTGAGCGGGAGAGCGCCGCTCGCACGCCCGTCGCCACCCGCGTACCCGGCG CAGCCAGAGCCACCAGCGCAGCGCTGCCATGGAGCCCAGCAGCAAGATGGTTCGGGTGGCCTGGCTCTTCCTCTTCTCCAAGTTCATTGA GCTGATGGACACAGTGATCTTTATTCTCCGAAAGAAAGACGGGCAGGTGACCTTCCTACATGTCTTCCATCACTCTGTGCTTCCCTGGAG CTGGTGGTGGGGGGTAAAGATTGCCCCGGGAGGAATGGGCTCTTTCCATGCCATGATAAACTCTTCCGTGCATGTCATAATGTACCTGTA CTACGGATTATCTGCCTTTGGCCCTGTGGCACAACCCTACCTTTGGTGGAAAAAGCACATGACAGCCATTCAGCTGATCCAGTTTGTCCT GGTCTCACTGCACATCTCCCAGTACTACTTTATGTCCAGCTGTAACTACCAGTACCCAGTCATTATTCACCTCATCTGGATGTATGGCAC CATCTTCTTCATGCTGTTCTCCAACTTCTGGTATCACTCTTATACCAAGGGCAAGCGGCTGCCCCGTGCACTTCAGCAAAATGGAGCTCC AGGTATTGCCAAGGTCAAGGCCAACTGAGAAGCATGGCCTAGATAGGCGCCCACCTAAGTGCCTCAGGACTGCACCTTAGGGCAGTGTCC GTCAGTGCCCTCTCCACCTACACCTGTGACCAAGGCTTATGTGGTCAGGACTGAGCAGGGGACTGGCCCTCCCCTCCCCACAGCTGCTCT ACAGGGACCACGGCTTTGGTTCCTCACCCACTTCCCCCGGGCAGCTCCAGGGATGTGGCCTCATTGCTGTCTGCCACTCCAGAGCTGGGG GCTAAAAGGGCTGTACAGTTATTTCCCCCTCCCTGCCTTAAAACTTGGGAGAGGAGCACTCAGGGCTGGCCCCACAAAGGGTCTCGTGGC CTTTTTCCTCACACAGAAGAGGTCAGCAATAATGTCACTGTGGACCCAGTCTCACTCCTCCACCCCACACACTGAAGCAGTAGCTTCTGG GCCAAAGGTCAGGGTGGGCGGGGGCCTGGGAATACAGCCTGTGGAGGCTGCTTACTCAACTTGTGTCTTAATTAAAAGTGACAGAGGAAA >In-frame_SLC2A1_ENST00000372500_chr1_43424305_-_ELOVL1_ENST00000413844_chr1_43830465_-_1262nt GAGGTAGCAACAGCGAGCGTGCCGGTCGCTAGTCGCGGGTCCCCGAGTGAGCACGCCAGGGAGCAGGAGACCAAACGACGGGGGTCGGAG TCAGAGTCGCAGTGGGAGTCCCCGGACCGGAGCACGAGCCTGAGCGGGAGAGCGCCGCTCGCACGCCCGTCGCCACCCGCGTACCCGGCG CAGCCAGAGCCACCAGCGCAGCGCTGCCATGGAGCCCAGCAGCAAGATGGTTCGGGTGGCCTGGCTCTTCCTCTTCTCCAAGTTCATTGA GCTGATGGACACAGTGATCTTTATTCTCCGAAAGAAAGACGGGCAGGTGACCTTCCTACATGTCTTCCATCACTCTGTGCTTCCCTGGAG CTGGTGGTGGGGGGTAAAGATTGCCCCGGGAGGAATGGGCTCTTTCCATGCCATGATAAACTCTTCCGTGCATGTCATAATGTACCTGTA CTACGGATTATCTGCCTTTGGCCCTGTGGCACAACCCTACCTTTGGTGGAAAAAGCACATGACAGCCATTCAGCTGATCCAGTTTGTCCT GGTCTCACTGCACATCTCCCAGTACTACTTTATGTCCAGCTGTAACTACCAGTACCCAGTCATTATTCACCTCATCTGGATGTATGGCAC CATCTTCTTCATGCTGTTCTCCAACTTCTGGTATCACTCTTATACCAAGGGCAAGCGGCTGCCCCGTGCACTTCAGCAAAATGGAGCTCC AGGTATTGCCAAGGTCAAGGCCAACTGAGAAGCATGGCCTAGATAGGCGCCCACCTAAGTGCCTCAGGACTGCACCTTAGGGCAGTGTCC GTCAGTGCCCTCTCCACCTACACCTGTGACCAAGGCTTATGTGGTCAGGACTGAGCAGGGGACTGGCCCTCCCCTCCCCACAGCTGCTCT ACAGGGACCACGGCTTTGGTTCCTCACCCACTTCCCCCGGGCAGCTCCAGGGATGTGGCCTCATTGCTGTCTGCCACTCCAGAGCTGGGG GCTAAAAGGGCTGTACAGTTATTTCCCCCTCCCTGCCTTAAAACTTGGGAGAGGAGCACTCAGGGCTGGCCCCACAAAGGGTCTCGTGGC CTTTTTCCTCACACAGAAGAGGTCAGCAATAATGTCACTGTGGACCCAGTCTCACTCCTCCACCCCACACACTGAAGCAGTAGCTTCTGG GCCAAAGGTCAGGGTGGGCGGGGGCCTGGGAATACAGCCTGTGGAGGCTGCTTACTCAACTTGTGTCTTAATTAAAAGTGACAGAGGAAA |
Top |
FusionGenePPI for SLC2A1_ELOVL1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SLC2A1 | COPS6, PDIA3, STOM, PTK2B, CANX, CALR, GIPC1, CD55, VCAM1, ATF2, ITGA4, VHL, TXNIP, ILK, IRAK1, JAK2, TYK2, HSPB2, STK17B, NCSTN, NEIL3, TRIM25 | ELOVL1 | PSMD10, TWF2, GLP1R, CERS2, HSD17B12, TECR, MOV10, NXF1, TCTN3 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SLC2A1_ELOVL1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SLC2A1_ELOVL1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SLC2A1 | C1847501 | Glut1 Deficiency Syndrome | 14 | CTD_human;ORPHANET;UNIPROT |
Hgene | SLC2A1 | C1842534 | DYSTONIA 18 (disorder) | 11 | CTD_human;ORPHANET;UNIPROT |
Hgene | SLC2A1 | C3553859 | EPILEPSY, IDIOPATHIC GENERALIZED, SUSCEPTIBILITY TO, 12 | 4 | UNIPROT |
Hgene | SLC2A1 | C0008073 | Developmental Disabilities | 3 | CTD_human |
Hgene | SLC2A1 | C0036572 | Seizures | 3 | CTD_human;HPO |
Hgene | SLC2A1 | C0025958 | Microcephaly | 2 | CTD_human |
Hgene | SLC2A1 | C1837206 | Cryohydrocytosis, Stomatin-Deficient, with Mental Retardation, Seizures, Cataracts, and Massive Hepatosplenomegaly | 2 | ORPHANET;UNIPROT |
Hgene | SLC2A1 | C0004134 | Ataxia | 1 | CTD_human |
Hgene | SLC2A1 | C0007124 | Noninfiltrating Intraductal Carcinoma | 1 | CTD_human |
Hgene | SLC2A1 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Hgene | SLC2A1 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Hgene | SLC2A1 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Hgene | SLC2A1 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
Hgene | SLC2A1 | C0023903 | Liver neoplasms | 1 | CTD_human |
Hgene | SLC2A1 | C0025521 | Inborn Errors of Metabolism | 1 | CTD_human |
Hgene | SLC2A1 | C0027765 | nervous system disorder | 1 | CTD_human |
Hgene | SLC2A1 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Hgene | SLC2A1 | C0031149 | Peritoneal Neoplasms | 1 | CTD_human |
Hgene | SLC2A1 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Hgene | SLC2A1 | C0919267 | ovarian neoplasm | 1 | CTD_human |
Hgene | SLC2A1 | C1176475 | Ductal Carcinoma | 1 | CTD_human |
Hgene | SLC2A1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Hgene | SLC2A1 | C2239176 | Liver carcinoma | 1 | CTD_human |
Hgene | SLC2A1 | C3714756 | Intellectual Disability | 1 | CTD_human;HPO |