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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 34294

FusionGeneSummary for SLC2A12_SGK1

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC2A12_SGK1
Fusion gene ID: 34294
HgeneTgene
Gene symbol

SLC2A12

SGK1

Gene ID

154091

6446

Gene namesolute carrier family 2 member 12serum/glucocorticoid regulated kinase 1
SynonymsGLUT12|GLUT8SGK
Cytomap

6q23.2

6q23.2

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 2, facilitated glucose transporter member 12GLUT-12glucose transporter type 12solute carrier family 2 (facilitated glucose transporter), member 12serine/threonine-protein kinase Sgk1Sgk1 variant i3serine/threonine protein kinase SGK
Modification date2018052320180523
UniProtAcc

Q8TD20

O00141

Ensembl transtripts involved in fusion geneENST00000275230, ENST00000367858, 
ENST00000524929, ENST00000413996, 
ENST00000237305, ENST00000367857, 
ENST00000528577, ENST00000475719, 
ENST00000489458, 
Fusion gene scores* DoF score3 X 3 X 4=367 X 7 X 5=245
# samples 49
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/245*10)=-1.4447848426729
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC2A12 [Title/Abstract] AND SGK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-BA-4078-01ASLC2A12chr6

134373516

-SGK1chr6

134583286

-
TCGARVUCECTCGA-BK-A139-01ASLC2A12chr6

134349519

-SGK1chr6

134583286

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000275230ENST00000367858SLC2A12chr6

134373516

-SGK1chr6

134583286

-
Frame-shiftENST00000275230ENST00000524929SLC2A12chr6

134373516

-SGK1chr6

134583286

-
5CDS-intronENST00000275230ENST00000413996SLC2A12chr6

134373516

-SGK1chr6

134583286

-
5CDS-intronENST00000275230ENST00000237305SLC2A12chr6

134373516

-SGK1chr6

134583286

-
5CDS-intronENST00000275230ENST00000367857SLC2A12chr6

134373516

-SGK1chr6

134583286

-
5CDS-intronENST00000275230ENST00000528577SLC2A12chr6

134373516

-SGK1chr6

134583286

-
5CDS-intronENST00000275230ENST00000475719SLC2A12chr6

134373516

-SGK1chr6

134583286

-
5CDS-intronENST00000275230ENST00000489458SLC2A12chr6

134373516

-SGK1chr6

134583286

-
Frame-shiftENST00000275230ENST00000367858SLC2A12chr6

134349519

-SGK1chr6

134583286

-
In-frameENST00000275230ENST00000524929SLC2A12chr6

134349519

-SGK1chr6

134583286

-
5CDS-intronENST00000275230ENST00000413996SLC2A12chr6

134349519

-SGK1chr6

134583286

-
5CDS-intronENST00000275230ENST00000237305SLC2A12chr6

134349519

-SGK1chr6

134583286

-
5CDS-intronENST00000275230ENST00000367857SLC2A12chr6

134349519

-SGK1chr6

134583286

-
5CDS-intronENST00000275230ENST00000528577SLC2A12chr6

134349519

-SGK1chr6

134583286

-
5CDS-intronENST00000275230ENST00000475719SLC2A12chr6

134349519

-SGK1chr6

134583286

-
5CDS-intronENST00000275230ENST00000489458SLC2A12chr6

134349519

-SGK1chr6

134583286

-

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FusionProtFeatures for SLC2A12_SGK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC2A12

Q8TD20

SGK1

O00141

Facilitative glucose transporter. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSGK1chr6:134373516chr6:134583286ENST00000237305-012131_141-30432Compositional biasNote=Glu/Lys-rich
TgeneSGK1chr6:134373516chr6:134583286ENST00000367857-011131_141-78422Compositional biasNote=Glu/Lys-rich
TgeneSGK1chr6:134373516chr6:134583286ENST00000367858-014131_14123527Compositional biasNote=Glu/Lys-rich
TgeneSGK1chr6:134373516chr6:134583286ENST00000413996-012131_141-110446Compositional biasNote=Glu/Lys-rich
TgeneSGK1chr6:134373516chr6:134583286ENST00000528577-012131_141-28460Compositional biasNote=Glu/Lys-rich
TgeneSGK1chr6:134373516chr6:134583286ENST00000237305-012356_431-30432DomainNote=AGC-kinase C-terminal
TgeneSGK1chr6:134373516chr6:134583286ENST00000237305-01298_355-30432DomainProtein kinase
TgeneSGK1chr6:134373516chr6:134583286ENST00000367857-011356_431-78422DomainNote=AGC-kinase C-terminal
TgeneSGK1chr6:134373516chr6:134583286ENST00000367857-01198_355-78422DomainProtein kinase
TgeneSGK1chr6:134373516chr6:134583286ENST00000367858-014356_43123527DomainNote=AGC-kinase C-terminal
TgeneSGK1chr6:134373516chr6:134583286ENST00000367858-01498_35523527DomainProtein kinase
TgeneSGK1chr6:134373516chr6:134583286ENST00000413996-012356_431-110446DomainNote=AGC-kinase C-terminal
TgeneSGK1chr6:134373516chr6:134583286ENST00000413996-01298_355-110446DomainProtein kinase
TgeneSGK1chr6:134373516chr6:134583286ENST00000528577-012356_431-28460DomainNote=AGC-kinase C-terminal
TgeneSGK1chr6:134373516chr6:134583286ENST00000528577-01298_355-28460DomainProtein kinase
TgeneSGK1chr6:134373516chr6:134583286ENST00000237305-012104_112-30432Nucleotide bindingNote=ATP
TgeneSGK1chr6:134373516chr6:134583286ENST00000367857-011104_112-78422Nucleotide bindingNote=ATP
TgeneSGK1chr6:134373516chr6:134583286ENST00000367858-014104_11223527Nucleotide bindingNote=ATP
TgeneSGK1chr6:134373516chr6:134583286ENST00000413996-012104_112-110446Nucleotide bindingNote=ATP
TgeneSGK1chr6:134373516chr6:134583286ENST00000528577-012104_112-28460Nucleotide bindingNote=ATP
TgeneSGK1chr6:134373516chr6:134583286ENST00000237305-0121_60-30432RegionNote=Necessary for localization to the mitochondria
TgeneSGK1chr6:134373516chr6:134583286ENST00000367857-0111_60-78422RegionNote=Necessary for localization to the mitochondria
TgeneSGK1chr6:134373516chr6:134583286ENST00000413996-0121_60-110446RegionNote=Necessary for localization to the mitochondria
TgeneSGK1chr6:134373516chr6:134583286ENST00000528577-0121_60-28460RegionNote=Necessary for localization to the mitochondria

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-15102_11534618Topological domainCytoplasmic
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-15137_13734618Topological domainExtracellular
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-15159_17234618Topological domainCytoplasmic
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-15194_19734618Topological domainExtracellular
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-151_4434618Topological domainCytoplasmic
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-15219_27834618Topological domainCytoplasmic
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-15300_31734618Topological domainExtracellular
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-15339_34534618Topological domainCytoplasmic
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-15367_46634618Topological domainExtracellular
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-15488_49834618Topological domainCytoplasmic
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-15520_52834618Topological domainExtracellular
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-15550_61734618Topological domainCytoplasmic
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-1566_8034618Topological domainExtracellular
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-15116_13634618TransmembraneHelical
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-15138_15834618TransmembraneHelical
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-15173_19334618TransmembraneHelical
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-15198_21834618TransmembraneHelical
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-15279_29934618TransmembraneHelical
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-15318_33834618TransmembraneHelical
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-15346_36634618TransmembraneHelical
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-1545_6534618TransmembraneHelical
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-15467_48734618TransmembraneHelical
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-15499_51934618TransmembraneHelical
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-15529_54934618TransmembraneHelical
HgeneSLC2A12chr6:134373516chr6:134583286ENST00000275230-1581_10134618TransmembraneHelical
TgeneSGK1chr6:134373516chr6:134583286ENST00000367858-0141_6023527RegionNote=Necessary for localization to the mitochondria


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FusionGeneSequence for SLC2A12_SGK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SLC2A12_ENST00000275230_chr6_134373516_-_SGK1_ENST00000367858_chr6_134583286_-_538aa
MVPVENTEGPSLLNQKGTAVETEGSGSRHPPWARGTKVDQEPNGQCGQASESQPEVHRLLHGAHPSRGARLRVFLVSNMPGXTCFPKRGS
PSGERVMFMGNSIWVXSERAMXSCQHPDQARSKNLLDXXXSSFHEAEEDGSERLYSEDCQXLLCMQTPXSSVHLEDLPTSGAXAYECQPF
SSTKSFSANQPWPVVQSSCXTIXLSLLESDRKGQFWKGSSSKTQGRRSVLCSQSFTEESNPEKERGEAYYVGAECSVEECEAPFPGGPSL
LFPDCXQIVLCPRLHXWWRVVLPSPEGTLLPGTTGSFLCCXNSQCLGLPAFTEHRLXRLKTREYFARFTGTHCPYXLRTLQGEHXTQQHN
IHLLWHAGVSRTXGASXAALXQDCGLVVPGSCLVXDAVWPAAFLXPKHSXNVRQHSEQASPAETKYYKFRKTPPGGPPAEGQDKAARGQG

>In-frame_SLC2A12_ENST00000275230_chr6_134349519_-_SGK1_ENST00000524929_chr6_134583286_-_612aa
MVPVENTEGPSLLNQKGTAVETEGSGSRHPPWARGCGMFTFLSSVTAAVSGLLVGYELGIISGALLQIKTLLALSCHEQEMVVSSLVIGA
LLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGIL
SAYISNYAFANVFHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEGAASKVLGRLRALSDTTEELTVIKSSLKDEYQYSFWDLFR
SKDNMRTRIMIGLTLVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCIGSSVMAASLVT
MGIVNLNIHMNFTHICRSHNSINQSLDESVIYGPGNLSTNNNTLRDHFKGISSHSRSSLMPLRNDVDKRGETTSASLLNAGLSHTEYQIV
TDPGDVPAFLKWLSLASLLVYVAAFSIGLGPSTKVDQEPNGQCGQASESQPEVHRLLHGAHPSRGARLRVFLVSNMPGXTCFPKRGSPSG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SLC2A12_ENST00000275230_chr6_134373516_-_SGK1_ENST00000367858_chr6_134583286_-_1615nt
ATGGTACCTGTTGAAAACACCGAGGGCCCCAGTCTGCTGAACCAGAAGGGGACAGCCGTGGAGACGGAGGGCAGCGGCAGCCGGCATCCT
CCCTGGGCGAGAGGTACGAAGGTGGATCAAGAGCCCAATGGTCAGTGTGGACAAGCATCAGAGTCCCAGCCTGAAGTACACCGGCTCCTC
CATGGTGCACATCCCTCCAGGGGAGCCAGACTTCGAGTCTTCCTTGTGTCAAACATGCCTGGGTGAACATGCTTTCCAAAGAGGGGTTCT
CCCTCAGGAGAACGAGTCATGTTCATGGGAAACTCAATCTGGGTGTGAAGTGAGAGAGCCATGTAATCATGCCAACATCCTGACCAAGCC
CGATCCAAGAACCTTCTGGACTAATGATGATCCAGCTTTCATGAAGCAGAGGAGGATGGGTCTGAACGACTTTATTCAGAAGATTGCCAA
TAACTCCTATGCATGCAAACACCCTGAAGTTCAGTCCATCTTGAAGATCTCCCAACCTCAGGAGCCTGAGCTTATGAATGCCAACCCTTC
TCCTCCACCAAGTCCTTCTCAGCAAATCAACCTTGGCCCGTCGTCCAATCCTCATGCTAAACCATCTGACTTTCACTTCTTGAAAGTGAT
CGGAAAGGGCAGTTTTGGAAAGGTTCTTCTAGCAAGACACAAGGCAGAAGAAGTGTTCTATGCAGTCAAAGTTTTACAGAAGAAAGCAAT
CCTGAAAAAGAAAGAGGAGAAGCATATTATGTCGGAGCGGAATGTTCTGTTGAAGAATGTGAAGCACCCTTTCCTGGTGGGCCTTCACTT
CTCTTTCCAGACTGCTGACAAATTGTACTTTGTCCTAGACTACATTAATGGTGGAGAGTTGTTCTACCATCTCCAGAGGGAACGCTGCTT
CCTGGAACCACGGGCTCGTTTCTATGCTGCTGAAATAGCCAGTGCCTTGGGCTACCTGCATTCACTGAACATCGTTTATAGAGACTTAAA
ACCAGAGAATATTTTGCTAGATTCACAGGGACACATTGTCCTTACTGACTTCGGACTCTGCAAGGAGAACATTGAACACAACAGCACAAC
ATCCACCTTCTGTGGCACGCCGGAGTATCTCGCACCTGAGGTGCTTCATAAGCAGCCTTATGACAGGACTGTGGACTGGTGGTGCCTGGG
AGCTGTCTTGTATGAGATGCTGTATGGCCTGCCGCCTTTTTATAGCCGAAACACAGCTGAAATGTACGACAACATTCTGAACAAGCCTCT
CCAGCTGAAACCAAATATTACAAATTCCGCAAGACACCTCCTGGAGGGCCTCCTGCAGAAGGACAGGACAAAGCGGCTCGGGGCCAAGGA
TGACTTCATGGAGATTAAGAGTCATGTCTTCTTCTCCTTAATTAACTGGGATGATCTCATTAATAAGAAGATTACTCCCCCTTTTAACCC
AAATGTGAGTGGGCCCAACGACCTACGGCACTTTGACCCCGAGTTTACCGAAGAGCCTGTCCCCAACTCCATTGGCAAGTCCCCTGACAG

>In-frame_SLC2A12_ENST00000275230_chr6_134349519_-_SGK1_ENST00000524929_chr6_134583286_-_1837nt
ATGGTACCTGTTGAAAACACCGAGGGCCCCAGTCTGCTGAACCAGAAGGGGACAGCCGTGGAGACGGAGGGCAGCGGCAGCCGGCATCCT
CCCTGGGCGAGAGGCTGCGGCATGTTTACCTTCCTGTCATCTGTCACTGCTGCTGTCAGTGGCCTCCTGGTGGGTTATGAACTTGGGATC
ATCTCTGGGGCTCTTCTTCAGATCAAAACCTTATTAGCCCTGAGCTGCCATGAGCAGGAAATGGTTGTGAGCTCCCTCGTCATTGGAGCC
CTCCTTGCCTCACTCACCGGAGGGGTCCTGATAGACAGATATGGAAGAAGGACAGCAATCATCTTGTCATCCTGCCTGCTTGGACTCGGA
AGCTTAGTCTTGATCCTCAGTTTATCCTACACGGTTCTTATAGTGGGACGCATTGCCATAGGGGTCTCCATCTCCCTCTCTTCCATTGCC
ACTTGTGTTTACATCGCAGAGATTGCTCCTCAACACAGAAGAGGCCTTCTTGTGTCACTGAATGAGCTGATGATTGTCATCGGCATTCTT
TCTGCCTATATTTCAAATTACGCATTTGCCAATGTTTTCCATGGCTGGAAGTACATGTTTGGTCTTGTGATTCCCTTGGGAGTTTTGCAA
GCAATTGCAATGTATTTTCTTCCTCCAAGCCCTCGGTTTCTGGTGATGAAAGGACAAGAGGGAGCTGCTAGCAAGGTTCTTGGAAGGTTA
AGAGCACTCTCAGATACAACTGAGGAACTCACTGTGATCAAATCCTCCCTGAAAGATGAATATCAGTACAGTTTTTGGGATCTGTTTCGT
TCAAAAGACAACATGCGGACCCGAATAATGATAGGACTAACACTAGTATTTTTTGTACAAATCACTGGCCAACCAAACATATTGTTCTAT
GCATCAACTGTTTTGAAGTCAGTTGGATTTCAAAGCAATGAGGCAGCTAGCCTCGCCTCCACTGGGGTTGGAGTCGTCAAGGTCATTAGC
ACCATCCCTGCCACTCTTCTTGTAGACCATGTCGGCAGCAAAACATTCCTCTGCATTGGCTCCTCTGTGATGGCAGCTTCGTTGGTGACC
ATGGGCATCGTAAATCTCAACATCCACATGAACTTCACCCATATCTGCAGAAGCCACAATTCTATCAACCAGTCCTTGGATGAGTCTGTG
ATTTATGGACCAGGAAACCTGTCAACCAACAACAATACTCTCAGAGACCACTTCAAAGGGATTTCTTCCCATAGCAGAAGCTCACTCATG
CCCCTGAGAAATGATGTGGATAAGAGAGGGGAGACGACCTCAGCATCCTTGCTAAATGCTGGATTAAGCCACACTGAATACCAGATAGTC
ACAGACCCTGGGGACGTCCCAGCTTTTTTGAAATGGCTGTCCTTAGCCAGCTTGCTTGTTTATGTTGCTGCTTTTTCAATTGGTCTAGGA
CCAAGTACGAAGGTGGATCAAGAGCCCAATGGTCAGTGTGGACAAGCATCAGAGTCCCAGCCTGAAGTACACCGGCTCCTCCATGGTGCA
CATCCCTCCAGGGGAGCCAGACTTCGAGTCTTCCTTGTGTCAAACATGCCTGGGTGAACATGCTTTCCAAAGAGGGGTTCTCCCTCAGGA
GAACGAGTCATGTTCATGGGAAACTCAATCTGGGTGTGAAGTAAGTTCATGTTCGCTCTGGATCTATTCTCCTGGAAAAATTCTGGGCCT
TTGTTTTTCTTGTATTTCTGCCAGAGTATACCCAAAAAATAATTTTTTAATGCATATTTATAAAGCTTCTGAGGAAGACCTAGAATTGTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_SLC2A12_ENST00000275230_chr6_134373516_-_SGK1_ENST00000367858_chr6_134583286_-_2793nt
AGAAACAAAGTTGGTCACAAATCACATTAGCTTTGCCCGAAGTTTTTCCCCACACTCTTCTTTAGCATGCTATTATGGGGAAAGTGACCA
CTCCTGGGAGCGGGGGTGGTCGGGGCGGTTTGGTGGCGGGGAAGCGGCTGTAACTTCTACGTGACCATGGTACCTGTTGAAAACACCGAG
GGCCCCAGTCTGCTGAACCAGAAGGGGACAGCCGTGGAGACGGAGGGCAGCGGCAGCCGGCATCCTCCCTGGGCGAGAGGTACGAAGGTG
GATCAAGAGCCCAATGGTCAGTGTGGACAAGCATCAGAGTCCCAGCCTGAAGTACACCGGCTCCTCCATGGTGCACATCCCTCCAGGGGA
GCCAGACTTCGAGTCTTCCTTGTGTCAAACATGCCTGGGTGAACATGCTTTCCAAAGAGGGGTTCTCCCTCAGGAGAACGAGTCATGTTC
ATGGGAAACTCAATCTGGGTGTGAAGTGAGAGAGCCATGTAATCATGCCAACATCCTGACCAAGCCCGATCCAAGAACCTTCTGGACTAA
TGATGATCCAGCTTTCATGAAGCAGAGGAGGATGGGTCTGAACGACTTTATTCAGAAGATTGCCAATAACTCCTATGCATGCAAACACCC
TGAAGTTCAGTCCATCTTGAAGATCTCCCAACCTCAGGAGCCTGAGCTTATGAATGCCAACCCTTCTCCTCCACCAAGTCCTTCTCAGCA
AATCAACCTTGGCCCGTCGTCCAATCCTCATGCTAAACCATCTGACTTTCACTTCTTGAAAGTGATCGGAAAGGGCAGTTTTGGAAAGGT
TCTTCTAGCAAGACACAAGGCAGAAGAAGTGTTCTATGCAGTCAAAGTTTTACAGAAGAAAGCAATCCTGAAAAAGAAAGAGGAGAAGCA
TATTATGTCGGAGCGGAATGTTCTGTTGAAGAATGTGAAGCACCCTTTCCTGGTGGGCCTTCACTTCTCTTTCCAGACTGCTGACAAATT
GTACTTTGTCCTAGACTACATTAATGGTGGAGAGTTGTTCTACCATCTCCAGAGGGAACGCTGCTTCCTGGAACCACGGGCTCGTTTCTA
TGCTGCTGAAATAGCCAGTGCCTTGGGCTACCTGCATTCACTGAACATCGTTTATAGAGACTTAAAACCAGAGAATATTTTGCTAGATTC
ACAGGGACACATTGTCCTTACTGACTTCGGACTCTGCAAGGAGAACATTGAACACAACAGCACAACATCCACCTTCTGTGGCACGCCGGA
GTATCTCGCACCTGAGGTGCTTCATAAGCAGCCTTATGACAGGACTGTGGACTGGTGGTGCCTGGGAGCTGTCTTGTATGAGATGCTGTA
TGGCCTGCCGCCTTTTTATAGCCGAAACACAGCTGAAATGTACGACAACATTCTGAACAAGCCTCTCCAGCTGAAACCAAATATTACAAA
TTCCGCAAGACACCTCCTGGAGGGCCTCCTGCAGAAGGACAGGACAAAGCGGCTCGGGGCCAAGGATGACTTCATGGAGATTAAGAGTCA
TGTCTTCTTCTCCTTAATTAACTGGGATGATCTCATTAATAAGAAGATTACTCCCCCTTTTAACCCAAATGTGAGTGGGCCCAACGACCT
ACGGCACTTTGACCCCGAGTTTACCGAAGAGCCTGTCCCCAACTCCATTGGCAAGTCCCCTGACAGCGTCCTCGTCACAGCCAGCGTCAA
GGAAGCTGCCGAGGCTTTCCTAGGCTTTTCCTATGCGCCTCCCACGGACTCTTTCCTCTGAACCCTGTTAGGGCTTGGTTTTAAAGGATT
TTATGTGTGTTTCCGAATGTTTTAGTTAGCCTTTTGGTGGAGCCGCCAGCTGACAGGACATCTTACAAGAGAATTTGCACATCTCTGGAA
GCTTAGCAATCTTATTGCACACTGTTCGCTGGAAGCTTTTTGAAGAGCACATTCTCCTCAGTGAGCTCATGAGGTTTTCATTTTTATTCT
TCCTTCCAACGTGGTGCTATCTCTGAAACGAGCGTTAGAGTGCCGCCTTAGACGGAGGCAGGAGTTTCGTTAGAAAGCGGACGCTGTTCT
AAAAAAGGTCTCCTGCAGATCTGTCTGGGCTGTGATGACGAATATTATGAAATGTGCCTTTTCTGAAGAGATTGTGTTAGCTCCAAAGCT
TTTCCTATCGCAGTGTTTCAGTTCTTTATTTTCCCTTGTGGATATGCTGTGTGAACCGTCGTGTGAGTGTGGTATGCCTGATCACAGATG
GATTTTGTTATAAGCATCAATGTGACACTTGCAGGACACTACAACGTGGGACATTGTTTGTTTCTTCCATATTTGGAAGATAAATTTATG
TGTAGACTTTTTTGTAAGATACGGTTAATAACTAAAATTTATTGAAATGGTCTTGCAATGACTCGTATTCAGATGCTTAAAGAAAGCATT
GCTGCTACAAATATTTCTATTTTTAGAAAGGGTTTTTATGGACCAATGCCCCAGTTGTCAGTCAGAGCCGTTGGTGTTTTTCATTGTTTA
AAATGTCACCTGTAAAATGGGCATTATTTATGTTTTTTTTTTTGCATTCCTGATAATTGTATGTATTGTATAAAGAACGTCTGTACATTG
GGTTATAACACTAGTATATTTAAACTTACAGGCTTATTTGTAATGTAAACCACCATTTTAATGTACTGTAATTAACATGGTTATAATACG
TACAATCCTTCCCTCATCCCATCACACAACTTTTTTTGTGTGTGATAAACTGATTTTGGTTTGCAATAAAACCTTGAAAAATATTTACAT

>In-frame_SLC2A12_ENST00000275230_chr6_134349519_-_SGK1_ENST00000524929_chr6_134583286_-_3956nt
AGAAACAAAGTTGGTCACAAATCACATTAGCTTTGCCCGAAGTTTTTCCCCACACTCTTCTTTAGCATGCTATTATGGGGAAAGTGACCA
CTCCTGGGAGCGGGGGTGGTCGGGGCGGTTTGGTGGCGGGGAAGCGGCTGTAACTTCTACGTGACCATGGTACCTGTTGAAAACACCGAG
GGCCCCAGTCTGCTGAACCAGAAGGGGACAGCCGTGGAGACGGAGGGCAGCGGCAGCCGGCATCCTCCCTGGGCGAGAGGCTGCGGCATG
TTTACCTTCCTGTCATCTGTCACTGCTGCTGTCAGTGGCCTCCTGGTGGGTTATGAACTTGGGATCATCTCTGGGGCTCTTCTTCAGATC
AAAACCTTATTAGCCCTGAGCTGCCATGAGCAGGAAATGGTTGTGAGCTCCCTCGTCATTGGAGCCCTCCTTGCCTCACTCACCGGAGGG
GTCCTGATAGACAGATATGGAAGAAGGACAGCAATCATCTTGTCATCCTGCCTGCTTGGACTCGGAAGCTTAGTCTTGATCCTCAGTTTA
TCCTACACGGTTCTTATAGTGGGACGCATTGCCATAGGGGTCTCCATCTCCCTCTCTTCCATTGCCACTTGTGTTTACATCGCAGAGATT
GCTCCTCAACACAGAAGAGGCCTTCTTGTGTCACTGAATGAGCTGATGATTGTCATCGGCATTCTTTCTGCCTATATTTCAAATTACGCA
TTTGCCAATGTTTTCCATGGCTGGAAGTACATGTTTGGTCTTGTGATTCCCTTGGGAGTTTTGCAAGCAATTGCAATGTATTTTCTTCCT
CCAAGCCCTCGGTTTCTGGTGATGAAAGGACAAGAGGGAGCTGCTAGCAAGGTTCTTGGAAGGTTAAGAGCACTCTCAGATACAACTGAG
GAACTCACTGTGATCAAATCCTCCCTGAAAGATGAATATCAGTACAGTTTTTGGGATCTGTTTCGTTCAAAAGACAACATGCGGACCCGA
ATAATGATAGGACTAACACTAGTATTTTTTGTACAAATCACTGGCCAACCAAACATATTGTTCTATGCATCAACTGTTTTGAAGTCAGTT
GGATTTCAAAGCAATGAGGCAGCTAGCCTCGCCTCCACTGGGGTTGGAGTCGTCAAGGTCATTAGCACCATCCCTGCCACTCTTCTTGTA
GACCATGTCGGCAGCAAAACATTCCTCTGCATTGGCTCCTCTGTGATGGCAGCTTCGTTGGTGACCATGGGCATCGTAAATCTCAACATC
CACATGAACTTCACCCATATCTGCAGAAGCCACAATTCTATCAACCAGTCCTTGGATGAGTCTGTGATTTATGGACCAGGAAACCTGTCA
ACCAACAACAATACTCTCAGAGACCACTTCAAAGGGATTTCTTCCCATAGCAGAAGCTCACTCATGCCCCTGAGAAATGATGTGGATAAG
AGAGGGGAGACGACCTCAGCATCCTTGCTAAATGCTGGATTAAGCCACACTGAATACCAGATAGTCACAGACCCTGGGGACGTCCCAGCT
TTTTTGAAATGGCTGTCCTTAGCCAGCTTGCTTGTTTATGTTGCTGCTTTTTCAATTGGTCTAGGACCAAGTACGAAGGTGGATCAAGAG
CCCAATGGTCAGTGTGGACAAGCATCAGAGTCCCAGCCTGAAGTACACCGGCTCCTCCATGGTGCACATCCCTCCAGGGGAGCCAGACTT
CGAGTCTTCCTTGTGTCAAACATGCCTGGGTGAACATGCTTTCCAAAGAGGGGTTCTCCCTCAGGAGAACGAGTCATGTTCATGGGAAAC
TCAATCTGGGTGTGAAGTAAGTTCATGTTCGCTCTGGATCTATTCTCCTGGAAAAATTCTGGGCCTTTGTTTTTCTTGTATTTCTGCCAG
AGTATACCCAAAAAATAATTTTTTAATGCATATTTATAAAGCTTCTGAGGAAGACCTAGAATTGTGGTCTTTGTTAGCTCATTATGTTAT
TTTTTTAAAGTAGGCTTTATATTTTAGAGCAGCTTTAAGTTCACAGCAACATTGAGCAGAAGGTACAGAGATTACCCATATACGCTTGTC
CCCATGCACGTATAACCTACTTTGCCATCAACATTCCCTAGCAGAGTTTTATGTTAGAGTTCACTCTTGGTGTTATACATTCTATGGGTT
TGGACTAATGTATAATAACATGCATCCACCATTACAGTATCATACAGTTAAGTTTCACTGCCCTAAAAATCCTCTGCCCTCCACTATTCA
TCCCCTCCTTACCCTGACCCCTAGCAACCACTGATCTTTTTACTGTCTCCATAGATTTGCCTTTTCCAGAATGTCATCTAGCTGAATCAT
GCAGTATGTTGTATTAATGTTTTACGTGGGTCCAAGACTGATACAGCAATGTGTTGGTAAACTGGCAATTCCTCAGAAGTGGTTTGATCA
CACAGGAGATCAAGTCTTAGATGATACAACGATTGTAATAGTCATCTACATGTTCGTAGCTTCCATTGAAATATTTAGTTCAACACGATT
TGATCCATTTACAGAGCACTATGTATACTTTTCATTATTTTTCTCAAGCTCATATATACTCACATTTTTACTAAGACTTATTTTCCCTGC
TACTCCAAGAGTTGTTTTTTAAAAATTTTGTTAATCCAAGAAAACCAGATAACTGATTCATCTTGCAGTTTCTAAGATTTCAAAAATTTA
AGATTATATTTTTAACTTATAACTTAATTAGGCCCATATTTATTTTGATTTTTAAAACCATTATATAAAATGCTTATATTATTTTTACCA
TCATACTGACATAAAAATACAATATTTAGAAGACAGAACATGTTATTACAAAGTACAGTTAATTGTAAGTGATCTTCCAAGTCAGTGCAT
CATAGAATGATAAACGTTAATAACCGCTCACCTTTTTTATTTTTAGCAAGGTAACCATTTTCCAGAGATAAAATAATCATTTAGCTGCTA
AAAGACTGAAGACATTAAATCTGAGTTCCTTTTCACTCTGAGTTATCACGCAATGTCGCTGAATCTGTTTCATAATTTGTCTACTTTCTT
TCTTTCTTTTTTTTTTTTTTTTGAGTTTCACTCTTGTTGCCCAGACTGGAGTGCAATGGCACGATCTCGGCTCACTGCAACCTCCGCTTC
CTGAGTTCAAGTAATTCTTCTGCCTCAGTCTCCCGAGTAGCTGGGATTACAGGCACCCAACACCACGCCTGGCTAATTTTTGTATTTTTA
ATAGAAACAGGGTTTCTCTATGTTGGTCAGGCTGGTGTCAAACTCCCAACCTCAGGTAATCCACCTGCGTCGGCTTTCCAAATTGCTGGG
ATTACAGGCATGAGCCACTACGCCGGCCCTTTTTTTGGGGGGGGTGGGGGTCGGGGACAGGGAGACAGGGGGACAGAGTCTTGCTCTGTA
ACCCTGACTTGAGTGCAGTAGTGCAATCATAACTCACTGTTACCTCAAACTCCTAGGTTCAAGTGATCCTCCCACCTCAACCCTCCCAAG
TAAATAAGACCACAGGCATACGCCAACAAACCTGGCTAATTAAAAAAAAAAAATTTTTTTTGTAGAAACAGGGTGTTGTCATACTGACCA
GGCTGGTCTTGAACTCCTGGCTTCAAGTGATCCTCCCAAAATGCTGGGATTATAGGTATGAGGCACAATGCCCAGCCTACTTGTCTACTT
TCTACGGTTATTGGAAAAATCAAATGAGATTGATATGAAATGTTTCATAATCTATAGAATGCCATGCAAATATAAATCATTATTGCTCAT
GTTTGCTGATTTACATATTAGCTAAGCCTGTGACTCTGTAACACTATATTAGACTTCCATAACTGGGTTAGCACTTTGCTGATCCATGAA


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FusionGenePPI for SLC2A12_SGK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC2A12TP53, TMEM242, TAMM41, MTFR2, ORMDL2, SLC25A23, SLC25A28, SLC25A51, TSPO, PIGW, SLC19A2, ABHD17B, METTL15, PEX16, SELT, SPPL3, PTPLB, ABCB8, SFXN5, SLC25A24, TMEM11, C4orf29, EFR3A, ATL2, ALG8, ATL3, NSUN3, ASMTL, ADCK4, DNAJC19, NR2F2, SERINC1, TTK, MTX1, CYBA, DNM3, KIRREL, GK, SMAP2, PDXDC1, RER1, GHITM, TARBP1, HOXD13, ACAD10, GNL1, FITM2, CHST11, SPG7, EBP, DOLK, BCS1L, PTPMT1, ORMDL3, WDFY3, TM2D3SGK1CDC37, LTF, TUFM, CD40, VCP, IGHA1, IARS, PA2G4, PIGR, FANCA, NEDD4, KPNA2, CAMKK2, MAPK7, SLC9A3R2, PDPK1, CARHSP1, PIK3CA, PPP2CA, MLLT3, IKBKG, PDK1, RICTOR, SYVN1, STUB1, TSC22D3, RAF1, COMMD1, SCNN1B, ELAVL1, HSPA4, NEDD4L, WNK4, WNK1, WNK2, MAPT, UBC, HSP90AA1, MAGEA1, GADD45G, TMEM184C, RABAC1, YWHAZ, YWHAQ, MTOR, RPTOR, AKT1S1, CDKN1B, NDRG1, SGK1, ARL5B, MYH14, FKBP5, RAP2A, PCCA, PIN1, ASPG, HRAS, MAPKAP1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC2A12_SGK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC2A12_SGK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSGK1C0011882Diabetic Neuropathies1CTD_human
TgeneSGK1C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneSGK1C0024667Animal Mammary Neoplasms1CTD_human
TgeneSGK1C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneSGK1C0041696Unipolar Depression1PSYGENET
TgeneSGK1C0041948Uremia1CTD_human
TgeneSGK1C1269683Major Depressive Disorder1PSYGENET